Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin
... 246 in the human sequence is not conserved in the murine and porcine sequences. The three TPO sequences contain four conserved cysteines located within the amino terminal half of the protein. There are seven potential N-linked glycosylation sites within murine TPO andsixwithin porcine TPO. Four glyc ...
... 246 in the human sequence is not conserved in the murine and porcine sequences. The three TPO sequences contain four conserved cysteines located within the amino terminal half of the protein. There are seven potential N-linked glycosylation sites within murine TPO andsixwithin porcine TPO. Four glyc ...
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... Interestingly, the TP53 induced glycolysis regulatory phosphatase (TIGAR) shows sequence homology to the phosphatase domain of PFKFB proteins [40]. TIGAR is induced upon acute activation of p53 in response to DNA damage. This blocks PFK1 activity by reducing Fru-2,6-BP levels. As a consequence, G6P ...
... Interestingly, the TP53 induced glycolysis regulatory phosphatase (TIGAR) shows sequence homology to the phosphatase domain of PFKFB proteins [40]. TIGAR is induced upon acute activation of p53 in response to DNA damage. This blocks PFK1 activity by reducing Fru-2,6-BP levels. As a consequence, G6P ...
FIST/HIPK3: a Fas/FADD-interacting Serine/Threonine Kinase that
... poly Ig receptor (not shown). An EMBL/GenBank/DDBJ search revealed that the sequences of clones 4, 16, 18, and 25 were contained in a murine gene recently identified as HIPK3, whereas clones 10 and 12 corresponded to murine HIPK1 (25). We cloned the full-length murine and human homologue of FIST/HIP ...
... poly Ig receptor (not shown). An EMBL/GenBank/DDBJ search revealed that the sequences of clones 4, 16, 18, and 25 were contained in a murine gene recently identified as HIPK3, whereas clones 10 and 12 corresponded to murine HIPK1 (25). We cloned the full-length murine and human homologue of FIST/HIP ...
Nutrient Sensing through the Plasma Membrane of Eukaryotic Cells
... transporter [42], is induced only by low levels of glucose because its promoter has binding sites for the Mig1 glucose repressor, which represses transcription when glucose levels are high (Figure 3) [43]. By contrast, expression of HXT1, which encodes a low-affinity glucose transporter [42], is ind ...
... transporter [42], is induced only by low levels of glucose because its promoter has binding sites for the Mig1 glucose repressor, which represses transcription when glucose levels are high (Figure 3) [43]. By contrast, expression of HXT1, which encodes a low-affinity glucose transporter [42], is ind ...
University of Groningen Stress responses and sugar metabolism in
... relatively simple developmental process); ...
... relatively simple developmental process); ...
A low carbohydrate, high protein diet combined
... pooled data from three independent studies and compared primary tumor sizes of mice on the four different diets after 3 weeks. With an increased sample size, we found that the 4T1 primary tumors grew statistically slower (P < 0.05) in the 15% CHO group than in the Western group and the addition of ...
... pooled data from three independent studies and compared primary tumor sizes of mice on the four different diets after 3 weeks. With an increased sample size, we found that the 4T1 primary tumors grew statistically slower (P < 0.05) in the 15% CHO group than in the Western group and the addition of ...
A role for interleukin-1 in epidermal differentiation
... Next we examined the levels of the two IL-1 receptors, IL1 RI and RII, expressed by keratinocytes at various stages of differentiation. Here, we induced differentiation in cultures by growth to confluence. Post-confluent keratinocyte cultures are stratified and express higher levels of markers of di ...
... Next we examined the levels of the two IL-1 receptors, IL1 RI and RII, expressed by keratinocytes at various stages of differentiation. Here, we induced differentiation in cultures by growth to confluence. Post-confluent keratinocyte cultures are stratified and express higher levels of markers of di ...
Table S1 Genes with similar expression patterns in Qing2
... Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 ...
... Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 ...
Saccharomyces cerevisiae.
... proteins may lead to gradients in the oxygen concentration as a result of imperfect mixing. In general, full levels of oxygenation are almost impossible to maintain in large-scale fermenters. Local and transient hypoxic or anaerobic conditions will trigger transcriptional and metabolic changes in th ...
... proteins may lead to gradients in the oxygen concentration as a result of imperfect mixing. In general, full levels of oxygenation are almost impossible to maintain in large-scale fermenters. Local and transient hypoxic or anaerobic conditions will trigger transcriptional and metabolic changes in th ...
1 - University of Pennsylvania
... • http://bioie.ldc.upenn.edu - release 0.9 available 1157 abstracts entity annotated, 318 also treebanked ...
... • http://bioie.ldc.upenn.edu - release 0.9 available 1157 abstracts entity annotated, 318 also treebanked ...
Document
... The yellow perch is one of a group of important fishes which exhibit a sexual size dimorphism (SSD) in which females grow faster than males. Studies have identified 17β-estradiol (E2) as a growth stimulator in yellow perch SSD (Malison et al., 1988; Malison et al., 1986; Malison et al., 1985) and Ro ...
... The yellow perch is one of a group of important fishes which exhibit a sexual size dimorphism (SSD) in which females grow faster than males. Studies have identified 17β-estradiol (E2) as a growth stimulator in yellow perch SSD (Malison et al., 1988; Malison et al., 1986; Malison et al., 1985) and Ro ...
SUC1 and SUC2: two sucrose transporters from Arabidopsis
... sucrose transporters; these sequences, however, are different from those found in STP1 and MST1 (Table 1). For various monosaccharide transporters it has been postulated that their present structure with 12 transmembrane segments might have evolved, by gene duplication and fusion of an ancestral tra ...
... sucrose transporters; these sequences, however, are different from those found in STP1 and MST1 (Table 1). For various monosaccharide transporters it has been postulated that their present structure with 12 transmembrane segments might have evolved, by gene duplication and fusion of an ancestral tra ...
Moore BA, Gonzalez Aviles GD, Larkins CE, Hillman MJ, Caspary T. Mamm Genome. 2010 Aug;21(7-8):350-60. Mitochondrial retention of Opa1 is required for mouse embryogenesis
... embryos, we verified that the predominant transcript produced from the mutant allele used the cryptic splice site, resulting in a 6-bp insertion of intronic sequence. This aberrant transcript was predicted to result in the translation of a cysteine (C) in place of a tryptophan (W) at amino acid 616, ...
... embryos, we verified that the predominant transcript produced from the mutant allele used the cryptic splice site, resulting in a 6-bp insertion of intronic sequence. This aberrant transcript was predicted to result in the translation of a cysteine (C) in place of a tryptophan (W) at amino acid 616, ...
PPT - Altogen Biosystems
... 5. Optional: Add 2 µl of Complex Condenser. This reagent reduces the size of transfection complex, therefore increasing transfection efficiency; however it may increase cell toxicity 6. Add prepared transfection complexes to 0.5 ml of complete growth medium with AGS cells (from step ...
... 5. Optional: Add 2 µl of Complex Condenser. This reagent reduces the size of transfection complex, therefore increasing transfection efficiency; however it may increase cell toxicity 6. Add prepared transfection complexes to 0.5 ml of complete growth medium with AGS cells (from step ...
Biology - Kenyon College
... of internal acidification, such as YfiD (9, 32) or InaA (64). Instead, in cultures grown in complex medium, we found largely opposite responses: most proteins induced by acetate were repressed by formate, and several proteins induced by formate were repressed by acetate. This pattern of responses su ...
... of internal acidification, such as YfiD (9, 32) or InaA (64). Instead, in cultures grown in complex medium, we found largely opposite responses: most proteins induced by acetate were repressed by formate, and several proteins induced by formate were repressed by acetate. This pattern of responses su ...
PPT - Altogen Biosystems
... 1. Plate 10,000 - 15,000 H9c2 cells per well in 0.5 ml of complete growth medium 12–24 hours prior to transfection 2. Wash with 1xPBS and add 0.5 ml of fresh growth medium 3. Prepare transfection complexes by mixing 40 µl of serum-free medium, 5.5 µl of transfection reagent, and • 750 ng DNA (or mRN ...
... 1. Plate 10,000 - 15,000 H9c2 cells per well in 0.5 ml of complete growth medium 12–24 hours prior to transfection 2. Wash with 1xPBS and add 0.5 ml of fresh growth medium 3. Prepare transfection complexes by mixing 40 µl of serum-free medium, 5.5 µl of transfection reagent, and • 750 ng DNA (or mRN ...
Matricellular Protein Cyr61 Bridges Lysophosphatidic Acid and
... temporal and spatial expression in SMCs. We observed specific and dramatic induction of Cyr61 expression stimulated by LPA in vascular SMCs. We further explored the role of Cyr61 in LPA-induced SMC migration and related molecular mechanisms. LPA elicits cellular responses mainly via its cognate G-pr ...
... temporal and spatial expression in SMCs. We observed specific and dramatic induction of Cyr61 expression stimulated by LPA in vascular SMCs. We further explored the role of Cyr61 in LPA-induced SMC migration and related molecular mechanisms. LPA elicits cellular responses mainly via its cognate G-pr ...
Developmental changes in barley microRNA expression profiles
... that are crucial regulators of gene expression which control plant development and response to environmental cues. We have analyzed microtranscriptomes of five barley developmental stages. Generally, during the barley development, miR168-3p and miR1432-5p levels increase while the 5’U-miR156-5p leve ...
... that are crucial regulators of gene expression which control plant development and response to environmental cues. We have analyzed microtranscriptomes of five barley developmental stages. Generally, during the barley development, miR168-3p and miR1432-5p levels increase while the 5’U-miR156-5p leve ...
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... the apoplastic space [12]. This unconventional mode of secretion was named enhanced secretion of proteins localized in ER bodies (ESPER), and was also found to be employed in protein PR1 secretion. ESPER was not commonly induced by inoculation of tested nonadapted Colletotrichum species, nor with fl ...
... the apoplastic space [12]. This unconventional mode of secretion was named enhanced secretion of proteins localized in ER bodies (ESPER), and was also found to be employed in protein PR1 secretion. ESPER was not commonly induced by inoculation of tested nonadapted Colletotrichum species, nor with fl ...
Practical Aspects of Estimating Energy Components in
... Results suggest that the relatively high affinity of SAA1.5 for high-density lipoprotein may cause the high serum concentration and may be related to the low susceptibility to amyloidosis. ...
... Results suggest that the relatively high affinity of SAA1.5 for high-density lipoprotein may cause the high serum concentration and may be related to the low susceptibility to amyloidosis. ...
Glycolytic strategy as a tradeoff between energy yield and protein cost
... known as “lower glycolysis.” In the EMP pathway, glucose is phosphorylated twice and cleaved into two triose-phosphates (G3P and dihydroxyacetone phosphate), both of which are used to produce ATP through substrate-level phosphorylation in lower glycolysis (2, 7) (Fig. 1B). In the ED pathway, glucose ...
... known as “lower glycolysis.” In the EMP pathway, glucose is phosphorylated twice and cleaved into two triose-phosphates (G3P and dihydroxyacetone phosphate), both of which are used to produce ATP through substrate-level phosphorylation in lower glycolysis (2, 7) (Fig. 1B). In the ED pathway, glucose ...
PhD Thesis - Cox Group
... Polyketides are formed by a similar biosynthetic pathway to that of fatty acids. They are formed by repetitive decarboxylative condensation of simple acetate units in the form of acetyl CoA 24 and malonyl CoA 25 (in some cases propionate and butyrate units) in a head to tail manner. In polyketide p ...
... Polyketides are formed by a similar biosynthetic pathway to that of fatty acids. They are formed by repetitive decarboxylative condensation of simple acetate units in the form of acetyl CoA 24 and malonyl CoA 25 (in some cases propionate and butyrate units) in a head to tail manner. In polyketide p ...
Structure and function of the eukaryotic ADP
... also identified and characterised. The ADPGK enzymes catalyse a phosphorylation reaction converting glucose and ADP to glucose-6-phosphate and AMP. The enzyme is well studied in extremophilic archaea, where ADPGK is part of a set of glycolytic enzymes that use ADP instead of ATP for the phosphorylat ...
... also identified and characterised. The ADPGK enzymes catalyse a phosphorylation reaction converting glucose and ADP to glucose-6-phosphate and AMP. The enzyme is well studied in extremophilic archaea, where ADPGK is part of a set of glycolytic enzymes that use ADP instead of ATP for the phosphorylat ...
Molecular cloning, characterization and gene expression of an
... Catalase is a very highly conserved enzyme that has been identified from numerous species including bacteria, fungi, plants and animals. This enzyme is ubiquitous and present in archaea [22], prokaryotes and eukaryotes [32e35]. To date, much information about the structure and regulation of catalase ...
... Catalase is a very highly conserved enzyme that has been identified from numerous species including bacteria, fungi, plants and animals. This enzyme is ubiquitous and present in archaea [22], prokaryotes and eukaryotes [32e35]. To date, much information about the structure and regulation of catalase ...
Oxide Expression of Foxp3 in T Cells via Nitric Myelin Basic Protein
... decrease in the activity and number of Tregs, leading to huge proliferation of self-reactive T cells and subsequent autoimmune attack. Foxp3 is an X chromosome-encoded transcription factor expressed exclusively in Tregs and critically important for the development and function of these cells. The Fo ...
... decrease in the activity and number of Tregs, leading to huge proliferation of self-reactive T cells and subsequent autoimmune attack. Foxp3 is an X chromosome-encoded transcription factor expressed exclusively in Tregs and critically important for the development and function of these cells. The Fo ...