Salvinorin A, an Active Component of the Hallucinogenic Sage
... using either G␣16 (A and B) or Gq-i5 (C and D). No responses were seen in untransfected cells or in cells transfected with hKOR alone (data not shown). Figure 2 also shows a representative dose-response study using Gq-i5 as the chimeric G protein. Because both methods seemed to yield equivalent resu ...
... using either G␣16 (A and B) or Gq-i5 (C and D). No responses were seen in untransfected cells or in cells transfected with hKOR alone (data not shown). Figure 2 also shows a representative dose-response study using Gq-i5 as the chimeric G protein. Because both methods seemed to yield equivalent resu ...
HUMAN PHARMACOLOGY AYAHUASCA Director de la Tesi:
... Colombia, Daime or Hoasca in Brazil, natema in Ecuador and pinde along the Pacific coast of Colombia. More than 70 indigenous groups are known to employ ayahuasca, for which 42 different vernacular names have been reported (Luna, 1986). The use of this pan-Amazonian psychotropic beverage appears to ...
... Colombia, Daime or Hoasca in Brazil, natema in Ecuador and pinde along the Pacific coast of Colombia. More than 70 indigenous groups are known to employ ayahuasca, for which 42 different vernacular names have been reported (Luna, 1986). The use of this pan-Amazonian psychotropic beverage appears to ...
Presentation
... simultaneously to reverse residual non-depolarising (competitive) neuromuscular block. Numerous clinical studies, which demonstrate this to be a safe and effective combination, have been published. Over 90% of the Glycopyrronium Bromide disappears from serum within 5 minutes following intravenous ad ...
... simultaneously to reverse residual non-depolarising (competitive) neuromuscular block. Numerous clinical studies, which demonstrate this to be a safe and effective combination, have been published. Over 90% of the Glycopyrronium Bromide disappears from serum within 5 minutes following intravenous ad ...
2015 Guidelines of the Taiwan Society of Cardiology and the
... hypertension. We disagreed with the ESH/ESH joint hypertension guidelines suggestion to loosen BP targets to <140/90 mmHg for all patients. We strongly disagree with the suggestion by the 2014 JNC report to raise the BP target to <150/90 mmHg for patients between 60-80 years of age. For patients wit ...
... hypertension. We disagreed with the ESH/ESH joint hypertension guidelines suggestion to loosen BP targets to <140/90 mmHg for all patients. We strongly disagree with the suggestion by the 2014 JNC report to raise the BP target to <150/90 mmHg for patients between 60-80 years of age. For patients wit ...
... Fig. 2. – Schematic diagram of the beta2-adrenoceptor and its binding domains for antagonists and agonists. The ligand core is located between 11–18 Å into the receptor. The approximate agonist (✩) and antagonist (✪) binding regions are marked on a shaded background, representing the overlap in agon ...
CURRICULUM VITAE
... the affinity and/or efficacy of the orthosteric (endogenous) ligands, thereby fine-tuning its actions. Putative advantages of CB1-receptor allosteric inhibitors, and very recently discovered functional enhancers, include greater receptor subtype selectivity and reduced side effects. My research work ...
... the affinity and/or efficacy of the orthosteric (endogenous) ligands, thereby fine-tuning its actions. Putative advantages of CB1-receptor allosteric inhibitors, and very recently discovered functional enhancers, include greater receptor subtype selectivity and reduced side effects. My research work ...
Seeing Through the MIST: Abundance Versus Percentage
... is rare that drugs themselves elicit this type of toxicity (an exception is direct alkylating agents used in cancer chemotherapy) but some drugs can be bioactivated to chemically reactive entities that can act directly by covalently binding to proteins. It is also possible that drugs can be bioactiv ...
... is rare that drugs themselves elicit this type of toxicity (an exception is direct alkylating agents used in cancer chemotherapy) but some drugs can be bioactivated to chemically reactive entities that can act directly by covalently binding to proteins. It is also possible that drugs can be bioactiv ...
Opioid Receptors and Legal Highs - The Salvia divinorum Research
... Hallucinations occur rapidly after administration and are typically very vivid (27). Salvia divinorum produces synesthesia as its characteristic psychotropic effect; many users report a confusion of the senses, like hearing colors or smelling sounds (27). Hallucinogenic effects are typically brief, ...
... Hallucinations occur rapidly after administration and are typically very vivid (27). Salvia divinorum produces synesthesia as its characteristic psychotropic effect; many users report a confusion of the senses, like hearing colors or smelling sounds (27). Hallucinogenic effects are typically brief, ...
effects of cytochrome p450 enzyme inhibitors and inducers
... plasma concentrations of oral S-ketamine. CYP3A4 induction by St. John´s wort or rifampicin decreased profoundly the concentrations of oral S-ketamine. However, after rifampicin, there were no significant differences in the plasma concentrations of S-ketamine when it was administered intravenously. ...
... plasma concentrations of oral S-ketamine. CYP3A4 induction by St. John´s wort or rifampicin decreased profoundly the concentrations of oral S-ketamine. However, after rifampicin, there were no significant differences in the plasma concentrations of S-ketamine when it was administered intravenously. ...
Pharmacological Effects
... Myocardial reperfusion injury has recently been considered to involve a type of inflammatory response, and myocardial infarction has been associated with the coordinated activation of a series of inflammatory responses, including complement activation, an increase in the expression of cytokines and ...
... Myocardial reperfusion injury has recently been considered to involve a type of inflammatory response, and myocardial infarction has been associated with the coordinated activation of a series of inflammatory responses, including complement activation, an increase in the expression of cytokines and ...
Hallucinogens - Multidisciplinary Association for Psychedelic Studies
... body organ. Cohen (1967) has stated, ‘‘Death directly caused by the toxicity of LSD is unknown.’’ This statement was reiterated 20 years later by Jaffe (1985), ‘‘In man, deaths attributable to direct effects of LSD are unknown.’’ This observation still remains true today. Hallucinogens do not cause ...
... body organ. Cohen (1967) has stated, ‘‘Death directly caused by the toxicity of LSD is unknown.’’ This statement was reiterated 20 years later by Jaffe (1985), ‘‘In man, deaths attributable to direct effects of LSD are unknown.’’ This observation still remains true today. Hallucinogens do not cause ...
product monograph including patient
... after nitrate withdrawal. The importance of these observations to the routine clinical use of nitroglycerin has not been fully elucidated, but patients should be monitored closely for increased anginal symptoms during drug-free periods. Tolerance to nitroglycerin with cross tolerance to other nitrat ...
... after nitrate withdrawal. The importance of these observations to the routine clinical use of nitroglycerin has not been fully elucidated, but patients should be monitored closely for increased anginal symptoms during drug-free periods. Tolerance to nitroglycerin with cross tolerance to other nitrat ...
2013 ESH/ESC Guidelines for the management of arterial
... priority, data from randomized, controlled trials (RCTs) and their meta-analyses, but not to disregard—particularly when dealing with diagnostic aspects—the results of observational and other studies of appropriate scientific calibre, and (iii) to grade the level of scientific evidence and the stren ...
... priority, data from randomized, controlled trials (RCTs) and their meta-analyses, but not to disregard—particularly when dealing with diagnostic aspects—the results of observational and other studies of appropriate scientific calibre, and (iii) to grade the level of scientific evidence and the stren ...
Phosphodiesterase 5 inhibitors: are they cardioprotective?
... model of regional myocardial ischaemia, followed by reperfusion: 0.014 mg/kg vardenafil, given 30 min prior to coronary artery occlusion resulted in 58% of infarct size reduction (14.3 + 2.2% of the risk area in comparison to 33.8 + 1.3% in control animals).43 This effect was blocked by an inhibitor ...
... model of regional myocardial ischaemia, followed by reperfusion: 0.014 mg/kg vardenafil, given 30 min prior to coronary artery occlusion resulted in 58% of infarct size reduction (14.3 + 2.2% of the risk area in comparison to 33.8 + 1.3% in control animals).43 This effect was blocked by an inhibitor ...
Fixed Combinations of Glaucoma Medications
... years of treatment in about 50% of glaucoma patients [2] and frequently more than one agent is required to achieve adequate IOP control. If the initial therapy seems to be ineffective or the first choice monotherapy is well tolerated and is effective in lowering IOP but does not succeed in reaching ...
... years of treatment in about 50% of glaucoma patients [2] and frequently more than one agent is required to achieve adequate IOP control. If the initial therapy seems to be ineffective or the first choice monotherapy is well tolerated and is effective in lowering IOP but does not succeed in reaching ...
Pharmacology of anabolic steroids
... prolonging the duration of action. Furthermore, testosterone undecanoate is also orally active, the 11 carbon chain ester making the molecule so lipophilic that its route of absorption is partially shifted from the hepatic portal vein to the lymph system, thus bypassing first-pass metabolism to some ...
... prolonging the duration of action. Furthermore, testosterone undecanoate is also orally active, the 11 carbon chain ester making the molecule so lipophilic that its route of absorption is partially shifted from the hepatic portal vein to the lymph system, thus bypassing first-pass metabolism to some ...
Cardizem LA
... conduction in isolated tissues and has a negative inotropic effect in isolated preparations. In the intact animal, prolongation of the AH interval can be seen at higher doses. In man, diltiazem prevents spontaneous and ergonovine-provoked coronary artery spasm. It causes a decrease in peripheral vas ...
... conduction in isolated tissues and has a negative inotropic effect in isolated preparations. In the intact animal, prolongation of the AH interval can be seen at higher doses. In man, diltiazem prevents spontaneous and ergonovine-provoked coronary artery spasm. It causes a decrease in peripheral vas ...
METOPROLOL ACTAVIS
... arrhythmias, as well as to limitation of infarct size. Metoprolol has also been shown to reduce the incidence of recurrent myocardial infarction. Due to its beta-blocking effect, metoprolol is suitable for the prevention of migraine. Metoprolol has been shown to reduce diuretic-induced increase in p ...
... arrhythmias, as well as to limitation of infarct size. Metoprolol has also been shown to reduce the incidence of recurrent myocardial infarction. Due to its beta-blocking effect, metoprolol is suitable for the prevention of migraine. Metoprolol has been shown to reduce diuretic-induced increase in p ...
FMRFamide-ACTIVATED SIGNAL TRANSDUCTION PATHWAYS IN
... arachidonic acid pathways are involved in the FMRFamide-induced responses. FMRFamide-induced responses were reduced by the protein kinase C inhibitors, H-7 (5 ×10-5 M) and BIM I (10-5 M), calcium-calmodulin kinase II inhibitor, KN-62 (10-5 M), phospholipase A2 inhibitor, 4-BPB (10-6 M), and the phos ...
... arachidonic acid pathways are involved in the FMRFamide-induced responses. FMRFamide-induced responses were reduced by the protein kinase C inhibitors, H-7 (5 ×10-5 M) and BIM I (10-5 M), calcium-calmodulin kinase II inhibitor, KN-62 (10-5 M), phospholipase A2 inhibitor, 4-BPB (10-6 M), and the phos ...
How Do Atrial-Selective Drugs Differ From Antiarrhythmic
... Abstract Current pharmacologic strategies for the management of atrial fibrillation (AF) include use of 1) sodium channel blockers, which are contraindicated in patients with coronary artery or structural heart disease because of their potent effect to slow conduction in the ventricles, 2) potassium ...
... Abstract Current pharmacologic strategies for the management of atrial fibrillation (AF) include use of 1) sodium channel blockers, which are contraindicated in patients with coronary artery or structural heart disease because of their potent effect to slow conduction in the ventricles, 2) potassium ...
Doctoral Thesis
... The coexistence of human beings and infectious diseases accompanies humankind from the beginnings. Novel interventions to reduce consequences of the infections were searched from that time, but the first significant success in the field of specific antimicrobial agents were obtained in the first hal ...
... The coexistence of human beings and infectious diseases accompanies humankind from the beginnings. Novel interventions to reduce consequences of the infections were searched from that time, but the first significant success in the field of specific antimicrobial agents were obtained in the first hal ...
Chapter 15 outline
... Characterized by pain or discomfort in the chest radiating to the left arm and shoulder ...
... Characterized by pain or discomfort in the chest radiating to the left arm and shoulder ...
Macrocycles in new drug discovery
... while macrocycle 4 had an IC50 value of 10 nM, representing retention of activity with respect to the acyclic parent compound. However, com pound 3 was observed to form an ionic inter action between the tertiary amine and the acid Glu91 within the ribose pocket, while 4 has an undecorated alkyl ch ...
... while macrocycle 4 had an IC50 value of 10 nM, representing retention of activity with respect to the acyclic parent compound. However, com pound 3 was observed to form an ionic inter action between the tertiary amine and the acid Glu91 within the ribose pocket, while 4 has an undecorated alkyl ch ...
Guideline for the diagnosis and management of hypertension in adults
... This work is copyright. No part of this publication may be reproduced in any form or language without prior written permission from the National Heart Foundation of Australia (national office). Enquiries concerning permissions should be directed to [email protected]. Cover image: © wa ...
... This work is copyright. No part of this publication may be reproduced in any form or language without prior written permission from the National Heart Foundation of Australia (national office). Enquiries concerning permissions should be directed to [email protected]. Cover image: © wa ...