Immunocomputing - Carleton University
... • Bind to carbohydrates on surface of self cells • Can’t recognize specific antigens unlike Tk cells ↓ or killer cells of the adaptive immune system • Healthy self cells express an inhibitory signal • Virus-infected cells may lose inhibitory ability thus activating NK cells • Activated NK cell injec ...
... • Bind to carbohydrates on surface of self cells • Can’t recognize specific antigens unlike Tk cells ↓ or killer cells of the adaptive immune system • Healthy self cells express an inhibitory signal • Virus-infected cells may lose inhibitory ability thus activating NK cells • Activated NK cell injec ...
Slide 1
... composed of >30 serum proteins produced in liver Activated as a cascade augments (or “complements”) the antibacterial activity of adaptive system ...
... composed of >30 serum proteins produced in liver Activated as a cascade augments (or “complements”) the antibacterial activity of adaptive system ...
Host Defense Mechanisms
... immunity and adaptive immunity. The immune system is composed of two major subdivisions, the innate or nonspecific immune system and the adaptive or specific immune system. The innate immune system is a primary defense mechanism against invading organisms, while the adaptive immune system acts as a ...
... immunity and adaptive immunity. The immune system is composed of two major subdivisions, the innate or nonspecific immune system and the adaptive or specific immune system. The innate immune system is a primary defense mechanism against invading organisms, while the adaptive immune system acts as a ...
File
... Allergies are hypersensitivities to substances such as pollen, food or animal hair that ordinarily would do no harm to the body. Immediate Allergic Response – can occur within seconds of contact with the antigen. The response is caused by the release of histamine by cells which brings about the alle ...
... Allergies are hypersensitivities to substances such as pollen, food or animal hair that ordinarily would do no harm to the body. Immediate Allergic Response – can occur within seconds of contact with the antigen. The response is caused by the release of histamine by cells which brings about the alle ...
Hypersensitivity
... When the allergen appears again (usually a few weeks after the first exposure), it cross-links the mIgEs and causes degranulation, releasing granules. Mediators within these granules act on the surrounding tissues such as smooth muscle, small blood vessels, and mucous glands. ...
... When the allergen appears again (usually a few weeks after the first exposure), it cross-links the mIgEs and causes degranulation, releasing granules. Mediators within these granules act on the surrounding tissues such as smooth muscle, small blood vessels, and mucous glands. ...
Innate Host Defenses - Interactive Physiology
... pathway, and the absence of inhibitory proteins activates the alternative pathway. Page 17: Complement: Pathways • The classical, alternative, and lectin pathways of complement activation converge at C3. • The splitting of complement components C3 and C5 produces products that promote inflammation ( ...
... pathway, and the absence of inhibitory proteins activates the alternative pathway. Page 17: Complement: Pathways • The classical, alternative, and lectin pathways of complement activation converge at C3. • The splitting of complement components C3 and C5 produces products that promote inflammation ( ...
At its Heart, Homeostasis Is About T Cells
... views of JACC or the American College of Cardiology. From the Department of Medicine and Center for Molecular Medicine, ...
... views of JACC or the American College of Cardiology. From the Department of Medicine and Center for Molecular Medicine, ...
03-Chapter
... Restricted to lymphoid tissues (e.g., lymph nodes) Secrete antibodies specific for the pathogen T cells - circulate through blood and lymph Helper T cells (Th) Direct the actions of other cells by secreting cytokines that signal and coordinate such activities Cytotoxic T cells (CTL) Recognize cells ...
... Restricted to lymphoid tissues (e.g., lymph nodes) Secrete antibodies specific for the pathogen T cells - circulate through blood and lymph Helper T cells (Th) Direct the actions of other cells by secreting cytokines that signal and coordinate such activities Cytotoxic T cells (CTL) Recognize cells ...
43.3 Active and Passive immunity Active Immunity Passive Immunity
... • Infect T cells with CD4 ( Th), use CD4 as receptor to gain access to cell. Also, coreceptor ( fusin on all HIV infected cells). Different ones on Th and Macrophages. Both are chemokine receptors. • CD4 also on macrophages and some B cells. • Co receptors on Th and macrophages used for chemokine at ...
... • Infect T cells with CD4 ( Th), use CD4 as receptor to gain access to cell. Also, coreceptor ( fusin on all HIV infected cells). Different ones on Th and Macrophages. Both are chemokine receptors. • CD4 also on macrophages and some B cells. • Co receptors on Th and macrophages used for chemokine at ...
Immunology for Anaesthetists Part 1 - Basic Immunology
... Activation of naïve T-cells occurs in a process called ‘antigen presentation’. Dendritic cells and macrophages involved in the innate response migrate to lymphoid tissue where they present antigen in association with MHC, this is why they are called antigen presenting cells (APCs). CD8+ T-cells are ...
... Activation of naïve T-cells occurs in a process called ‘antigen presentation’. Dendritic cells and macrophages involved in the innate response migrate to lymphoid tissue where they present antigen in association with MHC, this is why they are called antigen presenting cells (APCs). CD8+ T-cells are ...
Receptors
... • Imunoglobulins IgG, IgA, IgM – are able to bind antigens ( by their Fab fragments) and then are bound by their Fc fragment on FcR receptors on the surface of fagocyting cells. • IgE can bind to FcR on mastocyts by its Fc fragment even when the antigen is not yet bound on its Fab ...
... • Imunoglobulins IgG, IgA, IgM – are able to bind antigens ( by their Fab fragments) and then are bound by their Fc fragment on FcR receptors on the surface of fagocyting cells. • IgE can bind to FcR on mastocyts by its Fc fragment even when the antigen is not yet bound on its Fab ...
General Defence System
... This defence strategy uses defensive proteins against a particular pathogen. The defence proteins are called antibodies. The pathogen is identified as its surface has a chemical that is ‘foreign’ – to the body it is a ‘non-self’ chemical. This non-self chemical is called an antigen. White blood cell ...
... This defence strategy uses defensive proteins against a particular pathogen. The defence proteins are called antibodies. The pathogen is identified as its surface has a chemical that is ‘foreign’ – to the body it is a ‘non-self’ chemical. This non-self chemical is called an antigen. White blood cell ...
Innate Immunity I
... • Inhibited from killing by the presence of MHC molecules interacting with KIRs • When pathogens or transformation interfere with the expression of MHC, NK cells kill the deficient cell • They also release cytokines which stimulate other parts of the immune response ...
... • Inhibited from killing by the presence of MHC molecules interacting with KIRs • When pathogens or transformation interfere with the expression of MHC, NK cells kill the deficient cell • They also release cytokines which stimulate other parts of the immune response ...
Auto-immune diseases – 19/03/03
... Aeitology of autoimmune disease – Multifactorial (Abbas 179) So what is the cause of autoimmune disease? Basically, the cause is many. 1) Some proteins/cells and other components in the body are sequestered. This means, under normal circumstances the immune system is unaware of their existence (i.e. ...
... Aeitology of autoimmune disease – Multifactorial (Abbas 179) So what is the cause of autoimmune disease? Basically, the cause is many. 1) Some proteins/cells and other components in the body are sequestered. This means, under normal circumstances the immune system is unaware of their existence (i.e. ...
Immune Work-Up for the General Pediatrician
... seen after 6 months when maternal antibodies lost Growth usually normal unless patient with chronic infections ...
... seen after 6 months when maternal antibodies lost Growth usually normal unless patient with chronic infections ...
NVCC Bio 212
... Innate (Nonspecific) Defenses • Species Resistance • resistance to certain diseases to which other species are susceptible ...
... Innate (Nonspecific) Defenses • Species Resistance • resistance to certain diseases to which other species are susceptible ...
Complement system
The complement system is a part of the immune system that helps or complements the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the innate immune system, which is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system.The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum and can serve as opsonins.Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.