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domain bacteria
domain bacteria

... 1. last universal common ancestor – data showed that all organisms got their rRNA genes from one ancient form of life 2. all living things related to one of three lineages ; domains: a. Bacteria, Archaea, Eukarya  most things we know like plants & animals 3. Archaea – more recently found, more surp ...
No Slide Title
No Slide Title

... Hydrophobicity is the most important characteristic of amino acids. It is the hydrophobic effect that drives proteins towards folding. Actually, it is all done by water. Water does not like hydrophobic surfaces. When a protein folds, exposed hydrophobic side chains get buried, and release water of i ...
Surrounded By Microbes
Surrounded By Microbes

... Surrounded By Microbes The Small Organisms of Earth ...
ppt
ppt

... Diverse in function, similar in structure – Generally categorized by presence of SNARE domain  60-70 amino acid stretch  Heptad repeats  Propensity to form coiled-coils ...
Membrane-active antimicrobial drugs—a reappraisal of their mode
Membrane-active antimicrobial drugs—a reappraisal of their mode

... It will be recalled that the proton-motive force (A~I, - ZApH) is said to be responsible for the synthesis of adenosine triphosphate as part of the process of oxidative phosphorylation. It has been known almost from the beginning of this century that nitrophenols, especially 2,4.dinitrophenol (DNP), ...
Prokaryotes
Prokaryotes

... Eukaryotes originated by symbiosis among prokaryotes. The first eukaryotes to evolve from prokaryotic ancestors were probably unicellular. The primal eukaryotes were ancestral to plants, fungi, and animals, the eukaryotic organisms most familiar to us. ...
Prokaryotes
Prokaryotes

...  Phylogenetic studies (16S rRNA, 23S rRNA, EF’s and b subunits of ATPase) have identified at least 23 major evolutionary divergences  modes of generating cellular energy and nutrition are more superficial than other more basic housekeeping and basic biochemical functions  Diversity is described i ...
Membrane transport
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... Single-molecule fluorescence studies of a membranebound transport machine Solute carrier (SLC) membrane transport proteins control a broad range of vital physiological functions, such as the uptake of nutrients and the transport of ions. SLCs interact with several important drugs, and a quarter of t ...
Overriding Imatinib Resistance with a Novel ABL Kinase
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Creatine Kinase

...  Mi-CK evolved different folding pattern for catalyzing phosphoryl transfer  Allow compartmentalization of function ...
Active Transport
Active Transport

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Introduction to enzymes
Introduction to enzymes

... 1. Lysozyme attaches to a bacterial cell wall by binding to a hexasaccharide unit. The D residue is distorted towards the half-chair. 2. Glu 35 transfers its proton to the O1 of the D ring (general acid catalysis) C1-O1 bond is cleaved generating an oxonium ion at C1. 3. Asp 52 stabilizes the oxoniu ...
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The Molecules of Life
The Molecules of Life

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Slide 1
Slide 1

... However, it is also known that certain sets of independent domains are frequently found together, which may indicate functional cooperation. Supra- Domains : A supra-domain is defined as a domain combination in a particular N-to-C-terminal orientation that occurs in at least two different domain arc ...
bchm628_lect5_15
bchm628_lect5_15

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... All organisms need energy to survive. The energy comes either from sunlight (photosynthesis) or from burning food molecules (respiration), but in both cases the energy is converted to ATP by the organism. ATP is an energy stock that can be used by a multitude of processes in the cell. Eukaryote aero ...
Cell Physiology
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File - Ms. D. Science CGPA
File - Ms. D. Science CGPA

... • Bacteria are all around you • Some are autotrophs, while others are heterotrophs. • Members of domain Bacteria are prokaryotes (organisms) whose cells lack a nucleus. A nucleus is a dense area in a cell that contains nucleic acids, (DNA=Deoxyribonucleic acid) which are the chemicals that direct al ...
Gene Section NTRK3  (neurotrophic  tyrosine  kinase,  receptor,
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... The NTRK3 protein is composed of several regions. Starting at the amino terminus is the signal sequence (SS) responsible for directing the newly translated protein to the cell surface. Next is the Extracellular Ligand Binding Domain (ECD-LB), which binds Neurotrophin 3 and subsequent homo-dimerizati ...
PowerPoint ******
PowerPoint ******

DNA/Protein structure-function analysis and prediction - IBIVU
DNA/Protein structure-function analysis and prediction - IBIVU

... 3D domain swapping definitions. A: Closed monomers are comprised of tertiary or secondary structural domains (represented by a circle and square) linked by polypeptide linkers (hinge loops). The interface between domains in the closed monomer is referred to as the C- (closed) interface. Closed monom ...
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P-type ATPase



The P-type ATPases, also known as E1-E2 ATPases, are a large group of evolutionarily related ion and lipid pumps that are found in bacteria, archaea, and eukaryotes. They are α-helical bundle primary transporters referred to as P-type ATPases because they catalyze auto- (or self-) phosphorylation of a key conserved aspartate residue within the pump. In addition, they all appear to interconvert between at least two different conformations, denoted by E1 and E2.Most members of this transporter family are specific for the pumping of a large array of cations, however one subfamily is involved in flipping phospholipids to maintain the asymmetric nature of the biomembrane.Prominent examples of P-type ATPases are the sodium-potassium pump (Na+,K+-ATPase), the plasma membrane proton pump (H+-ATPase), the proton-potassium pump (H+,K+-ATPase), and the calcium pump (Ca2+-ATPase).
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