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Chronic Inflammation
Chronic Inflammation

... producing bacteria and indirectly by release of lysosomal enzymes ...
Hypersensitivity TYPE I Hypersensitivity Classic allergy Allergens
Hypersensitivity TYPE I Hypersensitivity Classic allergy Allergens

... Memory Th1 cells against DTH antigens are generated by dendritic cells during the sensitization stage. These Th1 cells can activate macrophages and trigger inflammatory response. ...
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... phagocytize the immune complexes these cells will degranulate in the area of immune complex deposition and trigger inflammation. Unable to eat -------try to digest outside cell. ...
Wobenzym - Henderson Chiropractic Clinic
Wobenzym - Henderson Chiropractic Clinic

... Therapeutic challenges attendant to the complexity of the immune response alluded to initially, and the critical role it plays in an array of chronic, proliferative diseases, a paradigm shift is gradually taking hold in healthcare. The once standard approach to target a specific step in a biochemic ...
12-Hour Outline - Michael Greer, MD
12-Hour Outline - Michael Greer, MD

... delicate task of distinguishing between pathogenic bacteria and toxins, and the beneficial substances like food particles and commensal bacteria. The gut mucosa, as well as the other mucosal surfaces, can be seen as an extension of our sensory system, or a "sixth sense”. Exposure to Gluten in the ge ...
Minimal Change Disease
Minimal Change Disease

... i) most believed to be autoimmune d) most glomeruls are normocellular or only mildly hypercellular ...
投影片 1 - 國防醫學院數位學習系統
投影片 1 - 國防醫學院數位學習系統

... SLE: C3 with Ig deposition(even in non-involved area) Evidence of complement activation: Autoimmune bullous disease(Pemphigus, bullous pemphigoid, epidermolysis bullosa) Acne: C3 in basement zones Psoriasis: C3a, C5a in lesion & complement activated products in serum ...
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Interstitial lung Disease(ILD)

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AUTOIMMUNITY
AUTOIMMUNITY

... • Failure of central tolerance. • Overcome of peripheral tolerance. • Polyclonal lymphocytes activation. ...
Molecular Medicine SF
Molecular Medicine SF

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IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... Most autoimmune diseases are multigenic, with multiple susceptibility genes working in concert to produce the abnormal phenotype. In general, the polymorphisms also occur in normal people and are compatible with normal immune function. Only when present with other susceptibility genes do they contri ...
PPoint - Doctor of the Future
PPoint - Doctor of the Future

... 1 – Each significant symptomatic report gives the practitioner opportunity to explain how that is part of a functional issue that can be cared for – this builds a strategy for the case 2 – When results can be attributed to the strategy patients will go further with you into very complex long-term jo ...
I. Physiology of the Immune System
I. Physiology of the Immune System

...  PTSD is, by definition, related to stress, and PTSD also produces suppression of the immune system.  Stress is less clearly related to the other anxiety disorders, partly because the overlap between anxiety and depression makes it difficult to disentangle these ...
PPT - Larry Smarr
PPT - Larry Smarr

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Accidents, Blindness, Rheumatic Fever

... • Carditis: 10 years/25 years- longer • Severe valvular disease: life-long treatment • One problem: patient compliance ...
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Heartworm Disease

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Univ.-Prof. Dr. med. Britta Siegmund
Univ.-Prof. Dr. med. Britta Siegmund

... Major interest of our group is to translate clinical findings of patients with inflammatory bowel diseases to the bench and vice versa with the ultimate goal to contribute to the understanding of the disease pathways as well as to identify possible novel therapeutic targets. Two main directions buil ...
Streptococcus pneumoniae
Streptococcus pneumoniae

... precipitous onset of fever (40EC) and headache. Within hours he felt pain in his neck upon movement of his head. He reported to the medical unit. Lumbar puncture was performed after determining that pressure was only slightly elevated (220 mm H2O). CSF was cloudy and contained 5,000 leukocytes/:l (7 ...
Inducing tissue specific tolerance in autoimmune disease with
Inducing tissue specific tolerance in autoimmune disease with

... differed between thymus versus pancreatic beta cells that was associated with lack of T-cell tolerance (9, 10). Finally, the finding that CD8 T cells, barely in contact with MHC and very low-affinity binding still have destructive abilities puts forward the need for efficient peripheral regulation o ...
- University of East Anglia
- University of East Anglia

... genetic variation and disease have tended to utilise in vitro or rodent inflammation models. In the current study, the authors investigated genetic variation in the autophagy gene ATG16L1 in the human population, and the consequences for inflammatory cytokine responses after stimulation of NOD2. The ...
Tibb Position on Autoimmune disease
Tibb Position on Autoimmune disease

... Autoimmunity  is  an  abnormal  reaction  to  the  body’s  tissues.  The  immune  system  reacts  to  the  body’s  cells  and   tissues  (‘self’)  as  if  they  were  foreign  substances  or  toxins  (‘non-­‐self’).  If  this  persists, ...
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... Mitotic inhibitos: vincristine and vinblastine ...
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Rheumatoid arthritis



Rheumatoid arthritis (RA) is a long lasting autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly the wrist and hands are involved with typically the same joints involved on both sides of the body. The disease may also affect other parts of the body. This may result in low red blood cells, inflammation around the lungs, and inflammation around the heart. Fever and low energy may also be present. Often symptoms come on gradually over weeks to months.While the cause of rheumatoid arthritis is not clear, it is believed to involve a combination of genetic and environmental factors. The underlying mechanism involves the body's immune system attacking the joints. This results in inflammation and thickening of the joint capsule. It also affects the underlying bone and cartilage. The diagnosis is made mostly on the basis of a person's signs and symptoms. X-rays and laboratory testing may support a diagnosis or exclude other diseases with similar symptoms. Other diseases that may present similarly include systemic lupus erythematosus, psoriatic arthritis, and fibromyalgia among others.The goal of treatment is to improve pain, decrease inflammation, and improve a person's overall functioning. This may be helped by balancing rest and exercise, the use of splints and braces, or the use of assistive devices. Pain medications, steroids, and NSAIDs are frequently used to help with symptoms. A group of medications called disease-modifying antirheumatic drugs (DMARDs) may be used to try to slow the progression of disease. They include the medications hydroxychloroquine and methotrexate. Biological DMARDs may be used when disease does not respond to other treatments. However, they may have a greater rate of adverse effects. Surgery to repair, replace, or fusion joints may help in certain situations. Most alternative medicine treatments are not supported by evidence.RA affects between 0.5 and 1% of adults in the developed world with between 5 and 50 per 100,000 people newly developing the condition each year. Onset is most frequent during middle age and women are affected 2.5 times as frequently as men. In 2013 it resulted in 38,000 deaths up from 28,000 deaths in 1990. The first recognized description of RA was made in 1800 by Dr. Augustin Jacob Landré-Beauvais (1772–1840) of Paris. The term rheumatoid arthritis is based on the Greek for watery and inflamed joints.
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