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Genetics Quiz
Genetics Quiz

... 4. Refer to the illustration above. The genotype represented in box “1” in the Punnett square would A. be homozygous for freckles. B. have an extra freckles chromosome. C. be heterozygous for freckles. D. have freckles chromosomes. ...
FDA Guidance for IRBs
FDA Guidance for IRBs

... activities listed should not be deemed to be of minimal risk simply because they are included on this list. Inclusion on this list merely means that the activity is eligible for review through the expedited review procedure when the specific circumstances of the proposed research involve no more tha ...
ppt - Sol Genomics Network
ppt - Sol Genomics Network

...  Awareness that not every genome and every community „is just the same“ ...
Drug Administration
Drug Administration

... 20.9 Pediatric and geriatric patients require extreme care when calculating doses due to the differences in how their bodies absorb, metabolize, eliminate, and distribute the medications. Treat pediatric patients with special care and communication to make the experience as positive as possible. Res ...
genetic testing - The University of Sydney
genetic testing - The University of Sydney

... You may wish to breed into a bloodline that is known to suffer from a genetic disorder. In this case, it is wise to test for the disorder if there is a genetic test available. This will enable you to choose safely from within the bloodline. Our understanding of the frequency of disorder genes in all ...
ANTI-INFLAMMATORY EFFECT OF THE SERRATIOPEPTIDASE
ANTI-INFLAMMATORY EFFECT OF THE SERRATIOPEPTIDASE

... approved. It even serves notices to online marketing websites (17). It is requirement of US FDA to do at least one placebo controlled clinical study to get approval for the marketing. However in India such norms are rarely followed. Its lack of mention of this drug in standard textbooks of pharmacol ...
tibbi̇ farmakoloji̇ anabi̇li̇m dali doktora programi
tibbi̇ farmakoloji̇ anabi̇li̇m dali doktora programi

... bioequivalence , guideline on the investigation of bioequivalence and regulations related to bioequivalence, validation, international and national regulations (Helsinki Declarations, who expert committee on specifications for pharmaceutical preparations, FDA regulations, new drug license applicatio ...
Patterns of Inheritance
Patterns of Inheritance

... Sex-linked genes • X-linked recessive alleles • More common in males than females – Males only needs to inherit one sex-linked recessive allele from mom to be expressed – Females has to inherit two sex-linked recessive alleles for expression ...
Making Gametes – The Principle of Independent Assortment
Making Gametes – The Principle of Independent Assortment

... Name  _________________________________________________            Date  _______________                Period  ______           ...
Presessional Prac Reading Test 2016 - Booklet 1
Presessional Prac Reading Test 2016 - Booklet 1

... limit their full use to only a small elite, so that over time society will segregate into what he calls the ‘GenRich’ and the ‘Naturals’. Paragraph 7 Silver imagines a future America in which the GenRich, all carrying synthetic genes that were created in the laboratory, accounts for 10 per cent of t ...
Bulletin #86
Bulletin #86

... Using a concurrent drug with moderate to high anticholinergic effects can reduce or negate the enhancement of cholinergic function resulting from the Aricept or Exelon. In addition, anticholinergic drugs are known to cause cognitive disorders in the elderly such as disorientation, confusion, and mem ...
the full case study to learn more
the full case study to learn more

... Drugs can interact by induction or inhibition of metabolizing enzymes. The most prominent enzyme thus regulated and involved in drug interactions is the CYP group. Enzyme inhibition leads to decreased drug metabolism, which in turn increases the drug levels in the body. Identifying the type of inhib ...
Dark Blue with Orange
Dark Blue with Orange

... Gene is a segment of DNA on a chromosome that controls a particular hereditary trait. Alleles are the different types of characteristics the gene can express. These alleles are represented by letters. G = capital means dominant g = lower case means recessive ...
failing to warn in the context of rare side effects
failing to warn in the context of rare side effects

... deliver to a patient a readily digestible account of the disease and its management. Even if a physician could disclose the entirety of information about the risks and benefits associated with different treatments, such a comprehensive disclosure would not necessarily promote patient self-determinat ...
Effects on ability to drive and use machines Dosage and
Effects on ability to drive and use machines Dosage and

... events have been reported. The most frequently reported adverse events and those reactions which are more clearly related to the drug are arranged below according to body system. Their frequencies (common ~ 1 %, uncommon ~ 0.1 % and < 1 %) are based on clinical trial data regardless of the causal re ...
Utilization Review Plan - Cumberland Heights Intranet
Utilization Review Plan - Cumberland Heights Intranet

... As part of the organization’s Quality Management Plan, the Utilization Management Plan was developed by clinical management and the leadership team and approved by the Board of Directors for the purpose ensuring efficient and effective use of resources in the clinical treatment of its patients. The ...
Word document - Personal Genetics Education Project
Word document - Personal Genetics Education Project

... height or your risk for developing a disease. It is important to note, however, that predispositions are not guarantees. For example, people who carry certain genetic variants are at increased risk for developing heart disease or type 2 diabetes, and knowing this information can be beneficial for ma ...
A MOUSE`S TAIL… Introduction: When you start to determine the
A MOUSE`S TAIL… Introduction: When you start to determine the

... When you start to determine the patterns of inheritance, it becomes important to understand a few concepts and key words. The inheritance of the characteristics or traits that you have depend on genes that you inherit from your father and mother. Many times only two genes are involved in the express ...
Pharmacology/Therapeutics II Block I Lectures
Pharmacology/Therapeutics II Block I Lectures

... in a human trial in the first trimester. c. Category C – Either animal studies revealed adverse fetal effects with no verification from human studies; or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus. d. ...
Adverse reactions
Adverse reactions

... • Five dopaminergic systems or pathways are important for understanding schizophrenia and the mechanism of action of antipsychotic drugs: 1) Mesolimbic-mesocortical pathway: the one most closely related to behavior and psychosis 2) Nigrostriatal pathway: it is involved in the coordination of volunta ...
SINAREST-LEVO TABLETS
SINAREST-LEVO TABLETS

... In vitro data indicate that levocetirizine is unlikely to produce pharmacokinetic interactions through inhibition or induction of liver drug metabolizing enzymes. Phenylephrine The coadministration of Monoamine Oxidase Inhibitors (MAOIs) or tricyclic antidepressants and an indirect or mixed-acting s ...
Chapter 11 Power point
Chapter 11 Power point

...  located on non-sex chromosomes  at least one parent is affected  does not skip generations  affected individuals are homozygous dominant or heterozygous  affects males & females Ex. Achondroplasia, Huntington disease, Lactose intolerance, Polydactyly ...
Genetics (Chapter 8) Test Review
Genetics (Chapter 8) Test Review

... 11. If a trait appears in every generation, it is usually __________________________. 12. If a trait skips generations, it is usually _________________________. 13. If a trait is more common in males than females, it is usually ________________________. 14. What does the law of independent assortmen ...
No Slide Title
No Slide Title

...  located on non-sex chromosomes  at least one parent is affected  does not skip generations  affected individuals are homozygous dominant or heterozygous  affects males & females Ex. Achondroplasia, Huntington disease, Lactose intolerance, Polydactyly ...
Results from the GAIT project: Genetic analysis of
Results from the GAIT project: Genetic analysis of

... Inference A single gene or set of genes influences variation in risk for thrombosis, factor VIII levels, von Willebrand factor levels, and activated protein C resistance. However, each of these traits is also affected by additional genes not shared with the others. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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