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Lecture PPT - Carol Lee Lab
Lecture PPT - Carol Lee Lab

... Evolution of transcription factors and epigenetic trans-regulators (micro RNAs) in the brain ...
Sample Chapter 3 (PDF, 30 Pages
Sample Chapter 3 (PDF, 30 Pages

... Within each gene, four basic chemical elements of DNA—the bases adenine, ­thymine, cytosine, and guanine, identified by the letters A, T, C, and G—are arranged in a particular order: for example, ACGTCTCTATA. . . . This sequence may contain thousands or even tens of thousands of “letters,” which tog ...
The molecular evolution of development
The molecular evolution of development

... approaches to this question have focused on dissecting the patterns by which developmental mechanisms diversify over evolutionary time.(1,2) Many of the present-day attempts to study the evolution of development are centered at the molecular level and exploit the remarkable progress that has been ma ...
SM 2 Gen Evn
SM 2 Gen Evn

... will need to apply this knowledge in different ways to show their understanding when they answer merit and excellence level questions. Examples of applied understanding are shown where appropriate but are only intended as an indication of the types of responses expected. Supplementary outcomes are i ...
New thinking, innateness and inherited representation
New thinking, innateness and inherited representation

... of interdependent adaptive changes, but it is not adapted to any one particular task or outcome. It appears to have been selected instead for its facility as a generalist: to perform an open-ended range of tasks with great skill, where the concrete outcomes that contribute to fitness vary widely. Tw ...
New thinking, innateness and inherited representation
New thinking, innateness and inherited representation

... of interdependent adaptive changes, but it is not adapted to any one particular task or outcome. It appears to have been selected instead for its facility as a generalist: to perform an open-ended range of tasks with great skill, where the concrete outcomes that contribute to fitness vary widely. Tw ...
is the population size of a species relevant to its evolution?
is the population size of a species relevant to its evolution?

... played by population size in evolution. When genetic drift interacts with the deterministic forces of selection and/or mutation, we obtain some fundamental quantities that have shaped much of our intuition about evolution: 4Nu is the nucleotide heterozygosity at neutral loci, where u is the rate of ...
Natural and economic selection
Natural and economic selection

... much insight can be gained by population thinking, where multiple agents interact at small scales. Thereby, some characteristics are spreading faster through the population then others, leading over time to changes on a macro level (see for a detailed comparison: Hodgson and Knudsen 2010 or Gowdy et ...
A phenotype-genotype model of a population and observation of the
A phenotype-genotype model of a population and observation of the

... influences the morphological one and the rates of both evolutions can be compared (Bradshaw & Holzapfel 2001, Carrol 2008, Seligmann 2010). Morphological and molecular evolutions are modelled separately according to the idea that each numerical variable needs to have its own model. But for models of ...
Epigenetics - Journal of Experimental Biology
Epigenetics - Journal of Experimental Biology

... taken very many generations to spread through whole populations, and many such mutations would have been required. ...
Genome Evolution in an Insect Cell: Distinct
Genome Evolution in an Insect Cell: Distinct

... symbiont the most AT-rich bacterial genome yet characterized (Clark et al., 2001). Analysis of six kilobases of Blochmannia sequences (unpubl. data) corroborates earlier evidence of low GC content for this bacterial genome (⬃30% GC; Dasch, 1975). This AT bias has a strong impact on the amino acid co ...
Pleiotropy and the evolution of floral integration
Pleiotropy and the evolution of floral integration

... traits, most affect a relatively small number of traits, allowing for substantial modularity in genetic architecture (Wagner et al., 2007). These results are consistent with patterns that have long been observed from quantitative trait locus (QTL) mapping (Juenger et al., 2005; Fig. 1), and they sug ...
1 Word count: title, abstract, body, notes, references - Philsci
1 Word count: title, abstract, body, notes, references - Philsci

... Wright’s two interpretations of the diagram can be shown to be equivalent. Without these demonstrations, Ruse’s critique is inconclusive. Whatever is to be made of the Provine–Ruse technical disagreement over interpreting the diagram, I do not think it matters much to understanding the adaptive lan ...
Autopoiesis and Natural Drift - University of the Basque Country
Autopoiesis and Natural Drift - University of the Basque Country

... defined by a recursive network of component production), and in negative ones (autopoiesis is not a result of the properties of certain cellular components, such as genetic materials). The negative presentation of the theory involves a criticism of the role played by biological concepts such as gene ...
The Darwin Course - University of Arkansas
The Darwin Course - University of Arkansas

... Lab Report on Radiometric Decay (20 pts). We will begin the lab in class and you will likely complete it at home and hand it in on Feb 24th. The lab should be written up on “lab report format” (see attached example sheet). Semester Paper (60 pts). Due Week #13B. Each student will select a different ...
- CURRENT ZOOLOGY
- CURRENT ZOOLOGY

... been placed on distinguishing divergent ecological selection from other mechanisms of speciation (Schluter, 2009). However, traits that diverge between taxa are very unlikely to all be under divergent selection. As well as those diverging through drift, traits under stabilizing selection can also co ...
Comparing the human and chimpanzee genomes: Searching for
Comparing the human and chimpanzee genomes: Searching for

... finished human genome (International Human Genome Sequencing Consortium 2004) provides such a catalog of genomic features that ultimately interact with the environment to determine our biology, physiology, and disease susceptibility. Completion of the draft chimpanzee genome sequence (The Chimpanzee ...
Evolutionary origins of invasive populations
Evolutionary origins of invasive populations

... et al. 1994; Lee and Bell 1999; Cristescu et al. 2001, 2004), giving rise to the vast majority of invaders between 1985 and 2000 (Ricciardi and MacIsaac 2000). The Ponto-Caspian basin has a history marked by fluctuations in environmental variables on multiple timescales (Kaplin 1995; Svitoch et al. ...
STATISTICAL GENETICS AND EVOLUTION
STATISTICAL GENETICS AND EVOLUTION

... finally between different species, a subject that carries us outside the field of genetics and which has been discussed mathematically by Lotka [l2], Volterra [l7] and Nicholson and Bailie [14], Selection among individuals may relate to the mating activities of one or both sexes, to differences in r ...
Folie 1
Folie 1

... Born in Canada, Endler took his PhD degree at the University of Edinburgh in Scotland and subsequently worked at the University of California, Santa Barbara and the James Cook University of North Queensland, Australia. Since 2006 he has been Anniversary Professor of Animal Behaviour in the School of ...
Macro-Evolution
Macro-Evolution

... “It has always been thought that early prokaryotes lacked introns and that later organisms developed them. We now have strong evidence that bacteria have lost their introns during evolution”. Gilbert speculates that bacteria may have evolved from larger, less efficient pre-eukaryotes, no examples of ...
Analyses of human–chimpanzee orthologous gene
Analyses of human–chimpanzee orthologous gene

... downloaded from ENSEMBL v.37 (Birney et al., 2006). Ka/Ks ratios were obtained only for genes for which we had the highest confidence, and we excluded pairs such as pseudogenes and poorly annotated genes. (Nonetheless, not eliminating gene pairs at all for any of these datasets did not significantly ...
Lecture Slides
Lecture Slides

... individuals, a movement from one allocation to another that can make at least one individual better off without making any other individual worse off is called a Pareto Improvement. An allocation is Pareto Optimal when no further Pareto Improvements can be made. This is often called a Strong Pareto ...
The Origins of Human Modernity
The Origins of Human Modernity

... prime mover of recent human development. All of these explanations of evolutionary processes contrasting with plain natural selection are at significant variance with the currently still dominant paleoanthropological and archaeological model of recent human evolution, the replacement hypothesis (“Af ...
Evolution on the X chromosome: unusual patterns and processes
Evolution on the X chromosome: unusual patterns and processes

... (provided that 2hsf + sm > 0; otherwise KX = 0). The ratio of K for X-linked and autosomal mutations (when both are > 0) is therefore: ...
< 1 ... 13 14 15 16 17 18 19 20 21 ... 90 >

Adaptive evolution in the human genome

Adaptive evolution results from the propagation of advantageous mutations through positive selection. This is the modern synthesis of the process which Darwin and Wallace originally identified as the mechanism of evolution. However, in the last half century there has been considerable debate as to whether evolutionary changes at the molecular level are largely driven by natural selection or random genetic drift. Unsurprisingly, the forces which drive evolutionary changes in our own species’ lineage have been of particular interest. Quantifying adaptive evolution in the human genome gives insights into our own evolutionary history and helps to resolve this neutralist-selectionist debate. Identifying specific regions of the human genome that show evidence of adaptive evolution helps us find functionally significant genes, including genes important for human health, such as those associated with diseases.
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