Direct-Coupling Analysis (DCA)
... Two (or more) genes/ proteins/ residues : 1) exert selective pressures on each other 2) evolve in response to each other • Molecular co-evolution can be due to specific co-adaptation between the two co-evolving elements, where changes in one of them are compensated by changes in the other, or by a l ...
... Two (or more) genes/ proteins/ residues : 1) exert selective pressures on each other 2) evolve in response to each other • Molecular co-evolution can be due to specific co-adaptation between the two co-evolving elements, where changes in one of them are compensated by changes in the other, or by a l ...
GREAT CHANGES IN HEALTH CARE IN THE PAST 40 YEARS
... ubiquitin tagging hypothesis 1980- 1990: Identification of enzymes involved in ubiquitin-mediated protein degradation 1990-present: Roles of the ubiquitin system in the control of cell division ...
... ubiquitin tagging hypothesis 1980- 1990: Identification of enzymes involved in ubiquitin-mediated protein degradation 1990-present: Roles of the ubiquitin system in the control of cell division ...
Distinguishing cell types with masks
... such as the formation of new synaptic contacts and long-lasting forms of synaptic plasticity. These processes, which are necessary for learning and memory, involve changes in the cellular proteome via protein synthesis, its posttranslational modifications and ultimately degradation. Researchers led ...
... such as the formation of new synaptic contacts and long-lasting forms of synaptic plasticity. These processes, which are necessary for learning and memory, involve changes in the cellular proteome via protein synthesis, its posttranslational modifications and ultimately degradation. Researchers led ...
Advanced Techniques in Molecular Biology
... glutamine to glutamate and ammonia. This protein (primarily expressed in the brain and kidney) plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Thus it makes sense that in case of decreasin ...
... glutamine to glutamate and ammonia. This protein (primarily expressed in the brain and kidney) plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Thus it makes sense that in case of decreasin ...
A proteomic platform that can also detect SNPs
... of affinity binding reagents made from single-stranded DNA engineered with hydrophobic side chains. These modifications on the 5-position of uracil greatly expand the physicochemical diversity of the large combinatorial SELEX libraries from which they are selected, resulting in binding molecules to ...
... of affinity binding reagents made from single-stranded DNA engineered with hydrophobic side chains. These modifications on the 5-position of uracil greatly expand the physicochemical diversity of the large combinatorial SELEX libraries from which they are selected, resulting in binding molecules to ...
No Slide Title
... protein-protein interactions may allow the precipitation of these proteins, forming intracellular and extracellular aggregates. These abnormal interactions may play a role in the dysfunction and death of neurons in several common neurodegenerative diseases, such as Alzheimers Disease (AD) and Parkin ...
... protein-protein interactions may allow the precipitation of these proteins, forming intracellular and extracellular aggregates. These abnormal interactions may play a role in the dysfunction and death of neurons in several common neurodegenerative diseases, such as Alzheimers Disease (AD) and Parkin ...
FIGURE LEGENDS FIGURE 9.1 Overview of G
... FIGURE 9.12 Frequency-dependent activation of CaMKII. Autophosphorylation occurs when both neighboring subunits in a holoenzyme are bound to calmodulin. At a high frequency of stimulation (rapid Ca2+ spikes), the interspike interval is too short to allow significant dephosphorylation or dissociation ...
... FIGURE 9.12 Frequency-dependent activation of CaMKII. Autophosphorylation occurs when both neighboring subunits in a holoenzyme are bound to calmodulin. At a high frequency of stimulation (rapid Ca2+ spikes), the interspike interval is too short to allow significant dephosphorylation or dissociation ...
Proteiinien rakenne ja laskostuminen
... gives information about the global conformation of a molecule rms distance from each atom of the molecule to their centroid ...
... gives information about the global conformation of a molecule rms distance from each atom of the molecule to their centroid ...
CAP5510 - Bioinformatics - Department of Computer and
... and pliability of a cell or set of cells ...
... and pliability of a cell or set of cells ...
Chow, Lu-Ping 周綠蘋 - 臺大基因體醫學研究中心
... Proteomics, a subset of functional genomics, is the study of the proteins expressed by an organism. These studies link genome sequence data and gene function. More than 200 proteomics facilities have been established worldwide. As a leading academic institution in Taiwan, National Taiwan University' ...
... Proteomics, a subset of functional genomics, is the study of the proteins expressed by an organism. These studies link genome sequence data and gene function. More than 200 proteomics facilities have been established worldwide. As a leading academic institution in Taiwan, National Taiwan University' ...
poster - Computer Science and Engineering
... RNA molecules play diverse functional and structural roles in cells: ...
... RNA molecules play diverse functional and structural roles in cells: ...
Book Reviews - Cancer Research
... the proteins play in biology. The fourteenth volume of this excellent series main tains the high standard of quality established by its predecessors. In the foreword it is mentioned that it was anticipated that there would be some duplication of the ...
... the proteins play in biology. The fourteenth volume of this excellent series main tains the high standard of quality established by its predecessors. In the foreword it is mentioned that it was anticipated that there would be some duplication of the ...
Automatic Protein Structure Clustering Using
... unknown object categories and revealing hidden correlations and pattern among objects. In this paper, we are involved in the problem of automatic clustering of protein structure. Protein clustering is very important and has applications in such diverse fields as drug design, molecular biology, and e ...
... unknown object categories and revealing hidden correlations and pattern among objects. In this paper, we are involved in the problem of automatic clustering of protein structure. Protein clustering is very important and has applications in such diverse fields as drug design, molecular biology, and e ...
exploring protein structure
... An amino acid is a relatively small molecule with characteristic groups of atoms that determine its chemical behaviour. The structural formula of an amino acid is shown at the end of the animation below. The R group is the only part that differs between the 20 amino acids. ...
... An amino acid is a relatively small molecule with characteristic groups of atoms that determine its chemical behaviour. The structural formula of an amino acid is shown at the end of the animation below. The R group is the only part that differs between the 20 amino acids. ...
Clean Solutions Fuel Affinity Chromatography
... of the recombinant protein possible. For this reason, the respective gene construct is often incorporated into bacterial systems (cloned) and overexpressed beforehand. The bacterium Escherichia coli usually serves as a host, but Bacillus strains or non -bacterial systems such as yeast, insect, mamma ...
... of the recombinant protein possible. For this reason, the respective gene construct is often incorporated into bacterial systems (cloned) and overexpressed beforehand. The bacterium Escherichia coli usually serves as a host, but Bacillus strains or non -bacterial systems such as yeast, insect, mamma ...
Biomolecules carbonylation in oxidative stress related human
... neurodegeneration, are characterized by elevated levels of oxidatively modified biomolecules (protein, lipids and DNA). Oxidation of biomolecules results in numerous functional dysfunctions associated with disease progression. One of the most abundant and hazardous class of modifications are reactiv ...
... neurodegeneration, are characterized by elevated levels of oxidatively modified biomolecules (protein, lipids and DNA). Oxidation of biomolecules results in numerous functional dysfunctions associated with disease progression. One of the most abundant and hazardous class of modifications are reactiv ...
Press release, July 18, 2014 A new cellular garbage control
... the journal Cell, are crucial for our understanding how cells remove cellular waste and will open new avenues for studies aimed to fight neurodegenerative diseases. ...
... the journal Cell, are crucial for our understanding how cells remove cellular waste and will open new avenues for studies aimed to fight neurodegenerative diseases. ...
File
... • Fibrous proteins, such as collagen, have structural functions. • Globular proteins, such as enzymes and haemoglobin, carry out metabolic functions. It is the very different structure and shape of each of these types of proteins that enables them to carry out their functions. ...
... • Fibrous proteins, such as collagen, have structural functions. • Globular proteins, such as enzymes and haemoglobin, carry out metabolic functions. It is the very different structure and shape of each of these types of proteins that enables them to carry out their functions. ...
Exploring how the organelles are organized
... Kathryn Lilley, of the University of Cambridge, encountered similar problems to Emili’s in her initial studies of Arabidopsis sp. proteomics. “We were seeing the same proteins over and over again, because we were just sampling the abundant cytosolic proteins,” she explains. She and her colleagues us ...
... Kathryn Lilley, of the University of Cambridge, encountered similar problems to Emili’s in her initial studies of Arabidopsis sp. proteomics. “We were seeing the same proteins over and over again, because we were just sampling the abundant cytosolic proteins,” she explains. She and her colleagues us ...
slides
... contacts in proteins leave an evolutionary record Although evolutionary couplings show promise for the identification of functional sites, homomultimer contacts, alternative conformations and functional sites, many of the predicted contacts involved in these protein features may appear as false posi ...
... contacts in proteins leave an evolutionary record Although evolutionary couplings show promise for the identification of functional sites, homomultimer contacts, alternative conformations and functional sites, many of the predicted contacts involved in these protein features may appear as false posi ...
How do we purify proteins? GFP as model system to learn
... GFP has long stretches of hydrophobic amino acids in its inner core Upon exposure of the protein to binding buffer, a conformational change occurs and the hydrophobic region is exposed Exposure of the hydrophobic region allows binding of GFP to the hydrophobic resin in the column ...
... GFP has long stretches of hydrophobic amino acids in its inner core Upon exposure of the protein to binding buffer, a conformational change occurs and the hydrophobic region is exposed Exposure of the hydrophobic region allows binding of GFP to the hydrophobic resin in the column ...
Protein–protein interaction
Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.