Antihistamines in pediatric allergy
... pharmacodynamic characteristics can differ greatly depending on the age group considered. These characteristics determine efficacy and particularly safety, and make it possible to predict the behavior of a given drug in the body. In general, antihistamines are well absorbed following oral administra ...
... pharmacodynamic characteristics can differ greatly depending on the age group considered. These characteristics determine efficacy and particularly safety, and make it possible to predict the behavior of a given drug in the body. In general, antihistamines are well absorbed following oral administra ...
... synthesis when dosed orally to volunteers. Zileuton had similar in vitro potency and selectivity to acetohydroxamates and inhibited leukotriene synthesis ex-vivo [49]. Zileuton inhibited airway microvascular leakage and bronchoconstriction induced by inhaled allergen in the sensitized guinea-pig mod ...
Potential arrhythmogenic role of cyclic adenosine
... coronary artery occlusion has been linked to the development of ventricular fibrillation by Podzuweit et al . (25). In baboons, the onset of ventricular fibrillation was preceded by a progressive elevation of cyclic AMP in ischemic myocardium . Observations obtained in pigs supported this concept (1 ...
... coronary artery occlusion has been linked to the development of ventricular fibrillation by Podzuweit et al . (25). In baboons, the onset of ventricular fibrillation was preceded by a progressive elevation of cyclic AMP in ischemic myocardium . Observations obtained in pigs supported this concept (1 ...
Basic concepts of Pharmacology. Pharmacokinetics of drugs.
... from prolonged using of hypnotics and acute poisoning by barbiturates (its features and treatment). 5) The alcohols: ethanol and its influence on organs and systems of organism during short and prolonged drinking. Acute poisoning by ethanol and its management. Acute poisoning by methanol, its featur ...
... from prolonged using of hypnotics and acute poisoning by barbiturates (its features and treatment). 5) The alcohols: ethanol and its influence on organs and systems of organism during short and prolonged drinking. Acute poisoning by ethanol and its management. Acute poisoning by methanol, its featur ...
Alternative antimicrobial drug(s) for treating penicillin
... A. decreases calcium entry through L type channels B. increases total peripheral resistance C. increases cardiac output D. increases heart rate E. increases gastrointestinal motility ...
... A. decreases calcium entry through L type channels B. increases total peripheral resistance C. increases cardiac output D. increases heart rate E. increases gastrointestinal motility ...
CALCIUM REPLACEMENT IN ADULT PATIENTS To standardize
... 6. Falsely low levels of calcium due to hypoalbuminaemia should be excluded by calculation of corrected calcium: Corrected calcium (mg/dl) + 0.8{ 4-serum albumin(g/dl)} 7. Monitor vital signs, being alert for bradycardia, dysrhythmias and postural hypotension. 8.When switching a patient to an altern ...
... 6. Falsely low levels of calcium due to hypoalbuminaemia should be excluded by calculation of corrected calcium: Corrected calcium (mg/dl) + 0.8{ 4-serum albumin(g/dl)} 7. Monitor vital signs, being alert for bradycardia, dysrhythmias and postural hypotension. 8.When switching a patient to an altern ...
Ouabain - the insulin of the heart - Herzinfarkt
... symptoms and slow the progression of contractile dysfunction. Despite these therapeutic advances, heart failure is still associated with an annual morta]jty rate of 10% (1). The search for better treatments and optimisation of existing ones remain major challenges in cardiology. Modulation of myocar ...
... symptoms and slow the progression of contractile dysfunction. Despite these therapeutic advances, heart failure is still associated with an annual morta]jty rate of 10% (1). The search for better treatments and optimisation of existing ones remain major challenges in cardiology. Modulation of myocar ...
QA_18_6_AmlodipinevsfelodipineAUG_15_FINAL
... of chronic stable angina pectoris. Felodipine can be used in combination with beta-blockers, ACE inhibitors or diuretics. Felodipine is well tolerated in patients with congestive heart failure but should be used with caution in patients with severe left ventricular dysfunction. (3) There are no sign ...
... of chronic stable angina pectoris. Felodipine can be used in combination with beta-blockers, ACE inhibitors or diuretics. Felodipine is well tolerated in patients with congestive heart failure but should be used with caution in patients with severe left ventricular dysfunction. (3) There are no sign ...
Stahl_3rd_ch12_Part1..
... for learning the mechanisms of action of so many drugs, the complex biological rationale for combining specific sets of drugs, and the practical tactics for tailoring a unique drug treatment portfolio to fit the needs of an individual patient. All known antidepressants studied in clinical trials des ...
... for learning the mechanisms of action of so many drugs, the complex biological rationale for combining specific sets of drugs, and the practical tactics for tailoring a unique drug treatment portfolio to fit the needs of an individual patient. All known antidepressants studied in clinical trials des ...
Misc topic, Medicine and Drugs
... cells by binding to specific receptor molecules (the "lock"), which are often located in the cell membrane. This binding "unlocks" the cell's response, so that the hormone or neurotransmitter can exert its effects. Many drugs work by mimicking a naturally occurring hormone or neurotransmitter in the ...
... cells by binding to specific receptor molecules (the "lock"), which are often located in the cell membrane. This binding "unlocks" the cell's response, so that the hormone or neurotransmitter can exert its effects. Many drugs work by mimicking a naturally occurring hormone or neurotransmitter in the ...
DESIGNING OF POTENTIAL NEW ESTROGEN ANTAGONISTS FOR TREATMENT OF
... It has become a chronic disease nowadays and it can be controlled by estrogen antagonist as estrogen antagonist inhibits the action of estrogen and proliferation of endometrial cell is stopped [6, 13, 18]. The discovery of the first design of Estrogen antagonist drug has inspired a number of continu ...
... It has become a chronic disease nowadays and it can be controlled by estrogen antagonist as estrogen antagonist inhibits the action of estrogen and proliferation of endometrial cell is stopped [6, 13, 18]. The discovery of the first design of Estrogen antagonist drug has inspired a number of continu ...
Newer Antihistamines
... peripheral histamine H1-receptors in children. Fifteen subjects with allergic rhinitis were tested before and 2-2.5 h after administration of diphenhydramine, hydroxyzine, or placebo in a double-blind, single-dose, three-way crossover study. Impairment of cognitive processing was assessed objectivel ...
... peripheral histamine H1-receptors in children. Fifteen subjects with allergic rhinitis were tested before and 2-2.5 h after administration of diphenhydramine, hydroxyzine, or placebo in a double-blind, single-dose, three-way crossover study. Impairment of cognitive processing was assessed objectivel ...
Fixed Combinations – Concept of Use
... and travoprost activate the FP receptor. FP activation alters second messenger signaling, stimulating intracellular production of pro-metalloproteinase. These convert to metalloproteinase outside the cell, and degrade collagen fibres, making the ciliary extracellular matrix more porous and facilitat ...
... and travoprost activate the FP receptor. FP activation alters second messenger signaling, stimulating intracellular production of pro-metalloproteinase. These convert to metalloproteinase outside the cell, and degrade collagen fibres, making the ciliary extracellular matrix more porous and facilitat ...
Product Monograph - Ask Novartis Pharma
... teratogenicity following exposure to angiotensin converting enzyme inhibitors (another class of therapeutic products interfering with the RAAS) during the first trimester of pregnancy has not been conclusive; however a small increase in risk cannot be excluded. Given the current evidence available o ...
... teratogenicity following exposure to angiotensin converting enzyme inhibitors (another class of therapeutic products interfering with the RAAS) during the first trimester of pregnancy has not been conclusive; however a small increase in risk cannot be excluded. Given the current evidence available o ...
Chronic Treatment with Dopamine Receptor Antagonists
... drugs (Tarsy and Baldessarini, 1974). The chronic treatment of rodents with neuroleptics does not usually result in the obvious dyskinetic movements of tardive dyskinesia, but does result in an increased sensitivity to the motor stimulatory effects of dopamine agonists, accompanied by an increase in ...
... drugs (Tarsy and Baldessarini, 1974). The chronic treatment of rodents with neuroleptics does not usually result in the obvious dyskinetic movements of tardive dyskinesia, but does result in an increased sensitivity to the motor stimulatory effects of dopamine agonists, accompanied by an increase in ...
GPCR ontology: development and application of a G protein
... the assay environment. Molecular target reflects a protein (or nucleic acid) modulated by a perturbagen. Filters can be adjusted based on a desired type of analysis. Analysis was initially performed per single screening campaign with compound categories defined as follows: an ‘active’ compound was o ...
... the assay environment. Molecular target reflects a protein (or nucleic acid) modulated by a perturbagen. Filters can be adjusted based on a desired type of analysis. Analysis was initially performed per single screening campaign with compound categories defined as follows: an ‘active’ compound was o ...
Antipsychotic Drugs - Pharmacological Reviews
... clozapine is a selective D4 receptor antagonist (Van Tol et al., 1991). Examination of the Ki values in Table 1 shows that the selectivity is low and had been overestimated previously owing to overestimation of the Ki at the D2 receptor when determined in competition versus [3H]spiperone. Problems w ...
... clozapine is a selective D4 receptor antagonist (Van Tol et al., 1991). Examination of the Ki values in Table 1 shows that the selectivity is low and had been overestimated previously owing to overestimation of the Ki at the D2 receptor when determined in competition versus [3H]spiperone. Problems w ...
Regulation of Brain Reward by the Endocannabinoid System: A
... heroin, as well as natural rewards, such as food, water and sucrose, although the conditions under which cannabinoids exert their rewarding effects may be more limited. The purpose of the present review is to briefly describe and evaluate the behavioral and pharmacological research concerning the ma ...
... heroin, as well as natural rewards, such as food, water and sucrose, although the conditions under which cannabinoids exert their rewarding effects may be more limited. The purpose of the present review is to briefly describe and evaluate the behavioral and pharmacological research concerning the ma ...
Causes and Consequences of Increased Sympathetic Activity in
... were increased several-fold after chronic NG-nitro-L-arginine methylester (L-NAME) treatment.31 Intracisternal NG-monomethyl-L-arginine (L-NMMA) administration resulted in a mild pressor response but in marked stimulation of RSNA.32 Recently, it was shown that the acute central antihypertensive acti ...
... were increased several-fold after chronic NG-nitro-L-arginine methylester (L-NAME) treatment.31 Intracisternal NG-monomethyl-L-arginine (L-NMMA) administration resulted in a mild pressor response but in marked stimulation of RSNA.32 Recently, it was shown that the acute central antihypertensive acti ...
... long-term vasodilator therapy. However, its safety and mode of administration for long-term use in PPH patients remains to be further evaluated. Adenosine. Adenosine, an intermediate product in the metabolism of adenosine triphosphate, has been shown to be a potent vasodilator agent in addition to o ...
Nefazodone in the rat: mimicry and antagonism of [À]-DOM
... specifically, as the dose of nefazodone administered intraperitoneally is increased, we observe an elevation in [ ]DOM appropriate responding. The interaction of a drug with its receptors may be characterized by the affinity of the drug for the receptors and its intrinsic activity at the receptors ( ...
... specifically, as the dose of nefazodone administered intraperitoneally is increased, we observe an elevation in [ ]DOM appropriate responding. The interaction of a drug with its receptors may be characterized by the affinity of the drug for the receptors and its intrinsic activity at the receptors ( ...
The UNSIN Report
... Devices) to measure intracellular calcium level changes in response to BZN and respective agonists [53,54]. Cells that expressed the following receptor subtypes Results were purchased (Millipore): 5-HT (1A, 1B, 2A, 3A), dopamine D2, alpha (1,2) and beta Results (Fig. 5) showed that there was (1, 2, ...
... Devices) to measure intracellular calcium level changes in response to BZN and respective agonists [53,54]. Cells that expressed the following receptor subtypes Results were purchased (Millipore): 5-HT (1A, 1B, 2A, 3A), dopamine D2, alpha (1,2) and beta Results (Fig. 5) showed that there was (1, 2, ...
Barbiturate
... mephobarbital (Mebaral) are prescribed for few reasons. When taken at bedtime, they help treat insomnia, and when taken during the day they have sedative effects that can aid in the treatment of tension and anxiety. However, prescription for the treatment of these conditions is now rare due to the r ...
... mephobarbital (Mebaral) are prescribed for few reasons. When taken at bedtime, they help treat insomnia, and when taken during the day they have sedative effects that can aid in the treatment of tension and anxiety. However, prescription for the treatment of these conditions is now rare due to the r ...
1 Name: Thyroglobulin (Proloid) Class: Thyroid Hormone Mech.: T3
... Dist.: Stored in fat and muscle. Tightly bound to vitamin D-binding protein. Metab.: Requires hydroxylation in liver and kidney for full activity. Excretion, t½: 1° = bile. Weeks. Toxicity/S.E.s: Excess accumulation in fat/muscle, hypervitaminosis D, hypercalcemia. Drug interactions—phenytoin and ph ...
... Dist.: Stored in fat and muscle. Tightly bound to vitamin D-binding protein. Metab.: Requires hydroxylation in liver and kidney for full activity. Excretion, t½: 1° = bile. Weeks. Toxicity/S.E.s: Excess accumulation in fat/muscle, hypervitaminosis D, hypercalcemia. Drug interactions—phenytoin and ph ...
Effect of novel adenosine A3 receptor antagonist
... Allergen challenge increases the bronchial level of adenosine [5], which can affect mast cell function [6]. Exogenous adenosine induces and/or enhances antigen-induced mast cell degranulation through the activation of A2b and/or A3 adenosine receptors [7-9]. Inhaled adenosine causes bronchoconstrict ...
... Allergen challenge increases the bronchial level of adenosine [5], which can affect mast cell function [6]. Exogenous adenosine induces and/or enhances antigen-induced mast cell degranulation through the activation of A2b and/or A3 adenosine receptors [7-9]. Inhaled adenosine causes bronchoconstrict ...