Macromolecular Interactions
... Protein-protein interfaces tend to be large (600 – 1300 Å2), involve 10 – 40 residues from each protein that interdigitate into multiple residues from the other protein, and are rich in aromatic residues (His, Phe, Tyr, Trp) and Arg Protein interactions are determined by hydrophobic effects and shap ...
... Protein-protein interfaces tend to be large (600 – 1300 Å2), involve 10 – 40 residues from each protein that interdigitate into multiple residues from the other protein, and are rich in aromatic residues (His, Phe, Tyr, Trp) and Arg Protein interactions are determined by hydrophobic effects and shap ...
mitochondria
... compartment as they bud and pinch off from its membrane - cargo becomes discharged into a second compartment by fusing with the membrane enclosing that compartment ...
... compartment as they bud and pinch off from its membrane - cargo becomes discharged into a second compartment by fusing with the membrane enclosing that compartment ...
Transcription and RNA Processing
... • Pol I - pre rRNA not known to be used by viruses • Pol II - makes mRNAs and some micro RNAs • Pol III - Adenovirus VA RNAs, EBV EBERs and some micro RNAs ...
... • Pol I - pre rRNA not known to be used by viruses • Pol II - makes mRNAs and some micro RNAs • Pol III - Adenovirus VA RNAs, EBV EBERs and some micro RNAs ...
Protein Family Classification using Sparse Markov Transducers
... is a model that predicts the next symbol in a sequence based on the previous symbols. This approach is based on the presence of common short sequences (motifs) through the protein family. One drawback of PSTs is that they rely on exact matches to the conditional sequences (e.g., 3-hydroxyacyl-Co ...
... is a model that predicts the next symbol in a sequence based on the previous symbols. This approach is based on the presence of common short sequences (motifs) through the protein family. One drawback of PSTs is that they rely on exact matches to the conditional sequences (e.g., 3-hydroxyacyl-Co ...
$doc.title
... releases of the database. Other ‘activities’ fields holding additional extracted data and annotations, such as assay descriptions, relevant experimental measurements, cell systems, compound concentrations and the substrates used in inhibition assays, may have only been partially completed in this re ...
... releases of the database. Other ‘activities’ fields holding additional extracted data and annotations, such as assay descriptions, relevant experimental measurements, cell systems, compound concentrations and the substrates used in inhibition assays, may have only been partially completed in this re ...
biochem ch 37 [2-9
... Protein Digestion and Amino Acid Absorption Proteolytic enzymes (proteases) break down dietary proteins into their constituent AAs in stomach and intestine o Many synthesized as zymogens In stomach, pepsin begins digestion of proteins by hydrolyzing them to smaller polypeptides In small intest ...
... Protein Digestion and Amino Acid Absorption Proteolytic enzymes (proteases) break down dietary proteins into their constituent AAs in stomach and intestine o Many synthesized as zymogens In stomach, pepsin begins digestion of proteins by hydrolyzing them to smaller polypeptides In small intest ...
How Do Plant Mitochondria Avoid Importing Chloroplast Proteins
... probably arose after the arrival of the chloroplast approximately 800 million years ago. The translocase in the outer mitochondrial membrane, or TOM complex, on the surface of mitochondria is a fascinating example of a molecular machine that has evolved to overcome a fundamental problem. In eukaryot ...
... probably arose after the arrival of the chloroplast approximately 800 million years ago. The translocase in the outer mitochondrial membrane, or TOM complex, on the surface of mitochondria is a fascinating example of a molecular machine that has evolved to overcome a fundamental problem. In eukaryot ...
Protease Inhibitor Cocktail VI, Plant Cells Catalog Number: J64576
... metalloproteases; extracts from animal tissues contain mainly serine, cysteine and metalloproteases. Additionally some animal extracts also contain aspartic proteases, while plant extracts contain large amounts of serine and cysteine proteases. Because cells contain different type of enzymes, our sp ...
... metalloproteases; extracts from animal tissues contain mainly serine, cysteine and metalloproteases. Additionally some animal extracts also contain aspartic proteases, while plant extracts contain large amounts of serine and cysteine proteases. Because cells contain different type of enzymes, our sp ...
Trichohyalin, an Intermediate Filament
... In earlier studies, S-carboxymethyl-modified keratins were separated from the arginine-rich trichohyalin fraction by ionexchange chromatography. This fraction, designated TR-PPT by Rogers et al. (34), yielded several bands on pH 2.7 and SDS acrylamide gels (Fig. 1), and because of this complexity, t ...
... In earlier studies, S-carboxymethyl-modified keratins were separated from the arginine-rich trichohyalin fraction by ionexchange chromatography. This fraction, designated TR-PPT by Rogers et al. (34), yielded several bands on pH 2.7 and SDS acrylamide gels (Fig. 1), and because of this complexity, t ...
Scientific abstract
... proteins. Early thoughts concerning the cellmembrane were that these lipids only functioned as a barrier and gave rigidity to the cell, whereas the proteins were responsible for all other tasks. Recent discoveries, however, show that certain membrane lipids seem to play a prominent role in all sorts ...
... proteins. Early thoughts concerning the cellmembrane were that these lipids only functioned as a barrier and gave rigidity to the cell, whereas the proteins were responsible for all other tasks. Recent discoveries, however, show that certain membrane lipids seem to play a prominent role in all sorts ...
GPS-Lipid Manual - CSS-Palm
... 3. GPS. Previously, we used the GPS to denote our Group-based Phosphorylation Scoring algorithm. Currently, we are developing an integrated computational platform for post-translational modifications (PTMs) of proteins. We re-denote the GPS as Group-based Prediction Systems. This software is an indi ...
... 3. GPS. Previously, we used the GPS to denote our Group-based Phosphorylation Scoring algorithm. Currently, we are developing an integrated computational platform for post-translational modifications (PTMs) of proteins. We re-denote the GPS as Group-based Prediction Systems. This software is an indi ...
Leukaemia Section t(8;17)(q24;q22) ???BCL3/MYC Atlas of Genetics and Cytogenetics
... Only one case to date, with no clinical data. ...
... Only one case to date, with no clinical data. ...
L. helveticus - NC State University
... SLAP extractions from these sixteen strains revealed a diverse array of banding profiles in each of the Slayer producing strains. Notably, compared to S-layer strains, there were very few proteins extracted from the non-S-layer forming strains using LiCl. These data indicate that the exoproteomes of ...
... SLAP extractions from these sixteen strains revealed a diverse array of banding profiles in each of the Slayer producing strains. Notably, compared to S-layer strains, there were very few proteins extracted from the non-S-layer forming strains using LiCl. These data indicate that the exoproteomes of ...
Functions and inhibitors of SecA, an essential protein in bacterial
... across cytoplasmic membranes. In addition to the high-affinity SecA-SecYEG-SecDF•YajC protein-conducting channels, we have found that there are low-affinity SecA-only channels that elicit ion channel activity and promote protein translocation. These pore channels are less efficient, and like Prl sup ...
... across cytoplasmic membranes. In addition to the high-affinity SecA-SecYEG-SecDF•YajC protein-conducting channels, we have found that there are low-affinity SecA-only channels that elicit ion channel activity and promote protein translocation. These pore channels are less efficient, and like Prl sup ...
Antibodies for Unfolded Protein Response
... Activating Transcription Factor 6 (ATF6) ATF6 is a transmembrane glycoprotein and transcription activator, which functions to initiate the UPR during ER stress. The predicted molecular weight of the canonical form of ATF6 is 74.5 kDa. However, ATF6 may be detected at approximately 90 kDa in Western ...
... Activating Transcription Factor 6 (ATF6) ATF6 is a transmembrane glycoprotein and transcription activator, which functions to initiate the UPR during ER stress. The predicted molecular weight of the canonical form of ATF6 is 74.5 kDa. However, ATF6 may be detected at approximately 90 kDa in Western ...
The PYRIN domain: a novel motif found in apoptosis and
... here that the PYRIN domain is a novel protein module that likely mediates protein-protein interactions in apoptotic and inflammatory signaling pathways. CARD4 (also called NOD1) is a CED-4/Apaf-1 family member that activates NF-kB signaling and induces apoptosis.3 ± 5 CARD4 contains three putative f ...
... here that the PYRIN domain is a novel protein module that likely mediates protein-protein interactions in apoptotic and inflammatory signaling pathways. CARD4 (also called NOD1) is a CED-4/Apaf-1 family member that activates NF-kB signaling and induces apoptosis.3 ± 5 CARD4 contains three putative f ...
Biological Molecules: Water and Carbohydrates
... Fibrous proteins are formed from parallel polypeptide chains held together by cross-links. These form long, rope-like fibres, with high tensile strength and are generally insoluble in water. ...
... Fibrous proteins are formed from parallel polypeptide chains held together by cross-links. These form long, rope-like fibres, with high tensile strength and are generally insoluble in water. ...
lecture 7
... - prefoldin can stabilize an unfolded protein for subsequent folding by chaperonin (explanation in class) - range of proteins archaeal prefoldin stabilizes is considerable: 14-62 kDa Archaeal prefoldin (with 2 different subunits) may play a general role in protein folding whereas the eukaryotic ch ...
... - prefoldin can stabilize an unfolded protein for subsequent folding by chaperonin (explanation in class) - range of proteins archaeal prefoldin stabilizes is considerable: 14-62 kDa Archaeal prefoldin (with 2 different subunits) may play a general role in protein folding whereas the eukaryotic ch ...
CHAP NUM="5" ID="CH
... Lipids are a diverse group of hydrophobic molecules Lipids are the one class of large biological molecules that does not include true polymers, and they are generally not big enough to be considered macromolecules. The compounds called lipids are grouped together because they share one important tra ...
... Lipids are a diverse group of hydrophobic molecules Lipids are the one class of large biological molecules that does not include true polymers, and they are generally not big enough to be considered macromolecules. The compounds called lipids are grouped together because they share one important tra ...
Signals and mechanisms for protein retention in the endoplasmic
... Key words: Endoplasmic reticulum, plant, retention signal, soluble proteins, membrane proteins. ...
... Key words: Endoplasmic reticulum, plant, retention signal, soluble proteins, membrane proteins. ...
Genetically engineered gold-binding polypeptides
... Molecular dynamics simulations using force elds of this type (a smoothed potential representing the metal surface and no charge-image contribution) have been shown to reproduce accurately the experimentally measurable surface concentrations of water [28] and hydrocarbons [29]. Explicitly including ...
... Molecular dynamics simulations using force elds of this type (a smoothed potential representing the metal surface and no charge-image contribution) have been shown to reproduce accurately the experimentally measurable surface concentrations of water [28] and hydrocarbons [29]. Explicitly including ...
Kinesin
... 8 nm per step (spacing of tubulin dimers along the microtubule) = 250 steps/second! Protein head = 7.5 X 4.5 X 4.5 nm ≈ speed and thrust of the supersonic car 60% efficiency ...
... 8 nm per step (spacing of tubulin dimers along the microtubule) = 250 steps/second! Protein head = 7.5 X 4.5 X 4.5 nm ≈ speed and thrust of the supersonic car 60% efficiency ...
Monte Carlo Simulations of HIV Capsid Protein
... Publication Date (Web): July 8, 2015 | doi: 10.1021/acs.jcim.5b00126 ...
... Publication Date (Web): July 8, 2015 | doi: 10.1021/acs.jcim.5b00126 ...
Intrinsically disordered proteins
An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure. IDPs cover a spectrum of states from fully unstructured to partially structured and include random coils, (pre-)molten globules, and large multi-domain proteins connected by flexible linkers. They constitute one of the main types of protein (alongside globular, fibrous and membrane proteins).The discovery of IDPs has challenged the traditional protein structure paradigm, that protein function depends on a fixed three-dimensional structure. This dogma has been challenged over the last decades by increasing evidence from various branches of structural biology, suggesting that protein dynamics may be highly relevant for such systems. Despite their lack of stable structure, IDPs are a very large and functionally important class of proteins. In some cases, IDPs can adopt a fixed three-dimensional structure after binding to other macromolecules.