Multiple RNA regulatory elements mediate distinct
... Pattern formation in the early development of many organisms relies on localized cytoplasmic proteins, which can be prelocalized as mRNAs. The Drosophila oskar gene, required both for posterior body patterning and germ cell determination, encodes one such mRNA. Localization of oskar mRNA is an elabo ...
... Pattern formation in the early development of many organisms relies on localized cytoplasmic proteins, which can be prelocalized as mRNAs. The Drosophila oskar gene, required both for posterior body patterning and germ cell determination, encodes one such mRNA. Localization of oskar mRNA is an elabo ...
A Comparative Study - Carlos Ibanez Lab @ KI
... NGF. Although all three NGFs were recognized equally well in the immunoblotting, only one-third of the chicken NGF protein could be detected by immunoprecipitation or by the EIA as compared to the rat and human NGFs. Thus, changes in the three-dimensional structure of the NGF molecule are most likel ...
... NGF. Although all three NGFs were recognized equally well in the immunoblotting, only one-third of the chicken NGF protein could be detected by immunoprecipitation or by the EIA as compared to the rat and human NGFs. Thus, changes in the three-dimensional structure of the NGF molecule are most likel ...
Supplementary materials - Stanford Artificial Intelligence Laboratory
... taking the regions to include the 500bp upstream of the transcription start site. In either case, we computed enrichment of the polymorphisms in a gene group of interest (case group) by comparing the distribution of the number of polymorphisms between the group and a control group. The control group ...
... taking the regions to include the 500bp upstream of the transcription start site. In either case, we computed enrichment of the polymorphisms in a gene group of interest (case group) by comparing the distribution of the number of polymorphisms between the group and a control group. The control group ...
Function and Control of the Spx-Family of Proteins Within
... uncovered quite novel players functioning as nodes in the stress management network. Such nodes are the targets of multiple stress-induced regulatory devices and upon stimulation exert their effects on a variety of response effectors. Among the factors that have emerged as important contributors to ...
... uncovered quite novel players functioning as nodes in the stress management network. Such nodes are the targets of multiple stress-induced regulatory devices and upon stimulation exert their effects on a variety of response effectors. Among the factors that have emerged as important contributors to ...
PDF hosted at the Radboud Repository of the Radboud University
... FIG. 2. The mitochondrial oxidative phosphorylation (OXPHOS) system. (A) Mitochondrial functioning depends on a sufficiently large proton motive force (PMF ) across the mitochondrial inner membrane (MIM). The PMF consists of an electrical (Dc) and a chemical (DpH) component and is maintained by the ...
... FIG. 2. The mitochondrial oxidative phosphorylation (OXPHOS) system. (A) Mitochondrial functioning depends on a sufficiently large proton motive force (PMF ) across the mitochondrial inner membrane (MIM). The PMF consists of an electrical (Dc) and a chemical (DpH) component and is maintained by the ...
Engineering Cytosolic Acetyl-CoA Metabolism in
... A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for biochemical production. However, it cannot grow on glucose as the sole carbon source due to the lack of cytosolic ace ...
... A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for biochemical production. However, it cannot grow on glucose as the sole carbon source due to the lack of cytosolic ace ...
The cuticle
... To whom correspondence should be addressed. E-mail: [email protected] or [email protected] ...
... To whom correspondence should be addressed. E-mail: [email protected] or [email protected] ...
- VU Research Repository
... Although the underlying causes of ethanol inhibition of cells are yet to be identified, it has been discovered that yeast acclimatise more quickly to ethanol stress in the presence of low acetaldehyde concentrations; however, the biochemical processes underpinning this effect are unknown. The object ...
... Although the underlying causes of ethanol inhibition of cells are yet to be identified, it has been discovered that yeast acclimatise more quickly to ethanol stress in the presence of low acetaldehyde concentrations; however, the biochemical processes underpinning this effect are unknown. The object ...
URINE is USEFUL! - Stark, William S.
... • Proteinuria may be the first indication of renovascular, glomerular, or tubulointerstitial renal disease, or may represent the flow of abnormal proteins in the urine in conditions such as multiple myeloma. • Transient proteinuria can be common, especially in the pediatric population and resolves ...
... • Proteinuria may be the first indication of renovascular, glomerular, or tubulointerstitial renal disease, or may represent the flow of abnormal proteins in the urine in conditions such as multiple myeloma. • Transient proteinuria can be common, especially in the pediatric population and resolves ...
Effect of Aminoguanidine (Inducible Nitric Oxide Synthase Inhibitor
... of E1 leading to impaired reactivation by PDP has been proposed as one possible explanation for the delay in PDC reactivation that is found in liver, heart and oxidative skeletal muscle on re-feeding after starvation [20,23]. The E1α mutants were constructed by converting the serine residues at diff ...
... of E1 leading to impaired reactivation by PDP has been proposed as one possible explanation for the delay in PDC reactivation that is found in liver, heart and oxidative skeletal muscle on re-feeding after starvation [20,23]. The E1α mutants were constructed by converting the serine residues at diff ...
Glucosamine-Induced Insulin Resistance in Primary Rat
... 142g/day (Felig, Marliss et al. 1969; Gottstein 1979). The second reason for regulating glucose concentration is that glucose is toxic. The amount of glucose in the bloodstream is tightly regulated by actions of insulin and glucagon during fed and fasting states (Flakoll PJ 2000). Insulin, a hormon ...
... 142g/day (Felig, Marliss et al. 1969; Gottstein 1979). The second reason for regulating glucose concentration is that glucose is toxic. The amount of glucose in the bloodstream is tightly regulated by actions of insulin and glucagon during fed and fasting states (Flakoll PJ 2000). Insulin, a hormon ...
A Truncated Laminin Chain Homologous to the B2 Chain: Structure
... This structure is stabilized by ionic interactions between the chains. Calculations of these interactions show that only heterotrimeric molecules with one A-type chain, one Bl-type chain, and one B2-type chain are favorable (20). Studies on the expression of laminin subunit genes and distribution of ...
... This structure is stabilized by ionic interactions between the chains. Calculations of these interactions show that only heterotrimeric molecules with one A-type chain, one Bl-type chain, and one B2-type chain are favorable (20). Studies on the expression of laminin subunit genes and distribution of ...
Flux limitations in the ortho pathway of benzoate
... by A . etltrophtls (Dols e t al., 1994; Zhou & Crawford, 1995). However, most studies reported on the regulation of the catabolism of aromatic compounds have been performed with low or very low concentrations of substrates (generally below 5 mM) which do not necessarily reflect the stress conditions ...
... by A . etltrophtls (Dols e t al., 1994; Zhou & Crawford, 1995). However, most studies reported on the regulation of the catabolism of aromatic compounds have been performed with low or very low concentrations of substrates (generally below 5 mM) which do not necessarily reflect the stress conditions ...
The metabolic basis of Candida albicans
... pathway and cAMP-PKA pathway. These lead to the activation of transcriptional regulators Cph1p and Efg1p, respectively, which promote filamentous growth. Nitrogen starvation activates both the MAP Kinase and cAMP-PKA pathways via ammonium permease (Mep2p). Adenylyl cyclase (Cdc35p) not only responds ...
... pathway and cAMP-PKA pathway. These lead to the activation of transcriptional regulators Cph1p and Efg1p, respectively, which promote filamentous growth. Nitrogen starvation activates both the MAP Kinase and cAMP-PKA pathways via ammonium permease (Mep2p). Adenylyl cyclase (Cdc35p) not only responds ...
ABA overlysensitive5 (ABO5), encoding a pentatricopeptide repeat
... ABA treatment in the wild type, but only to a moderate level in abo5, probably because abo5 already expressed high levels of mitochondrial-encoded cox2 and nad genes under no ABA treatment. More H2O2 accumulated in the root tips of abo5 than in the wild type, and H2O2 accumulation was further enhanc ...
... ABA treatment in the wild type, but only to a moderate level in abo5, probably because abo5 already expressed high levels of mitochondrial-encoded cox2 and nad genes under no ABA treatment. More H2O2 accumulated in the root tips of abo5 than in the wild type, and H2O2 accumulation was further enhanc ...
Biochemical, biophysical and interaction studies of the stress
... ii. Copies of this thesis, either in full or in extracts and whether in hard or electronic copy, may be made only in accordance with the Copyright, Designs and Patents Act 1988 (as amended) and regulations issued under it or, where appropriate, in accordance with licensing agreements which the Unive ...
... ii. Copies of this thesis, either in full or in extracts and whether in hard or electronic copy, may be made only in accordance with the Copyright, Designs and Patents Act 1988 (as amended) and regulations issued under it or, where appropriate, in accordance with licensing agreements which the Unive ...
Caroline Jeya Sheeba Daniel Sunder Singh
... existing between AER/FGF and ZPA/SHH for limb hairy2 expression regulation. Importantly, we demonstrate that this joint requirement is not a signaling relay but a convergence of both signals at the level of hairy2 expression making hairy2 a readout of AER/FGF and ZPA/SHH signals at both time and spa ...
... existing between AER/FGF and ZPA/SHH for limb hairy2 expression regulation. Importantly, we demonstrate that this joint requirement is not a signaling relay but a convergence of both signals at the level of hairy2 expression making hairy2 a readout of AER/FGF and ZPA/SHH signals at both time and spa ...
The SRA gen - uri=dna.kdna.ucla
... altered, indicating a telomeric location, which was confirmed by genomic mapping (data not shown). A HindIII 1 HpaI digest revealed the presence of a HpaI site downstream from the gene in one of the two copies (bottom band in second panel). Expression of the ETat 1.2 gene in ETat 1.2CR was linked to ...
... altered, indicating a telomeric location, which was confirmed by genomic mapping (data not shown). A HindIII 1 HpaI digest revealed the presence of a HpaI site downstream from the gene in one of the two copies (bottom band in second panel). Expression of the ETat 1.2 gene in ETat 1.2CR was linked to ...
Interaction between calmodulin and ER
... blocking interaction with coactivators. Gene transcription is thus inhibited. ...
... blocking interaction with coactivators. Gene transcription is thus inhibited. ...
The semi-phosphorylative Entner–Doudoroff pathway in
... as the pathway for glucose catabolism on the basis of 14 Clabelling studies and identification of the characteristic intermediates (KDG and GA) [5], as well as characterization of key enzyme activities [5,21,22]. The GDH and KDG aldolase of S. solfataricus have been studied in detail, and more recen ...
... as the pathway for glucose catabolism on the basis of 14 Clabelling studies and identification of the characteristic intermediates (KDG and GA) [5], as well as characterization of key enzyme activities [5,21,22]. The GDH and KDG aldolase of S. solfataricus have been studied in detail, and more recen ...
Regulation of Ketone Body Metabolism and the Role of PPAR
... in the systemic metabolism during fasting is triggered by glucagon and involves the mobilization of lipids stored in adipose tissue and break down of triglycerides to free fatty acids and glycerol [1,2]. These two components are subsequently catabolized in liver: fatty acids undergo β-oxidation to p ...
... in the systemic metabolism during fasting is triggered by glucagon and involves the mobilization of lipids stored in adipose tissue and break down of triglycerides to free fatty acids and glycerol [1,2]. These two components are subsequently catabolized in liver: fatty acids undergo β-oxidation to p ...
Regulation of Starch Synthesis in Cassava Yona Baguma
... of PP2A, did not, suggesting that sugar and ABA signaling pathways converge at the PP1 level downstream of the sugar signaling pathway. Chloramphenicol, which specifically inhibits plastid de novo protein synthesis, with or without sucrose, blocked sbe expression but cycloheximide, a cytosolic de no ...
... of PP2A, did not, suggesting that sugar and ABA signaling pathways converge at the PP1 level downstream of the sugar signaling pathway. Chloramphenicol, which specifically inhibits plastid de novo protein synthesis, with or without sucrose, blocked sbe expression but cycloheximide, a cytosolic de no ...
mTOR complex 2 (mTORC2) controls hydrophobic motif
... hydrophobic motif of Akt (Ser473 ). mTORC1 consists of mTOR, raptor (regulatory associated protein of mTOR) and mLST8 (mammalian lethal with SEC13 protein 8; previously known as GβL). mTORC1 is activated by growth factors via a PI3Kregulated pathway, involving Akt-mediated phosphorylation of TSC2 (t ...
... hydrophobic motif of Akt (Ser473 ). mTORC1 consists of mTOR, raptor (regulatory associated protein of mTOR) and mLST8 (mammalian lethal with SEC13 protein 8; previously known as GβL). mTORC1 is activated by growth factors via a PI3Kregulated pathway, involving Akt-mediated phosphorylation of TSC2 (t ...
attached paper highlights
... cardiac hypertrophy with preserved systolic function and signs of heart failure that develop with aging, together with the abnormal mitochondrial structure,34 suggesting that PPARg could also play a role in mitochondrial biogenesis. However, it is not yet firmly established whether the mitochondrial ...
... cardiac hypertrophy with preserved systolic function and signs of heart failure that develop with aging, together with the abnormal mitochondrial structure,34 suggesting that PPARg could also play a role in mitochondrial biogenesis. However, it is not yet firmly established whether the mitochondrial ...