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11.03.2011
11.03.2011

...  Allospecific serums (obtained from multiple natal to 6 weeks after birth, obtained by vaccination of volunteers, or commercially prepared sets of typing serums (monoclonal antibodies))  Principle - the incubation of lymphocytes with typing serums in the presence of rabbit complement, then is adde ...
mast cells
mast cells

... Cell-mediated cytotoxicity that requires prior binding of antibodies to target cells K(iller) cells: Lymphocyte-like cells (not B or T) that kill a variety of tumor cells and virus-infected cells but only after previous immunization Errant or uncontrolled plasma cells produce antibodies against self ...
Document
Document

B Cells - School of Mathematical and Computer Sciences
B Cells - School of Mathematical and Computer Sciences

... Clonal and Negative Selection In the picture, we see the fate of five different B-cells, each with A different receptor molecule. Note, these are also called antibodies. Much simplified: 1 & 5. These ones find themselves recognising a `self-antigen’. This leads to them getting killed off (`clonal d ...
MLAB 1315- Hematology Fall 2007 Keri Brophy
MLAB 1315- Hematology Fall 2007 Keri Brophy

... Types of Autoimmune Hemolytic Anemia ...
Lecture 7 Host Defense Against Infection
Lecture 7 Host Defense Against Infection

... Clostridium tetani is an anaerobic gram-positive rod that is widespread in the environment. Clostridium tetani contaminates wounds, and the spores germinate in the anaerobic environment of the devitalized tissue. The vegetative forms of Clostridium tetani produce toxin tetanospasmin. Toxin reaches t ...
Ch 12 2nd and 3rd Lines of Defense
Ch 12 2nd and 3rd Lines of Defense

... • Examples of autoimmune diseases (continued) • Systemic lupus erythematosus (SLE) – attacks connective tissue in general. Affects kidney, heart, lung and skin • Glomerulonephritis – impairment of renal function ...
Table of Contents - Milan Area Schools
Table of Contents - Milan Area Schools

... • Four groups of proteins play key roles in defending against disease:  Antibodies, secreted by B cells, bind specifically to certain substances.  T cell receptors are cell surface receptors that bind nonself substances on the surface of other cells.  Major histocompatibility complex (MHC) protei ...
Chapter 21
Chapter 21

HYPERSENSITIVITY REACTIONS The immune system is required
HYPERSENSITIVITY REACTIONS The immune system is required

... of domesticated animals, mold spores, and proteins in the feces of house dust mites. Injected materials include insect venoms, vaccines, and drugs. Ingested materials include some foods (e.g. peanuts, eggs, shellfish) and orally administered drugs. Symptoms of allergic disease are developed only aft ...
5 AcquiredImmFor242L
5 AcquiredImmFor242L

... complexes (MHC).  All body cells have MHC Class I proteins.  Our immune cells do not attack our own proteins  Our cells in another person’s body can trigger an immune response because they are foreign • Restricts donors for transplants ...
Document
Document

... O Lamprey and Hagfish have a distinct lymphocyte derived molecule. O These molecules are believed to bind pathogenic antigens in a similar way to antibodies. ...
Immune system
Immune system

... tuberculosis, etc. that activates macrophages involved in inflammatory response and promotes fever •  Interleukins – IL-1 and IL-6 generated as a result of inflammatory response promotes fever which helps in fighting infections as ...
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Document

... • Has the capability of activating 1%-10% of peripheral T cells • Exposure to a SAg can lead to massive T cell activation ...
FREE Sample Here
FREE Sample Here

... There are two forms of C4 encoded by separate genes residing in the class II region of the MHC. b. Evolution of the different forms of C4 probably occurred as a result of gene duplication and diversification. c. Because there are two forms of C4, C4 deficiency is the least common human ...
The Immune System
The Immune System

... Monocytes change into these as they leave the blood and enter the tissues. • Macrophages enter lymph vessels carring bacteria fragments to lymph nodes • This starts a specific immune response ...
Immunology – Immune System Overview
Immunology – Immune System Overview

... Why is the immune system important? The immune system is important because it acts as barriers for pathogens to get through. If the pathogens do not find a break in our immune system – then they cannot prevail. Most pathogens initially find this break and incompatibility but eventually the body’s im ...
Autoimmune Disease
Autoimmune Disease

Antibody Production and Use in Immunodetection
Antibody Production and Use in Immunodetection

... antibody molecules with slightly different amino acid sequences that can further tested to find the one with the most affinity for an antigen  The recombinant DNA can be engineered to encode a human antibody molecule with the binding portion of a mouse. This type of antibody is called “humanized” o ...
Bacterial Immunity and Host Defense Mechanisms
Bacterial Immunity and Host Defense Mechanisms

The Immune System
The Immune System

... Monocytes change into these as they leave the blood and enter the tissues. – These are phagocytic cells – Can eat many (100’s) of pathogens and survive. – Eat old blood cells and bits of dead tissue – Stimulate the immune response. • Increase production of white blood cells in bone marrow ...
Immunology powerpoint
Immunology powerpoint

... Nucleic acids are poor Ag due to lack of molecular flexibility and rapid degradation ...
immune - varmeckygahs
immune - varmeckygahs

... Pathogens - disease carriers - have different protein markers Pathogens are opposed by 3 lines of defense ...
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File

... T-lymphocytes or T-cells: cells involved in the activation of B-cells (helper T-cells) and the destruction of infected cells (killer T-cells)  Mature in the Thymus ...
Workshop Proceedings - Federation of Indian Physiological
Workshop Proceedings - Federation of Indian Physiological

... On the second day of the workshop a talk on Regulatory T cell: Recent player in defense game was delivered by Dr. Tapas Goswami, Principal Scientist from Indian Veterinary Research Institute, Bareilly. Dr. Ritu Agarwal, invited from Post Graduate Institute, Chandigarh delivered a lecture on Toll li ...
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Complement system



The complement system is a part of the immune system that helps or complements the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the innate immune system, which is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system.The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum and can serve as opsonins.Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.
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