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Antigen arrays for antibody profiling - Robinson Lab
Antigen arrays for antibody profiling - Robinson Lab

... autoantibodies targeting immunoglobulin (rheumatoid factor) and/or citrullinated peptides contributes to the diagnosis of rheumatoid arthritis (RA) [1], whereas detection of autoantibodies targeting nuclear antigens (antinuclear antibodies [ANAs]) suggests the diagnosis of systemic lupus erythematos ...
Pathogenesis of Autoimmune Diseases: A Short
Pathogenesis of Autoimmune Diseases: A Short

... organism called as autoimmunity. 1 Autoimmunity is the mechanism where an organism fails to recognize its Autoimmunity is characterized by the reaction of cells (auto reactive T-lymphocytes) or products (autoantibodies) of own constituent parts (down to the submolecular levels) the immune system aga ...
Understanding Autoimmune Disease – a review article for the layman
Understanding Autoimmune Disease – a review article for the layman

... since the original theoretical description thereof in 1901. Autoimmunity is a necessary process of the immune regulatory networks in the body which need to sustain the body’s health. It is yet unknown fully why autoimmunity sometimes progresses to pathologic states which are generally characterized ...
What is Tangier DISEASE?
What is Tangier DISEASE?

... body is not processed correctly. This causes cholesterol to build up in certain tissues of the body causing the symptoms associated with Tangier Disease. Tissues affected include the tonsils, thymus, lymph nodes, bone marrow, liver, intestines, immune system cells such as macrophages, cornea of the ...
View - Dr Falk
View - Dr Falk

... up to 4 times more common in women than men, and it can affect any age group. AIH is typically chronic, meaning it can last for years. If it isn’t treated, the persistent inflammation can lead to scarring and hardening of the liver known as cirrhosis. Eventually, liver failure can result. ...
Anti-Inflammatory - Pinhook Chiropractic Clinic
Anti-Inflammatory - Pinhook Chiropractic Clinic

... short-lived white blood cells containing enzyme-filled granules that dissolve foreign substances. Complement is an array of circulating proteins produced in a cascade of enzymatic activity in the presence of microbes. The second process, adaptive immunity, is directed specifically at microbes that h ...
Information about Pathology of the Immune System and Lymphatics
Information about Pathology of the Immune System and Lymphatics

... – Consult physician if client is under treatment. – Avoid excessive pressure. – Because the client is immunosuppressed, do not massage if you have an infection. – Use ice packs in areas that have bled or bleed. Systemic Lupus Erythematosus Description: chronic autoimmune inflammatory disease Cause: ...
Professional Practice Guidelines Science, Politics, and Values: The
Professional Practice Guidelines Science, Politics, and Values: The

... when a professional organization bases its work on the weight of science there can be no improper restraint of trade. After spending more than a quarter of a million dollars on legal expenses, IDSA agreed to settle with the attorney general (without admitting any fault), assenting to an ombudsmen-re ...
11. Interstitial lung diseases
11. Interstitial lung diseases

... If the disease is mild, no specific therapy is used. If the ILD is progressive, corticosteroids are administered. ...
Acute and chronic inflammation
Acute and chronic inflammation

... •  eliminate the initial cause of cell injury •  Remove necrotic cells and tissue •  Initiate the process of repair ...
Lecture 1- Rheumatic Fever and Heart Disease
Lecture 1- Rheumatic Fever and Heart Disease

... • To understand basis of rheumatic fever as an immunologically mediated late complication of Streptococcal infection • To know that autoimmunity results from production of cross reacting antibodies against Streptococcal antigens • To describe rheumatic heart disease as one of the several manifestati ...
lecture 1 - Rheumatic Fever and Heart Disease (2013).
lecture 1 - Rheumatic Fever and Heart Disease (2013).

... • To understand basis of rheumatic fever as an immunologically mediated late complication of Streptococcal infection • To know that autoimmunity results from production of cross reacting antibodies against Streptococcal antigens • To describe rheumatic heart disease as one of the several manifestati ...
Host Microbe Interactions
Host Microbe Interactions

... endotoxins are lioopolysaccharides (LPS) found in the lipid portion of the outer wall of Gram – bacteria – endotoxins are released when Gram – bacteria die and the cell wall undergoes lysis antibiotics that are used to treat Gram – diseases can lyse the bacterial cells, releasing the endotoxin – thi ...
Joint injections
Joint injections

... What to warn the patient • Pain returns after 2 hours, when the local anaesthetic wears off – may be worse than before. • If pain is severe or increasing after 48hrs, seek advice • Warn of local side effects • Advise to seek help if systemic s/es develop ...
Consultant Urological Surgeon Benenden Hospital Tunbridge Wells
Consultant Urological Surgeon Benenden Hospital Tunbridge Wells

... (LUTS) It can comprise voiding or storage urinary symptoms and can arise from any of the following organ problem: Prostate: benign prostate enlargement (BPH), prostate cancer, prostatitis Urethra: strictures, inflammation Bladder: Cystitis, Detrusor muscle weakness or overactivity, Bladder pain Synd ...
Reactive And Enteropathic Arthritis
Reactive And Enteropathic Arthritis

... synovial tissues and peripheral lood of ReA patients . The mechanisms accounting for the persistence of Chlamydia and the thwarting f host immune defenses have been studied from several erspectives. In chronic disease, altered regulation of pecific Chlamydia genes is apparent, with reduced xpression ...
Jelly Fish Anaphylaxis
Jelly Fish Anaphylaxis

... 3. Edwards, L.P.; Whitter, E.; Hessinger, D.A. Apparent membrane pore-formation by Portuguese Man-of-war (Physalia physalis). Toxicon, 2002, 40(9), 1299-1305. 4. Burnett, J.W. Treatment of Atlantic cnidarian envenomations. Toxicon, 2009, 54(8), 1201-1205.5. 5. Tibballs, J. Australian venomous jellyf ...
CHAPTER 18
CHAPTER 18

... IMMUNOLOGIC DISORDERS AND TESTS  Chapter Overview Although the immune system is most noted for its beneficial effects, unfortunately it also makes us painfully aware of its detrimental effects. Immunologic disorders such as hypersensitivities, autoimmunities, and immunodeficiencies have become impo ...
COMMON - Canadian Immunodeficiencies Patient Organization
COMMON - Canadian Immunodeficiencies Patient Organization

... Although patients with CVID have a depressed antibody response and low levels of immunoglobulin in their blood (hypogammaglobulinemia), some of the antibodies that are produced by these patients may attack their own tissues (autoantibodies). These autoantibodies may attack and destroy blood cells (e ...
Consider unilateral SC joint pain as infection until proven otherwise
Consider unilateral SC joint pain as infection until proven otherwise

... • Septic arthritis is a medical emergency, with a mortality rate of 10% (Gupta et al 2001) • Even after treatment of septic arthritis, considerable morbidity (amputation, lost of joint function) affects one-third of patients. (Kaandorp et al, 1997) ...
COMMON VARIABLE IMMUNODEFICIENCY
COMMON VARIABLE IMMUNODEFICIENCY

... the antibodies that are produced by these patients may attack their own tissues (autoantibodies). These autoantibodies may attack and destroy blood cells (e.g. red cells, white cells or platelets). Although, most individuals with CVID present first with recurrent bacterial infections, in about 20% o ...
Exam II
Exam II

... Please read each question carefully and provide complete answers. Good luck! (100 pts total) 1. (10 pts) Scott Williams discussed the use of family selection in commercial aquaculture. What two diseases has Clear Springs Foods been attempting to select resistant rainbow trout strains for. Explain wh ...
TATA Molecular Immunology
TATA Molecular Immunology

... and chronic infection play a critical role Both innate and adoptive immunity are involved Immune modulation have the potential of protecting against atherosclerosis New possibilities for significant cost effective reduction of CVD burden ...
AUTOIMMUNITY
AUTOIMMUNITY

... fulminant lupus, lupus nephritis or central nervous system complications. Five year survival rate is 80 to 90%. ...
09-ACUTE INFLAMMATION.morphology, pptx
09-ACUTE INFLAMMATION.morphology, pptx

... sediment more rapidly at unit gravity than do individual erythrocytes. This is the basis for measuring the erythrocyte sedimentation rate (ESR) as a simple test for the systemic inflammatory response, Increased erythrocyte sedimentation rate during inflammation ...
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Rheumatoid arthritis



Rheumatoid arthritis (RA) is a long lasting autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly the wrist and hands are involved with typically the same joints involved on both sides of the body. The disease may also affect other parts of the body. This may result in low red blood cells, inflammation around the lungs, and inflammation around the heart. Fever and low energy may also be present. Often symptoms come on gradually over weeks to months.While the cause of rheumatoid arthritis is not clear, it is believed to involve a combination of genetic and environmental factors. The underlying mechanism involves the body's immune system attacking the joints. This results in inflammation and thickening of the joint capsule. It also affects the underlying bone and cartilage. The diagnosis is made mostly on the basis of a person's signs and symptoms. X-rays and laboratory testing may support a diagnosis or exclude other diseases with similar symptoms. Other diseases that may present similarly include systemic lupus erythematosus, psoriatic arthritis, and fibromyalgia among others.The goal of treatment is to improve pain, decrease inflammation, and improve a person's overall functioning. This may be helped by balancing rest and exercise, the use of splints and braces, or the use of assistive devices. Pain medications, steroids, and NSAIDs are frequently used to help with symptoms. A group of medications called disease-modifying antirheumatic drugs (DMARDs) may be used to try to slow the progression of disease. They include the medications hydroxychloroquine and methotrexate. Biological DMARDs may be used when disease does not respond to other treatments. However, they may have a greater rate of adverse effects. Surgery to repair, replace, or fusion joints may help in certain situations. Most alternative medicine treatments are not supported by evidence.RA affects between 0.5 and 1% of adults in the developed world with between 5 and 50 per 100,000 people newly developing the condition each year. Onset is most frequent during middle age and women are affected 2.5 times as frequently as men. In 2013 it resulted in 38,000 deaths up from 28,000 deaths in 1990. The first recognized description of RA was made in 1800 by Dr. Augustin Jacob Landré-Beauvais (1772–1840) of Paris. The term rheumatoid arthritis is based on the Greek for watery and inflamed joints.
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