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Biost 536, Spring 2013 Homework #1 September 26, 2013, Page 1
Biost 536, Spring 2013 Homework #1 September 26, 2013, Page 1

... h. What proportion of the drugs with significant results will be truly beneficial? 0.8065 50 / 62 = 0.8065 or ...
Document
Document

... for the purpose of engaging in investment activity may expose an individual to a significant risk of losing all of the property or other assets invested. This presentation does not constitute or form part of any offer for sale or subscription or solicitation of any offer to buy or subscribe for any ...
Research and Development at Sun Pharma
Research and Development at Sun Pharma

...  Key Features of technology developed Can produce controlled particle size for facile injection through conventional needle to reduce patient trauma and pain No local anaesthetic required while delivering the drug Closed semi-automatic process to give kilogram scale, reproducible, consistent and ...
Mendelian Genetics
Mendelian Genetics

... Gregor Mendel 1. Who is responsible for our laws of inheritance? 2. What organism did Mendel study? 3. When was Mendel's work recognized? 4. When did Mendel perform his experiments & how many plants did he grow? 5. What did Mendel notice about offspring traits? 6. How is Mendel referred to today? 7. ...


... Tetrahydrogestrinone (THG) was ini- keted under the names Prastera, Fidelin, tially developed to avoid detection by and Fluasterone, is another precursor of testing protocols current at the time.-^'-'' testosterone. It is produced in the adrenal This drug has garnered significant media cortex and ha ...
Mendel and Heredity
Mendel and Heredity

... that a child will have it even if only one parent has one of the alleles. If both parents are heterozygous for a dominant disorder, they both have symptoms of the disorder, and there is a 75 percent chance that a child will inherit the disorder. What is the genotype of a carrier of a recessive disor ...
Maintenance asthma medication
Maintenance asthma medication

... person to specific allergens that trigger their allergy symptoms. • IT is not effective for food allergies or intolerances, irritants such as cigarette smoke, odors or fumes. • Allergy mixtures are tailored specifically for each patient based on their standardized skin tests. Our board certified all ...
Frailty and treatments for benign prostatic hyperplasia
Frailty and treatments for benign prostatic hyperplasia

... with alpha-blockers is the risk of additive hypotension. This can occur with most classes of drugs prescribed for cardiovascular disorders and some centrally-acting drugs such as tricyclic antidepressants (SSRIs are an alternative). Phosphodiesterase type 5 (PDE5) inhibitors, eg sildenafil, which ar ...
Controlled Substance Agreement
Controlled Substance Agreement

... dependence, addiction, withdrawal and potential death from overdose. I understand that I have responsibilities when I receive and use controlled substances. I accept these responsibilities and agree: 1. To actively participate in programs for improving my function and/or return to work. 2. To use my ...
Analgesics, Opioid Antagonists, and Nonopioid Centrally Acting
Analgesics, Opioid Antagonists, and Nonopioid Centrally Acting

... Most widely prescribed drug in the United States Combined with aspirin, acetaminophen, or ibuprofen Analgesic effects equivalent to oxycodone ...
Phosphatidylcholine in the treatment of localized fat
Phosphatidylcholine in the treatment of localized fat

... drugs, such as botulinum toxin, which has been used for cosmetic purposes since 1990. However, the permitted offlabel use allowed physicians to study the drug and its benefits in wrinkle treatment for over 10 years before the FDA finally approved its cosmetic use in 2002. Conclusions Phosphatidylcho ...
File
File

... • Depressed mood for most of the day, for more days than not for at least 2 years in adults and one year in children • Plus two or more of the following: Decreased or increased appetite Insomnia or hypersomnia Low energy or chronic fatigue Decreased self-esteem Poor concentration or difficulty ...
the role of germline polymorphisms in the t-cell
the role of germline polymorphisms in the t-cell

... These findings provide weak evidence of possible germline-coded susceptibility to AS close to or within the TCRB locus with no evidence of an effect from the TCRA/TCRD locus. The finding that adjacent markers (D7S509, TCRVb6.7, D7S688) give complementary results makes it unlikely that this is an exp ...
Material - Kowa Pharmaceutical Europe Co. Ltd.
Material - Kowa Pharmaceutical Europe Co. Ltd.

... structure, contributing to a more effective inhibition of the HMG-CoA reductase enzyme to inhibit cholesterol production, and allowing for the use of a lower dose. While few drugs, including pitavastatin, are free from drug-drug interactions, pitavastatin may be an attractive option for physicians t ...
Ankylosing spondylitis – The history of medical therapies
Ankylosing spondylitis – The history of medical therapies

... adjunct to treatment (3). The immedi ate effect was the reduction of back pain and stiffness, as well as local tenderness, and more often there was partial improvement. The more recently involved regions showed a better response than the regions that were involved for many years. In some patients th ...
chapter 4
chapter 4

... IV. Several Genes Affecting the Same Character The cellular functions of products encoded by more than one gene affect the phenotype of one trait. The key to determining that you have one trait controlled by more than one gene is modified (i.e. not 3:1) Mendelian ratios in a cross of 2 heterozygous ...
NIDA InfoFacts- Hallucinogens
NIDA InfoFacts- Hallucinogens

... produce tolerance, so some users who take the drug repeatedly must take progressively higher doses to achieve the state of intoxication that they had previously achieved. This is an extremely dangerous practice, given the unpredictability of the drug. In addition, cross-tolerance between LSD and oth ...
Darwin`s Theories
Darwin`s Theories

... suffer from sickle-cell anemia. Heterozygous (AS) individuals carry the mutant allele but do not suffer from its debilitating effects. They have both normal and sickle-shaped red blood cells. In the United Sates, about 1 in 500 African- Americans develops sickle-cell anemia. But in Africa, about 1 i ...
Other Major Side Effects to Immunomodulators and/or Biologics in
Other Major Side Effects to Immunomodulators and/or Biologics in

... • Much less common but much more serious: • Nodular regenerative hyperplasia: 1.2% at 10 years of AZA (but there may be a baseline of NRH in thiopurine-naïve IBD • Veno-occlusive disease of liver ...
S1-1-12 - Canola to Die for
S1-1-12 - Canola to Die for

... weeds, some of the canola plants die, an occurrence which was not the farmer’s intent. The discrepancy lies in the genotype and phenotype of the canola. The event has been written for Senior 1 science students, but with some adaptation could be used in other settings. Specific Learning Outcomes The ...
Committee on Law Enforcement/Legislation
Committee on Law Enforcement/Legislation

... months, the FDA has issued a number of regulatory letters to pharmacists asserting that the activities engaged in by these pharmacists was manufacturing. In November of 1991, NABP released draft definitions of compounding and manufacturing for comment. It has received back comments from the state bo ...
dominant allele
dominant allele

...  Genes affect the traits of an offspring.  An organism’s appearance (the way they look) is known as its phenotype.  In pea plants, possible phenotypes for the characteristic of flower color would be purple flowers or white flowers or it could be a yellow or green seed.  Phenotypes for humans are ...
Use of selective serotonin reuptake inhibitor medications for the
Use of selective serotonin reuptake inhibitor medications for the

... across any of the RCTs included in these systematic reviews. The FDA analyses of suicidal adverse events among participants treated with an SSRI for depres­ sion revealed an overall RR of 1.66 (95% CI 1.02 to 2.68).[24] A more recent meta-analysis included unpub­ lished RCT data along with the studi ...
No Slide Title
No Slide Title

... drugs in earlier development focused on hospital multiresistant Gram-positive indications no agents for Gram-negative infection ...
new hope in acute myeloid leukemia treatment
new hope in acute myeloid leukemia treatment

... With imatinib and other compounds like dasatinib on the market, outcomes for CML patients suddenly improved considerably — and left the oncology expert looking for another type of cancer where he could help make the same impact on patients’ lives. Acute myeloid leukemia (AML) seemed to be the perfec ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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