A New Method to Detect Related Function Among Proteins
... 0022-2836/02/$ - see front matter q 2002 Elsevier Science Ltd. All rights reserved ...
... 0022-2836/02/$ - see front matter q 2002 Elsevier Science Ltd. All rights reserved ...
Biological Molecules: Structure and Methods of Analysis
... and straight, unlike the coiled chains of amylose. Over a dozen of these long straight chains can form hydrogen bonds between the OH and H groups of neighboring chains leading to the formation of microfibrils. These microfibrils of cellulose are very strong, and they are the major component of plant ...
... and straight, unlike the coiled chains of amylose. Over a dozen of these long straight chains can form hydrogen bonds between the OH and H groups of neighboring chains leading to the formation of microfibrils. These microfibrils of cellulose are very strong, and they are the major component of plant ...
Protein - HCC Learning Web
... 100 amino acids. The monomer units in the chain are known as amino acid residues. The average protein contains about 350 amino acid residues although proteins with as many as 1000 residues and those with as few as 100 are not uncommon. The sequence or order of amino acids along a polypeptide chain i ...
... 100 amino acids. The monomer units in the chain are known as amino acid residues. The average protein contains about 350 amino acid residues although proteins with as many as 1000 residues and those with as few as 100 are not uncommon. The sequence or order of amino acids along a polypeptide chain i ...
Protein Misfolding and Disease Protein Misfolding and Disease
... bodies. It is believed that intrinsic instability owing to a low transition energy to an unfolded state or/and relative stable folding intermediates, that escape the protein quality control systems is a precondition for aggregate formation (21). However, although all proteins under adverse in vitro ...
... bodies. It is believed that intrinsic instability owing to a low transition energy to an unfolded state or/and relative stable folding intermediates, that escape the protein quality control systems is a precondition for aggregate formation (21). However, although all proteins under adverse in vitro ...
The origin of the eukaryotic cell: A genomic investigation
... would have been enormously greater than occurs in DNA-based systems’’ (12). This solution to the paradox implies that if the actin and FtsA (tubulin and FtsZ) did have a common ancestor, then it was not to be found in either in Archaea or Bacteria, but in some hypothetical RNA-based ‘‘urkaryote,’’ o ...
... would have been enormously greater than occurs in DNA-based systems’’ (12). This solution to the paradox implies that if the actin and FtsA (tubulin and FtsZ) did have a common ancestor, then it was not to be found in either in Archaea or Bacteria, but in some hypothetical RNA-based ‘‘urkaryote,’’ o ...
A statistical physics perspective on alignment-independent pro
... peaks in the plot can correlate well with regions highly enriched in hydrophobic residues. Hitherto, it has proved difficult to interpret such plots other than by a peak-spotting. Several decades ago, most predictors were based on identifying maximally valued regions of sequences; essentially lookin ...
... peaks in the plot can correlate well with regions highly enriched in hydrophobic residues. Hitherto, it has proved difficult to interpret such plots other than by a peak-spotting. Several decades ago, most predictors were based on identifying maximally valued regions of sequences; essentially lookin ...
Lecture 3 – Membrane potential
... Lecture 3 – Different types of pumps An electrochemical gradient is a gradient of electrochemical potential, usually for an ion that can move across a membrane. The gradient consists of two parts, the chemical gradient, or difference in solute concentration across a membrane, and the electrical gra ...
... Lecture 3 – Different types of pumps An electrochemical gradient is a gradient of electrochemical potential, usually for an ion that can move across a membrane. The gradient consists of two parts, the chemical gradient, or difference in solute concentration across a membrane, and the electrical gra ...
Review Article
... Retention of proteins in the ER Soluble proteins of the ER in animal cells share a common C-terminal tetrapeptide sequence, usually LysAsp-Glu-Leu (KDEL) that is essential for retention in the ER (Munro & Pelham, 1987). Variations on the KDEL theme are found in different organisms but the principles ...
... Retention of proteins in the ER Soluble proteins of the ER in animal cells share a common C-terminal tetrapeptide sequence, usually LysAsp-Glu-Leu (KDEL) that is essential for retention in the ER (Munro & Pelham, 1987). Variations on the KDEL theme are found in different organisms but the principles ...
With-the-great-explosion-of-use-of
... With the great explosion of use of Internet With the great explosion of use of Internet we can find there large amounts of biological data and genomic information for development of computational methods. There are available all kind of information to elucidate peptide/protein structures obtained by ...
... With the great explosion of use of Internet With the great explosion of use of Internet we can find there large amounts of biological data and genomic information for development of computational methods. There are available all kind of information to elucidate peptide/protein structures obtained by ...
... Inward-looking membrane proteins. (A) The alternating-access model of transport for the bacterial transporters LacY (left) and GlpT (right). LacY catalyzes the coupled transport of lactose and H+ from one side of the membrane to the other, whereas GlpT mediates the exchange of glycerol3-phosphate (G ...
Signal Transduction
... 2. Hormone binding, usually to an extracellular domain of a 7-helix receptor (GPCR), causes a conformational change in the receptor that is transmitted to a G-protein on the cytosolic side of the membrane. ...
... 2. Hormone binding, usually to an extracellular domain of a 7-helix receptor (GPCR), causes a conformational change in the receptor that is transmitted to a G-protein on the cytosolic side of the membrane. ...
Short review - BioPublisher
... subcellular locations or labeled as “fragment”, or having a term of “by similarity” or “probable” or “predicted” in subcellular location annotation were removed. A total of 6908 proteins having annotated subcellular locations were selected. The results are shown in Table 1. If we ignore the subcellu ...
... subcellular locations or labeled as “fragment”, or having a term of “by similarity” or “probable” or “predicted” in subcellular location annotation were removed. A total of 6908 proteins having annotated subcellular locations were selected. The results are shown in Table 1. If we ignore the subcellu ...
Issues in predicting protein function from sequence
... thought to persist only if they acquire `novel' functions. This apparent paradox is resolved when it is considered that `function' is an umbrella term that covers phenomena at the scales of atoms (catalysis, binding events), domains, proteins, complexes, networks, cells and organisms. For example, t ...
... thought to persist only if they acquire `novel' functions. This apparent paradox is resolved when it is considered that `function' is an umbrella term that covers phenomena at the scales of atoms (catalysis, binding events), domains, proteins, complexes, networks, cells and organisms. For example, t ...
Biology and computers
... Asterisk represents identity : represents high similarity . represents low similarity ...
... Asterisk represents identity : represents high similarity . represents low similarity ...
Caldicellulosiruptor tāpirins bind to crystalline cellulose! ! 1 Discrete
... described by Nam et al. (41). Briefly, for induction of recombinant protein, yeast cultures were initially sub-cultured into liquid SDCAA (as above, including 1:100 Pen-Strep [Invitrogen, CA] without sorbitol and agar) and allowed to grow overnight at 30°C and 250 rpm in a shaking incubator. Culture ...
... described by Nam et al. (41). Briefly, for induction of recombinant protein, yeast cultures were initially sub-cultured into liquid SDCAA (as above, including 1:100 Pen-Strep [Invitrogen, CA] without sorbitol and agar) and allowed to grow overnight at 30°C and 250 rpm in a shaking incubator. Culture ...
Slide 1
... •Select FER1_SPIOL. Right click on FER1_SPIOL. Select structure > Associate structure with sequences > discover PDB ids. •Now again, right click on FER1_SPIOL. Select structure > View structure of FER1_SPIOL. This will open a window where you can view its structure (PDB 1A70). The viewer is Jmol. Tr ...
... •Select FER1_SPIOL. Right click on FER1_SPIOL. Select structure > Associate structure with sequences > discover PDB ids. •Now again, right click on FER1_SPIOL. Select structure > View structure of FER1_SPIOL. This will open a window where you can view its structure (PDB 1A70). The viewer is Jmol. Tr ...
Membrane Proteins: Capturing the signal | eLife
... 1989). Intriguingly, Voorhees and Hegde observe a stable three-part complex between the SRP, the ribosome and a translational factor. This lends support to the idea that SRP binding and translation are not mutually exclusive events under physiological conditions. The new high-resolution structures a ...
... 1989). Intriguingly, Voorhees and Hegde observe a stable three-part complex between the SRP, the ribosome and a translational factor. This lends support to the idea that SRP binding and translation are not mutually exclusive events under physiological conditions. The new high-resolution structures a ...
Poster
... affinity purification. The co-expressed AH and RIIa were depleted in the flow through and co-purified in the elute. Similarly, co-expressed DPY-30 domain and the AH were purified together as well. Thus the same AH can recognize both the RIIa and DPY-30 domain. ...
... affinity purification. The co-expressed AH and RIIa were depleted in the flow through and co-purified in the elute. Similarly, co-expressed DPY-30 domain and the AH were purified together as well. Thus the same AH can recognize both the RIIa and DPY-30 domain. ...
Gene Section MAPK12 (mitogen activated protein kinase 12) -
... over-expression of p38gamma in skeletal muscle cells leads to differentiation from myoblast to myotubes, and that a dominant-negative mutant of p38gamma prevented this differentiation process (Lechner et al., 1996). Recently, Gillespie et al. (2009) reported that p38gamma phosphorylates the transcip ...
... over-expression of p38gamma in skeletal muscle cells leads to differentiation from myoblast to myotubes, and that a dominant-negative mutant of p38gamma prevented this differentiation process (Lechner et al., 1996). Recently, Gillespie et al. (2009) reported that p38gamma phosphorylates the transcip ...
Creutzfeldt-Jakob Disease - Clayton State University
... Researchers are examining whether the transmissible agent is a prion or a product of an infection, and they are trying to discover factors that influence prion infectivity and how the disorder damages the brain. Researchers are also trying to determe how abnormal prion proteins lead to disease ...
... Researchers are examining whether the transmissible agent is a prion or a product of an infection, and they are trying to discover factors that influence prion infectivity and how the disorder damages the brain. Researchers are also trying to determe how abnormal prion proteins lead to disease ...
Intrinsically disordered proteins
An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure. IDPs cover a spectrum of states from fully unstructured to partially structured and include random coils, (pre-)molten globules, and large multi-domain proteins connected by flexible linkers. They constitute one of the main types of protein (alongside globular, fibrous and membrane proteins).The discovery of IDPs has challenged the traditional protein structure paradigm, that protein function depends on a fixed three-dimensional structure. This dogma has been challenged over the last decades by increasing evidence from various branches of structural biology, suggesting that protein dynamics may be highly relevant for such systems. Despite their lack of stable structure, IDPs are a very large and functionally important class of proteins. In some cases, IDPs can adopt a fixed three-dimensional structure after binding to other macromolecules.