• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Relationships among Populations
Relationships among Populations

... patterns, having bright colors to warn predators of their poisonous nature or mimic colors of poisonous organisms ...
Genetically modified organisms at population and landscape scales.
Genetically modified organisms at population and landscape scales.

... Pacific herring Surf smelt ...
Non-Cardiac Chest Pain - Old
Non-Cardiac Chest Pain - Old

... Acetycholine – employed at most junctions of the PNS • All preganglion neurons of PNS • All preganglion neurons of the SNS • All postganglionic neurons of PNS • All motor neurons to skeletal muscles • Most postganglionic neurons of the SNS that go to sweat glands ...
Interactions annotations
Interactions annotations

... Every organism has some unique characteristics that enable it to live in its environment. In response to their environment, species evolve, or change over time. The changes that make organisms better suited to their environment occur by a process called natural selection. Individuals whose character ...
Basic Pharmacology of the Alpha
Basic Pharmacology of the Alpha

...  They are generally well tolerated, but they are not usually recommended as monotherapy for hypertension because other classes of antihypertensives are more effective in preventing heart failure.  Their major adverse effect is orthostatic hypotension, which may be severe after the first few doses( ...
Lecture 3 – intro to ANS drugs – cholinergic
Lecture 3 – intro to ANS drugs – cholinergic

... and baroreceptors in the carotid body) ▪ Therefore = there will be an BP with a corresponding HR, despite the direct action of NE to the heart ...
Introduction to Autonomic Drugs: Cholinergic agents
Introduction to Autonomic Drugs: Cholinergic agents

... ▪ Generally hydrophilic, but more lipid soluble than carbamates = better absorbed in skin, gut and lungs ▪ Potentially more dangerous to humans, but can kill more insects ▪ Relatively shorter half-life in the environment than carbamates ...
药效学2
药效学2

... Growth factor receptors ...
03. adrenergic drugs..
03. adrenergic drugs..

... 1) diffuse out of synaptic space & enter general circulation --- OR 2) metabolized by COMT to O-methylated derivatives in synaptic space------OR 3) recaptured by uptake system that pumps back NE into neurons ...
Document
Document

... neurotoxicity and hirsutism (多毛症). 2) A increased incidence of lymphoma and other cancers, infection 3) Very little bone marrow toxicity 4. Drug interactions Cyclosporine is able to inhibit the hepatic cytochrome P450 pathway, and there is a potential for many drug ...
Energetics of anti-predator behaviour (PDF File 81.3 KB)
Energetics of anti-predator behaviour (PDF File 81.3 KB)

... introduced predators. Most research has focused on direct effects of predation leading to mortality, yet there is an increasing realisation that the indirect effects of predation might be equally or more important to prey populations. This study will focus on an obvious gap in our knowledge of how t ...
General Anesthesia
General Anesthesia

... Indicates that two components of anesthesia can be mediated by GABAA receptor ...
Lexapro Information
Lexapro Information

... 4. Stereochemical designations: s/r-mirror images; d/l-rotate a plane of polarized light in opposite directions. 5. As most receptors can distinguish between stereoisomers, they can have different biologic activity. Examples include R-carvone vs. S-carvone(spearmint, caraway), Darvon vs. Novrad, and ...
Antipsychotic/Neuroleptic Agents and Lithium
Antipsychotic/Neuroleptic Agents and Lithium

... b. Stimulation of these receptors also can cause the depolarization of Glutamate neurons, by which may modulate behaviour of a human being ...
Physiological Psychology
Physiological Psychology

... voltage- and Ca+dependent K+ currents. Combined, these effects may prevent recall of previous memory from interfering with the learning of new memories. (Adapted from Hasselmo, 1995) ...
Possible Test Questions
Possible Test Questions

... Common Neurotransmitter Receptors found in Psych. Drugs and their effects - SERT – Serotonin Transporter – Serotoin Reuptake Inhibitors (SRI’s or SSRI’s) – i.e. some drugs, particularly the SSRIs, blockade (antagonize) the SERT  leading to ↓ reuptake of serotonin back into the presynaptic neurons a ...
Opioids part 1
Opioids part 1

... • Leads to direct inhibition ascending transmission of pain signals from spinal cord dorsal horn and to activate pain modulating descending circuits from midbrain through medulla (rostral ventromedial medulla RVM) and PAG (periaqueductal gray) to dorsal horn ...
VETS 238 Surgical Nursing and Anesthesia
VETS 238 Surgical Nursing and Anesthesia

... 4. Minimal adverse effects except in liver disease and neonates?? (poor metabolism ) 5. appetite stimulant/cats 0.05 cc IV valium = magic 6. modify behavior (inappropriate urination) ...
Darifenacin Hydrobromide
Darifenacin Hydrobromide

... selectivity better, Nmonosubstituted, N, Ndisubstituted or ester is anticholinergic activity decreases even without anticholinergic activity. ...
Ecology
Ecology

...  Abiotic factors: non-living, includes: temperature, humidity, pH, availability of sunlight, etc  Biotic factors: all living things ...
Dagmar Etkin
Dagmar Etkin

...  How do the various crude oils compare in their chemical composition and toxicity to organisms in aquatic ecosystems?  How do microbial processes affect crude oils in aquatic ecosystems, thereby modifying their physical and chemical properties and toxicity?  Is the research community able to rela ...
rhessys-rama
rhessys-rama

... Provide Nowcast/Forecasts of water and carbon cycle variables for the conterminous United States with the Terrestrial Observation and Prediction System (TOPS) ...
Tobacco - MeadeHealth10
Tobacco - MeadeHealth10

... esophagus, bladder, kidney and pancreas decrease. Even after a decade of not smoking however, your risk of lung cancer remains higher than in people who have never smoked. Your risk of ulcer also decreases.  In 15 years, your risk of coronary heart disease and heart attack is similar to that of peo ...
For synthetic chemicals tested in both mice and rats
For synthetic chemicals tested in both mice and rats

... has been found: a lack of certain vitamins (especially folic acid) in unhealthy diets (among the poor) leads to 4-fold increase in cancer! This is likely due to the crippling of natural cancer fighting mechanisms. Surprising conclusion: There is always orders of magnitude more “food” molecules in fo ...
Drugs affecting reproductive system
Drugs affecting reproductive system

... Multiple ovulation with multiple pregnancy (多胎) ...
< 1 ... 101 102 103 104 105 106 107 108 109 ... 126 >

Toxicodynamics



Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report