SAbDab: the structural antibody database | Nucleic Acids Research
... are aligned to antibody sequence profiles using MUSCLE (19). A chain must have a sequence identity of <35% to any antibody sequence profile for it to be considered a potential antigen. Those that exceed this threshold are flagged for manual inspection. In addition, any structure whose header details co ...
... are aligned to antibody sequence profiles using MUSCLE (19). A chain must have a sequence identity of <35% to any antibody sequence profile for it to be considered a potential antigen. Those that exceed this threshold are flagged for manual inspection. In addition, any structure whose header details co ...
Gene Section ABL (v-abl Abelson murine leukemia viral oncogene homolog 1)
... mRNA of 6 and 7 kb (with 1a and 1b respectively), giving rise to 2 proteins of 145 kDa. ...
... mRNA of 6 and 7 kb (with 1a and 1b respectively), giving rise to 2 proteins of 145 kDa. ...
Metabolic Abnormalities in the Burn Patient, part 1 of 2
... Catabolism: Destructive Metabolism: protein breakdown producing tissue degradation. ...
... Catabolism: Destructive Metabolism: protein breakdown producing tissue degradation. ...
Advances in Natural and Applied Sciences Aedes aegypti Aulanni’am
... endemic area. Protein profile from Salivary Glands (SG) of Ae. aegypti was observed by 12% SDS-PAGE from lab. scale cultures and from landing populations. Identification of immunogenic proteins from both sample was carried out by using Western Blot Analysis after cross reaction of Salivary Gland Ext ...
... endemic area. Protein profile from Salivary Glands (SG) of Ae. aegypti was observed by 12% SDS-PAGE from lab. scale cultures and from landing populations. Identification of immunogenic proteins from both sample was carried out by using Western Blot Analysis after cross reaction of Salivary Gland Ext ...
Coarse-Grained Modeling of ProteinDynamics
... 2010; Best and Hummer 2008). Despite their simplicity, in many cases they correctly capture unfolding pathways, FEL and mechanical stability of proteins. For example, a complete description of mechanical unfolding pathways of single and multidomain Ubiquitin at the level of secondary structure was o ...
... 2010; Best and Hummer 2008). Despite their simplicity, in many cases they correctly capture unfolding pathways, FEL and mechanical stability of proteins. For example, a complete description of mechanical unfolding pathways of single and multidomain Ubiquitin at the level of secondary structure was o ...
KASH `n Karry: The KASH domain family of cargo
... within a polarized cell are essential processes for the development of nearly all eukaryotes (for review see Refs. 1–3). Our story begins with a group of Drosophila and C. elegans mutants with mispositioned nuclei (Fig. 1). As described below, molecular characterization of these mutants has identifi ...
... within a polarized cell are essential processes for the development of nearly all eukaryotes (for review see Refs. 1–3). Our story begins with a group of Drosophila and C. elegans mutants with mispositioned nuclei (Fig. 1). As described below, molecular characterization of these mutants has identifi ...
Hemoglobin
... lowest oxygen tensions found in very active tissues the binding affinity of hemoglobin for oxygen is very low allowing maximal delivery of oxygen to the tissue. In contrast the oxygen binding curve for myoglobin is hyperbolic in character indicating the absence of allosteric interactions in this pro ...
... lowest oxygen tensions found in very active tissues the binding affinity of hemoglobin for oxygen is very low allowing maximal delivery of oxygen to the tissue. In contrast the oxygen binding curve for myoglobin is hyperbolic in character indicating the absence of allosteric interactions in this pro ...
Initiation of Innate Immune Responses in the
... The activation of the humoral immune system is contributed by several reactions such as proteolytic cascades leading to blood clotting, melanin formation, opsonization, and a transient synthesis of potent antibacterial peptides (Hoffmann et al., 1999) The clotting system is an important reaction in ...
... The activation of the humoral immune system is contributed by several reactions such as proteolytic cascades leading to blood clotting, melanin formation, opsonization, and a transient synthesis of potent antibacterial peptides (Hoffmann et al., 1999) The clotting system is an important reaction in ...
Basic Local Alignment Search Tool (BLAST) IMBB 19, May 2015
... ü StaCsCcal measures like E-‐value. P-‐Value and bit score ü Percentage idenCty (% of idenCcal residues between sequences) ü The length of sequence stretch that is similar 2. Homology; homologs diverse f ...
... ü StaCsCcal measures like E-‐value. P-‐Value and bit score ü Percentage idenCty (% of idenCcal residues between sequences) ü The length of sequence stretch that is similar 2. Homology; homologs diverse f ...
Nup153 is an M9containing mobile nucleoporin with a novel
... 1997; Yang et al., 1998). Each NPC is comprised of 50–100 different proteins, termed nucleoporins, that assemble in multiple copies to form the complex. Biochemical, genetic and genome sequencing approaches have led to the identification of ~30 yeast nucleoporins or NPCassociated proteins, while abo ...
... 1997; Yang et al., 1998). Each NPC is comprised of 50–100 different proteins, termed nucleoporins, that assemble in multiple copies to form the complex. Biochemical, genetic and genome sequencing approaches have led to the identification of ~30 yeast nucleoporins or NPCassociated proteins, while abo ...
Ribosome
... That’s the end of the quiz (whew)! Any questions so far? Okay, that’s taken care of. And now, without further ado, we move on to… ...
... That’s the end of the quiz (whew)! Any questions so far? Okay, that’s taken care of. And now, without further ado, we move on to… ...
Slide 1 - Biskit
... Voronoi Shelling Order (VSO) provides an unambiguous, quantitative measure for an atom’s “depth” within the protein – protein interface while accounting for both geometry and topology. In contrast to current ad-hoc interface definitions (based on residue contacts or loss of solvent exposed surface), ...
... Voronoi Shelling Order (VSO) provides an unambiguous, quantitative measure for an atom’s “depth” within the protein – protein interface while accounting for both geometry and topology. In contrast to current ad-hoc interface definitions (based on residue contacts or loss of solvent exposed surface), ...
Chemistry Worksheet Name: ___________________________ Functional Groups and Amino Acids
... Name: ___________________________ Block: ___________ ...
... Name: ___________________________ Block: ___________ ...
Gene Section LCK (lymphocyte-specific protein tyrosine kinase) Atlas of Genetics and Cytogenetics
... unique amino-terminal regions, followed by Src homology domains SH3 and SH2, a tyrosine kinase catalytic domain, and C-terminal regulatory domain. Lck associates with the inner face of the plasma membrane through its amino-terminus. This interaction is mediated by both myristic acid and palmitic aci ...
... unique amino-terminal regions, followed by Src homology domains SH3 and SH2, a tyrosine kinase catalytic domain, and C-terminal regulatory domain. Lck associates with the inner face of the plasma membrane through its amino-terminus. This interaction is mediated by both myristic acid and palmitic aci ...
Asgeirsson, B., Renzetti, G., Invernizzi, G ., Papaleo, E. (2013)
... cold-active alkaline phosphatase (VAP)1. Asymmetric dynamics have been suggested to play a part in the catalytic cycle in homodimeric alkaline phosphatases. A conformational change might be the rate-limiting step since the chemical transformations are much faster than kcat2. Asymmetric protein dynam ...
... cold-active alkaline phosphatase (VAP)1. Asymmetric dynamics have been suggested to play a part in the catalytic cycle in homodimeric alkaline phosphatases. A conformational change might be the rate-limiting step since the chemical transformations are much faster than kcat2. Asymmetric protein dynam ...
pGADT7 AD Vector Information
... pGADT7 AD is the AD Cloning Vector provided in Clontech's Matchmaker™ Gold Yeast One- and Two-Hybrid Screening Systems (Cat. Nos. 630491 and 630489, respectively). The vector allows the generation of GAL4 AD fusion proteins from either a gene of interest or a cDNA library. Important: Genes must be c ...
... pGADT7 AD is the AD Cloning Vector provided in Clontech's Matchmaker™ Gold Yeast One- and Two-Hybrid Screening Systems (Cat. Nos. 630491 and 630489, respectively). The vector allows the generation of GAL4 AD fusion proteins from either a gene of interest or a cDNA library. Important: Genes must be c ...
Molecular Weight Estimation - Bio-Rad
... antibodies, and to the detection reagents used to develop the blotted membrane (blot). After the remaining binding sites are blocked with a detergent or protein reagent, the blot is probed with the primary antibody and then washed. The antibody-antigen complexes are subsequently identified by horser ...
... antibodies, and to the detection reagents used to develop the blotted membrane (blot). After the remaining binding sites are blocked with a detergent or protein reagent, the blot is probed with the primary antibody and then washed. The antibody-antigen complexes are subsequently identified by horser ...
Protein domain
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural domains. One domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. Domains vary in length from between about 25 amino acids up to 500 amino acids in length. The shortest domains such as zinc fingers are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be ""swapped"" by genetic engineering between one protein and another to make chimeric proteins.