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CNS Depressants - Wayne State University
CNS Depressants - Wayne State University

... effects—β & α blockers, ca channel blkers, D1 blockers, and anticonvulsants Meds: antidepress, DA agonists, antipark, primarily to ↓cravings Supportive environment—craving can be triggered by being near assoc environ ...
Organisms that eat only other animals
Organisms that eat only other animals

... Section 4-3 section assessment questions #1-3 & 5 pg 105 ...
Notes Chapter 19 Introduction to Ecology
Notes Chapter 19 Introduction to Ecology

... nonliving portion of their environment 2) Their survival depends on these interactions 3) Thus, each ecosystem is a network in which organisms are linked to other organisms and to the nonliving environment 4) Ecologists refer to this quality as interconnectedness or interdependence 5) Any disturbanc ...
GHS Labeling Elements
GHS Labeling Elements

... Pictogram: a symbol plus other graphic elements, such as a border, background pattern, or color that is intended to convey specific information about the hazards of a chemical. Each pictogram consists of a different symbol on a white background within a red square frame set on a point (i.e. a red di ...
Clinical Pharmacology
Clinical Pharmacology

... – 2 major routes: renal and biliary – Clearance: rate of elimination of drug from the body = dose AUC – Half-life: time required for drug concentration in plasma to  by half • alpha -rate of distribution into tissues • beta - rate of elimination from body • gamma - in case of slow, delayed eliminat ...
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Factors influencing Toxicity

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Emerging Issues on Chemical and Drug Residues in Meat (2)

... This paper addresses emerging drug and chemical residues of meat safety significance. The beef industry will continue to meet new challenges related to chemical residues. The events of September 11, 2001 have raised concerns about the possibility of economic terrorism in the United States. As far as ...
Anticancer Antibiotics
Anticancer Antibiotics

... natural sources with several of these being obtained from microbial sources (antibiotics). Many of the antineoplastic antibiotics are produced by the soil fungus Streptomyces. Both the antibiotic and natural product classes have multiple inhibitory effects on cell growth; however, they primarily act ...
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Chapter 19 – Introduction to Ecology

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Important side effects to be considered when choosing antipsychotic

... also alter temperature-regulating mechanisms and can produce poikilothermia (body temperature varies with the environment). In the pituitary, neuroleptics block D2 receptors, leading to an increase in prolactin release. Atypical neuroleptics are less likely to produce prolactin elevations. Sedation ...
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Relationships in Ecosystems

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Biosphere Vocab

... Symbiotic relationship in which one organism benefits by living on or inside another which is harmed ...
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Everything is Connected

... All organisms, or living things, are linked together in the web of life. In this web, energy and resources pass between organisms and their surroundings. The study of how different organisms interact with one another and their environment is ecology. An alligator may hunt along the edge of a river. ...
Antipsychotics
Antipsychotics

... • Weight gain, diabetes, and dyslipidemia are the components of metabolic syndrome usually associated with second generation antipsychotics, along with the consequent risks of diabetic ketoacidosis and cardiovascular disease • The mechanism is not entirely clear, but there is evidence for both incre ...
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... host) and harms the host. Parasites act more slowly than predators, and often do not kill their host. Examples: A tick lives on the skin of a deer, and sucks its blood as a food source. The tick benefits while the deer is harmed, but not killed. A tapeworm lives in the large intestine of a dog. The ...
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... - DBH is located in vesicles - EPI is stored in vesicles. - EPI (~80%) and NE (~20%) released into blood ...
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... The same agent (e.g. glutamate, 5-HT (5hydroxytryptamine), acetylcholine) may act through both ligand-gated channels and Gprotein-coupled receptors. Many chemical mediators, including glutamate, nitric oxide and arachidonic acid metabolites, are produced by glia as well as neurons. Many other media ...
Bromo-DragonFly
Bromo-DragonFly

... negative experiences include phobias. The marked constriction of blood vessels associated with Bromo-DragonFly is also known to cause tissue necrosis in limbs. As Bromo-DragonFly acts via the body’s serotonin system, it can increase the risk of so-called serotonin syndrome. As little is known about ...
CHEMICAL SIGNALLING IN THE NERVOUS SYSTEM
CHEMICAL SIGNALLING IN THE NERVOUS SYSTEM

... The same agent (e.g. glutamate, 5-HT (5hydroxytryptamine), acetylcholine) may act through both ligand-gated channels and Gprotein-coupled receptors. Many chemical mediators, including glutamate, nitric oxide and arachidonic acid metabolites, are produced by glia as well as neurons. Many other media ...
DRUGS AFFECTING THE RESPIRATORY SYSTEM
DRUGS AFFECTING THE RESPIRATORY SYSTEM

...  Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants  Treatment is “empiric therapy,” treating the most likely cause  Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
Roger_12 - DEB2015
Roger_12 - DEB2015

... Definition1: the process for evaluating how likely it is that the environment may be impacted as a result of exposure to one or more environmental stressors. ERA involves predicting effects of exposure on populations, communities and ecosystems – including “ecosystem services” such as nutrient cycli ...
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Toxicodynamics



Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.
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