Doc - PAGE meetings
... combining emerging clinical and prior preclinical information: an example in oncology ......................48 Sonya Tate A-36 Tumour growth inhibition modelling and prediction of overall survival in patients with metastatic breast cancer treated with paclitaxel alone or in combination with gemcitab ...
... combining emerging clinical and prior preclinical information: an example in oncology ......................48 Sonya Tate A-36 Tumour growth inhibition modelling and prediction of overall survival in patients with metastatic breast cancer treated with paclitaxel alone or in combination with gemcitab ...
Which neuroreceptors mediate the subjective effects of MDMA in
... In preclinical studies, 3,4-methylenedioxymethamphetamine (MDMA, `Ecstasy') has been shown to release serotonin (5-HT), dopamine and norepinephrine. However, the role of these neurotransmitters and their corresponding receptor sites in mediating the subjective effects of MDMA has not yet been studie ...
... In preclinical studies, 3,4-methylenedioxymethamphetamine (MDMA, `Ecstasy') has been shown to release serotonin (5-HT), dopamine and norepinephrine. However, the role of these neurotransmitters and their corresponding receptor sites in mediating the subjective effects of MDMA has not yet been studie ...
Herbal Medicines
... Herbal Medicines • WHO estimates that herbal remedies are most frequent used therapies worldwide and 80% (4 billion) of world population uses them for primary health care • Dietary supplements, including herbal products, are regulated under the Dietary Supplement Health and Education Act of 1994 as ...
... Herbal Medicines • WHO estimates that herbal remedies are most frequent used therapies worldwide and 80% (4 billion) of world population uses them for primary health care • Dietary supplements, including herbal products, are regulated under the Dietary Supplement Health and Education Act of 1994 as ...
Quantifying usage of the marine environment by terns
... correctly predict validation data from another colony, and confirmed that Phase 2 models performed well in their predictive ability. ...
... correctly predict validation data from another colony, and confirmed that Phase 2 models performed well in their predictive ability. ...
EFFECTS OF AN INVASIVE CONSUMER ON ZOOPLANKTON COMMUNITIES ARE by
... mass sea urchin die-offs around Caribbean coral reefs were due to a combination of disease and overharvesting of fish), but these experiments were designed to explore potential reasons behind species loss, and did not pose specific multiple stressor questions about how anthropogenic stressors could ...
... mass sea urchin die-offs around Caribbean coral reefs were due to a combination of disease and overharvesting of fish), but these experiments were designed to explore potential reasons behind species loss, and did not pose specific multiple stressor questions about how anthropogenic stressors could ...
GABAA receptors signal bidirectional reward transmission from the
... receiving intra-VTA bicuculline (50 ng) in either the opiate-naive (Fig. 1A) or opiate-dependent and withdrawn states (Fig. 1B) or intraVTA muscimol (50 ng) in either the opiate-naive (Fig. 1C) or opiatedependent and withdrawn (Fig. 1D) state. Cresyl Violet analysis revealed substantial gliotic dama ...
... receiving intra-VTA bicuculline (50 ng) in either the opiate-naive (Fig. 1A) or opiate-dependent and withdrawn states (Fig. 1B) or intraVTA muscimol (50 ng) in either the opiate-naive (Fig. 1C) or opiatedependent and withdrawn (Fig. 1D) state. Cresyl Violet analysis revealed substantial gliotic dama ...
Neural mechanisms underlying morphine withdrawal in addicted
... in prolonged abstinence and acute morphine withdrawal. Memory deficit following morphine withdrawal results in drug relapse (21,27). Cortical and limbic activities are suppressed in the withdrawal that may pertain to the memory impairment (25). It was shown that hippocampus plays an important role i ...
... in prolonged abstinence and acute morphine withdrawal. Memory deficit following morphine withdrawal results in drug relapse (21,27). Cortical and limbic activities are suppressed in the withdrawal that may pertain to the memory impairment (25). It was shown that hippocampus plays an important role i ...
Glucagon Receptor Agonists and Antagonists
... precursor, proglucagon.8 Proglucagon belongs to the secretinglucagon superfamily of peptides, which act through a matching family of G-protein-coupled receptors coupled to stimulation of adenylyl cyclase, phospholipase C, or other effector mechanisms.9 Glucagon-like immunoreactivity is found in a si ...
... precursor, proglucagon.8 Proglucagon belongs to the secretinglucagon superfamily of peptides, which act through a matching family of G-protein-coupled receptors coupled to stimulation of adenylyl cyclase, phospholipase C, or other effector mechanisms.9 Glucagon-like immunoreactivity is found in a si ...
Ketamine - thblack.com
... Bell et al. (2006) reviewed 37 RCT (over 2240 participants) use of periop ketamine or placebo. Subanesthetic doses of ketamine (ranging from 10 mg - 270 mg) given at all different time periods (pre-induction, induction, intraop, first ...
... Bell et al. (2006) reviewed 37 RCT (over 2240 participants) use of periop ketamine or placebo. Subanesthetic doses of ketamine (ranging from 10 mg - 270 mg) given at all different time periods (pre-induction, induction, intraop, first ...
The Effects of the Preferential 5
... these findings and the fact that especially hallucinogenic 5HT2A agonists and NMDA antagonists mimic some features of schizophrenia in humans (Vollenweider, 1998, 2001; Vollenweider and Geyer, 2001), PPI has been proposed as an animal model for detecting antipsychotic activity (Swerdlow et al, 1994; ...
... these findings and the fact that especially hallucinogenic 5HT2A agonists and NMDA antagonists mimic some features of schizophrenia in humans (Vollenweider, 1998, 2001; Vollenweider and Geyer, 2001), PPI has been proposed as an animal model for detecting antipsychotic activity (Swerdlow et al, 1994; ...
Modelling of tolerance and rebound in normal and
... The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, potential risks can be minimized. In this thesis nicotinic acid (NiAc)-induced chan ...
... The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, potential risks can be minimized. In this thesis nicotinic acid (NiAc)-induced chan ...
Docking and Ligand Binding Affinity: Uses and Pitfalls
... Due to their technological and fundamental importance, noncovalent interactions are studied very extensively using a broad range of experimental, theoretical, and computational approaches. [16,43,44] In particular, theory and computations are indispensable not only for understanding, interpretation, ...
... Due to their technological and fundamental importance, noncovalent interactions are studied very extensively using a broad range of experimental, theoretical, and computational approaches. [16,43,44] In particular, theory and computations are indispensable not only for understanding, interpretation, ...
insulin
... Ca2+ channels f) degranulation of B-cells and insulin release to the extra cellular space ...
... Ca2+ channels f) degranulation of B-cells and insulin release to the extra cellular space ...
Abstract Ethnopharmacological relevance Achillea millefolium L
... disturbances (Andreatini et al., 2001, Carlini, 2003 and Mitte et al., 2005). Medicinal plants continue to have anxiolytic potential (Carlini, 2003 and Faustino et al., 2010). The elevated plus maze is likely the most frequently used animal model for studying anxiety and anxiolytic-like drugs (Caro ...
... disturbances (Andreatini et al., 2001, Carlini, 2003 and Mitte et al., 2005). Medicinal plants continue to have anxiolytic potential (Carlini, 2003 and Faustino et al., 2010). The elevated plus maze is likely the most frequently used animal model for studying anxiety and anxiolytic-like drugs (Caro ...
Landscape-scale eco-evolutionary dynamics: Selection by seed
... isolated ranges that lack red squirrels are uncommon compared to the wide range of lodgepole pine in North America; thus, an unanswered question is whether landscape-scale variability in percentage serotiny within continuous forests can be explained by the interaction of these two factors. If select ...
... isolated ranges that lack red squirrels are uncommon compared to the wide range of lodgepole pine in North America; thus, an unanswered question is whether landscape-scale variability in percentage serotiny within continuous forests can be explained by the interaction of these two factors. If select ...
pharmacology basic principles
... Phenobarbitol cleared in alkaline urine as pKa is 7.4) Note, some drugs are NOT significantly influenced by pH (eg. Penicillin) Drug Absorption Route of administration: PO: absorption in gut is via lipid diffusion as cells joined by tight junctions; absorption favoured by large SA of GI tract, mixin ...
... Phenobarbitol cleared in alkaline urine as pKa is 7.4) Note, some drugs are NOT significantly influenced by pH (eg. Penicillin) Drug Absorption Route of administration: PO: absorption in gut is via lipid diffusion as cells joined by tight junctions; absorption favoured by large SA of GI tract, mixin ...
Nicotine sensitization and the effects of extended withdrawal
... Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy at University of Gothenburg Gothenburg, Sweden ...
... Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy at University of Gothenburg Gothenburg, Sweden ...
Pharmacokinetics and pharmacodynamics of oral oxycodone in
... of noroxycodone to ␣- and -noroxycodol and reduction of oxymorphone to ␣- and -oxymorphol are feasible. There is no available information on the opioid receptor binding characteristics of these reduced metabolites. Some or all of these primary and secondary metabolites of oxycodone may contribute ...
... of noroxycodone to ␣- and -noroxycodol and reduction of oxymorphone to ␣- and -oxymorphol are feasible. There is no available information on the opioid receptor binding characteristics of these reduced metabolites. Some or all of these primary and secondary metabolites of oxycodone may contribute ...
Dear Dr Neurologist - Fluoroquinolone Toxicity of the Thyroid
... and asymptomatic patients over time. As such, it is not a reliable “gateway screening” criterion in patients with negative ANA’s and obvious symptomatology representative of a variety of known neurological, neuromuscular, and rheumatological conditions. Based on current knowledge, FDA warnings, and ...
... and asymptomatic patients over time. As such, it is not a reliable “gateway screening” criterion in patients with negative ANA’s and obvious symptomatology representative of a variety of known neurological, neuromuscular, and rheumatological conditions. Based on current knowledge, FDA warnings, and ...
neuroregulatory effects of nicotine
... Interactions between the two systems also have been observed. For example, anatomical data suggest that some nicotine receptors in brain have a presynaptic location (Clarke et al., 1986), and there is evidence for nicotinic autoreceptors promoting acetylcholine release in the cerebral cortex (Armita ...
... Interactions between the two systems also have been observed. For example, anatomical data suggest that some nicotine receptors in brain have a presynaptic location (Clarke et al., 1986), and there is evidence for nicotinic autoreceptors promoting acetylcholine release in the cerebral cortex (Armita ...
CAS no.: 056-23-5 Molecular formula: CCl4 Melting point
... However, weakly positive results were reported at cytotoxic levels in an alkaline elution-rat hepatocyte assay that measures DNA single-strand breaks. It has caused point mutations and gene recombination in a eukaryotic (yeast) test system (25). Carbon tetrachloride induced cell transformation in Sy ...
... However, weakly positive results were reported at cytotoxic levels in an alkaline elution-rat hepatocyte assay that measures DNA single-strand breaks. It has caused point mutations and gene recombination in a eukaryotic (yeast) test system (25). Carbon tetrachloride induced cell transformation in Sy ...
Document
... Possible new hypothesis to test: • Long term effects of caffeine in combination with supplements found in energy drinks • Increasing risk of caffeine overdoses due to the trends of rising concentrations and availability of caffeinated ...
... Possible new hypothesis to test: • Long term effects of caffeine in combination with supplements found in energy drinks • Increasing risk of caffeine overdoses due to the trends of rising concentrations and availability of caffeinated ...
Anabolic–androgenic steroid dependence? Insights from animals and humans Ruth I. Wood Review
... [86], both in terms of the number of users, and the types and amounts of steroids used. As the current population of AAS users ages, it will be important to investigate this question in larger groups of subjects. Psychiatric side effects due to AAS are another source of concern. Early studies in the ...
... [86], both in terms of the number of users, and the types and amounts of steroids used. As the current population of AAS users ages, it will be important to investigate this question in larger groups of subjects. Psychiatric side effects due to AAS are another source of concern. Early studies in the ...
Corticotropin-Releasing Factor: Physiology, Pharmacology, And
... The sequence of urocortin has been determined in both rats and humans. In rat, urocortin was identified using a library derived from rat midbrain and a carp urotensin cDNA probe. A full-length cDNA was described and encoded a putative 40-amino acid peptide that was related to CRF (20). The human for ...
... The sequence of urocortin has been determined in both rats and humans. In rat, urocortin was identified using a library derived from rat midbrain and a carp urotensin cDNA probe. A full-length cDNA was described and encoded a putative 40-amino acid peptide that was related to CRF (20). The human for ...
GP/Locum Drug List – 5 May 2013
... Initiate at 1.25mg OM and weekly-2 weekly titration by 1.25mg daily until a maximum of 10mg OM See above See above See below Long acting with increased tissue distribution 1st dose hypotension, ACE-I induced cough (more common in women), to monitor creatinine and urea 2-4 weeks into initiation or es ...
... Initiate at 1.25mg OM and weekly-2 weekly titration by 1.25mg daily until a maximum of 10mg OM See above See above See below Long acting with increased tissue distribution 1st dose hypotension, ACE-I induced cough (more common in women), to monitor creatinine and urea 2-4 weeks into initiation or es ...
Toxicodynamics
Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.