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DG-041 Single Dose Results
DG-041 Single Dose Results

... for cancer and for death due to cancer (15 years ago – 40,000 deaths per year before PSA used ) Best treatment is early detection We have tools for curative treatment if detected early More emphasis needs to be made on early detection vs late treatment The only major risk factors are ethnicity and f ...
NEWS Physician Data Query (PDQ®) Update
NEWS Physician Data Query (PDQ®) Update

... summary was updated to include results from a study in which a recurrent germline mutation in the HOXB13 gene was associated with hereditary prostate cancer. The exons of 200 genes in 17q21-22, a chromosomal region that previously had been identified as a candidate region for prostate cancer suscepti ...
Circulating biomarkers of neuroendocrine prostate cancer: an unmet
Circulating biomarkers of neuroendocrine prostate cancer: an unmet

... of androgen receptor (AR) signalling, even in advanced disease [4]. The marker NSE is considered to be generic, with high sensitivity but low specificity; CGA is a more specific neuroendocrine tumour biomarker and a common constituent of neuroendocrine tumour secretory granules. Abnormal CGA levels ha ...
Prostate cancer progression
Prostate cancer progression

PSA Screening: A Modern Medical and Societal Dilemma
PSA Screening: A Modern Medical and Societal Dilemma

... Instructions for Physician: Locate the patient’s PSA on the PSA axis. Draw a line straight upwards to the Points axis to determine how many points towards recurrence the patient receives for his PSA. Repeat this process for the Clinical Stage and Biopsy Gleason Sum axes, each time drawing straight u ...
information - Debiopharm
information - Debiopharm

A Prostate Cancer Alert
A Prostate Cancer Alert

original article
original article

... forms pro PSA/ Benign PSA (BPSA) give more information, however these are costlier and more sophisticated investigations that are not available at peripheral centers, in India. INTRODUCTION: Prostate specific antigen (PSA) is a popular and time tested investigation used in diagnosis and management o ...
Treatment or monitoring for early prostate cancer
Treatment or monitoring for early prostate cancer

... intermediate-risk)1 prostate cancer remains unknown. Specifically, does active monitoring with the use of prostate-specific antigen (PSA) testing as opposed to treatment lead to increased metastasis and death from prostate cancer? If yes, then which treatment, radical prostatectomy or radiation with ...
Radiotherapy In prostate cancer
Radiotherapy In prostate cancer

... There are no randomized trials that have resolved the question of what constitutes the best treatment for these men The goal of RT for men with localized prostate cancer is the delivery of the planned dose of radiation to the tumor while minimizing radiation to surrounding normal tissues ...
A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the
A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the

... alkaline phosphatase over 200 U/l may have excluded a number of men with osteoblastic bone lesions from metastases. This inherent selection bias does not allow us to examine the potential role of Apatone as salvage therapy, potentially after failure of docetaxol chemotherapy in hormone refractory pa ...
Androgen deprivation therapy (ADT)
Androgen deprivation therapy (ADT)

... - Locally advanced or high-risk non-metastatic - Recurrent disease (biochemical recurrence) - Primary ADT ...
PG12-24 Robson Lay summary Principal Investigator: Professor
PG12-24 Robson Lay summary Principal Investigator: Professor

... This study may help to identify treatment targets for those men with prostate cancer that have become resistant to hormone therapy. In addition, although not the main focus of the work, this study will also build on our pilot data showing that certain stem cell markers are associated with worse clin ...
Gleason score predicted mortality rate to 20 years - Evidence
Gleason score predicted mortality rate to 20 years - Evidence

Prostate Diseases - Harvard Health Publications
Prostate Diseases - Harvard Health Publications

... Studies question benefit of PSA screening Does PSA screening save lives by enabling doctors to treat aggressive prostate cancers early? Or does it harm men who would never die from the disease by subjecting them to the side effects of treatment? Two studies—one conducted in the United States and the ...
Limits of Tumorectomy in clinical localized renal cell cancer
Limits of Tumorectomy in clinical localized renal cell cancer

... definition of castration-resistant prostate hormonerefractory prostate cancer (HRPC) • serume testosteron at castration level • secondary hormonal treatment without effect • ketoconazole • estrogens ...
reduce your colon cancer risk
reduce your colon cancer risk

... We hear about prostate cancer awareness for men and breast cancer awareness for women, but there's one cancer that both genders have an equal risk of developing: colon cancer. Colorectal cancer surpasses both breast and prostate cancer as the second-leading cause of cancer in the United States. Howe ...
Options after Radical Prostatectomy
Options after Radical Prostatectomy

... • Few patients will die from prostate cancer within 15 years of radical prostatectomy, despite the presence of adverse clinical features. • Favorable prognosis may be related to the effectiveness of RP (with or without secondary therapy) or the low lethality of screen-detected cancers. • Given the l ...
Detecting prostate cancer - Cancer Research UK Publications
Detecting prostate cancer - Cancer Research UK Publications

... that are much less serious than cancer. But if you develop any of them, it is best to see your doctor to get them checked out. What will happen at the doctor’s? Your doctor will ask about your symptoms and may suggest a blood test. This will tell the doctor about the level of a protein called PSA (p ...
September - Southeast Health District
September - Southeast Health District

... disease that will kill an estimated 30,350 American men in this year alone…that’s one death every 18 minutes. ...
Dr_Chatterjee - Prostate Cancer Canada Network Brampton
Dr_Chatterjee - Prostate Cancer Canada Network Brampton

here - Prostate Cancer Support Group
here - Prostate Cancer Support Group

... DRE (Digital Rectal Examination) DRE can be undertaken by your GP. Involves insertion of gloved finger into the rectum to feel prostate for any abnormality (tenderness, ...
Hormonal Therapy Treatment Options for Advanced Prostate Cancer
Hormonal Therapy Treatment Options for Advanced Prostate Cancer

... But medical castration happens in the form of the LHRH analogs that are listed below. Starting with leuprolide (Lupron), degarelix (Firmagon), triptorelin (Trelstar) and goserelin (Zoladex). And they all work by basically telling your brain to shut down testicular production of testosterone. So that ...
- Mid Essex Hospital Services NHS Trust
- Mid Essex Hospital Services NHS Trust

... have prostate cancer, it can also detect early prostate cancer before it causes symptoms or any abnormality of the prostate. Although using the PSA test in this way to screen for prostate cancer is sometimes recommended, some doctors do not think it is necessarily a good thing because it may detect ...
Prostate Cancer Awareness - LSUHSC School of Nursing
Prostate Cancer Awareness - LSUHSC School of Nursing

...  Prostate specific antigen (PSA) test: A blood test measures the level of PSA in the blood. PSA is a substance made by the prostate. The levels of PSA in the blood can be higher in men who have prostate cancer. The PSA level may also be elevated in other conditions that affect the prostate. ...
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Prostate-specific antigen

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus.PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. The United States Preventive Services Task Force (USPSTF, 2012) does not recommend PSA screening, noting that the test may result in “overdiagnosis” and “overtreatment” because ""most prostate cancer is asymptomatic for life"" and treatments involve risks of complications including impotence (erectile dysfunction) and incontinence. The USPSTF concludes ""the potential benefit does not outweigh the expected harms."" PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia. 30 percent of patients with high PSA have prostate cancer diagnosed after biopsy.
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