fire hazards - Hindu College Of Pharmacy
... Many chemicals can cause severe burns, if these coming to contact with living tissue or other routes like inhalation. Living tissue may be destroyed by chemical reactions such as dehydration, digestion, oxidation etc. Eye and mucous membrane of the throat are particularly susceptible to the effect o ...
... Many chemicals can cause severe burns, if these coming to contact with living tissue or other routes like inhalation. Living tissue may be destroyed by chemical reactions such as dehydration, digestion, oxidation etc. Eye and mucous membrane of the throat are particularly susceptible to the effect o ...
Biron_JSBMB_2015_rev - Corpus UL
... In the absence of ligands, the AR predominantly resides in the cytoplasm where it is associated with heat shock proteins in a transcriptionally inactive form until it is activated by testosterone or the more potent metabolite, 5-dihydrotestosterone (DHT) [36, 37]. Upon ligand binding, the AR underg ...
... In the absence of ligands, the AR predominantly resides in the cytoplasm where it is associated with heat shock proteins in a transcriptionally inactive form until it is activated by testosterone or the more potent metabolite, 5-dihydrotestosterone (DHT) [36, 37]. Upon ligand binding, the AR underg ...
Therapy of systemic hypertension
... Hypomagnesaemia: Hyovolaemia and hyponatraemia: Hyperuricaemic: Ototoxicity (more with ethacrynic acid): It is common with impaired renal functions and in patients receiving other ototoxic drugs such as aminoglycoside antibiotics. Glucose intolerance (hyperglycemia): this is due to inhibition of ins ...
... Hypomagnesaemia: Hyovolaemia and hyponatraemia: Hyperuricaemic: Ototoxicity (more with ethacrynic acid): It is common with impaired renal functions and in patients receiving other ototoxic drugs such as aminoglycoside antibiotics. Glucose intolerance (hyperglycemia): this is due to inhibition of ins ...
Anxiolytic, Sedative, and Hypnotic Drugs
... A diffuse, anticipatory response to an uncertain, potentially threatening situation. [anxiety disorders are characterized by an unrealistic or inappropriate expression of fear (i.e. a dysregulated stress response)] Brain circuits of fear and anxiety • The limbic system is the brain system controllin ...
... A diffuse, anticipatory response to an uncertain, potentially threatening situation. [anxiety disorders are characterized by an unrealistic or inappropriate expression of fear (i.e. a dysregulated stress response)] Brain circuits of fear and anxiety • The limbic system is the brain system controllin ...
CLONIDINE PREMEDICATION AND ANESTHETIC EFFECTS
... to α1 receptor ratio of 200:1). Alpha-2 receptors are adrenoreceptors that are located primarily on presynaptic nerve terminals. Activation of these receptors inhibits adenylate cyclase activity, which in turn decreases the entry of calcium into the neuronal terminal, which limits norepinephrine rel ...
... to α1 receptor ratio of 200:1). Alpha-2 receptors are adrenoreceptors that are located primarily on presynaptic nerve terminals. Activation of these receptors inhibits adenylate cyclase activity, which in turn decreases the entry of calcium into the neuronal terminal, which limits norepinephrine rel ...
投影片 1
... recommended unless the problem is severe . In patients with BPSD, the mortality rate was 1.6–1.7-fold higher in the antipsychoticstreated group than in the placebo-treated group. ...
... recommended unless the problem is severe . In patients with BPSD, the mortality rate was 1.6–1.7-fold higher in the antipsychoticstreated group than in the placebo-treated group. ...
Name ______________________________ CH 204, Fall 2014 Assignment 9 – Cannabinoids
... All of the above None of the above ...
... All of the above None of the above ...
00024 - CAM in UME Project
... Administration of chemotherapeutic agents results in a greater degree of oxidative stress than is induced by the cancer itself Oxidative stress reduces the rate of cell proliferation-may interfere with CTX which depend on the rapid proliferation of cancer cells for optimal activity High oxidative st ...
... Administration of chemotherapeutic agents results in a greater degree of oxidative stress than is induced by the cancer itself Oxidative stress reduces the rate of cell proliferation-may interfere with CTX which depend on the rapid proliferation of cancer cells for optimal activity High oxidative st ...
PSY650-Antipsychotics-Sedative-Hypnotics
... Mechanisms of Action • Classicals are usually D2 and D2-like receptor antagonists • Atypicals antagonize D2-like receptors plus some 5-HTa action – LSD – The serotonin hypothesis of negative symptoms ...
... Mechanisms of Action • Classicals are usually D2 and D2-like receptor antagonists • Atypicals antagonize D2-like receptors plus some 5-HTa action – LSD – The serotonin hypothesis of negative symptoms ...
Biological Diversity Review Booklet
... Give 2 examples of dominant traits and 2 examples of recessive traits. _____________________________________ ______________________________________ _____________________________________ ______________________________________ Certain characteristics are non-inherited and depend on factors other than ...
... Give 2 examples of dominant traits and 2 examples of recessive traits. _____________________________________ ______________________________________ _____________________________________ ______________________________________ Certain characteristics are non-inherited and depend on factors other than ...
Drugs For The Treatment Of Heroin Addiction
... morphine, and becomes “trapped” by the barrier The morphine interacts with receptors and causes the effects. ...
... morphine, and becomes “trapped” by the barrier The morphine interacts with receptors and causes the effects. ...
Analgesia
... Most common reason people seek health care Tissue damage activates free nerve endings (pain receptors) Generally indicates tissue damage ...
... Most common reason people seek health care Tissue damage activates free nerve endings (pain receptors) Generally indicates tissue damage ...
from membrane-embedded targets to amyloid fibrils
... process. The technique of SSNMR (solid-state NMR) promises to be a useful counterpart to the conventional experimental techniques of X-ray crystallography and solution-state NMR for providing structural features of drug targets that can guide medicinal chemistry towards drug candidates. This article ...
... process. The technique of SSNMR (solid-state NMR) promises to be a useful counterpart to the conventional experimental techniques of X-ray crystallography and solution-state NMR for providing structural features of drug targets that can guide medicinal chemistry towards drug candidates. This article ...
Developmental Neurotoxicity from Environmental Chemical Exposures
... Drug and Chemical Exposures in Animal Models Related to ASD Theodore Slotkin, Ph.D. Department of Pharmacology & Cancer Biology Integrated Toxicology & Environmental Health Program Duke University Support: NIH ES10356 ...
... Drug and Chemical Exposures in Animal Models Related to ASD Theodore Slotkin, Ph.D. Department of Pharmacology & Cancer Biology Integrated Toxicology & Environmental Health Program Duke University Support: NIH ES10356 ...
Liver toxicity: the Achilles’ heel of endothelin receptor antagonist therapy? EDITORIAL
... It has been known for years that ERAs, or at least bosentan and sitaxentan, that share a sulphonamide structure, can be hepatotoxic [5]. This issue is not yet clear for ambrisentan, the newest agent of this group, which chemically belongs to the propanoic acid class. So, what is the particular cause ...
... It has been known for years that ERAs, or at least bosentan and sitaxentan, that share a sulphonamide structure, can be hepatotoxic [5]. This issue is not yet clear for ambrisentan, the newest agent of this group, which chemically belongs to the propanoic acid class. So, what is the particular cause ...
Severe hepatitis associated with sitaxentan and response to glucocorticoid therapy LETTER
... figure 1, liver aminotransferase levels were normal during the first 6 months of bosentan therapy but then increased (alanine aminotransferase (ALT) to ,46upper level of normal and aspartate aminotransferase (AST) to ,26upper level of normal). A follow-up test 2 weeks later showed a further increase ...
... figure 1, liver aminotransferase levels were normal during the first 6 months of bosentan therapy but then increased (alanine aminotransferase (ALT) to ,46upper level of normal and aspartate aminotransferase (AST) to ,26upper level of normal). A follow-up test 2 weeks later showed a further increase ...
Pharmacodynamics: How Drugs Work
... Pharmacokinetics is about how drugs move around the body, being absorbed, distributed to their sites of action, and being eliminated. Pharmacodynamics is about all those matters that are concerned with the pharmacological actions of drugs when they get to their sites of action, whether they be deter ...
... Pharmacokinetics is about how drugs move around the body, being absorbed, distributed to their sites of action, and being eliminated. Pharmacodynamics is about all those matters that are concerned with the pharmacological actions of drugs when they get to their sites of action, whether they be deter ...
Publishers_version
... Results and Discussion When the vessels focus on the most rewarding fishing grounds depending on their own experience this led to a higher overall fishing profit and energy efficiency, while slightly affecting the distribution of profit among the vessels (Figure 2). Surprisingly, these higher profit ...
... Results and Discussion When the vessels focus on the most rewarding fishing grounds depending on their own experience this led to a higher overall fishing profit and energy efficiency, while slightly affecting the distribution of profit among the vessels (Figure 2). Surprisingly, these higher profit ...
Hormonal therapy in acne
... androgenetic alopecia. However, there is no reduction of sebum secretion, possibly because it does not affect the type 1 isoenzyme in the sebaceous gland. Dutasteride also a 4-azasteroid inhibits both the isoenzymes. These molecules have not been found to be effective in women. Besides dutasteride ...
... androgenetic alopecia. However, there is no reduction of sebum secretion, possibly because it does not affect the type 1 isoenzyme in the sebaceous gland. Dutasteride also a 4-azasteroid inhibits both the isoenzymes. These molecules have not been found to be effective in women. Besides dutasteride ...
introduction to ecology
... • No two organisms can occupy the same niche • One organism will “out-compete” the other • Those organism which are more poorly suited will either die or have to find a new niche where they can survive ...
... • No two organisms can occupy the same niche • One organism will “out-compete” the other • Those organism which are more poorly suited will either die or have to find a new niche where they can survive ...
prevent escape
... holes, and operational accidents lead to spills of fish. Sea-cage equipment is marketed and used across Europe, thus knowledge relevant to the culture of numerous species in diverse environments is required to produce robust equipment and implement risk adverse operations. Solving technical and oper ...
... holes, and operational accidents lead to spills of fish. Sea-cage equipment is marketed and used across Europe, thus knowledge relevant to the culture of numerous species in diverse environments is required to produce robust equipment and implement risk adverse operations. Solving technical and oper ...
Biotic and abiotic factors interact in complex ways in communities
... What are the interactions between the levels of biological communities? What is the difference between an organism’s habitat and its niche? ...
... What are the interactions between the levels of biological communities? What is the difference between an organism’s habitat and its niche? ...
Pharmacokinetic and Pharmacodynamic Data Analysis
... popular recently. However in a PK/PD context model independent implies fewer assumptions about the structural PK/PD model. Even with these methods one is often faced with fitting some empirical expression to the data, for example a sum of exponentials, and when I talk about fitting models to data, i ...
... popular recently. However in a PK/PD context model independent implies fewer assumptions about the structural PK/PD model. Even with these methods one is often faced with fitting some empirical expression to the data, for example a sum of exponentials, and when I talk about fitting models to data, i ...
Toxicodynamics
Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.