G-protein-coupled receptor kinases
... presence of agonist. This homologous desensitization of Gprotein-coupled receptors appears to be mediated, in part, by G-protein-coupled receptor kinases (GRKs) that have the unique property of phosphorylating their receptor substrates only when they are in their activated or agonist-occupied forms ...
... presence of agonist. This homologous desensitization of Gprotein-coupled receptors appears to be mediated, in part, by G-protein-coupled receptor kinases (GRKs) that have the unique property of phosphorylating their receptor substrates only when they are in their activated or agonist-occupied forms ...
Identification of the first invertebrate interleukin
... The evidence presented here indicates that domeless encodes a receptor of the Drosophila JAK/STAT pathway and shows that the pathway is conserved in invertebrates. The previous failure to detect the receptor was due to sequence similarity being restricted to a few critical amino acids in otherwise q ...
... The evidence presented here indicates that domeless encodes a receptor of the Drosophila JAK/STAT pathway and shows that the pathway is conserved in invertebrates. The previous failure to detect the receptor was due to sequence similarity being restricted to a few critical amino acids in otherwise q ...
Differential Internalization of the Prostaglandin F2α Receptor
... which in turn initiates clathrin-dependent internalization. However, other mechanisms of GPCR internalization exist that, for example, involve an initial phosphorylation by protein kinase C (PKC) instead of GPCR kinase (Ferrari et al., 1999; Hipkin et al., 2000; Xiang et al., 2001). An important dev ...
... which in turn initiates clathrin-dependent internalization. However, other mechanisms of GPCR internalization exist that, for example, involve an initial phosphorylation by protein kinase C (PKC) instead of GPCR kinase (Ferrari et al., 1999; Hipkin et al., 2000; Xiang et al., 2001). An important dev ...
Ionotropic glutamate receptors
... 1. Ionotropic glutamate receptors Ionotropic glutamate receptors (iGluRs) are a major class of heteromeric ligand-gated ion channels and mediate the majority of the excitatory neurotransmission in the vertebrate central nervous system (CNS). Following the cloning of the first subunit from rat in 198 ...
... 1. Ionotropic glutamate receptors Ionotropic glutamate receptors (iGluRs) are a major class of heteromeric ligand-gated ion channels and mediate the majority of the excitatory neurotransmission in the vertebrate central nervous system (CNS). Following the cloning of the first subunit from rat in 198 ...
Aldosterone in Australia and Mineralocorticoids in
... aldosterone-mediated effects. Other clues to the possible mechanisms regulating this pathological MR activation arose from coronary angioplasty studies in pigs at the Baker Institute, where luminal diameter was preserved and the restenosis response was reduced by pretreatment with the selective MR a ...
... aldosterone-mediated effects. Other clues to the possible mechanisms regulating this pathological MR activation arose from coronary angioplasty studies in pigs at the Baker Institute, where luminal diameter was preserved and the restenosis response was reduced by pretreatment with the selective MR a ...
Effect of Steroid Hormones and Retinoids on the Formation of
... stimulators of the formation of capillary-like tubular structures. These effects are mediated by their respective nuclear hormone receptors as demonstrated by the use of specific synthetic receptor agonists and antagonists. 17b-estradiol, progesterone, and 1,25-dihydroxyvitamin D3 did not affect or ...
... stimulators of the formation of capillary-like tubular structures. These effects are mediated by their respective nuclear hormone receptors as demonstrated by the use of specific synthetic receptor agonists and antagonists. 17b-estradiol, progesterone, and 1,25-dihydroxyvitamin D3 did not affect or ...
MECHANISMS OF INTERCELLULAR COMMUNICATION
... DIRECT EFFECTS • CONFORMATIONAL CHANGE OF RECEPTOR MOLECULE CHANGES MEMBRANE PERMEABILITY • ESPECIALLY SODIUM, CHLORIDE AND CALCIUM IONS • ACETYLCHOLINE—a neurotransmitter • SEROTONIN---a hormone and neurotransmitter • GLYCINE—a neurotransmitter • GABA---a neurotransmitter • GROWTH HORMONE---a horm ...
... DIRECT EFFECTS • CONFORMATIONAL CHANGE OF RECEPTOR MOLECULE CHANGES MEMBRANE PERMEABILITY • ESPECIALLY SODIUM, CHLORIDE AND CALCIUM IONS • ACETYLCHOLINE—a neurotransmitter • SEROTONIN---a hormone and neurotransmitter • GLYCINE—a neurotransmitter • GABA---a neurotransmitter • GROWTH HORMONE---a horm ...
Hormones - (canvas.brown.edu).
... Including TSH (Thyroid Stimulating Hormone), which stimulates the release of thyroxine from the Thyroid. ...
... Including TSH (Thyroid Stimulating Hormone), which stimulates the release of thyroxine from the Thyroid. ...
Retinal Neurotransmitters
... Fast synaptic signaling in the vertebrate retina encodes presynaptic voltages as time-varying modulations in extracellular neurotransmitter concentrations that are decoded by postsynaptic transmembrane ionotropic or heptahelical receptor arrays. Additional heptahelical receptor pathways conditionall ...
... Fast synaptic signaling in the vertebrate retina encodes presynaptic voltages as time-varying modulations in extracellular neurotransmitter concentrations that are decoded by postsynaptic transmembrane ionotropic or heptahelical receptor arrays. Additional heptahelical receptor pathways conditionall ...
The Carboxyl Terminus of the Prolactin
... also express these PDZ domain proteins. We thus demonstrate that PrRP receptor interacts with the same PDZ domain proteins as the AMPA-Rs, raising the possibility that these two proteins could be scaffolded together at the synapse. These results may help to gain important insights into PrRP function ...
... also express these PDZ domain proteins. We thus demonstrate that PrRP receptor interacts with the same PDZ domain proteins as the AMPA-Rs, raising the possibility that these two proteins could be scaffolded together at the synapse. These results may help to gain important insights into PrRP function ...
receptors
... • When a messenger binds to a G protein-linked receptor the resulting change in receptor conformation causes a G protein to associate with it and release its GDP • The G then binds a new GTP molecule and detaches from the complex • Either the G or the G initiates signal transduction depending on ...
... • When a messenger binds to a G protein-linked receptor the resulting change in receptor conformation causes a G protein to associate with it and release its GDP • The G then binds a new GTP molecule and detaches from the complex • Either the G or the G initiates signal transduction depending on ...
WRI116-Research_Review
... invade tumor cells. Clinical studies tested antibodies and peptides that bind to the integrin receptors such as the fibronectin III domain, AgRP peptide, and cystine knots, as a method to detect cancer; Specifically, the identification of pancreatic cancer by translation of the cysteine knots bindin ...
... invade tumor cells. Clinical studies tested antibodies and peptides that bind to the integrin receptors such as the fibronectin III domain, AgRP peptide, and cystine knots, as a method to detect cancer; Specifically, the identification of pancreatic cancer by translation of the cysteine knots bindin ...
The role of P2 receptors in controlling infections by intracellular
... The involvement of ATPe in Chagas’ disease Chagas’ disease is caused by the facultative intracellular protozoan pathogen, T. cruzi. The disease is a chronic inflammatory condition characterised by cardiomyopathy and digestive disorders [59, 60]. T. cruzi infection affects over 17 million people in e ...
... The involvement of ATPe in Chagas’ disease Chagas’ disease is caused by the facultative intracellular protozoan pathogen, T. cruzi. The disease is a chronic inflammatory condition characterised by cardiomyopathy and digestive disorders [59, 60]. T. cruzi infection affects over 17 million people in e ...
Nuclear receptor ligand-binding domains: three
... helices. In the apo-RXRa (Fig. 2a), helix H11 is almost perpendicular to H10 and points towards the LBP, and some of the hydrophobic residues of H11 partially fill and stabilize the LBP. Helix H12, which contains the residues of the AF-2 activation domain (AD) core (Fig. 1), extends away from the LB ...
... helices. In the apo-RXRa (Fig. 2a), helix H11 is almost perpendicular to H10 and points towards the LBP, and some of the hydrophobic residues of H11 partially fill and stabilize the LBP. Helix H12, which contains the residues of the AF-2 activation domain (AD) core (Fig. 1), extends away from the LB ...
- Wiley Online Library
... The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target ...
... The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target ...
Molecular Cell Biology course 1BL320 Spring
... b) The cellular response to Erk activation depends on whether the activation is transient or sustained. Describe why a sustained Erk activation is necessary to promote cell cycle progression and why a transient burst of Erk activation fails to do so. (2p) c) Signaling pathways often lead to changes ...
... b) The cellular response to Erk activation depends on whether the activation is transient or sustained. Describe why a sustained Erk activation is necessary to promote cell cycle progression and why a transient burst of Erk activation fails to do so. (2p) c) Signaling pathways often lead to changes ...
Receptor Fragments: Intracellular Signaling and
... An intracellular fragment is also produced from the GPCR, D-frizzled 2, a post-synaptic protein which interacts with the presynaptic protein, “wingless”. Following endosome internalization, the cytoplasmic domain is cleaved and translocated to the nucleus where it is involved in transcriptional even ...
... An intracellular fragment is also produced from the GPCR, D-frizzled 2, a post-synaptic protein which interacts with the presynaptic protein, “wingless”. Following endosome internalization, the cytoplasmic domain is cleaved and translocated to the nucleus where it is involved in transcriptional even ...
Nuclear Translocation of Fibroblast Growth Factor (FGF) Receptors
... Nuclei were isolated from Swiss 3T3 flbroblasts by several different techniques. In all cases, the integrity and quality of the nuclei were evaluated by light microscopy. In most cases, the purity of the nuclear fractions was also assessed by immunoblotting with an anti-EGF receptor antibody and ass ...
... Nuclei were isolated from Swiss 3T3 flbroblasts by several different techniques. In all cases, the integrity and quality of the nuclei were evaluated by light microscopy. In most cases, the purity of the nuclear fractions was also assessed by immunoblotting with an anti-EGF receptor antibody and ass ...
From Hans Selye`s discovery of biological stress to the
... mune, and visceral efferent limbs of the stress response. For instance brain CRF activates the sympathetic nervous system inducing the systemic release of catecholamines involved in the ”fight or flight” response. The locus coeruleus is also activated by CRF and its noradrenergic projections to the ...
... mune, and visceral efferent limbs of the stress response. For instance brain CRF activates the sympathetic nervous system inducing the systemic release of catecholamines involved in the ”fight or flight” response. The locus coeruleus is also activated by CRF and its noradrenergic projections to the ...
Slide 1
... 4. Vesicles bind to specific sites on the presynaptic element and open, spilling their contents (a neurotransmitter) into the synaptic cleft 5. Neurotransmitters (the ligand) bind to receptors at specific binding sites on the post synaptic cell membrane causing either: • Deformation of the receptor ...
... 4. Vesicles bind to specific sites on the presynaptic element and open, spilling their contents (a neurotransmitter) into the synaptic cleft 5. Neurotransmitters (the ligand) bind to receptors at specific binding sites on the post synaptic cell membrane causing either: • Deformation of the receptor ...
Novel Antipeptide Antibodies to the Human Glucocorticoid Receptor
... Since numerous laboratories, including our own, have reported that GRs form even larger oligomeric complexes in the presence of sodium molybdate (17, 18) (presumably due to the interaction of receptors with additional accessory proteins), we wished to determine if molybdate-stabilized GR complexes c ...
... Since numerous laboratories, including our own, have reported that GRs form even larger oligomeric complexes in the presence of sodium molybdate (17, 18) (presumably due to the interaction of receptors with additional accessory proteins), we wished to determine if molybdate-stabilized GR complexes c ...
Gene repression by nuclear hormone receptors
... with HDAC II family members (HDACs 4–7). In addition, association of co-repressors with class I HDAC complexes have been reported. The Sin3A– Sin-associated protein (SAP) complex harbours the SAPs, the retinoblastomaassociated proteins 46 and 48 (RbAp46 and RbAp48), the HDACs 1 and 2, and the Sin3A ...
... with HDAC II family members (HDACs 4–7). In addition, association of co-repressors with class I HDAC complexes have been reported. The Sin3A– Sin-associated protein (SAP) complex harbours the SAPs, the retinoblastomaassociated proteins 46 and 48 (RbAp46 and RbAp48), the HDACs 1 and 2, and the Sin3A ...
beyond binding: molecular and cell biological approaches to
... occurs during posttranscriptional processing of the RNA. Another interesting example of such receptor diversity is the 5-HT2C receptor, which exists in variant forms determined by a posttranscriptional process called RNA editing (18). In many cases the functional significance of such variation among ...
... occurs during posttranscriptional processing of the RNA. Another interesting example of such receptor diversity is the 5-HT2C receptor, which exists in variant forms determined by a posttranscriptional process called RNA editing (18). In many cases the functional significance of such variation among ...
Receptor Cell Biology: Receptor-Mediated Endocytosis
... coated pits (21, 22). However, only those receptor proteins mediating endocytosis are "trapped" via specific signals in the cytoplasmic tail which interact with structural components of the coated pit (see below). Coated pits. The coated pit is the cellular machinery for ligand-receptor internalizat ...
... coated pits (21, 22). However, only those receptor proteins mediating endocytosis are "trapped" via specific signals in the cytoplasmic tail which interact with structural components of the coated pit (see below). Coated pits. The coated pit is the cellular machinery for ligand-receptor internalizat ...