Susan Viggiano and Michael S. Cosgrove
... complexes are linked to H3K4 monomethylation at active enhancers (39). In contrast, it has been suggested that SETd1A/B complexes catalyze the bulk of H3K4 trimethylation in cells (40, 41), but it is dependent on other factors that are unique to SETd1A/B complexes, such as WDR82 (Swd2 in yeast) (40, ...
... complexes are linked to H3K4 monomethylation at active enhancers (39). In contrast, it has been suggested that SETd1A/B complexes catalyze the bulk of H3K4 trimethylation in cells (40, 41), but it is dependent on other factors that are unique to SETd1A/B complexes, such as WDR82 (Swd2 in yeast) (40, ...
Mutation specific therapies
... parts). The reasoning for this approach is explained here in detail. Exon skipping can be used to restore the genetic code for different mutations types. The following figures contain three parts: at the top the situation at DNA level (so the level of the gene) is depicted, in the middle the RNA cop ...
... parts). The reasoning for this approach is explained here in detail. Exon skipping can be used to restore the genetic code for different mutations types. The following figures contain three parts: at the top the situation at DNA level (so the level of the gene) is depicted, in the middle the RNA cop ...
The different roles of tryptophan transfer RNA in regulating trp
... transport and chorismate biosynthesis, and it also autoregulates its own synthesis [2]. Whenever a cell lacks sufficient tryptophan to activate the trp repressor, repression is relieved. Complete relief results in an 80-fold increase in the rate of initiation of transcription of the trp operon [16]. ...
... transport and chorismate biosynthesis, and it also autoregulates its own synthesis [2]. Whenever a cell lacks sufficient tryptophan to activate the trp repressor, repression is relieved. Complete relief results in an 80-fold increase in the rate of initiation of transcription of the trp operon [16]. ...
A conserved N-‐terminal domain of Rif2 regulates telomere length in
... The regulation of telomere length equilibrium is essential for cell growth and survival since critically short telomeres signal DNA damage and cell cycle arrest. While the broad principles of length regulatio ...
... The regulation of telomere length equilibrium is essential for cell growth and survival since critically short telomeres signal DNA damage and cell cycle arrest. While the broad principles of length regulatio ...
Cyclic Adenosine Monophosphate Signaling Pathway
... vasculature, the cellular or molecular mechanisms underlying these beneficial effects is still unknown. A recent study suggests that genistein-induced vascular relaxation may be at least partially mediated by the cAMPdependent mechanisms (26). Other reports demonstrate that genistein may increase cA ...
... vasculature, the cellular or molecular mechanisms underlying these beneficial effects is still unknown. A recent study suggests that genistein-induced vascular relaxation may be at least partially mediated by the cAMPdependent mechanisms (26). Other reports demonstrate that genistein may increase cA ...
Investigating the link between tRNA and mRNA - EMBL-EBI
... which mrna can be translated into proteins. On the one hand, this serves to explain the need for the observed, stable trna abundance. On the other hand, this also raises questions: the change of expression of protein-coding genes means that different, specifically highly expressed protein-coding gen ...
... which mrna can be translated into proteins. On the one hand, this serves to explain the need for the observed, stable trna abundance. On the other hand, this also raises questions: the change of expression of protein-coding genes means that different, specifically highly expressed protein-coding gen ...
Dateien anzeigen - Universität Düsseldorf
... metabolism of G. oxydans also poses a problem, which is the low cell yield resulting in high costs for biomass production. This study aimed at an increase of the cell yield of G. oxydans on glucose in order to improve its application potential. For this purpose, prevention of incomplete glucose oxid ...
... metabolism of G. oxydans also poses a problem, which is the low cell yield resulting in high costs for biomass production. This study aimed at an increase of the cell yield of G. oxydans on glucose in order to improve its application potential. For this purpose, prevention of incomplete glucose oxid ...
Ethylene is involved in strawberry fruit ripening in an organ
... is not that simple and have generated some controversy in the field (Trainotti et al., 2005; Iannetta et al., 2006). It has been reported that, despite its low concentration, ethylene presents a characteristic pattern of production during different developmental stages; it is relatively high in gree ...
... is not that simple and have generated some controversy in the field (Trainotti et al., 2005; Iannetta et al., 2006). It has been reported that, despite its low concentration, ethylene presents a characteristic pattern of production during different developmental stages; it is relatively high in gree ...
Molecular analysis and biological implications of STAT3 signal
... STAT3 ser727 phosphorylation. PKCδ is the end-point kinase of the Rac-MEKK-SEK-1 signal transduction cascade and phosphorylates STAT3 on the ser727 residue in response to IL-6. It is plausible that JNK-1 and PKCδ are anchored in different signal transduction protein complexes and that these complexe ...
... STAT3 ser727 phosphorylation. PKCδ is the end-point kinase of the Rac-MEKK-SEK-1 signal transduction cascade and phosphorylates STAT3 on the ser727 residue in response to IL-6. It is plausible that JNK-1 and PKCδ are anchored in different signal transduction protein complexes and that these complexe ...
University of Groningen Lactococcus lactis systems biology Eckhardt
... thoroughly investigate the hundreds of proteins in a proteome, high-throughput nongel-based techniques are increasingly used and have paved the way for a proteomics analysis that describes all proteins of a proteome. The most common technique is mass spectrometry (MS), a very sensitive method to det ...
... thoroughly investigate the hundreds of proteins in a proteome, high-throughput nongel-based techniques are increasingly used and have paved the way for a proteomics analysis that describes all proteins of a proteome. The most common technique is mass spectrometry (MS), a very sensitive method to det ...
Farnesyl diphosphate synthase, the target for nitrogen
... imaged by use of epifluorescence microscopy at the times indicated after addition of either alendronate or G418. All images were captured with the same exposure times and processed identically. An enhanced image of G418-selected cells is included to show the high percentage of low-expressing cells. ...
... imaged by use of epifluorescence microscopy at the times indicated after addition of either alendronate or G418. All images were captured with the same exposure times and processed identically. An enhanced image of G418-selected cells is included to show the high percentage of low-expressing cells. ...
THE INFLUENCE OF NUTRITIONAL PHOSPHATE DEPRIVATION ARABIDOPSIS THALIANA
... Abstract This thesis examines the influence of nutritional phosphate (Pi) deprivation on extracellular proteins secreted by the model plant Arabidopsis thaliana. Initial studies compared the secretome of Pi-sufficient (+Pi) versus Pi-deficient (-Pi) Arabidopsis cell cultures by 2-dimensional gel el ...
... Abstract This thesis examines the influence of nutritional phosphate (Pi) deprivation on extracellular proteins secreted by the model plant Arabidopsis thaliana. Initial studies compared the secretome of Pi-sufficient (+Pi) versus Pi-deficient (-Pi) Arabidopsis cell cultures by 2-dimensional gel el ...
Obesity and the regulation of fat metabolism
... endocrine organ (Rondinone, 2006; Trayhurn and Bing, 2006). This was principally based on the discovery of leptin, a cytokine-like hormone secreted from white adipose tissue in proportion to fat mass (Friedman and Halaas, 1998). Activation of hypothalamic leptin receptors suppresses food intake and ...
... endocrine organ (Rondinone, 2006; Trayhurn and Bing, 2006). This was principally based on the discovery of leptin, a cytokine-like hormone secreted from white adipose tissue in proportion to fat mass (Friedman and Halaas, 1998). Activation of hypothalamic leptin receptors suppresses food intake and ...
as a PDF
... For example, the coding sequences of trpE and trpD overlap by 29 nucleotides. Recent results establish that translation of trpD is coupled to translation of trpE and that formation of the trpE SD blocking hairpin regulates expression of trpD via translational coupling (43a). Thus, it is possible tha ...
... For example, the coding sequences of trpE and trpD overlap by 29 nucleotides. Recent results establish that translation of trpD is coupled to translation of trpE and that formation of the trpE SD blocking hairpin regulates expression of trpD via translational coupling (43a). Thus, it is possible tha ...
Multiomics of tomato glandular trichomes reveals
... Intermediates of secondary metabolite precursor pathways are overrepresented in trichomes Since GTs of LA4024 and LA1777 in particular produce terpenoids from both the mevalonate (MEV) and the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathways, metabolites of these pathways we ...
... Intermediates of secondary metabolite precursor pathways are overrepresented in trichomes Since GTs of LA4024 and LA1777 in particular produce terpenoids from both the mevalonate (MEV) and the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathways, metabolites of these pathways we ...
pdf file - College of Computer, Mathematical, and Natural Sciences
... 2000). LUG encodes a glutamine-rich protein with seven WD repeats and was predicted to act as a transcriptional corepressor (Conner and Liu, 2000). lug and ap2 mutations enhance each others’ effects with respect to floral organ identity transformation and floral organ loss (Liu and Meyerowitz, 1995) ...
... 2000). LUG encodes a glutamine-rich protein with seven WD repeats and was predicted to act as a transcriptional corepressor (Conner and Liu, 2000). lug and ap2 mutations enhance each others’ effects with respect to floral organ identity transformation and floral organ loss (Liu and Meyerowitz, 1995) ...
STRIVE Report Series No.65
... the styrene catabolic genes may lead to greater levels of enzyme activity and thus to increased styrene degradation. A number of recombinant strains were generated and analysis suggests that non-styrenecontrolled expression and multiple copies of the genes are ...
... the styrene catabolic genes may lead to greater levels of enzyme activity and thus to increased styrene degradation. A number of recombinant strains were generated and analysis suggests that non-styrenecontrolled expression and multiple copies of the genes are ...
Full-Text PDF
... identified rare variants in the topoisomerase DNA binding II binding protein 1 (TOPBP1). The protein encoded by this gene binds to double- and single-stranded DNA and inhibits E2F transcription factor 1-mediated apoptosis leading to increased cell survival. Pulmonary artery endothelial cells isolate ...
... identified rare variants in the topoisomerase DNA binding II binding protein 1 (TOPBP1). The protein encoded by this gene binds to double- and single-stranded DNA and inhibits E2F transcription factor 1-mediated apoptosis leading to increased cell survival. Pulmonary artery endothelial cells isolate ...
as a PDF
... PhoP/PhoR, have been identified. The catabolite control protein CcpA controls expression of glycolytic genes and tricarboxylic acid cycle and respiratory chain enzymes, while PhoP/ PhoR controls the ArcA/ArcB analogs (called ResE/ResD) (3, 54). In L. lactis, an FNR homologue and two-component system ...
... PhoP/PhoR, have been identified. The catabolite control protein CcpA controls expression of glycolytic genes and tricarboxylic acid cycle and respiratory chain enzymes, while PhoP/ PhoR controls the ArcA/ArcB analogs (called ResE/ResD) (3, 54). In L. lactis, an FNR homologue and two-component system ...
NOVEL SPERM-SPECIFIC GLYCOLYTIC ISOZYMES GENERATED
... Aldoart2. Unique nucleotide sequence in Aldoart1 provided evidence for an alternatively spliced exon in Aldoa_v2. Expression of all three isozymes was restricted to the male germline and was regulated at transcriptional and translational levels. Both ALDOART1 and ALDOA_V2 are tightly bound to the fi ...
... Aldoart2. Unique nucleotide sequence in Aldoart1 provided evidence for an alternatively spliced exon in Aldoa_v2. Expression of all three isozymes was restricted to the male germline and was regulated at transcriptional and translational levels. Both ALDOART1 and ALDOA_V2 are tightly bound to the fi ...
mineralization of chlorobenzene. of the meta
... fluid during turnover of chlorobenzene, benzene, or toluene were measured by high-performance liquid chromatography (HPLC) directly after inactivation and removal of the cells by acidification with 0.4% H3PO4 and centrifugation. Conversion of several catechols. The capacity of crude extract of tolue ...
... fluid during turnover of chlorobenzene, benzene, or toluene were measured by high-performance liquid chromatography (HPLC) directly after inactivation and removal of the cells by acidification with 0.4% H3PO4 and centrifugation. Conversion of several catechols. The capacity of crude extract of tolue ...
Eater, a Transmembrane Protein Mediating
... Drosophila melanogaster has a primitive yet highly effective immune system that relies exclusively on innate effector mechanisms, including epithelial and systemic responses generating antimicrobial peptides, a phenoloxidase reaction leading to melanin deposition, and a cellular response resulting i ...
... Drosophila melanogaster has a primitive yet highly effective immune system that relies exclusively on innate effector mechanisms, including epithelial and systemic responses generating antimicrobial peptides, a phenoloxidase reaction leading to melanin deposition, and a cellular response resulting i ...
Microbial degradation of chloroaromatics Mars, Astrid E.
... Muconate cycloisomerase was measured by determining the decrease in substrate concentration at 260 nm. Reaction mixtures contained (in 1 ml) 30 mmol of Tris-HCl (pH 8.0), 1 mmol of MnCl2, and 0.1 mmol of cis,cis-muconic acid. The reaction was started by adding crude extract (0.02 to 0.2 mg of protei ...
... Muconate cycloisomerase was measured by determining the decrease in substrate concentration at 260 nm. Reaction mixtures contained (in 1 ml) 30 mmol of Tris-HCl (pH 8.0), 1 mmol of MnCl2, and 0.1 mmol of cis,cis-muconic acid. The reaction was started by adding crude extract (0.02 to 0.2 mg of protei ...
A non-hemorrhagic hybrid heparin/heparan sulfate with
... similar to porcine heparin (∼16 kDa) and lower than bovine heparan sulfate (∼25 kDa). The compound was characterized by 1 H/13 C heteronuclear single-quantum coherence (HSQC)-NMR analysis, as shown in Fig. 3A and B and Table 2. Following H/C signal correlation, the compound isolated from shrimp head ...
... similar to porcine heparin (∼16 kDa) and lower than bovine heparan sulfate (∼25 kDa). The compound was characterized by 1 H/13 C heteronuclear single-quantum coherence (HSQC)-NMR analysis, as shown in Fig. 3A and B and Table 2. Following H/C signal correlation, the compound isolated from shrimp head ...