Winter 2013 - Ontario College of Pharmacists
... new professionals. We know that hospital and community pharmacists are examining their work processes to determine how best to add regulated technicians to the workflow, appreciating that this can have a major impact in freeing up pharmacists’ time so they can focus on the delivery of more clinical ...
... new professionals. We know that hospital and community pharmacists are examining their work processes to determine how best to add regulated technicians to the workflow, appreciating that this can have a major impact in freeing up pharmacists’ time so they can focus on the delivery of more clinical ...
Developing Cures, Creating Jobs
... to not only more effectively treat disease, but also to predict, preempt and prevent it. Biotechnology medicines are developed through biological processes using living cells or organisms, rather than traditional chemical synthesis, the mainstay of pharmaceutical development for decades. Such novel ...
... to not only more effectively treat disease, but also to predict, preempt and prevent it. Biotechnology medicines are developed through biological processes using living cells or organisms, rather than traditional chemical synthesis, the mainstay of pharmaceutical development for decades. Such novel ...
Cytarabine Injection
... Cytarabine is metabolized by deoxycytidine kinase and other nucleotide kinases to the nucleotide triphosphate, an effective inhibitor of DNA polymerase; it is inactivated by pyrimidine nucleoside deaminase which converts it to the non-toxic uracil derivative. It appears that the balance of kinase an ...
... Cytarabine is metabolized by deoxycytidine kinase and other nucleotide kinases to the nucleotide triphosphate, an effective inhibitor of DNA polymerase; it is inactivated by pyrimidine nucleoside deaminase which converts it to the non-toxic uracil derivative. It appears that the balance of kinase an ...
Doxylamine Succinate - IARC Monographs on the Evaluation of
... central nervous system tumours and 232 other cancers) had been diagnosed in the regional paediatric oncology clinics of three Health Service regions of England were interviewed (McKinney et al., 1985). For each case, two controls matched on age and sex were selected, one on the list of the same gene ...
... central nervous system tumours and 232 other cancers) had been diagnosed in the regional paediatric oncology clinics of three Health Service regions of England were interviewed (McKinney et al., 1985). For each case, two controls matched on age and sex were selected, one on the list of the same gene ...
clindamycin phosphate Pharmaco-therapeutic group (ATC
... three healthcare clinics in central Michigan from March through November 1998.9 The prevalence of BV ranged from 15% to 30% across the three clinics. Depending on the clinic site, the frequency of BV among Black women ranged from 19% to 42%, while the range among White women was 14% to 25%. Yen and ...
... three healthcare clinics in central Michigan from March through November 1998.9 The prevalence of BV ranged from 15% to 30% across the three clinics. Depending on the clinic site, the frequency of BV among Black women ranged from 19% to 42%, while the range among White women was 14% to 25%. Yen and ...
Migranal - Valeant Pharmaceuticals
... The efficacy of Migranal® (dihydroergotamine mesylate, USP) Nasal Spray for the acute treatment of migraine headaches was evaluated in four randomized, double blind, placebo controlled studies in the U.S. The patient population for the trials was predominantly female (87%) and Caucasian (95%) with a ...
... The efficacy of Migranal® (dihydroergotamine mesylate, USP) Nasal Spray for the acute treatment of migraine headaches was evaluated in four randomized, double blind, placebo controlled studies in the U.S. The patient population for the trials was predominantly female (87%) and Caucasian (95%) with a ...
Guidelines that are no longer current are archived as
... may, however, benefit from such testing. In prepubertal children, the signs include acne, early-onset body odor, axillary or pubic hair, accelerated growth, advanced bone age, and genital maturation. After puberty, common virilizing signs and symptoms are infrequent menses, hirsutism, male or female ...
... may, however, benefit from such testing. In prepubertal children, the signs include acne, early-onset body odor, axillary or pubic hair, accelerated growth, advanced bone age, and genital maturation. After puberty, common virilizing signs and symptoms are infrequent menses, hirsutism, male or female ...
Download CV
... Director, Brain Science Institute, Drug Discovery Program Professor, Neurology (primary), Medicine, Psychiatry and Neuroscience Director, Johns Hopkins Drug Discovery Program Director, JHU NIMH Therapeutic Core ...
... Director, Brain Science Institute, Drug Discovery Program Professor, Neurology (primary), Medicine, Psychiatry and Neuroscience Director, Johns Hopkins Drug Discovery Program Director, JHU NIMH Therapeutic Core ...
EPAR - Assessment Report - Variation - EMA
... During the first two rounds of assessment major objections were formulated relating to: ...
... During the first two rounds of assessment major objections were formulated relating to: ...
CLINDAMYCIN Phosphate CLINDAMYCIN Hydrochloride
... Clostridium difficile is a primary cause of “antibiotic-associated colitis.” After the primary diagnosis of pseudomembranous colitis has been established, therapeutic measures should be initiated. Mild cases of psedomembranous colitis usually respond to drug discontinuation alone. In moderate-to-sev ...
... Clostridium difficile is a primary cause of “antibiotic-associated colitis.” After the primary diagnosis of pseudomembranous colitis has been established, therapeutic measures should be initiated. Mild cases of psedomembranous colitis usually respond to drug discontinuation alone. In moderate-to-sev ...
Word - corporate
... anticipated in mid-2017. Pending positive data from ARIEL3, we intend to follow up with a supplemental NDA for second-line maintenance therapy in women with ovarian cancer who have responded to platinum-based therapy. Rucaparib is also being developed in patients with mutant BRCA tumors and other DN ...
... anticipated in mid-2017. Pending positive data from ARIEL3, we intend to follow up with a supplemental NDA for second-line maintenance therapy in women with ovarian cancer who have responded to platinum-based therapy. Rucaparib is also being developed in patients with mutant BRCA tumors and other DN ...
Product Monograph
... Response to LUPRON® and LUPRON DEPOT® should be monitored by measuring serum levels of testosterone, as well as prostate-specific antigen and prostatic acid phosphatase. In the majority of patients, testosterone levels increased above baseline during the first week, declining thereafter to baseline ...
... Response to LUPRON® and LUPRON DEPOT® should be monitored by measuring serum levels of testosterone, as well as prostate-specific antigen and prostatic acid phosphatase. In the majority of patients, testosterone levels increased above baseline during the first week, declining thereafter to baseline ...
VALIDATED HPLC METHOD FOR SIMULTANEOUS QUANTITATION OF TADALAFIL AND
... Hydrochloride, respectively. Also, excipients from formulation were not interfering with the assay. Recovery Studies As shown from the data in Table 3 good recoveries of the Tadalafil and Dapoxetine Hydrochloride in the range from 99 to 101 % were obtained at various added concentrations. Analysis o ...
... Hydrochloride, respectively. Also, excipients from formulation were not interfering with the assay. Recovery Studies As shown from the data in Table 3 good recoveries of the Tadalafil and Dapoxetine Hydrochloride in the range from 99 to 101 % were obtained at various added concentrations. Analysis o ...
Inhaled nicotine replacement therapy
... accordance with good manufacturing processes (GMPs) and approved by regulatory agencies based on clinical data. In contrast, a variety of electronic nicotine delivery devices such as e-cigarettes are already available in many countries which provide an alternative to cigarettes and a potentially ‘sa ...
... accordance with good manufacturing processes (GMPs) and approved by regulatory agencies based on clinical data. In contrast, a variety of electronic nicotine delivery devices such as e-cigarettes are already available in many countries which provide an alternative to cigarettes and a potentially ‘sa ...
EMMANUEL ORMAN - Kwame Nkrumah University of Science
... likely to be coding for Artemisinin resistance, it has become pertinent to extend the search for new agents. This study was undertaken to evaluate the In-vivo antiplasmodial effects of traditionally used medicinal plants for malaria treatment. It also sought to evaluate them for possible future comp ...
... likely to be coding for Artemisinin resistance, it has become pertinent to extend the search for new agents. This study was undertaken to evaluate the In-vivo antiplasmodial effects of traditionally used medicinal plants for malaria treatment. It also sought to evaluate them for possible future comp ...
Dopamine-Serotonin System Stabilizer
... Aripiprazole, a novel antipsychotic agent, is assumed to be a “dopamine-serotonin system stabilizer”. According to preclinical studies, aripiprazole exerts partial agonistic action on D2 and 5-HT1A receptors. Thus, it may block a receptor if it is overstimulated and stimulate a receptor when activit ...
... Aripiprazole, a novel antipsychotic agent, is assumed to be a “dopamine-serotonin system stabilizer”. According to preclinical studies, aripiprazole exerts partial agonistic action on D2 and 5-HT1A receptors. Thus, it may block a receptor if it is overstimulated and stimulate a receptor when activit ...
annexure – ii
... In this case, improved bioavailability can be achieved by the use of delivery systems, which can enhance the rate and/or the extent of drug solubilizing into aqueous intestinal fluids. Phospholipids play a major role in drug delivery technology. There are numerous advantages of phospholipids in addi ...
... In this case, improved bioavailability can be achieved by the use of delivery systems, which can enhance the rate and/or the extent of drug solubilizing into aqueous intestinal fluids. Phospholipids play a major role in drug delivery technology. There are numerous advantages of phospholipids in addi ...
Cluster h eadache and o... t rigemino - a utonomic c ephalgias
... diagnostic criteria are given in table 11.3. SUNCT syndrome is characterized by very short (5–240 s) attacks with neuralgiform pain quality and severe intensity. The attacks occur in a frequency of in average 60 per day (3–200 per day), are strictly unilateral (periorbital), and are often triggered ...
... diagnostic criteria are given in table 11.3. SUNCT syndrome is characterized by very short (5–240 s) attacks with neuralgiform pain quality and severe intensity. The attacks occur in a frequency of in average 60 per day (3–200 per day), are strictly unilateral (periorbital), and are often triggered ...
Effects of grapefruit juice on the pharmacokinetics of selected
... About ten years ago, grapefruit juice was observed to increase the plasma concentrations and effects of felodipine. Since then, grapefruit juice has been found to interact with more than 20 different drugs. However, many factors affecting the susceptibility of drugs to interaction with grapefruit ju ...
... About ten years ago, grapefruit juice was observed to increase the plasma concentrations and effects of felodipine. Since then, grapefruit juice has been found to interact with more than 20 different drugs. However, many factors affecting the susceptibility of drugs to interaction with grapefruit ju ...
HIGHLIGHTS OF PRESCRIBING INFORMATION because of risk of overdose. (5.3) Candida albicans
... LABA, such as salmeterol, one of the active ingredients in ADVAIR DISKUS, increase the risk of asthma-related death. Currently available data are inadequate to determine whether concurrent use of inhaled corticosteroids or other long-term asthma control drugs mitigates the increased risk of asthma-r ...
... LABA, such as salmeterol, one of the active ingredients in ADVAIR DISKUS, increase the risk of asthma-related death. Currently available data are inadequate to determine whether concurrent use of inhaled corticosteroids or other long-term asthma control drugs mitigates the increased risk of asthma-r ...
Potential Novel Uses of Thalidomide
... inflammatory bowel disease, Sjögren’s syndrome, lupus erythematosus and a variety of solid tumours is currently being explored. Furthermore, in preliminary studies, thalidomide has been found to be effective in several syndromes related to advanced cancer, such as the cancer cachexia syndrome, chron ...
... inflammatory bowel disease, Sjögren’s syndrome, lupus erythematosus and a variety of solid tumours is currently being explored. Furthermore, in preliminary studies, thalidomide has been found to be effective in several syndromes related to advanced cancer, such as the cancer cachexia syndrome, chron ...
This is the breakthrough of Lithium Orotate
... 1. Vestergaard P, Schou M. Kidney morphology and function in lithium-treated patients. Bibl Psychiatr. 1981;(161):104-14. “We hypothesize that lithiuminduced changes of kidney function may become less frequent and less pronounced if patients are maintained at serum lithium levels somewhat lower (0.5 ...
... 1. Vestergaard P, Schou M. Kidney morphology and function in lithium-treated patients. Bibl Psychiatr. 1981;(161):104-14. “We hypothesize that lithiuminduced changes of kidney function may become less frequent and less pronounced if patients are maintained at serum lithium levels somewhat lower (0.5 ...
Naproxen Naproxen Sodium
... Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis. For the symptomatic treatment of osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, but excluding acute gouty arthritis), the usual adult dosage of naproxen is 250–500 mg (275–550 mg of naproxen sodium) twice daily in th ...
... Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis. For the symptomatic treatment of osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, but excluding acute gouty arthritis), the usual adult dosage of naproxen is 250–500 mg (275–550 mg of naproxen sodium) twice daily in th ...
biodegradable implants with different drug release - diss.fu
... For biodegradable polyesters such as PLA, PGA and PLGA, the monomers are connected to each other by ester bonds. After water penetration into the polymer bulk the ester bonds are cleaved randomly by hydrolytic chain scission or hydrolysis. The bulk is eventually eroded through the bulk erosion mecha ...
... For biodegradable polyesters such as PLA, PGA and PLGA, the monomers are connected to each other by ester bonds. After water penetration into the polymer bulk the ester bonds are cleaved randomly by hydrolytic chain scission or hydrolysis. The bulk is eventually eroded through the bulk erosion mecha ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.