the concept of the therapeutic window in the choice of h1
... therapeutic window will differ between intranasal (topical) and oral (systemic) drug administration. The issues discussed in this paper will focus on those pertaining to oral H1-antihistamine administration. Within any given therapeutic window for H1 antihistamines, a range of factors may influence ...
... therapeutic window will differ between intranasal (topical) and oral (systemic) drug administration. The issues discussed in this paper will focus on those pertaining to oral H1-antihistamine administration. Within any given therapeutic window for H1 antihistamines, a range of factors may influence ...
Serotonergic Modulation of Rat Pineal Gland Activity: In Vivo
... Experiment 2. The aim of this experiment was to assess the effects of 5-HT receptor activation by m-CPP on the pineal melatonin production during the night, when the gland is physiologically activated by NE. To this purpose, 54 rats (weighing 200 –250 g) were used in this experiment. At 9:00 PM, in ...
... Experiment 2. The aim of this experiment was to assess the effects of 5-HT receptor activation by m-CPP on the pineal melatonin production during the night, when the gland is physiologically activated by NE. To this purpose, 54 rats (weighing 200 –250 g) were used in this experiment. At 9:00 PM, in ...
Invited Review - International Journal of Pharmaceutical Science
... H37Rv strain by both micro dilution assay method. Compound [12] and [13] showed best activity. They revealed that the compounds that have shown more than 90% inhibition were obtained by S-alkylation with acetonitrile. It was noted that the cyano group may not have any role in increase in the activit ...
... H37Rv strain by both micro dilution assay method. Compound [12] and [13] showed best activity. They revealed that the compounds that have shown more than 90% inhibition were obtained by S-alkylation with acetonitrile. It was noted that the cyano group may not have any role in increase in the activit ...
Pharmacotherapy In Cardiopulmonary Resuscitation (CPR)
... the duration of the action potential. It also causes block in sodium and calcium channels and alpha and beta adrenergic receptors. As a result of its direct effect on smooth muscle, and its ability to block calcium channels and alpha adrenergic receptors, amiodarone dilates coronary arteries. It als ...
... the duration of the action potential. It also causes block in sodium and calcium channels and alpha and beta adrenergic receptors. As a result of its direct effect on smooth muscle, and its ability to block calcium channels and alpha adrenergic receptors, amiodarone dilates coronary arteries. It als ...
New horizons in pulmonary arterial hypertension therapies
... well tolerated by the patients in this trial and, notably, adverse events commonly associated with the ERA drug class (elevated liver aminotransferases and peripheral oedema) occurred at a similar rate to patients who received placebo across all groups [27]. Macitentan has recently been approved by ...
... well tolerated by the patients in this trial and, notably, adverse events commonly associated with the ERA drug class (elevated liver aminotransferases and peripheral oedema) occurred at a similar rate to patients who received placebo across all groups [27]. Macitentan has recently been approved by ...
Downloaded
... started because of maternal depression about an existing pregnancy complication or whether the complication occurred after drug therapy was initiated for other reasons, it is difficult to ascribe cause and effect. Not surprisingly, therefore, reports of the teratogenic risk of maternal TCA use have ...
... started because of maternal depression about an existing pregnancy complication or whether the complication occurred after drug therapy was initiated for other reasons, it is difficult to ascribe cause and effect. Not surprisingly, therefore, reports of the teratogenic risk of maternal TCA use have ...
Heart Glucocorticoids Activate Cardiac Mineralocorticoid Receptors
... commonly considered a GR/progesterone receptor antagonist, is equipotent with the classic glucocorticoid agonist dexamethasone in terms of increasing infarct size; addition of spironolactone at equimolar concentrations again reversed this effect down to control levels. Because myocardial apoptosis p ...
... commonly considered a GR/progesterone receptor antagonist, is equipotent with the classic glucocorticoid agonist dexamethasone in terms of increasing infarct size; addition of spironolactone at equimolar concentrations again reversed this effect down to control levels. Because myocardial apoptosis p ...
Document
... • Because the antimuscarinic drugs slow gastric emptying, they may increase symptoms in patients with gastric ulcer. Nonselective antimuscarinic agents should never be used to treat acid-peptic disease. ...
... • Because the antimuscarinic drugs slow gastric emptying, they may increase symptoms in patients with gastric ulcer. Nonselective antimuscarinic agents should never be used to treat acid-peptic disease. ...
Kinetics of metoclopramide effects on human 5
... current suppression by 200 nM metoclopramide, Fig. I). Therefore, persuasive evidence that metoclopramide inhibits radioligand binding of specific 5-HT3 receptor antagonists and contrasting reports of 5-HT3 antagonists acting via non-competitive mechanisms (for review, See [2]) need not be a contrad ...
... current suppression by 200 nM metoclopramide, Fig. I). Therefore, persuasive evidence that metoclopramide inhibits radioligand binding of specific 5-HT3 receptor antagonists and contrasting reports of 5-HT3 antagonists acting via non-competitive mechanisms (for review, See [2]) need not be a contrad ...
Body Temperature and Analgesic Effects of Selective Mu and Kappa
... Accepted for publication December 5, 1996 ...
... Accepted for publication December 5, 1996 ...
Chapter - 6 Evaluation ofCNS depressant and anticonvulsant
... consumed life long, the administration o f other drugs predisposes to the risk o f drug interaction (Basavaraj et a l, 2011; Venkateswarulu et at., 2012). Thus it is necessary to investigate for antiepileptic agents that are safe, efficacious and free from toxicity. The main intention o f treating a ...
... consumed life long, the administration o f other drugs predisposes to the risk o f drug interaction (Basavaraj et a l, 2011; Venkateswarulu et at., 2012). Thus it is necessary to investigate for antiepileptic agents that are safe, efficacious and free from toxicity. The main intention o f treating a ...
Interventional Role of Piperazine Citrate in Barium Chloride Induced
... buffering effect [47], and contributes to its anti-arrhythmic action. Similarly, piperazine may negate the arrhythmogenic effect of BaCl2 by blocking the K+ channels. Since most K+ channel blocking drugs also interact with beta-adrenergic receptors, such as sotolol that prolongs cardiac action poten ...
... buffering effect [47], and contributes to its anti-arrhythmic action. Similarly, piperazine may negate the arrhythmogenic effect of BaCl2 by blocking the K+ channels. Since most K+ channel blocking drugs also interact with beta-adrenergic receptors, such as sotolol that prolongs cardiac action poten ...
Thromboxane Receptors Antagonists and/or Synthase Inhibitors
... Western countries. Several clinical conditions are characterized by increased incidence of cardiovascular events and enhanced thromboxane (TX)-dependent platelet activation. Enhanced TX generation may be explained by mechanisms relatively insensitive to aspirin. More potent drugs possibly overcoming ...
... Western countries. Several clinical conditions are characterized by increased incidence of cardiovascular events and enhanced thromboxane (TX)-dependent platelet activation. Enhanced TX generation may be explained by mechanisms relatively insensitive to aspirin. More potent drugs possibly overcoming ...
Amvasc 2.5 mg Capsule REGIONAL ADMINISTRATIVE INFORMATI
... AmvascTM is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist). Amlodipine is a member of the dihydropyridine class of calcium antagonists. Mechanism of Action: AmvascTM inhibits transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, with a g ...
... AmvascTM is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist). Amlodipine is a member of the dihydropyridine class of calcium antagonists. Mechanism of Action: AmvascTM inhibits transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, with a g ...
D I NEW DRUGS - Ontario Pharmacists Association
... Hypertension Trial Group. Cardiovasc Drugs Ther. 1995 Jun;9(3):413-20. Ruddy TD, Wright JM, Savard D, Handa SP, Chockalingam A, Fischer L, et al. 24 hour blood pressure control with once-daily versus twice-daily formulations of diltiazem. ...
... Hypertension Trial Group. Cardiovasc Drugs Ther. 1995 Jun;9(3):413-20. Ruddy TD, Wright JM, Savard D, Handa SP, Chockalingam A, Fischer L, et al. 24 hour blood pressure control with once-daily versus twice-daily formulations of diltiazem. ...
Metabolic Syndrome
... When "I“, the Ego, was with me, then I couldn’t realize the almighty within; Now, the Almighty "is" ever with me and there is no place for this Ego. All the darkness (illusion) within me is mitigated, on realizing the light (illumination) within. ...
... When "I“, the Ego, was with me, then I couldn’t realize the almighty within; Now, the Almighty "is" ever with me and there is no place for this Ego. All the darkness (illusion) within me is mitigated, on realizing the light (illumination) within. ...
A comparison of the cardiovascular ... formoterol, salbutamol and fenoterol
... maximum inotropic effect of formoterol was considerably less than that due to fenoterol. This difference occurred despite the cumulative dose response design employed, which effectively "biased" the results against formoterol, due to its longer duration of action. The chronotropic effect of fenotero ...
... maximum inotropic effect of formoterol was considerably less than that due to fenoterol. This difference occurred despite the cumulative dose response design employed, which effectively "biased" the results against formoterol, due to its longer duration of action. The chronotropic effect of fenotero ...
Diabetic Hypertension targetted Rx. by Dr. Sarma
... When "I“, the Ego, was with me, then I couldn’t realize the almighty within; Now, the Almighty "is" ever with me and there is no place for this Ego. All the darkness (illusion) within me is mitigated, on realizing the light (illumination) within. ...
... When "I“, the Ego, was with me, then I couldn’t realize the almighty within; Now, the Almighty "is" ever with me and there is no place for this Ego. All the darkness (illusion) within me is mitigated, on realizing the light (illumination) within. ...
Epinephrine Injection, USP
... anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic rather than in non-asthmatic peopl ...
... anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic rather than in non-asthmatic peopl ...
Anti-Rheumatic Medications During Pregnancy and Lactation (Part 2) Topical Medical Issues
... concentrations and fetal-cord blood).1,2 There is no evidence of increased teratogenicity or congenital malformations in fetuses that have been exposed to gold during pregnancy.1-3,5,6 According to the Food and Drug Administration (FDA), gold salts fall under “category C” (see bottom of Table on pag ...
... concentrations and fetal-cord blood).1,2 There is no evidence of increased teratogenicity or congenital malformations in fetuses that have been exposed to gold during pregnancy.1-3,5,6 According to the Food and Drug Administration (FDA), gold salts fall under “category C” (see bottom of Table on pag ...
the PDF
... high affinity toward GABAB receptors (IC50 = 2 nM; inhibition of binding of [3H]baclofen to GABAB receptors of cat cerebellum; Bittiger et al., 1988; Froestl et al., 1995a). Due to its 15 times higher potency, high specific binding, and the possibility to carry out filtration assays, [3H]CGP27492 ha ...
... high affinity toward GABAB receptors (IC50 = 2 nM; inhibition of binding of [3H]baclofen to GABAB receptors of cat cerebellum; Bittiger et al., 1988; Froestl et al., 1995a). Due to its 15 times higher potency, high specific binding, and the possibility to carry out filtration assays, [3H]CGP27492 ha ...
Gaba - American College of Neuropsychopharmacology
... by numerous firms, with slight variations in pharmacokinetics and other details, and quite a few nonbenzodiazepine structures were discovered that act at the benzodiazepine site on the GABAR to enhance GABA-mediated inhibition (Fig. 12.4) (46). This group includes compounds called carbolines, some ...
... by numerous firms, with slight variations in pharmacokinetics and other details, and quite a few nonbenzodiazepine structures were discovered that act at the benzodiazepine site on the GABAR to enhance GABA-mediated inhibition (Fig. 12.4) (46). This group includes compounds called carbolines, some ...
Structure- Activity Relationships (SAR)
... agents and approaches for treating and preventing these illnesses. • Most drugs act at a specific site such as an enzyme or receptor. Compounds with similar structures often tend to have similar pharmacological activity. However, they usually exhibit difference in potency and unwanted side effects a ...
... agents and approaches for treating and preventing these illnesses. • Most drugs act at a specific site such as an enzyme or receptor. Compounds with similar structures often tend to have similar pharmacological activity. However, they usually exhibit difference in potency and unwanted side effects a ...
DMAT PA-1
... dec release of renin from kidneys dec stimulation of sympathetic NS in heart & vascular smooth muscle negative chronotropic effect negative inotropic effect some posess antiarrhythmic properties / class II antiarrhythmic ...
... dec release of renin from kidneys dec stimulation of sympathetic NS in heart & vascular smooth muscle negative chronotropic effect negative inotropic effect some posess antiarrhythmic properties / class II antiarrhythmic ...