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Reappraisal of the European guidelines on hypertension management
Reappraisal of the European guidelines on hypertension management

... (Hypertension in the Very Elderly Trial) were available, suggesting beneficial effects for mor‑ bidity but not mortality. This gap in the evidence has been filled with the publication of the re‑ sults from the main HYVET outcome trial, which showed that antihypertensive treatment has ben‑ efits also ...
Recent DNA evidence DNA analysis of other “animals” Linking
Recent DNA evidence DNA analysis of other “animals” Linking

... Using bioinformatics to link genetics  and traits Get a clue: CSI and the science of forensics (2016) Bioinformatics and Research Computing ...
new recreational drug use
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... Diagnosis and treatment of toxic effects from recreational club-drugs, acute or long-term, can be very challenging, both in the emergency department and in the community. In view of the illicit nature of most club drugs, patients may not be forthcoming about a history of recent drug ingestion, and b ...
Q1. The diagram shows the genetic inheritance of cystic fibrosis (CF
Q1. The diagram shows the genetic inheritance of cystic fibrosis (CF

... ) in the box next to your answer. ...
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3 Basic properties of protozoa

... They are not very effective in acute amoebic desentry but afford relief in chronic intestinal amoebiasis. They are totally valueless in extraintestnal Amoebiasis. They are widely used for the prophylaxis and treatment of ...
Introducing new research results in daily clinical practice: how much
Introducing new research results in daily clinical practice: how much

... during start of morphine to cancer patients: a RC-DB trial. Pain 2003 – A titration procedure using immediate-release morphine given 4hourly is recommended during start of oral morphine for cancer pain. This recommendation is not based on evidence from controlled studies, and many physicians start m ...
Evaluation of H1-Antihistamine usage among dermatology
Evaluation of H1-Antihistamine usage among dermatology

... second generation antihistamines have a lesser propensity to cause CNS side effects, they have few or no anticholinergic effects. Some second-generation drugs are also said to have anti-allergic and anti-inflammatory effects which may contribute to their therapeutic benefit. [4] ...
LLog6 - CH 7 - Our Flesh and Blood
LLog6 - CH 7 - Our Flesh and Blood

... Cancer is a disease where cells rapidly divide and replicate at an uncontrolled speed which consequently creates tumors. This is due to mutations that compromise mechanisms of cell division and cell interaction. Some of these mutations allow cells to reproduce without being checked, to leave their l ...
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IV The physical examination in clinical genetics

... The phenotype of a developing or developed organism is held to be the result of interaction between the inherited genotype (the genetic makeup of the individual), transmitted epigenetic factors (those changes in genome function that do not alter the nucleotide sequence within the DNA), and nonheredi ...
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Dangerous abbreviations, acronyms, and symbols

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MODELING POLYGENIC INHERITANCE
MODELING POLYGENIC INHERITANCE

this PDF file - International Journal of Ayurvedic Medicine
this PDF file - International Journal of Ayurvedic Medicine

... problem in the medical world because of its higher incidence, incomplete aetio-pathogenesis, relapse and severe consequences. In spite of phenomenal process in H. pylori researches a great relapses in APD are found. A relative failure of modern medicine has made the majority of population to turn to ...
the Agrylin
the Agrylin

... Anagrelide hydrochloride was administered orally to pregnant rats and rabbits during the period of organogenesis at doses up to 900 mg/kg/day in rats and up to 20 mg/kg/day in rabbits (875 and 39 times, respectively, the maximum clinical dose of 10 mg/day based on body surface area). In rats, develo ...
Pharmacy Updates in Cardiology
Pharmacy Updates in Cardiology

... Eriksson BI, Dahl OE, Rosencher N, et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. Lancet 2007;370:949-56. Eriksson BI, Dahl OE, Rosencher N, et al. Oral dabigatran etexilate vs sub ...
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... Rarely is a drug placed at its site of action, most drugs are given orally and yet they act in the brain, heart, or elsewhere!!!! Which means a drug has to move from the site of administration to the site of action. Therefore to administer drugs optimally, knowledge is needed not only of the mechani ...
Copy of CHAPTER 1
Copy of CHAPTER 1

... Rarely is a drug placed at its site of action, most drugs are given orally and yet they act in the brain, heart, or elsewhere!!!! Which means a drug has to move from the site of administration to the site of action. Therefore to administer drugs optimally, knowledge is needed not only of the mechani ...
Section 7 - Glow Blogs
Section 7 - Glow Blogs

... ◦ Traits will be written on the board – the dominant, recessive or codominant version will be described. ◦ You cannot choose which trait your baby has, this will be determined by rolling the dice. If you have an even number, it is dominant, odd numbers are recessive. ◦ Work through all the character ...
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... Equilibrium dialysis is the gold standard method. Ultrafiltration, ultracentrifugation, microdialysis, and plasmom resonance methods are used ...
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Understanding Human Genetic Variation

... As important as they were, the techniques of transmission genetics and cytology were not enough to help scientists understand human genetic variation at the level of detail that is now possible. The central advantage that today's molecular techniques offer is that they allow researchers to study DNA ...
Lecture 12
Lecture 12

... • An example would be loci that are on two different chromosomes and encode unrelated, non-interacting proteins. • If two genes are in linkage disequilibrium, it means that certain alleles of each gene are inherited together more often that would be expected by chance. • This may be due to actual ge ...
Analgesia
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... Most common reason people seek health care Tissue damage activates free nerve endings (pain receptors) Generally indicates tissue damage ...
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Weighted Gene Co-expression Network Analysis in

... individuals in the San Antonio Family Heart study, identifying 323 unique genes and 342 transcripts that were significantly correlated with smoking behavior at a FDR of 5% [2]. Other studies have been performed on buccal mucosa [3], B cells in women [4], small airway epithelium, and alveolar macroph ...
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...  Main role for p450 system is metabolism and detoxification of substances  P450 system can be altered (metabolic rate depends on whats being metabolized (induction vs. inhibition)  Can vary from person to person (There are >30 human p450 isozyme systems) CYP-450 Isozymes to know: 1A2  Inducing a ...
Stimulants and Related Agents
Stimulants and Related Agents

... other available treatment options. 36  Stimulants  are  also  used  to  treat  another  psychiatric  disorder  called  Narcolepsy.  Narcolepsy  is  defined  as  excessive daytime sleepiness, even when there is a sufficient amount of sleep time from the night. There are  also  four  other  symptoms  ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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