BIOL260
... 1. What are the first and second lines of defense of nonspecific host mechanisms? 2. How does the nonspecific defense system differ from the specific defense system? 3. Know examples of the different barriers in the non-specific defense. 4. What is the role of normal microbiota (flora) in the non-sp ...
... 1. What are the first and second lines of defense of nonspecific host mechanisms? 2. How does the nonspecific defense system differ from the specific defense system? 3. Know examples of the different barriers in the non-specific defense. 4. What is the role of normal microbiota (flora) in the non-sp ...
Document
... Definition: Glycoprotein molecules that are produced by plasma cells in response to an immunogen and which function as antibodies ...
... Definition: Glycoprotein molecules that are produced by plasma cells in response to an immunogen and which function as antibodies ...
09 Antibodies
... colostrum, saliva, tears, and respiratory, intestinal, and genital tract secretions. It prevents attachment of bacteria and viruses to mucous membranes. Each secretory IgA molecule consists of two H2L2 units plus one molecule each of J (joining) chain and secretory component. The secretory component ...
... colostrum, saliva, tears, and respiratory, intestinal, and genital tract secretions. It prevents attachment of bacteria and viruses to mucous membranes. Each secretory IgA molecule consists of two H2L2 units plus one molecule each of J (joining) chain and secretory component. The secretory component ...
LACZIK_Pharmacology - 4 practice
... Variability in different regions of the Ig determines Ig classes or specificity ...
... Variability in different regions of the Ig determines Ig classes or specificity ...
Immunology (B)
... 8. A B cell can express on its cell surface A. membrane IgM and IgD at the same time B. both types of light chain C. secretory component D. IgG that can bind several different unrelated antigens 9. The T cell antigen receptor A. recognizes epitopes on linear peptides associated with MHC determinants ...
... 8. A B cell can express on its cell surface A. membrane IgM and IgD at the same time B. both types of light chain C. secretory component D. IgG that can bind several different unrelated antigens 9. The T cell antigen receptor A. recognizes epitopes on linear peptides associated with MHC determinants ...
Humoral Immunity
... switch the particular class of Antibody that it is producing in order to fight an infection in a different way. ...
... switch the particular class of Antibody that it is producing in order to fight an infection in a different way. ...
Complement in urochordates: cloning and
... at least 600–700 million years ago, long before the appearance of the immunoglobulins, thus pointing to complement as an evolutionary link between the vertebrate and invertebrate immune systems. The complement system of higher vertebrates consists of more than 30 humoral and cell membrane proteins, ...
... at least 600–700 million years ago, long before the appearance of the immunoglobulins, thus pointing to complement as an evolutionary link between the vertebrate and invertebrate immune systems. The complement system of higher vertebrates consists of more than 30 humoral and cell membrane proteins, ...
U8-Topic3_Protecting against disease
... What is the body’s third line of defense? Pathogens have unique proteins, called antigens, on their surfaces. Antigens help the body identify pathogens as invaders. A macrophage is a white blood cell that ingests and destroys general pathogens. After a macrophage destroys a pathogen, it displays the ...
... What is the body’s third line of defense? Pathogens have unique proteins, called antigens, on their surfaces. Antigens help the body identify pathogens as invaders. A macrophage is a white blood cell that ingests and destroys general pathogens. After a macrophage destroys a pathogen, it displays the ...
(non-specific) immune system
... Adaptive immune mechanisms • Antibodies → neutralization and opsonization (specific „adapter“) of microbes, complement system activation • T cells → cytotoxic effects to microbes, help for B cells, macrophages activation, ...
... Adaptive immune mechanisms • Antibodies → neutralization and opsonization (specific „adapter“) of microbes, complement system activation • T cells → cytotoxic effects to microbes, help for B cells, macrophages activation, ...
Non Specific Host Defense Mechanisms
... The complement system “C” • 30 different proteins (C1 – C9 & others) • “Complementary” to immune system • Complement cascade (stepwise) • Consequences of “C” activation: 1. Initiation/amplification of inflammation 2. Attraction of phagocytes to site 3. Activation of leukocytes 4. Lysis of bacteria/ ...
... The complement system “C” • 30 different proteins (C1 – C9 & others) • “Complementary” to immune system • Complement cascade (stepwise) • Consequences of “C” activation: 1. Initiation/amplification of inflammation 2. Attraction of phagocytes to site 3. Activation of leukocytes 4. Lysis of bacteria/ ...
ANTIBODY
... It is a plasma cell dyscrasia in which unchecked proliferation of one clone of plasma cells resulting in the excessive production of particular Ig. Multiple myeloma involve plasma cells synthesizing any of the 5 classes of Ig. Multiple myeloma involving IgM producing plasma cells – “Waldenstro ...
... It is a plasma cell dyscrasia in which unchecked proliferation of one clone of plasma cells resulting in the excessive production of particular Ig. Multiple myeloma involve plasma cells synthesizing any of the 5 classes of Ig. Multiple myeloma involving IgM producing plasma cells – “Waldenstro ...
Genetic Disorders
... Fc receptors, and other immune molecules, such as complement proteins. Thus, Ab mediates different physiological effects including opsonization, cell lysis, and degranulation of mast cells, basophils and eosinophils. ...
... Fc receptors, and other immune molecules, such as complement proteins. Thus, Ab mediates different physiological effects including opsonization, cell lysis, and degranulation of mast cells, basophils and eosinophils. ...
type II
... Schematic illustration of three different mechanisms of antibody-mediated injury in type II hypersensitivity. (A) Complement-dependent reactions that lead to lysis of cells or render them susceptible to phagocytosis. (B) Antibody-dependent cell-mediated cytotoxicity (ADCC). IgGcoated target cells ar ...
... Schematic illustration of three different mechanisms of antibody-mediated injury in type II hypersensitivity. (A) Complement-dependent reactions that lead to lysis of cells or render them susceptible to phagocytosis. (B) Antibody-dependent cell-mediated cytotoxicity (ADCC). IgGcoated target cells ar ...
Antibodies and Antigens
... IgA (dimer in secretions) – secreted Ab; mucosal immunity IgD (monomer) – minor Ab involved in development IgE (monomer) – bound to basophils and mast cells, important in elimination of parasites, allergies ...
... IgA (dimer in secretions) – secreted Ab; mucosal immunity IgD (monomer) – minor Ab involved in development IgE (monomer) – bound to basophils and mast cells, important in elimination of parasites, allergies ...
Слайд 1 - sechenov.ru
... hypoplasia of the thymus and parathyroid gland Manifestations: ● peripheral blood T-cell levels are reduced; B-cell levels - normal ● paracortical areas of the lymph nodes, periarteriolar sheaths of the spleen are depleted ● serum immunoglobulin concentrations are frequently normal, but Ab responses ...
... hypoplasia of the thymus and parathyroid gland Manifestations: ● peripheral blood T-cell levels are reduced; B-cell levels - normal ● paracortical areas of the lymph nodes, periarteriolar sheaths of the spleen are depleted ● serum immunoglobulin concentrations are frequently normal, but Ab responses ...
TUTORIAL 4 Multiple Choices For each of the questions below
... Clearance of antigen-specific IgE immune complexes Greater production of circulating high affinity IgG antibody Depletion of the mast cell pool by repeated degranulation Specific tolerance induction ...
... Clearance of antigen-specific IgE immune complexes Greater production of circulating high affinity IgG antibody Depletion of the mast cell pool by repeated degranulation Specific tolerance induction ...
Complement system
The complement system is a part of the immune system that helps or complements the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the innate immune system, which is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system.The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum and can serve as opsonins.Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.