Discriminative Stimulus Properties of MDMA
... Rationale: ±3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) produces unique and complex subjective effects which distinguish it from other recreationally used drugs. An understanding of the neurochemical mechanisms that underlie these effects is important in order to assess the potential for MDM ...
... Rationale: ±3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) produces unique and complex subjective effects which distinguish it from other recreationally used drugs. An understanding of the neurochemical mechanisms that underlie these effects is important in order to assess the potential for MDM ...
CLARITIN® Rapid Dissolve
... suppression model in healthy male volunteers. All doses were significantly more effective than placebo in suppressing the formation of histamine-induced skin wheals (See DETAILED PHARMACOLOGY / Human Pharmacology). Alcohol: The ability of healthy male volunteers to concentrate was not impaired by lo ...
... suppression model in healthy male volunteers. All doses were significantly more effective than placebo in suppressing the formation of histamine-induced skin wheals (See DETAILED PHARMACOLOGY / Human Pharmacology). Alcohol: The ability of healthy male volunteers to concentrate was not impaired by lo ...
Rx Only Cyclobenzaprine Hydrochloride Extended
... Cyclobenzaprine hydrochloride extended-release capsules is closely related to the tricyclic antidepressants, e.g., amitriptyline and imipramine. In short term studies for indications other than muscle spasm associated with acute musculoskeletal conditions, and usually at doses somewhat greater than ...
... Cyclobenzaprine hydrochloride extended-release capsules is closely related to the tricyclic antidepressants, e.g., amitriptyline and imipramine. In short term studies for indications other than muscle spasm associated with acute musculoskeletal conditions, and usually at doses somewhat greater than ...
PRODUCT MONOGRAPH Pr CLINDOXYL® ADV Gel Pr
... Benzoyl peroxide: Avoid contact with the mouth, eyes, lips, other mucous membranes or areas of irritated or broken skin. In the event of accidental contact with sensitive surfaces (eyes, abraded skin, mucous membranes), rinse with copious amounts of cool tap water. In addition, care should be taken ...
... Benzoyl peroxide: Avoid contact with the mouth, eyes, lips, other mucous membranes or areas of irritated or broken skin. In the event of accidental contact with sensitive surfaces (eyes, abraded skin, mucous membranes), rinse with copious amounts of cool tap water. In addition, care should be taken ...
The Placebo Effect (A comprehensive Review of the Placebo Effect
... that would have happened regardless of the intervention. Another example is regression to the mean, a statistical phenomenon that assumes that in a given population, extremes in reported pain intensity will change over time toward the average of that population. In the case of pain, this phenomenon ...
... that would have happened regardless of the intervention. Another example is regression to the mean, a statistical phenomenon that assumes that in a given population, extremes in reported pain intensity will change over time toward the average of that population. In the case of pain, this phenomenon ...
Gamma-butyrolactone (GBL) - World Health Organization
... studies of GBL. In one study in which GBL was intentionally administered to human subjects under experimental conditions, Schrock and colleagues 28 administered a single dose of 1.5 ml of GBL spiked to a soft drink to each of two volunteers. The dose of GBL was estimated to be equivalent to 2.1 g of ...
... studies of GBL. In one study in which GBL was intentionally administered to human subjects under experimental conditions, Schrock and colleagues 28 administered a single dose of 1.5 ml of GBL spiked to a soft drink to each of two volunteers. The dose of GBL was estimated to be equivalent to 2.1 g of ...
Biopharmaceutical considerations and in vitro
... I would like to express my appreciation to Dr M. Begona Delgado-Charro (University of Bath) and Prof Dr Clive G. Wilson (Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow) for kind acceptance to be the examiner of my thesis. Dr Karen Edler is also acknowle ...
... I would like to express my appreciation to Dr M. Begona Delgado-Charro (University of Bath) and Prof Dr Clive G. Wilson (Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow) for kind acceptance to be the examiner of my thesis. Dr Karen Edler is also acknowle ...
Neuroscience of psychoactive substance use and dependence
... contributed reviews that formed the basis for the final report: Helena M. T. Barros, Federal University of Medical Sciences Foundation, Porto Alegre, Brazil; Lucy Carter, Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia; David Collier, Section of Genetics ...
... contributed reviews that formed the basis for the final report: Helena M. T. Barros, Federal University of Medical Sciences Foundation, Porto Alegre, Brazil; Lucy Carter, Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia; David Collier, Section of Genetics ...
Arkansas Medicaid Pharmacy Prior Authorization Criteria
... Prescribers may request an override for nonpreferred drugs by calling the UAMS College of Pharmacy Evidence-Based Prescription Drug Program Help Desk at 1-866-250-2518 (toll-free) or 501-526-4200 (local.) The Arkansas Medicaid Preferred Drug List may be found at this link. https://arkansas.magellanr ...
... Prescribers may request an override for nonpreferred drugs by calling the UAMS College of Pharmacy Evidence-Based Prescription Drug Program Help Desk at 1-866-250-2518 (toll-free) or 501-526-4200 (local.) The Arkansas Medicaid Preferred Drug List may be found at this link. https://arkansas.magellanr ...
Methamphetamine - Department of Electrical Engineering
... rank and division, from elite forces to tank crews and aircraft personnel, with many millions of tablets being distributed throughout the war.[23] From 1942 until his death in 1945, Adolf Hitler may have been given intravenous injections of methamphetamine by his personal physician Theodor Morell. I ...
... rank and division, from elite forces to tank crews and aircraft personnel, with many millions of tablets being distributed throughout the war.[23] From 1942 until his death in 1945, Adolf Hitler may have been given intravenous injections of methamphetamine by his personal physician Theodor Morell. I ...
PRODUCT MONOGRAPH Codeine Contin
... Withdrawal Effects: Withdrawal symptoms may occur following abrupt discontinuation of therapy or upon administration of an opioid antagonist (see ADVERSE REACTIONS, Withdrawal (Abstinence) Syndrome). Therefore, patients on prolonged therapy should be withdrawn gradually from the drug if it is no lon ...
... Withdrawal Effects: Withdrawal symptoms may occur following abrupt discontinuation of therapy or upon administration of an opioid antagonist (see ADVERSE REACTIONS, Withdrawal (Abstinence) Syndrome). Therefore, patients on prolonged therapy should be withdrawn gradually from the drug if it is no lon ...
Piracetam: A Review of Pharmacological
... The interaction of piracetam with membranes has also been reported in another, recent, in vitro study investigating the toxic effect of amyloid peptide aggregates on neuronal membranes (47). Amyloid peptide was shown to cause lipid disorganization within the cell membranes, and incubation with pirac ...
... The interaction of piracetam with membranes has also been reported in another, recent, in vitro study investigating the toxic effect of amyloid peptide aggregates on neuronal membranes (47). Amyloid peptide was shown to cause lipid disorganization within the cell membranes, and incubation with pirac ...
Analysis of submissions: Proposal to Classify
... The possibility of a legal market leading to the release of an increasing range of little understood psychoactive compounds; ...
... The possibility of a legal market leading to the release of an increasing range of little understood psychoactive compounds; ...
Clearing of Metabolic Waste via Enterohepatic Recirculation Table
... Thesis statement: The nature of bile lends itself to the recycling of metabolic waste, causing these waste products to reenter the blood stream through the process known as enterohepatic recirculation. This recycling could possibly become a concern as exposure to potentially harmful waste products i ...
... Thesis statement: The nature of bile lends itself to the recycling of metabolic waste, causing these waste products to reenter the blood stream through the process known as enterohepatic recirculation. This recycling could possibly become a concern as exposure to potentially harmful waste products i ...
Pharmacokinetics and pharmacodynamics of oral oxycodone in
... characteristics of oxycodone. An earlier study by Kalso et al5 suggested the presence of pharmacologically active metabolites in circulation after the oral administration of oxycodone. Displacement of tritium-labeled dihydromorphine binding to rat brain homogenates by plasma extracts from subjects a ...
... characteristics of oxycodone. An earlier study by Kalso et al5 suggested the presence of pharmacologically active metabolites in circulation after the oral administration of oxycodone. Displacement of tritium-labeled dihydromorphine binding to rat brain homogenates by plasma extracts from subjects a ...
Potential applications of chitosan in veterinary medicine
... The chemical structure of chitosan, which is similar to that of hyaluronic acid, suggested that it would act as a wound healing agent [18]. Mechanisms of acceleration of wound healing have been investigated in vitro and in vivo by several groups [19 – 21]. Since 1985, Minami and his group have been ...
... The chemical structure of chitosan, which is similar to that of hyaluronic acid, suggested that it would act as a wound healing agent [18]. Mechanisms of acceleration of wound healing have been investigated in vitro and in vivo by several groups [19 – 21]. Since 1985, Minami and his group have been ...
Methotrexate - Pfizer Canada
... sustained use often shows histologic changes, and fibrosis and cirrhosis have been reported; these latter lesions may not be preceded by symptoms or abnormal liver function tests in the psoriasis population. Periodic liver biopsies are usually recommended for psoriatic patients who are under long-te ...
... sustained use often shows histologic changes, and fibrosis and cirrhosis have been reported; these latter lesions may not be preceded by symptoms or abnormal liver function tests in the psoriasis population. Periodic liver biopsies are usually recommended for psoriatic patients who are under long-te ...
product monograph
... convulsions or cardiovascular collapse with accompanying hypotension. Patients with severe liver impairment should be administered a lower initial dose because they may have reduced clearance of loratadine; an initial dose of one tablet daily is recommended. Use in Elderly: In patients 60 years of a ...
... convulsions or cardiovascular collapse with accompanying hypotension. Patients with severe liver impairment should be administered a lower initial dose because they may have reduced clearance of loratadine; an initial dose of one tablet daily is recommended. Use in Elderly: In patients 60 years of a ...
SERETIDE ACCUHALER/DISKUS™
... Salmeterol acts locally in the lung therefore plasma levels are not an indication of therapeutic effects. In addition there are only limited data available on the pharmacokinetics of salmeterol because of the technical difficulty of assaying the drug in plasma due to the low plasma concentrations at ...
... Salmeterol acts locally in the lung therefore plasma levels are not an indication of therapeutic effects. In addition there are only limited data available on the pharmacokinetics of salmeterol because of the technical difficulty of assaying the drug in plasma due to the low plasma concentrations at ...
GHB, GBL and 1,4-BD Addiction - Trimbos
... trend, albeit more modest, was seen in the United Kingdom between 2006 and 2010 [29]. Also, in general, the nature of GHB intoxications at EDs was more serious than that with most other drugs of abuse, like ecstasy or cannabis [30]. Likewise, the number of information requests for GHB and GBL intoxi ...
... trend, albeit more modest, was seen in the United Kingdom between 2006 and 2010 [29]. Also, in general, the nature of GHB intoxications at EDs was more serious than that with most other drugs of abuse, like ecstasy or cannabis [30]. Likewise, the number of information requests for GHB and GBL intoxi ...
Handbook of Pharmaceutical Excipients, 7th ed. Sample chapter.
... USP35–NF30, the General Chapter 5.8 in PhEur 7.4, along with the ‘State of Work’ document on the PhEur EDQM website, and also the General Information Chapter 8 in the JP XV. Mannitol is an isomer of sorbitol, the difference between the two polyols occurring in the planar orientation of the OH group ...
... USP35–NF30, the General Chapter 5.8 in PhEur 7.4, along with the ‘State of Work’ document on the PhEur EDQM website, and also the General Information Chapter 8 in the JP XV. Mannitol is an isomer of sorbitol, the difference between the two polyols occurring in the planar orientation of the OH group ...
The Diagnostic Applications of Saliva— A Review
... CF patients contains increased calcium levels (Mandel et al., EGF anomaly might contribute to the pathology of CF 1967; Blomfield et al., 1976; Mangos and Donnelly, 1981). (Aubert et al., 1990). Further, abnormally elevated levels of Elevated levels of calcium and proteins in submandibular saliva pr ...
... CF patients contains increased calcium levels (Mandel et al., EGF anomaly might contribute to the pathology of CF 1967; Blomfield et al., 1976; Mangos and Donnelly, 1981). (Aubert et al., 1990). Further, abnormally elevated levels of Elevated levels of calcium and proteins in submandibular saliva pr ...
DOVOBET® Gel
... 30%. The effects of DOVOBET gel on calcium metabolism following treatment durations of more than 8 weeks have not been evaluated. ...
... 30%. The effects of DOVOBET gel on calcium metabolism following treatment durations of more than 8 weeks have not been evaluated. ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.