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Cannabinoids for Gastrointestinal Diseases: Potential Therapeutic
Cannabinoids for Gastrointestinal Diseases: Potential Therapeutic

... increase the concentration of endocannabinoids at cannabinoid receptors. Although the indirect activation of cannabinoid receptors is expected to be more selective than direct receptor agonists, as it would produce effects only at sites where ongoing production of endocannabinoids is taking place, t ...
Systematic Review of Combined Angiotensin
Systematic Review of Combined Angiotensin

... blocker. We conducted a meta-analysis of randomized trials with searches of MEDLINE, EMBASE, and Cochrane databases. Overall, the combination of an ACE inhibitor and an angiotensin receptor blocker reduced ambulatory blood pressure by 4.7/3.0 mm Hg (95% confidence interval [CI], 2.9 to 6.5/1.6 to 4. ...
Bimatoprost (AGN 192024) in glaucoma treatment
Bimatoprost (AGN 192024) in glaucoma treatment

... the development of OAG [7]. In the accompanying editorial [8], it is concluded that lowering IOP helps preserve visual function in OAG, NTG, and OHT, and for patients with each of these diagnoses, a 3 mmHg reduction in IOP roughly corresponds to a 50% reduction in the risk of the development or prog ...
Monitoring and management of right ventricular function following
Monitoring and management of right ventricular function following

... therefore does not rely on the stimulation of β-receptors, which can be down-regulated or desensitized in prolonged catecholamine therapy or cardiac insufficiency (11). Thus, the combination of β-agonists and phosphodiesterase III inhibitors leads to an increase in cAMP levels and synergistic hemody ...
Piracetam reverses haloperidol-induced - Tubitak Journals
Piracetam reverses haloperidol-induced - Tubitak Journals

... catalepsy in mice treated with haloperidol. Haloperidol is a classic neuroleptic drug that induces motor abnormalities and cognitive impairment due to a blockade of dopamine D2 receptors in the striatum. Materials and methods: Catalepsy was induced by intraperitoneal haloperidol (2 mg/kg) administra ...
Pharmacological Approaches to Fat Loss: Targeting
Pharmacological Approaches to Fat Loss: Targeting

... The assertion that beta-agonists such as clenbuterol and ephedrine have no anabolic effects in humans is premature. There is a large difference in the dosages normally given to animals (4 mg/kg) as compared to humans (up to 40 µg/day). Slow release Salbutamol has been shown to increase voluntary mus ...
Review Article Pro- and Anticonvulsant Effects of Anesthetics (Part 11)
Review Article Pro- and Anticonvulsant Effects of Anesthetics (Part 11)

... (N,O) activated EEG epileptiform activity in more than 75% of the patients (176,181). The well-known EEG activating effects of N,O cannot be ruled out as an additive factor in these two reports. Furthermore, correlation between EEG and clinical seizure activity may have been prevented by concomitant ...
Targeting the dopamine D receptor in schizophrenia
Targeting the dopamine D receptor in schizophrenia

... explored for the mode of action of chlorpromazine, including its action on mitochondrial enzymes, sodium–potassium-ATPase and related enzymes, as well as its membrane-stabilising action, such as its strong potency to inhibit membrane action potentials, and to stabilise cellular and subcellular membr ...
HERE - INDIGO Biosciences
HERE - INDIGO Biosciences

... a b s t r a c t Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. Aims: Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen to bind to nuclear receptors. Materials and methods: In sil ...
John Salamone: Dopamine, Motivation and Schizophrenia
John Salamone: Dopamine, Motivation and Schizophrenia

... antipsychotic drugs are directly related to their clinical effects DA mediates “motivational salience” or “motivational significance” • DA mediates instrumental responses to appetitive and aversive events • DA antagonists “change the drive to obtain food and sex” or “decrease motivational drive” • D ...
Opioid Pharmacology : new insight and clinical relevance
Opioid Pharmacology : new insight and clinical relevance

... – 1. Tolerance to analgesic or side effect of opioid 2. Specific withdrawal or abstinence syndrome resulting from physiologic dependence 3. Craving for drug from psychological dependence ...
Appendix D: Commonly Used Antihypertensive Drugs 1
Appendix D: Commonly Used Antihypertensive Drugs 1

... Footnotes: a Not an exhaustive list; b For normal renal and hepatic function. Consult product monograph for detailed dosing instructions and dose adjustments for unique patient populations; c Pricing is approximate as per PharmaNet from 2014/05/30 to 2014/06/16 and does not include dispensing fee or ...
Effects of Commonly Used Benzodiazepines - E
Effects of Commonly Used Benzodiazepines - E

... syndrome. However, several other investigators did not accept the existence of this syndrome (43,44). Low birth weight and small head circumference were reported in a study of 17 infants born to women who took diazepam or other benzodiazepines during pregnancy (45). The weights of these children had ...
$doc.title

... ii. At  that  time,  the  presumed  risks  of  cocaine  overdose  included  cerebrovascular  accident,  lethal   arrhythmias,  and  high  output  congestive  heart  failure  (CHF)   b. 1982-­‐  The  first  report  of  myocardial  ischemia  and ...
Striatal  D2 / D3  Receptor  Occupancy, ... and Side Effects with Amisulpride: An Iodine-123-Iodobenzamide SPET Study
Striatal D2 / D3 Receptor Occupancy, ... and Side Effects with Amisulpride: An Iodine-123-Iodobenzamide SPET Study

... anticholinergic and sedative effects and EPS [11, 21]. A recent meta-analysis of 18 clinical trials showed that amisulpride is an effective and welltolerated atypical antipsychotic for the treatment of both positive and negative symptoms [8]. Up to now, there are different models about the mechanism ...
Assessment of the Influence of Histaminergic Actions on Cocaine
Assessment of the Influence of Histaminergic Actions on Cocaine

... of the parent compound BZT are antimuscarinic and antihistaminic effects (Richelson, 1981; McKearney, 1982a). The present study was conducted to assess the potential of actions at histamine receptors to explain these anomalous effects of BZT analogs. In previous studies, we have examined the influen ...
Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence
Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence

... antagonists, and disopyramide.1,2 In general, b-blockers are most effective on the latent, exercise-related form of LVOT obstruction, but tend to be less effective when severe obstruction is present at rest. Non-dihidropiridinic calcium antagonists such as verapamil or diltiazem are even less effect ...
Drug Information Letter  New Drug Evaluation Multaq (dronedarone) Tablets
Drug Information Letter New Drug Evaluation Multaq (dronedarone) Tablets

... patients in EURIDIS and ADONIS in an outpatient setting. Patients ranged in age from 20 to 88 years of age, with the majority being Caucasian (97%). Patients were also taking conventional therapies for cardiovascular diseases. Patients were followed for 12 months. The primary endpoint was time to fi ...
CLENBUTEROL TABLETS 40mcg/tab
CLENBUTEROL TABLETS 40mcg/tab

... Clenbuterol is a prescribed Asthma medication which is catabolic to fat and anabolic to muscle. Clenbuterol’s most valid application seems to be as a pre-contest, cutting drug. It is a Beta-2 adrenergic agonist. This means it acts just like adrenaline (epinephrine) at a certain type of receptor name ...
Topiramate in Migraine Prevention
Topiramate in Migraine Prevention

... experience, half of the patients are able to terminate drug therapy after intervention for one year and half will have to continue a longer period of drug therapy. The most commonly used drugs for the prevention of migraine are the beta-blockers propranolol and metoprolol. Their use is supported by ...
Clinical case scenarios
Clinical case scenarios

... Each case scenario includes details of the person’s initial presentation, their medical history and their care. Clinical decisions about diagnosis and management are then considered using a “question and answer” approach that relates to the recommendations in the NICE guideline. However, in practice ...
Intestinal Permeability of Lamivudine Using Single Pass Intestinal
Intestinal Permeability of Lamivudine Using Single Pass Intestinal

... single pass intestinal perfusion technique in male Wistar rats. Single pass intestinal perfusion was performed in small intestine at a flow rate of 0.20 ml/min. Lamivudine exhibits a high intestinal permeability over the length of the small intestine indicative of compounds that are well absorbed. T ...
Eliot Gardner, Ph.D. - Nysam
Eliot Gardner, Ph.D. - Nysam

... † AUC (0-15) P < 0.05 and # AUC (15-60) P < 0.001 for analgesics vs NaCl 0.9 % ...
Part 2: Recommendations for Hypertension Treatment
Part 2: Recommendations for Hypertension Treatment

... adverse effects, other classes of antihypertensive drugs may be combined (such as alpha blockers or centrally acting agents). 2011 Canadian Hypertension Education Program Recommendations ...
Clenbuterol - National Drug Strategy
Clenbuterol - National Drug Strategy

... Hypertension (high blood pressure) ...
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Discovery and development of beta-blockers

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