![Acetylcholinesterase: A gorgeous enzyme It`s always said “Don`t](http://s1.studyres.com/store/data/002531710_1-dd15a410b87302d4fd44a9eca6d3a8d5-300x300.png)
Zinc finger family
... In a multi-finger protein some fingers contact base pairs and some will not, but rather function as bridges Fingers 1–2–3, separated by typical linkers, wrap smoothly around the major groove like those of Zif268 In contrast, fingers 4–5–6 form an open, extended structure running along one side of ...
... In a multi-finger protein some fingers contact base pairs and some will not, but rather function as bridges Fingers 1–2–3, separated by typical linkers, wrap smoothly around the major groove like those of Zif268 In contrast, fingers 4–5–6 form an open, extended structure running along one side of ...
Multivalent cross-linking of actin filaments and microtubules through
... Microtubule-associated proteins regulate microtubule dynamics, bundle actin filaments and cross-link actin filaments with microtubules. In addition, aberrant interaction of the microtubule-associated protein Tau with filamentous actin is connected to synaptic impairment in Alzheimer’s disease. Here ...
... Microtubule-associated proteins regulate microtubule dynamics, bundle actin filaments and cross-link actin filaments with microtubules. In addition, aberrant interaction of the microtubule-associated protein Tau with filamentous actin is connected to synaptic impairment in Alzheimer’s disease. Here ...
Hydrogen exchange mass spectrometry for the analysis of protein
... especially in the case of analysis of protein complexes, may dictate D2O introduction of a specific type. The primary method for introducing deuterium into a protein sample is by dilution. Typically, a solution of protein in a protiated buffer is diluted with a deuterated buffer that has a deuterium ...
... especially in the case of analysis of protein complexes, may dictate D2O introduction of a specific type. The primary method for introducing deuterium into a protein sample is by dilution. Typically, a solution of protein in a protiated buffer is diluted with a deuterated buffer that has a deuterium ...
PDGF receptor β and leukemia
... Carroll M, Tomasson MH, Barker GF, Golub TR, and Gilliland DG (1996) The TEL/plateletderived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta Leukemia R kinase-dependent signaling pathways. Proc ...
... Carroll M, Tomasson MH, Barker GF, Golub TR, and Gilliland DG (1996) The TEL/plateletderived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta Leukemia R kinase-dependent signaling pathways. Proc ...
北京聚合美生物科技有限公司 Mei5 Biotechnology, Co., Ltd M5 GFP
... IP of extracts from COS7 cells transfected with a GFP-tagged protein using GFP rabbit polyclonal antibody (5μl ,lane 3) or using normal rabbit IgG(lane 2) as control,followed by Western blot using GFP (7G9) Mouse mAb(dilution:1:5000).Lane 1 was loaded with 10 μg of COS7 cell lysate over-expressing a ...
... IP of extracts from COS7 cells transfected with a GFP-tagged protein using GFP rabbit polyclonal antibody (5μl ,lane 3) or using normal rabbit IgG(lane 2) as control,followed by Western blot using GFP (7G9) Mouse mAb(dilution:1:5000).Lane 1 was loaded with 10 μg of COS7 cell lysate over-expressing a ...
Phospholipase C-γ1 is a guanine nucleotide exchange factor for
... detected (Liu and Robinson, 1995; Urrutia et al., 1997). Dynamin-1 is exclusively expressed in neuronal cells (Nakata et al., 1991). But dynamin-2 is ubiquitously expressed (Cook et al., 1994) and dynamin-3 is primary expressed in Sertoli cells of the testis (Nakata et al., 1993). Dynamin’s role in ...
... detected (Liu and Robinson, 1995; Urrutia et al., 1997). Dynamin-1 is exclusively expressed in neuronal cells (Nakata et al., 1991). But dynamin-2 is ubiquitously expressed (Cook et al., 1994) and dynamin-3 is primary expressed in Sertoli cells of the testis (Nakata et al., 1993). Dynamin’s role in ...
This presentation introduces the topics we will
... mainly that the data set often contains many spectra, multiplying the information content. However, at the single spectrum level, there is little to choose. In a peptide mass fingerprint, the boundary condition is that the peptides all originate from a single protein. In an MS/MS search, the boundar ...
... mainly that the data set often contains many spectra, multiplying the information content. However, at the single spectrum level, there is little to choose. In a peptide mass fingerprint, the boundary condition is that the peptides all originate from a single protein. In an MS/MS search, the boundar ...
Membrane-coating lattice scaffolds in the nuclear pore
... Gemin2-7 and coordinates the assembly of small nuclear ribonucleoproteins (snRNPS) important to motor neurons. Another example is the Tup1 protein found in yeast, which together with Cyc8 forms a complex that functions as a general repressor of transcription mediated by a diverse collection of repre ...
... Gemin2-7 and coordinates the assembly of small nuclear ribonucleoproteins (snRNPS) important to motor neurons. Another example is the Tup1 protein found in yeast, which together with Cyc8 forms a complex that functions as a general repressor of transcription mediated by a diverse collection of repre ...
Task - Illustrative Mathematics
... This is a full-blown modeling problem (SMP 4). Students must come up with the idea on their own that they can set up two equations in two unknowns to solve the problem, and they must then read, understand and extract information from the nutrition labels to set up the equations in the system (SMP 1) ...
... This is a full-blown modeling problem (SMP 4). Students must come up with the idea on their own that they can set up two equations in two unknowns to solve the problem, and they must then read, understand and extract information from the nutrition labels to set up the equations in the system (SMP 1) ...
Stabilization by GroEL, a Molecular Chaperone, and a Periplasmic
... found in the periplasm, but the physiological functions of only a few such proteins are known. Furthermore, the periplasm of Escherichia coli has been of great interest with respect to the functional expression of a wide variety of recombinant proteins from different sources. However, the periplasmi ...
... found in the periplasm, but the physiological functions of only a few such proteins are known. Furthermore, the periplasm of Escherichia coli has been of great interest with respect to the functional expression of a wide variety of recombinant proteins from different sources. However, the periplasmi ...
Pore-Forming Proteins and Adaptation of Living Organisms to
... cells, as well as various eukaryotic tissues. The cytolytic activity of melittin is underlain by its ability to form pores in membranes using an amphiphilic α-helix formed by two chain regions (residues 1-10 and 13-26). Depending on the type of preferable fatty acids of the membrane bilayer, on meli ...
... cells, as well as various eukaryotic tissues. The cytolytic activity of melittin is underlain by its ability to form pores in membranes using an amphiphilic α-helix formed by two chain regions (residues 1-10 and 13-26). Depending on the type of preferable fatty acids of the membrane bilayer, on meli ...
Diapositive 1 - LBGI Bioinformatique et Génomique Intégratives
... Actin Related Proteins (ARPs) are key players in major biological processes important for cell life. In cytoskeleton activities, the ARP2/3 complex is essential for actin dynamics, ARP1 and ARP11 are involved in microtubule based vesicle trafficking, in nuclear functions (transcriptional activation, ...
... Actin Related Proteins (ARPs) are key players in major biological processes important for cell life. In cytoskeleton activities, the ARP2/3 complex is essential for actin dynamics, ARP1 and ARP11 are involved in microtubule based vesicle trafficking, in nuclear functions (transcriptional activation, ...
High Resolution Structure of the Neisseria gonorrhoeae Type IV
... diameter, and are comprised of thousands of copies of a single subunit, the pilin protein. Type IV pilins from different bacterial species share a common sequence of mostly hydrophobic amino acids in their N-terminus, as well as a pair of cysteines in their Cterminus, but differ substantially beyond ...
... diameter, and are comprised of thousands of copies of a single subunit, the pilin protein. Type IV pilins from different bacterial species share a common sequence of mostly hydrophobic amino acids in their N-terminus, as well as a pair of cysteines in their Cterminus, but differ substantially beyond ...
P1 and P2 protein heterodimer binding to the P0 protein of
... The stalk is a functional domain of the large ribosomal subunit that is directly involved in the interaction and GTPase activity of several soluble factors during translation (1). In eukaryotes, the stalk is formed by a central 32-kDa protein, P0, which interacts through its N-terminal domain (NTD) ...
... The stalk is a functional domain of the large ribosomal subunit that is directly involved in the interaction and GTPase activity of several soluble factors during translation (1). In eukaryotes, the stalk is formed by a central 32-kDa protein, P0, which interacts through its N-terminal domain (NTD) ...
Eukaryotically Encoded and Chloroplast
... searches failed to predict the N-terminal extension of the G. theta rubredoxin as a transit peptide. In Vitro Import Assays of G. theta Rubredoxin—Because the N-terminal extension of the nmRub is not predicted to be a transit peptide, we undertook in vitro import assays into isolated plastids. As sh ...
... searches failed to predict the N-terminal extension of the G. theta rubredoxin as a transit peptide. In Vitro Import Assays of G. theta Rubredoxin—Because the N-terminal extension of the nmRub is not predicted to be a transit peptide, we undertook in vitro import assays into isolated plastids. As sh ...
Structure and function of steroid receptor AF1 transactivation domains
... by the presence of an N-terminal 165-amino-acid extension (reviewed in [57]). The AF1 domain has been mapped to 91 amino acids preceding the DBD [58,59] (Figure 1). Interestingly, the autonomous function of this domain required the PR-DBD, suggesting intra-domain communication [57]. A second transac ...
... by the presence of an N-terminal 165-amino-acid extension (reviewed in [57]). The AF1 domain has been mapped to 91 amino acids preceding the DBD [58,59] (Figure 1). Interestingly, the autonomous function of this domain required the PR-DBD, suggesting intra-domain communication [57]. A second transac ...
Functional Requirements of the Yellow Fever Virus Capsid Protein
... representation of the YFV genome, with open boxes denoting regions coding for the structural (white) and nonstructural (light gray) proteins that are translated as a polyprotein. The 5⬘- and 3⬘-untranslated regions (UTR) are depicted as solid lines. Also shown is a schematic representation of the YF ...
... representation of the YFV genome, with open boxes denoting regions coding for the structural (white) and nonstructural (light gray) proteins that are translated as a polyprotein. The 5⬘- and 3⬘-untranslated regions (UTR) are depicted as solid lines. Also shown is a schematic representation of the YF ...
Protein domain
![](https://commons.wikimedia.org/wiki/Special:FilePath/Pyruvate_kinase_protein_domains.png?width=300)
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural domains. One domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. Domains vary in length from between about 25 amino acids up to 500 amino acids in length. The shortest domains such as zinc fingers are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be ""swapped"" by genetic engineering between one protein and another to make chimeric proteins.