Chapter 1 Key Terms
... An adverse effect (allergic response) resulting from 10. The process by which medications are taken into previous exposure to the drug or a similar drug. the body. An expected, but unintended, action or effect of a 11. The process of elimination of drug molecules from drug. the body. Artificial mani ...
... An adverse effect (allergic response) resulting from 10. The process by which medications are taken into previous exposure to the drug or a similar drug. the body. An expected, but unintended, action or effect of a 11. The process of elimination of drug molecules from drug. the body. Artificial mani ...
Epidural Analgesia and Anesthesia
... the practitioner adjusts the dose of drug accordingly. Generally, a dose reduction of 40% to 50% is recommended. It must be remembered that the animal has then received a spinal injection and not an epidural injection. Spinal injections result in a more rapid onset of effect and also have the potent ...
... the practitioner adjusts the dose of drug accordingly. Generally, a dose reduction of 40% to 50% is recommended. It must be remembered that the animal has then received a spinal injection and not an epidural injection. Spinal injections result in a more rapid onset of effect and also have the potent ...
Report on the Deliberation Results August 25, 2009 Evaluation and
... The efficacy of the product has been shown in phase III clinical studies (P054, P055, ONO-5435-08 to -10) etc. No major safety problems have been identified in phase III clinical studies etc. Cardiovascular events and tumor development etc. during long-term use and the safety in patients with modera ...
... The efficacy of the product has been shown in phase III clinical studies (P054, P055, ONO-5435-08 to -10) etc. No major safety problems have been identified in phase III clinical studies etc. Cardiovascular events and tumor development etc. during long-term use and the safety in patients with modera ...
DRUGDEX DRUG EVALUATIONS
... 1. Summary: Cholestyramine can bind oral anticoagulants in the gut and limit their absorption, thus impairing their activity. Separating the doses of the drugs by several hours may lessen the impact of this interaction, but because anisindione undergoes enterohepatic recirculation, time separation o ...
... 1. Summary: Cholestyramine can bind oral anticoagulants in the gut and limit their absorption, thus impairing their activity. Separating the doses of the drugs by several hours may lessen the impact of this interaction, but because anisindione undergoes enterohepatic recirculation, time separation o ...
LUPANETA PACK
... Because norethindrone acetate may cause some degree of fluid retention, carefully observe women with conditions that might be influenced by this effect, such as epilepsy, migraine, cardiac or renal dysfunctions. 5.9 Convulsions There have been postmarketing reports of convulsions in patients on leup ...
... Because norethindrone acetate may cause some degree of fluid retention, carefully observe women with conditions that might be influenced by this effect, such as epilepsy, migraine, cardiac or renal dysfunctions. 5.9 Convulsions There have been postmarketing reports of convulsions in patients on leup ...
Dronabinol and Marijuana in HIV
... to 80% of the American public supports a policy whereby physicians can prescribe marijuana, and 10 states have passed medical marijuana ballot initiatives in opposition to federal policy prohibiting the use of marijuana.7,8 Reasons for smoking marijuana cited by medical marijuana proponents and pati ...
... to 80% of the American public supports a policy whereby physicians can prescribe marijuana, and 10 states have passed medical marijuana ballot initiatives in opposition to federal policy prohibiting the use of marijuana.7,8 Reasons for smoking marijuana cited by medical marijuana proponents and pati ...
MICROMEDEX® Healthcare Series OXCARBAZEPINE
... compared to adults (Prod Info TRILEPTAL(R) oral tablets, oral suspension, 2005) a) Partial seizure, monotherapy 1) 4 to 16 year old, initiation of monotherapy, 8-10 mg/kg/day ORALLY divided doses; may increase dose by 5 mg/kg/day every 3 days to the recommended maintenance dose (Prod Info TRILEPTAL( ...
... compared to adults (Prod Info TRILEPTAL(R) oral tablets, oral suspension, 2005) a) Partial seizure, monotherapy 1) 4 to 16 year old, initiation of monotherapy, 8-10 mg/kg/day ORALLY divided doses; may increase dose by 5 mg/kg/day every 3 days to the recommended maintenance dose (Prod Info TRILEPTAL( ...
Paediatric formulations of L-arginine for the use in urea cycle disorders
... has been internationally recognised [146]. Often unlicensed and off-label medicines are the only ones available yet which have not been clinically tested for safety, efficacy and quality in this age group. Most medicines administered to adults have a product licence that outlines the particular indi ...
... has been internationally recognised [146]. Often unlicensed and off-label medicines are the only ones available yet which have not been clinically tested for safety, efficacy and quality in this age group. Most medicines administered to adults have a product licence that outlines the particular indi ...
Nowhere to hide: interrogating different metabolic parameters of Plasmodium
... high-throughput assays [38, 41, 42]. However, since these assays interrogate different metabolic pathways in the parasite, notable discrepancies in the outputs regarding the identification of compounds with gametocytocidal activity have been observed in the literature. Potential target compounds may ...
... high-throughput assays [38, 41, 42]. However, since these assays interrogate different metabolic pathways in the parasite, notable discrepancies in the outputs regarding the identification of compounds with gametocytocidal activity have been observed in the literature. Potential target compounds may ...
hydrocodone bitartrate and acetaminophen tablets, usp
... There have been post-marketing reports of hypersensitivity and anaphylaxis associated with use of acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent reports of life-threatening anaphylax ...
... There have been post-marketing reports of hypersensitivity and anaphylaxis associated with use of acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent reports of life-threatening anaphylax ...
© Information - Universitätsmedizin Mainz
... e authors, especially the right to reproduction and d distribution as well as translation in any langua age. This leaflet is intended for p private p purp poses by p y patients p – anyy other use needs written consent of the authors. Version Sep 2014 ...
... e authors, especially the right to reproduction and d distribution as well as translation in any langua age. This leaflet is intended for p private p purp poses by p y patients p – anyy other use needs written consent of the authors. Version Sep 2014 ...
EAU Guidelines Male Sexual Dysfunction 2009
... patients with clinically localised prostate cancer (PCa) and a life expectancy of at least 10 years. This procedure may lead to treatment-specific sequelae affecting health-related QoL. This outcome has become increasingly important with the more frequent diagnosis of PCa in younger patients (11-13) ...
... patients with clinically localised prostate cancer (PCa) and a life expectancy of at least 10 years. This procedure may lead to treatment-specific sequelae affecting health-related QoL. This outcome has become increasingly important with the more frequent diagnosis of PCa in younger patients (11-13) ...
Mash-Summary-Ibogain..
... degenerashowed that high doses of ibogaine (100 mg kg-l or 3 x 100 mg kg-I) causes the dose effects tion of the cerebellar purkinje cells in rats. Molinari et at.63 reevaluate,d in reducof ibogaine. In this study, a lower dose (40 mg/kg) of ibogaine, one effective the above ation degener no d displa ...
... degenerashowed that high doses of ibogaine (100 mg kg-l or 3 x 100 mg kg-I) causes the dose effects tion of the cerebellar purkinje cells in rats. Molinari et at.63 reevaluate,d in reducof ibogaine. In this study, a lower dose (40 mg/kg) of ibogaine, one effective the above ation degener no d displa ...
Ampicillin
... reaction. The occurrence of a maculopapular rash during ampicillin use does not necessarily preclude the subsequent use of other penicillins. However, since it may be difficult in practice to distinguish between hypersensitive and toxic responses, skin testing for hypersensitivity may be advisable b ...
... reaction. The occurrence of a maculopapular rash during ampicillin use does not necessarily preclude the subsequent use of other penicillins. However, since it may be difficult in practice to distinguish between hypersensitive and toxic responses, skin testing for hypersensitivity may be advisable b ...
Unveiling the compatibility of eugenol with formulation excipients by
... state of the mixture (semisolid type except for the mixture with Tween 80 where is a change in the viscosity), which is different from the individual ones (liquid and solids), could also contribute toward this type of response. Moreover, it is difficult to expect a result as we do in solid samples w ...
... state of the mixture (semisolid type except for the mixture with Tween 80 where is a change in the viscosity), which is different from the individual ones (liquid and solids), could also contribute toward this type of response. Moreover, it is difficult to expect a result as we do in solid samples w ...
METHOTREXATE 25 MG/ML SOLUTION FOR INJECTION
... The application and dosage recommendations for the administration of methotrexate (low-dose therapy, mostly as part of polychemotherapy) for different indications varies considerably. Some common dosages and therapy protocols, which have proved to be efficacious in the therapy of the disorder in eac ...
... The application and dosage recommendations for the administration of methotrexate (low-dose therapy, mostly as part of polychemotherapy) for different indications varies considerably. Some common dosages and therapy protocols, which have proved to be efficacious in the therapy of the disorder in eac ...
Ewrramt~amm=nts I
... year. 1 Nobody knows exactly how many headaches that represents. The use of aspirin for disorders other than headaches is also quite substantial. It is commonly used for fever, arthritis, and other so-called “minor” discomforts, as advertisements in the English-language press keep reminding us. Aspi ...
... year. 1 Nobody knows exactly how many headaches that represents. The use of aspirin for disorders other than headaches is also quite substantial. It is commonly used for fever, arthritis, and other so-called “minor” discomforts, as advertisements in the English-language press keep reminding us. Aspi ...
Therapeutic monitoring of vancomycin in adult patients
... AUC/MIC and the free vancomycin AUC/MIC [AUC × 50% protein binding/MIC] have been interchangeably reported for vancomycin. Unless designated fAUC/MIC, this consensus review refers to total AUC/MIC.) Craig and Andes32 recently evaluated the use of free vancomycin AUC0–24hr/MIC (fAUC/MIC) as the prima ...
... AUC/MIC and the free vancomycin AUC/MIC [AUC × 50% protein binding/MIC] have been interchangeably reported for vancomycin. Unless designated fAUC/MIC, this consensus review refers to total AUC/MIC.) Craig and Andes32 recently evaluated the use of free vancomycin AUC0–24hr/MIC (fAUC/MIC) as the prima ...
Word - corporate
... that involve risks and uncertainties. We often use words such as “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue,” and other words and terms of similar meaning to help identify forward- ...
... that involve risks and uncertainties. We often use words such as “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue,” and other words and terms of similar meaning to help identify forward- ...
Print - Circulation
... cardiac contractility has not been assessed directly. Methods and Results—Under physiological conditions (37°C, pH 7.35, 1.25 mmol/L Ca2⫹), there was a dose-dependent decrease in contractile force in ventricular trabeculae isolated from end-stage failing human hearts superfused with pantoprazole. Th ...
... cardiac contractility has not been assessed directly. Methods and Results—Under physiological conditions (37°C, pH 7.35, 1.25 mmol/L Ca2⫹), there was a dose-dependent decrease in contractile force in ventricular trabeculae isolated from end-stage failing human hearts superfused with pantoprazole. Th ...
Berberine Monograph - Alternative Medicine Review
... Diarrhea caused by Vibrio cholera and Escherichia coli has been the focus of numerous berberine studies, and results indicate several mechanisms which may explain its ability to inhibit bacterial diarrhea. An animal study found berberine reduced the intestinal secretion of water and electrolytes ind ...
... Diarrhea caused by Vibrio cholera and Escherichia coli has been the focus of numerous berberine studies, and results indicate several mechanisms which may explain its ability to inhibit bacterial diarrhea. An animal study found berberine reduced the intestinal secretion of water and electrolytes ind ...
product monograph
... (CNS) depressant effects. Depending on the route of administration and dose used, midazolam can produce sedative-hypnotic effects or induce anesthesia. The administration of midazolam may often be followed by anterograde amnesia. Onset of sedative effects after intramuscular administration is about ...
... (CNS) depressant effects. Depending on the route of administration and dose used, midazolam can produce sedative-hypnotic effects or induce anesthesia. The administration of midazolam may often be followed by anterograde amnesia. Onset of sedative effects after intramuscular administration is about ...
AIDS Drug Assistance Programs: Utilization, Program Restrictions
... Capped enrollment – no new clients can enter the program ADAP waiting lists – clients have been placed on a waiting list to receive drugs through ADAP – Expenditure caps – a limit on monthly or annual spending on drugs per client – Client cost-sharing – a requirement that clients contribute a portio ...
... Capped enrollment – no new clients can enter the program ADAP waiting lists – clients have been placed on a waiting list to receive drugs through ADAP – Expenditure caps – a limit on monthly or annual spending on drugs per client – Client cost-sharing – a requirement that clients contribute a portio ...
Cellulose, Chitosan, and Keratin Composite Materials. Controlled
... because of the square root of time dependence of drug released, is based on Fickian diffusion of the drug from the matrix.31,32 This relation is taken to be valid during the early times of drug release, namely the time up to 60% release of the drug.31,32 Because not all systems can be described by th ...
... because of the square root of time dependence of drug released, is based on Fickian diffusion of the drug from the matrix.31,32 This relation is taken to be valid during the early times of drug release, namely the time up to 60% release of the drug.31,32 Because not all systems can be described by th ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.