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Print this article - Annals of Gastroenterology
Print this article - Annals of Gastroenterology

... family showed inheritance of HLA B18. Indeed, the analysis of the HLA pattern showed that the two patients with the most severe disease were homozygous for HLA antigen B18, whereas the third patient with milder symptoms had no alleles for B18. On the other hand, the chromosomal study revealed normal ...
Crataegus oxyacantha (aubepine) in the use as herb
Crataegus oxyacantha (aubepine) in the use as herb

... University of Michigan College of Pharmacy, University of Michigan Health Systems, Ann Arbor, Michigan, USA. Hawthorn, an herbal supplement, is currently being evaluated for the treatment of heart failure. The flavonoid components of hawthorn may be responsible for hawthorn's beneficial effects in t ...
Lecture 11 Beyond Mendel
Lecture 11 Beyond Mendel

... molecules under genetic control. Using genetic analysis one can often detect the patterns of these interactions. For example: • a. In the dihybrid cross AaBb´ x AaBb, nine genotypes will result. If each allelic pair controls a distinct trait and exhibits complete dominance, a 9;3;3;1 phenotypic rati ...
meiosis_6
meiosis_6

... This is because the first gene codes for an intermediate colourless pigment, if the dominant C allele is present The second gene codes for an enzyme that converts the intermediate compound to the purple pigment, if the dominant R allele is present ...
OTAREX®
OTAREX®

... Epinephrine should not be used. Syrup of ipecac should not be administered in symptomatic patients or those who could rapidly become obtunded, comatose or convulsing, as this could lead to aspiration pneumonitis. Gastric lavage with prior endotracheal intubation may be performed if a clinically sign ...
Mylan Laboratories Inc. (MYL)
Mylan Laboratories Inc. (MYL)

... • Mylan has taken steps to expand geographically and into new markets • Lack of proprietary advantages is compensated for higher margins and profitability • Many inherent risk exist being in the generic drug industry that could affect profitability • Mylan competes well against other companies in it ...
Case Report
Case Report

... Long QT syndrome (LQTS) is a rare familial congenital cardiac disorder characterized by a prolonged QT interval on electrocardiograph corrected for heart rate (QTc) and associated with lifethreatening ventricular arrhythmias (1). The prevalence of the disease ranged from 1/5000 to 1/2000. Each year ...
ACUROX TABLETS NEW DRUG APPLICATION ACCEPTED FOR
ACUROX TABLETS NEW DRUG APPLICATION ACCEPTED FOR

... This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 (the "Act"). When used in this press release, the words “intend,” “expect,” “believe” and similar expressions are intended to identify forward-looking statements. Example ...
PuraMed-Power-Point
PuraMed-Power-Point

... The company has developed a migraine treatment that outperforms the number one selling prescription treatment in the relief of pain and associated symptoms, safety, ease of use, ease of access(no Rx needed) while cutting treatment costs by at least 75%. On January 3, 2011 the company announced that ...
chapter 11 and 14
chapter 11 and 14

... dimples, and no dimples. Label your pedigree with phenotypes and genotypes. ...
Adverse reaction to Amoxicillin: a case report
Adverse reaction to Amoxicillin: a case report

... this is not universally accepted.10,29 Immune mechanisms involved in adverse reactions to penicillins may also be related to genetic markers of immune response.24 Penicillin is a hapten and, therefore, not immunogenic by itself; it is rather its metabolic products that form the allergenic haptens.4, ...
Spinout Equinox Pharma speeds up and reduces the cost of drug
Spinout Equinox Pharma speeds up and reduces the cost of drug

... and academic partners and our next project will be to apply INDDEx to search for novel antibiotics, which will address one of the global challenges in healthcare.” ...
SERIES ‘‘CONTROVERSIAL ISSUES IN TUBERCULOSIS’’ Number 3 in this Series
SERIES ‘‘CONTROVERSIAL ISSUES IN TUBERCULOSIS’’ Number 3 in this Series

... read after incubation for 4 weeks. Given these conditions, reliable results can be obtained with tests that use a single drug-containing slope for each slope, though it is advisable to set up the test on two strains obtained at much the same time or in duplicate. The critical concentrations for scre ...
Renagel 800mg film-coated tablets
Renagel 800mg film-coated tablets

... Interaction studies have not been conducted in patients on dialysis. In interaction studies in healthy volunteers, Renagel decreased the bioavailability of ciprofloxacin by approximately 50% when co-administered with Renagel in a single dose study. Consequently, Renagel should not be taken simultane ...
Anthelmintic drugs
Anthelmintic drugs

... tissue directly. Their adverse reaction are more and severe, their irritative action is strong, can cause vomiting(emesis) by oral ad-ministration, therefore, they are only injected by deep muscle. And they may cause heart toxicity, so that they are only used in severe amebic infection and when metr ...
mucoadhesion, floating drug delivery systems
mucoadhesion, floating drug delivery systems

... Site-Specific Drug Delivery These systems are particularly advantageous for drugs that are specifically absorbed from stomach or the proximal part of the small intestine, eg, riboflavin and furosemide. By targeting drugs to the stomach, desired therapeutic levels achieved and drug waste could b ...
Hands on Exercise - Berkeley`s D-Lab
Hands on Exercise - Berkeley`s D-Lab

... b. Adj.P.Val tells you whether or not the gene expression levels are significantly different between patient samples and control samples. If the value in this column is <0.05, the gene expression change is significant. c. logFC tells you the magnitude of the gene expression change. It is in log2 sca ...
GENERAL GENETICS
GENERAL GENETICS

... If the recombination frequency between cv and ct is 6.3, and ct and vermillion eyes (v) is 13, the order on the chromosome could either be cv-ct-v, or ct-cv-v. We can determine which of these is correct by measuring the recombination frequency between cv and v. If cv and v are found to recombine wit ...
Daclatasvir - Daklinza - Bristol
Daclatasvir - Daklinza - Bristol

... intervention have been reported when amiodarone is coadministered with sofosbuvir in combination with another HCV direct-acting antiviral, including DAKLINZA. A fatal cardiac arrest was reported in a patient receiving a sofosbuvir-containing regimen (ledipasvir/sofosbuvir). Bradycardia has generally ...
What`s the Latest in Stable Ischemic Heart Disease?
What`s the Latest in Stable Ischemic Heart Disease?

... Mechanism originally based on inhibition of FA oxidation but now postulated that it works through inhibition of the late Na+ current  reduction in intracellular Ca+2/Na+  increased myocardial relaxation during diastole Has not been shown to delay or reduce mortality or other major adverse cardiac ...
Pharma 10
Pharma 10

... 2. other uses of testosterone is in anemia cases ;because it stimulate the formation erythropoietin of the kidney. so it treat bone marrow failure or renal failure , when erythropoietin is not produced in enough concentration . Nowadays recombinant erythropoietin replace the androgen use. So supple ...
1 ADDICTION, WITHDRAWAL, AND AGGRESSIVENESS IN
1 ADDICTION, WITHDRAWAL, AND AGGRESSIVENESS IN

... much weaker, and it also determines a series of adverse effects such as hypoventilation, nausea and regurgitation. The first cases of codeine toxicomany were reported in the US in the ‘30s, when patients were treated for morphine dependence; d) methadone (diphenyilpropylamine) is a synthesis product ...
Brief Bioinform-2015-Siavelis-bib_bbv048
Brief Bioinform-2015-Siavelis-bib_bbv048

... treatments, cell types and gene signatures based on L1000 highthroughput technology [12]. For cMap and sscMap, a preceding step was undertaken to convert gene symbols to unique databases’ required format of HG-U133A probe sets via NetAffx database [27]. Six common probe sets between up- and down-reg ...
06Gout_-_Copy[1].
06Gout_-_Copy[1].

... uric acid level below the saturation point (<6 mg/dL), thus preventing the deposition of urate crystals. This can be accomplished by: 1.interfering with uric acid synthesis with allopurinol 2.increasing uric acid excretion with probenecid or sulfinpyrazone 3.inhibiting leukocyte entry into the affec ...
GUIDELINES ON MALE SEXUAL DYSFUNCTION: Erectile
GUIDELINES ON MALE SEXUAL DYSFUNCTION: Erectile

... It is the most efficacious monotherapy for intracavernous treatment using 5-40 μg doses. The patient should been rolled in an office-based training programme (one or two visits) to learn the correct injection process. Complications of intracavernosal prostadil include penile pain (50% of patients), ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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