• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Lorcaserin : The Serotonergic Weight Loss Medication
Lorcaserin : The Serotonergic Weight Loss Medication

... Belviq Increases Fullness and Decreases Hunger and Cravings Without Any of the Typical Weight Loss Medication Side Effects Unlike the anti-depressant SSRIs, Belviq works by controlling appetite — specifically by activating specific nerve cell receptors for serotonin in the appetite centers of the b ...
Slide 1
Slide 1

... The normally high concentration of DA in the basal ganglia of the brain is reduced in PD, and pharmacologic attempts to restore DA-ergic activity with levodopa and DA agonists have been successful in alleviating many of the clinical features of the disorder. An alternative but complementary approac ...
Consent to Diet Treatment - R. Jay Kohn Medical and Weight Loss
Consent to Diet Treatment - R. Jay Kohn Medical and Weight Loss

... helpful for periods far in excess of 12 weeks and at times in larger doses then those suggested in the labeling. As a physician, I am not required to use the medication as the labeling suggests, but I do use the labeling as a source of information along with my own experience, the experience of rece ...
9/18 Recombination and chromosome mapping
9/18 Recombination and chromosome mapping

... Calculating Recombination Frequency • Recombination frequency = (number of recombinant progeny / total number of progeny) ...
False-Positive and False-Negative Rates in Meconium Drug Testing
False-Positive and False-Negative Rates in Meconium Drug Testing

... sensitivity is of primary importance. A sensitive screen assay sacrifices specificity; therefore, a specific con.firinatory procedure is necessary. Such an approach does not lend itself to reporting screen-only results. Healthcare professionals should be aware of the possible consequences that may a ...
ESBRIET Product Monograph
ESBRIET Product Monograph

... moderate hepatic impairment (i.e., Child-Pugh Class A and B) given the potential for increased ESBRIET exposure. Patients should be monitored closely for signs of toxicity especially if they are concomitantly taking a known CYP1A2 inhibitor (see DRUG INTERACTIONS and ACTION AND CLINICAL PHARMACOLOGY ...
Corticosteroids_November 2010 FINAL
Corticosteroids_November 2010 FINAL

... The general warnings on systemic side-effects in section 4.8 of the SmPC should be reflected in the Patient Information Leaflet using suitable lay terms and with information on the rarity of these reactions. Since specific examples of effects which may occur are described in section 4.4 of the SmPC ...
Sulfonylurea Drugs Increase Early Mortality in Patients With
Sulfonylurea Drugs Increase Early Mortality in Patients With

... Potential explanations for increased mortality with sulfonylurea drugs. Experimentally, sulfonylureas increase infarct size and accelerate the death of hypoxic cardiomyocytes through blockade of KATP channels that mediate ischemic preconditioning in myocardium (8,27,28). Increased vulnerability of m ...
Guidelines for genetic studies in single patients
Guidelines for genetic studies in single patients

... establishes a causal bridge between a candidate genotype and a clinical phenotype. With the notable exceptions of hematological and immunological patients (Orkin and Nathan, 2009; Ochs et al., 2014), and to a lesser extent patients with inborn errors of metabolism (Scriver et al., 2001), the descrip ...
Geriatric Pain Management - S-COPE
Geriatric Pain Management - S-COPE

...  Recognize the distinctions between neuropathic pain and nociceptive pain  Use validated clinical questioning and screening tools to identify patients with neuropathic pain  Develop evidence-based comprehensive treatment plan for patients with chronic pain in geriatic population ...
anticoagulantpresent..
anticoagulantpresent..

... • Furthermore, clopidogrel has a better overall side-effect profile although TTP may also occur with this agent. ...
File
File

... Calculate the percentage of each. In this example, three fourths of the chicks will have large beaks, but only one in two will be heterozygous. ...
NORCO 667C00 8-14_Layout 1 8/28/14 11:11 AM Page 1
NORCO 667C00 8-14_Layout 1 8/28/14 11:11 AM Page 1

... acetaminophen 500 mg did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selectio ...
Drug Discovery Stage
Drug Discovery Stage

... reduced psychological and physical burden on patients who ...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF

... which tablets are most popular dosage forms available in the market and most preferred by patients and physicians. In case of chronic disease condition, long term therapy will be essential. Hence conventional dosage forms are required to be administered as multiple doses which have several disadvant ...
FDA accepts for filing a New Drug Application (NDA) for
FDA accepts for filing a New Drug Application (NDA) for

... Food and Drug Administration (FDA) has accepted the filing of its NDA for Somatuline® Autogel® (60, 90, 120 mg) in the United States as 28-day sustained-release formulation to treat patients with acromegaly. This acceptance signifies the start of the review process of the NDA with a “prescription dr ...
Genetics Powerpoint
Genetics Powerpoint

... - two genes, 4 alleles Black fur is dominant to brown fur Short fur is dominant to long fur What is the genotype of a guinea pig that is heterozygous for both black and short fur? ...
MRI (radio) phenotypes - Cancer Imaging Archive Wiki
MRI (radio) phenotypes - Cancer Imaging Archive Wiki

... However, otherwise, the large plethora of genomic information remains largely unused and drug development based on genomics has been limited. This is largely due to the inability for early identification of genomic targets through which clinically meaningful and applicable therapeutic targets can be ...
Genes, Cognition, and Communication
Genes, Cognition, and Communication

... the same DNA sequence—this means that one can track how the DNA sequence in a given chromosome region relates to the phenotype in multiple people from the same family. A common misconception is that discovery of linkage equates to identification of genes that cause disorder. In fact, the highly vari ...
Protocol S1.
Protocol S1.

... reduced synovial inflammation [13-15]. The effects of adalimumab have not been studied previously. Of importance is the fact that analysis of serial synovial samples from RA subjects who received either placebo or unsuccessful treatment with recombinant human interleukin-10, IFN-beta, and anti-CD4 a ...
HYMAN, PHELPS 8 MCNAMARA, P. C.
HYMAN, PHELPS 8 MCNAMARA, P. C.

... Efficacyof a diagnosticradiopharmaceuticalmaybe expressedas its abilityto provide informationthat contributes to a patient’sdiagnosisor treatment(e.g., facilitatedvisualizationof lesions/structuresor norrnal/abnorrnalblood flow), or alternatively,as the diagnosticperformanceof the agent(e.g., sensit ...
Hemophilia
Hemophilia

... RR stands for dominant alleles. rr is a recessive allele. Rr is the dominant gene over the recessive gene. The dominant gene produces the same phenotype in the organism whether or not its allele identical. The recessive gene produces its characteristic phenotype only when its allele is identical. ...
CHAPTER 2 LITERATURE REVIEW Piper sarmentosum Roxb
CHAPTER 2 LITERATURE REVIEW Piper sarmentosum Roxb

... cord to become hyperexcitable (William, 1998). When A-delta fibers produce the acute sensation of sharp and bright pain, their neurotransmitter in the dorsal horn is glutamate acting on Alphaamino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. The C fibers can respond to a broad ran ...
Genome-wide scan with SNPs
Genome-wide scan with SNPs

... Difference in the genome from one individual is about 0.1% and this difference has the potential to effect the function of the gene and hence the phenotype of the individual. But not all markers are associated with visual phenotype. Most commonly used genetic markers these days are microsatellites a ...
Rivastigmine - Nottinghamshire APC
Rivastigmine - Nottinghamshire APC

... Baseline screening / investigations to exclude other causes of cognitive impairment will have been carried out by the GP before initial referral to the Specialist Service. For patients with existing or suspected cardiac disease or bradycardia (including those with cardiac arrhythmias or valve proble ...
< 1 ... 532 533 534 535 536 537 538 539 540 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report