Practical part
... Objective: To learn the general pathways of amino acids metabolism, to get acquainted with methods of identification of amino acid metabolites, to interpret obtained results. Actuality: Protein metabolism plays the most important role in general whole body metabolism. The competence and understandin ...
... Objective: To learn the general pathways of amino acids metabolism, to get acquainted with methods of identification of amino acid metabolites, to interpret obtained results. Actuality: Protein metabolism plays the most important role in general whole body metabolism. The competence and understandin ...
"Central Pathways of Carbohydrate Metabolism". In: Microbial
... in lactic acid bacteria (Streptococcus, Lactococcus, Lactobacillus), pyruvate is reduced to lactate. Other microorganisms that use the EMP pathway have the capacity to convert pyruvate to a wide variety of other fermentation end products. These fermentation pathways are discussed in more detail in C ...
... in lactic acid bacteria (Streptococcus, Lactococcus, Lactobacillus), pyruvate is reduced to lactate. Other microorganisms that use the EMP pathway have the capacity to convert pyruvate to a wide variety of other fermentation end products. These fermentation pathways are discussed in more detail in C ...
- Wiley Online Library
... The pathogenesis of type 2 diabetes is characterized by impaired insulin action and increased hepatic glucose production (HGP). Despite the importance of hepatic metabolic aberrations in diabetes development, there is currently no molecular probe that allows measurement of hepatic gluconeogenic path ...
... The pathogenesis of type 2 diabetes is characterized by impaired insulin action and increased hepatic glucose production (HGP). Despite the importance of hepatic metabolic aberrations in diabetes development, there is currently no molecular probe that allows measurement of hepatic gluconeogenic path ...
Lactic acidosis
... Treatment by moderate protein restriction (2.0 g/kg body weight/day) failed to alleviate the lactic acidosis. Restriction of dietary carbohydrate to 40% of the total caloric intake for two weeks carried a worsening of the acidosis. After informed consent, oral administration of lipoic acid (25 to 50 ...
... Treatment by moderate protein restriction (2.0 g/kg body weight/day) failed to alleviate the lactic acidosis. Restriction of dietary carbohydrate to 40% of the total caloric intake for two weeks carried a worsening of the acidosis. After informed consent, oral administration of lipoic acid (25 to 50 ...
Differential effects of heptanoate and hexanoate on myocardial citric
... the preischemic LAD flow. Arterial and interventricular venous samples were drawn 5 and 3 min before ischemia; at 5, 20, 26, 40, 50, and 57 min of ischemia; and at 7, 20, and 30 min of reperfusion. From 30 min of ischemia to the end of the protocol, animals were treated with an infusion of either 1) ...
... the preischemic LAD flow. Arterial and interventricular venous samples were drawn 5 and 3 min before ischemia; at 5, 20, 26, 40, 50, and 57 min of ischemia; and at 7, 20, and 30 min of reperfusion. From 30 min of ischemia to the end of the protocol, animals were treated with an infusion of either 1) ...
Supporting Information Legends Figure S1. Lipid and fatty acid
... Figure S2. Diacylglycerol content in R. irregularis and L. japonicus. DAG was analyzed by Q-TOF MS/MS in the nonpolar lipid fraction of extraradical mycelium (ERM), and in mockinfected (-P mock) and mycorrhized (-P myc) roots of L. japonicus grown with low phosphate. Data are means and SD of at leas ...
... Figure S2. Diacylglycerol content in R. irregularis and L. japonicus. DAG was analyzed by Q-TOF MS/MS in the nonpolar lipid fraction of extraradical mycelium (ERM), and in mockinfected (-P mock) and mycorrhized (-P myc) roots of L. japonicus grown with low phosphate. Data are means and SD of at leas ...
R Is for Arginine Metabolism of Arginine Takes off Again, in New
... concentrations may be limiting for NOS in specific subcellular locales. Moreover, the presence of endogenous competitive inhibitors of NOS (discussed below) may raise the effective intracellular arginine concentration needed for full enzyme activity. In any event, the action of NOS on l-arginine yie ...
... concentrations may be limiting for NOS in specific subcellular locales. Moreover, the presence of endogenous competitive inhibitors of NOS (discussed below) may raise the effective intracellular arginine concentration needed for full enzyme activity. In any event, the action of NOS on l-arginine yie ...
R Is for Arginine
... concentrations may be limiting for NOS in specific subcellular locales. Moreover, the presence of endogenous competitive inhibitors of NOS (discussed below) may raise the effective intracellular arginine concentration needed for full enzyme activity. In any event, the action of NOS on l-arginine yie ...
... concentrations may be limiting for NOS in specific subcellular locales. Moreover, the presence of endogenous competitive inhibitors of NOS (discussed below) may raise the effective intracellular arginine concentration needed for full enzyme activity. In any event, the action of NOS on l-arginine yie ...
Summary - University of Amsterdam
... possiblee presence of transporters for these metabolites, the ability of proteoliposomes containing peroxisomall membrane protein to take up various radiolabeled substrates was investigated, as describedd in chapter 5. It was observed that the peroxisomal membrane contains one or more proteinss that ...
... possiblee presence of transporters for these metabolites, the ability of proteoliposomes containing peroxisomall membrane protein to take up various radiolabeled substrates was investigated, as describedd in chapter 5. It was observed that the peroxisomal membrane contains one or more proteinss that ...
Ketone Bodies Mimic the Life Span Extending
... has demonstrated that ROS-mediated signaling is required for some mechanisms of life span extension. The toxicity of ROS/RNS is ameliorated by the NADPH system (Fig. 2), the redox potential of which is made more negative by the metabolism of ketone bodies (19,38,39). The redox potential of the free ...
... has demonstrated that ROS-mediated signaling is required for some mechanisms of life span extension. The toxicity of ROS/RNS is ameliorated by the NADPH system (Fig. 2), the redox potential of which is made more negative by the metabolism of ketone bodies (19,38,39). The redox potential of the free ...
View/Open - Digital Knowledge
... conditions, on infertile soils with low water binding capacity. It is high in carbohydrates and a source of proteins and essential amino acids. Anti-nutritional constituents naturally present in pearl millet such as alpha-amylase inhibitors, limit the digestibility of and starch. In recent times, ho ...
... conditions, on infertile soils with low water binding capacity. It is high in carbohydrates and a source of proteins and essential amino acids. Anti-nutritional constituents naturally present in pearl millet such as alpha-amylase inhibitors, limit the digestibility of and starch. In recent times, ho ...
Lipotoxicity in steatohepatitis occurs despite an increase in
... fluxes were converted to absolute fluxes by normalizing with EGP (16, 35). The [13C3]propionate tracer by itself does not alter EGP or hepatic mitochondrial fluxes (33), and the utility of this method has been extensively validated and discussed (6, 27). Targeted metabolomics. Frozen livers were gro ...
... fluxes were converted to absolute fluxes by normalizing with EGP (16, 35). The [13C3]propionate tracer by itself does not alter EGP or hepatic mitochondrial fluxes (33), and the utility of this method has been extensively validated and discussed (6, 27). Targeted metabolomics. Frozen livers were gro ...
Банк тестових завдань до модульного контролю №2 з англійської
... A) зародок; B) немовля; C) підліток; D) плід. sample A) санація; B) зразок; C) слина; D) мішечок. clamp A) шина; B) затискач; C) пах; D) гіпс. bruise A) вивих; B) розрив; C) набряк; D) синяк. particle A) частка; B) паста; C) прохід; D) параліч. deposit A) депресія; B) відкладення; ...
... A) зародок; B) немовля; C) підліток; D) плід. sample A) санація; B) зразок; C) слина; D) мішечок. clamp A) шина; B) затискач; C) пах; D) гіпс. bruise A) вивих; B) розрив; C) набряк; D) синяк. particle A) частка; B) паста; C) прохід; D) параліч. deposit A) депресія; B) відкладення; ...
EPISTASIS & METABOLISM Presented by Chintan Joshi
... - Our method can not evaluate effects of intragenic mutations which affect the protein properties. This can be fixed by partially shutting off fluxes. - Our method is not capturing the effect of mutations which might allow survivability even if the organisms growth requirements are not met exactly. ...
... - Our method can not evaluate effects of intragenic mutations which affect the protein properties. This can be fixed by partially shutting off fluxes. - Our method is not capturing the effect of mutations which might allow survivability even if the organisms growth requirements are not met exactly. ...
Protein relative abundance patterns associated with sucrose
... to catalog the functional potential of all microbial genes within a smaller subset of subjects. One of the key findings was that healthy sites from different people were broadly similar with respect to their functional profiles, even though there was extensive individual variation in their taxonomic ...
... to catalog the functional potential of all microbial genes within a smaller subset of subjects. One of the key findings was that healthy sites from different people were broadly similar with respect to their functional profiles, even though there was extensive individual variation in their taxonomic ...
Control of grape berry development
... scale wines Analysis of volatiles in headspace (SPME-GC-MS) • 128 compounds identified - 14 higher in ‘NAA wine’ – 10 of these were esters - 5 higher in ‘Control wine’ – 4 aliphatic alcohols and linalool • The differences were small, only one compound, more than two-fold different ...
... scale wines Analysis of volatiles in headspace (SPME-GC-MS) • 128 compounds identified - 14 higher in ‘NAA wine’ – 10 of these were esters - 5 higher in ‘Control wine’ – 4 aliphatic alcohols and linalool • The differences were small, only one compound, more than two-fold different ...
disturbances of metabolic homeostasis in liver disease
... adipose tissue. Only the remnant iipoproteins wiii eventualiy be cieared by the iiver together with the reieased giyceroi. Absorbed short chain fatty acids wiil, however, enter the portal vem and b~ taken by the iiver and serve as a further source of acetyi CoA. The hepatic action of the cataboiic h ...
... adipose tissue. Only the remnant iipoproteins wiii eventualiy be cieared by the iiver together with the reieased giyceroi. Absorbed short chain fatty acids wiil, however, enter the portal vem and b~ taken by the iiver and serve as a further source of acetyi CoA. The hepatic action of the cataboiic h ...
Kinetic models of metabolism: model construction, model
... are inadequate and instead a kinetic modelling approach is necessary. Given the large number of reactions included in the network, a pipeline has been built to automatically generate kinetic laws from reaction stoichiometries. In this context a precise description of the reactional mechanism is impo ...
... are inadequate and instead a kinetic modelling approach is necessary. Given the large number of reactions included in the network, a pipeline has been built to automatically generate kinetic laws from reaction stoichiometries. In this context a precise description of the reactional mechanism is impo ...
Growth-limiting Intracellular Metabolites in Yeast Growing Under Diverse Nutrient Limitations.
... limiting intracellular metabolites, according to Eq. 5. In this equation, the nutrient limitation is denoted by n 僆 {C, N, P, U}. xn is a normalized measure of the concentration of a particular candidate limiting nutrient: specifically, xn ⫽ 2yn, where yn represents the mean-centered log2(fold-chang ...
... limiting intracellular metabolites, according to Eq. 5. In this equation, the nutrient limitation is denoted by n 僆 {C, N, P, U}. xn is a normalized measure of the concentration of a particular candidate limiting nutrient: specifically, xn ⫽ 2yn, where yn represents the mean-centered log2(fold-chang ...
Altered Fermentative Metabolism in
... pyruvate into formate and acetyl-CoA. This reaction is dependent on a radical S-adenosylmethionine–dependent activating enzyme, designated PFL-AE (Atteia et al., 2006; Hemschemeier et al., 2008). PFL-AE is typically present in an inactive form in aerobic cells and is allosterically activated by pyru ...
... pyruvate into formate and acetyl-CoA. This reaction is dependent on a radical S-adenosylmethionine–dependent activating enzyme, designated PFL-AE (Atteia et al., 2006; Hemschemeier et al., 2008). PFL-AE is typically present in an inactive form in aerobic cells and is allosterically activated by pyru ...
Hyperammonemia in review: pathophysiology, diagnosis, and
... with urea cycle defects (UCD), organic acidemias, fatty acid oxidation defects, bypass of the major site of detoxification (liver) (such as that seen in cirrhosis), Reye syndrome, postchemotherapy, or exposure to various toxins and drugs can all present with elevations in ammonia. Delayed diagnosis ...
... with urea cycle defects (UCD), organic acidemias, fatty acid oxidation defects, bypass of the major site of detoxification (liver) (such as that seen in cirrhosis), Reye syndrome, postchemotherapy, or exposure to various toxins and drugs can all present with elevations in ammonia. Delayed diagnosis ...
Purine metabolism - mustafaaltinisik.org.uk
... * when the base is purine, then the nucleoside ends in OSINE (AdenOSINE, GuanOSINE, InOSINE) when the base is pyrimidine, then the nucleoside ends in IDINE (UrIDINE, CytIDINE, ThymIDINE) ...
... * when the base is purine, then the nucleoside ends in OSINE (AdenOSINE, GuanOSINE, InOSINE) when the base is pyrimidine, then the nucleoside ends in IDINE (UrIDINE, CytIDINE, ThymIDINE) ...
4th European Phenylketonuria Group (EPG) Symposium “Advances
... While dietary restriction of phenylalanine still remains the mainstay of treatment, phenylketonuria (PKU) is an active area of research, and new treatment options are emerging that may reduce the burden of a difficult and limiting diet in these patients and in their families. Basic and clinical rese ...
... While dietary restriction of phenylalanine still remains the mainstay of treatment, phenylketonuria (PKU) is an active area of research, and new treatment options are emerging that may reduce the burden of a difficult and limiting diet in these patients and in their families. Basic and clinical rese ...
Emergency Department Management of the Salicylate
... in select patients, such as children and patients with compromised skin such as burn patients or patients who have severe psoriasis [29–31]. In therapeutic doses, the major route of salicylate biotransformation is conjugation with glycine in the liver. A small amount of aspirin is excreted unchanged ...
... in select patients, such as children and patients with compromised skin such as burn patients or patients who have severe psoriasis [29–31]. In therapeutic doses, the major route of salicylate biotransformation is conjugation with glycine in the liver. A small amount of aspirin is excreted unchanged ...
Quantitative iTRAQ Proteomics Revealed Possible Roles for
... sorghum, the cellular, and genetic components that constitute Altolerance pathways and networks are still unclear. Quantitative studies of dynamic changes in protein expression profiles during the processes of induction and development of Al resistance in sorghum might provide us new insights into t ...
... sorghum, the cellular, and genetic components that constitute Altolerance pathways and networks are still unclear. Quantitative studies of dynamic changes in protein expression profiles during the processes of induction and development of Al resistance in sorghum might provide us new insights into t ...