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Screening for Prostate Cancer
Screening for Prostate Cancer

... SWOG trial of chemotherapy in metastatic disease. SWOG Intergroup 9916 randomized phase III study of docetaxel + estramustine versus mitoxantrone + prednisone in patients with hormone-refractory prostate cancer; 620 patients must be entered to detect a 33% survival difference. ...
Urological Tumours
Urological Tumours

Investigation and Management of Prostate Cancer
Investigation and Management of Prostate Cancer

... radiotherapy, radical prostatectomy, and watchful waiting have been performed • Similar local control rates, and 10 year disease-free survival rates to radical prostatectomy • Good “free from PSA failure” rates • Similar Complication rates to Radical Prostatectomy ...
Prostate Problems By Dr Mahya Mirfattahi GPST1 HDR Wednesday 17
Prostate Problems By Dr Mahya Mirfattahi GPST1 HDR Wednesday 17

... Many causes of raised levels 2/3 of men with raised PSA do NOT have cancer May lead to unnecessary anxiety and further investigations when no cancer is present Can provide reassurance if normal May miss diagnosis too (false reassurance) Does not distinguish between aggressive and nonaggressive tumou ...
Sipuleucel-T - The Prostate Net
Sipuleucel-T - The Prostate Net

... Safety of Ipilimumab 10 mg/kg +/- additional XRT in patients with mCRPC – No new emergent toxicity due to XRT in 32 subjects – Tolerated in both chemo naïve and chemo experienced population – 15/50 patients (30%) with Grade 3 or 4 irAE – Severity, rate and duration similar to Ipilimumab oncology pro ...
PSA Screening - Heart Screen, Inc.
PSA Screening - Heart Screen, Inc.

... other conditions annual testing is KEY! Prostate Specific Antigen (PSA), a blood test Digital Rectal Examination (DRE), a physical exam Basic tools to find Prostate Cancer EARLY! ...
Take a Moment in Time
Take a Moment in Time

... Smoking has not been thought to be a risk factor for low-risk prostate cancer, but it may be a risk factor for aggressive prostate cancer. Lack of vegetables in the diet (especially broccoli-family such as cauliflower, kale and sprouts) is linked to a higher risk of aggressive prostate cancer, but n ...
The Treatment of Advanced Prostate Cancer
The Treatment of Advanced Prostate Cancer

... With PSA screening, most men present with early stage disease. In fact only 4% of men present with  distant disease. Prior to the PSA era, up to 30% of men presented with advanced disease. If PSA  screening is abandoned, models predict that we will see more men presenting with advanced prostate  can ...
2016-09-23 Beyond Monitoring Prostates
2016-09-23 Beyond Monitoring Prostates

... The disease progressed significantly more often among the men randomly assigned to monitoring, but that is hardly a surprise. The very point of immediate treatment for localized prostate cancer is to nip the malady in the proverbial bud, and forestall progression. Catching and treating cancer early ...
Prostate Cancer ACTIVE SURVEILLANCE Program
Prostate Cancer ACTIVE SURVEILLANCE Program

... growth beyond the prostate and who are not experiencing any symptoms are reasonable candidates for active surveillance. However, this approach is not likely to be a good option if you are have a fast growing cancer, or you are older and have other health issues. The doctor’s recommendation for Activ ...
Shiuan Chen, Ph.D., Professor and Chair, Department of Cancer
Shiuan Chen, Ph.D., Professor and Chair, Department of Cancer

... cancer and in the understanding of aromatase inhibitor (AI) response in breast cancer treatment. Dr. Chen is also known for his research on the demonstration of anti-cancer properties of mushrooms, grape seed extract, pomegranate, and blueberries against breast cancer and prostate cancer. Importantl ...
Current Diagnosis and Management of Prostate Cancer
Current Diagnosis and Management of Prostate Cancer

... • Characterized by cytologically atypical cells with architecturally benign glands • Approximately 20% of patients with PIN will go on to have a subsequently positive biopsy • ASAP-atypical small acinar proliferation – Atypical glands and cells but can’t quite call it cancer • Up to 50% will have a ...
Prostate Disease Masterclass Primary Care
Prostate Disease Masterclass Primary Care

The role of prostate-specific antigen (PSA) testing in
The role of prostate-specific antigen (PSA) testing in

... PSA became the first biomarker (indicator of biological state) approved for screening asymptomatic men for cancer in 1994, when the FDA approved its use in conjunction with the digital rectal exam (DRE) to screen for prostate cancer. A PSA level of 4.0 µg/L was traditionally considered the upper lim ...
How can the cost/benefit of PSA tests for men between the ages of
How can the cost/benefit of PSA tests for men between the ages of

... However, there is a lack of evidence indicating that earlier treatment improves health outcomes. The treatment for prostate cancer also has a risk for harm including reduced sexual function, urinary problems, and bowel problems (Harris et al.). Ferrini & Woolf said that “many men die with prostate c ...
Sept. 1, 2015 - Prostate Cancer Second Leading Cause of Cancer
Sept. 1, 2015 - Prostate Cancer Second Leading Cause of Cancer

... PERRYTON, Texas (Sept. 1, 2015) – Affecting an estimated three million American men each year, prostate cancer is the second leading cause of cancer deaths among men in the nation. Ochiltree General Hospital (OGH) wants to make sure men in Ochiltree County over the age of 50 talk with their physicia ...
June 2015 - Prostate Cancer Support Group
June 2015 - Prostate Cancer Support Group

... pathology under the microscope - as well as how it can vary within one man who may have multiple tumour types in his prostate," says Dr. Bristow. He goes on to say, "these sub-types may be important to determining the response to surgery or radiotherapy between patients." Dr. Bristow says about half ...
Objectives Prostate cancer (PCa) is the most common malignancy in
Objectives Prostate cancer (PCa) is the most common malignancy in

... to PSA test screening. Prostate cancer is diagnosed via a biopsy that determines the presence of tumour cells in the prostate, the biopsy being performed as a result of an elevated level of PSA in the blood. Recently, the Rotterdam-based European Randomised Study of Screening for Prostate Cancer dem ...
Baylor Sammons Cvetko Center PC Information and Support Group
Baylor Sammons Cvetko Center PC Information and Support Group

... In its early stages, prostate cancer typically has no symptoms. But new diagnostic methods and changes in men s attitudes due to increased awareness of the disease mean that more and more prostate cancers are found at an early stage, when treatment options are more effective. ...
Logothetis.pps
Logothetis.pps

... growth will result in effective therapy ...
Insight into the mechanisms linking the metabolism of fat to prostate
Insight into the mechanisms linking the metabolism of fat to prostate

... This study aims to improve our understanding of what makes prostate cancer either aggressive or indolent by learning how fat metabolism can drive prostate cancer progression. The scientists will start by monitoring the migration and invasive ability (measurements to test aggressiveness) of prostate ...
A tale of four prostates
A tale of four prostates

Prostate Cancer Screening: FAQs
Prostate Cancer Screening: FAQs

... third of people have side effects from the procedure such as pain, bleeding or infection 4,5. These cores are examined under the microscope to look for cancer cells. You might have a scan as well. Then the results are reviewed with you and if cancer is found the treatment is discussed. It is not alw ...
Practical Pearls for Primary Care Evaluation and Treatment of
Practical Pearls for Primary Care Evaluation and Treatment of

PG12-02 Worthington Lay summary Principal Investigator: Dr Jenny
PG12-02 Worthington Lay summary Principal Investigator: Dr Jenny

... laboratory and in the clinic, have shown that hypoxic cells are important in making prostate cancer more malignant/aggressive, in particular in forming tumours in other parts of the body (metastasis). This is very important because these metastatic deposits (often found in bone) cause considerable p ...
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Prostate-specific antigen

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus.PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. The United States Preventive Services Task Force (USPSTF, 2012) does not recommend PSA screening, noting that the test may result in “overdiagnosis” and “overtreatment” because ""most prostate cancer is asymptomatic for life"" and treatments involve risks of complications including impotence (erectile dysfunction) and incontinence. The USPSTF concludes ""the potential benefit does not outweigh the expected harms."" PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia. 30 percent of patients with high PSA have prostate cancer diagnosed after biopsy.
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