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Morphine FAQs leaflet (courtesy Sundridge Court)
Morphine FAQs leaflet (courtesy Sundridge Court)

... Morphine is a strong painkilling drug. It works very well on many types of pain, although it is most commonly associated with cancer pain. It is also sometimes used to control feelings of breathlessness. ...
russell-silver syndrome
russell-silver syndrome

... The main feature of Russell-Silver syndrome (RSS) is low birth weight followed by continued growth delays after birth. Individuals with RSS typically have proportionately short stature and normal head circumference. Certain characteristic facial features may also be present (triangular face, down-tu ...
投影片 1
投影片 1

... • LOD score > 3.0: evidence for linkage. (A score of 3.0 means the likelihood of observing the given pedigree if the two loci are not linked is less than 1 in 1000). • LOD score < -2.0: evidence to exclude linkage ...
Anaesthetic Drugs
Anaesthetic Drugs

... unconsciousness Many reflexes  (airway, gag, CN) Awareness +/- NMJ paralysis ...
Office-Based Opioid Therapy: Methadone/Buprenorphine Nexus
Office-Based Opioid Therapy: Methadone/Buprenorphine Nexus

... • The panel based it conclusion that methadone is coming from other sources on data showing that the greatest growth in methadone distribution in recent years is associated with its use as a prescription analgesic prescribed for pain, primarily in solid tablet or diskette form, and not in the liquid ...
taking charge
taking charge

... Once your specific information is gathered, your doctor may review one of the highly regarded treatment guidelines that exist. These guidelines are written by kidney cancer experts who convene on a regular basis to determine which treatment options may be recommended for each patient type. The guide ...
Lithium sulfate
Lithium sulfate

1
1

... acute lymphoblastic leukemia who require L-asparaginase in their treatment regimen, but are hypersensitive to the native forms of L-asparaginase. PEG modified liposomes containing doxorubicin are indicated for patients with AIDS-related advanced Kaposi’s sarcoma [18]. Macromolecular therapeutics has ...
Sustained Release Drug Delivery System Potential
Sustained Release Drug Delivery System Potential

... A floating dosage form is a feasible approach especially for drugs which have limited absorption sites in upper small intestine. The controlled, slow delivery of drug to the stomach provides sufficient local therapeutic levels and limits the systemic exposure to the drug. This reduces side effects t ...
Detoxification Methods of Benzodiazepines Mono
Detoxification Methods of Benzodiazepines Mono

... half-life benzodiazepine drug before tapering, especially when patients are difficult to be treated or have low compliance to treatment. However, there is no obvious evidence suggesting the optimum rate of tapering. ...
Mendel and Heredity
Mendel and Heredity

... About 1 in 2,500 Caucasian infants in the U.S. is homozygous for the CF allele. There is no cure. ...
Nemaline body myopathy caused by a novel mutation in Troponin
Nemaline body myopathy caused by a novel mutation in Troponin

... the protein. The phenotype is similar to that described in the Amish population affected by the p.Glu180* nonsense mutation, though several differences should be noted. The Palestinian families were not knowingly related. The short shared haplotype segment of only 1.1 Mb enhances the assumption that ...
Core SPC Clopixol® Depot 200 500 mg/ml SUMMARY OF
Core SPC Clopixol® Depot 200 500 mg/ml SUMMARY OF

... The antipsychotic effect of neuroleptics is related to their dopamine receptor blocking effect but possibly also 5-HT (5-hydroxytryptamine) receptor blockade contributes. In vitro zuclopenthixol has high affinity for both dopamine D1 and D2 receptors, for α1-adrenoceptors and 5-HT2 receptors but no ...
(2004). Genetic Influence on Human Psychological Traits
(2004). Genetic Influence on Human Psychological Traits

... relevant. What kind of gene action is involved? Is it a simple additive influence, with the effects of genes simply adding up so that more genes cause greater expression of the trait, or is the mode of action more complex? Are the effects of genes for a particular trait more pronounced in men or wom ...
Lecture 3
Lecture 3

... Mutation ...
of Administering Medications to Elderly Patients
of Administering Medications to Elderly Patients

... Medications contribute to extended longevity by treating chronic conditions effectively; however, they also create risks for elderly persons. This course explains how the physiological and pathophysiological effects of aging place elderly persons at risk for adverse drug events (ADEs). Of the many f ...
TRILEPTAL draft PI
TRILEPTAL draft PI

... epileptic drugs (AEDs), including carbamazepine, gabapentin, lamotrigine, phenytoin and valproate, confirm efficacy when these AEDs were substituted by Trileptal. Two trials were conducted in children (aged 3 to 17 years), one in adjunctive therapy versus placebo, the other a monotherapy comparison ...
Economic regulation of the pharmaceutical market (2)
Economic regulation of the pharmaceutical market (2)

... involving minors were imposed, the basic requirements for the protection of study subjects were approved, particularly issues related to providing the information to patients ...
Product Monograph
Product Monograph

... second dose or when the dose was increased. It is more likely to occur in patients who are volume and salt depleted as a result of diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. In patients with ischemic heart disease or cerebrovascular disease, an excessive fall in blo ...
Leflunomide
Leflunomide

... It is important that you have regular blood tests, including those for liver function, while taking this medication. You should not take leflunomide if you have a pre-existing liver disease such as hepatitis or cirrhosis. Alcohol may increase the risk of liver damage from leflunomide, and should be ...
core modules & forms of tobacco
core modules & forms of tobacco

... “I realize that quitting is difficult. It is the most important thing you can do to protect your health now and in the future. I have training to help my patients quit, and when you are ready, I will work with you to design a specialized treatment plan.” ...
From, Dr. GEETHA SAWKAR, 1st MD Dept of Rasashastra, B.L.D.E.
From, Dr. GEETHA SAWKAR, 1st MD Dept of Rasashastra, B.L.D.E.

... Brief resume of the intended work: 6.1 Need for the study of Reproduction is a fundamental feature of all known life each individual organism exists as the result of reproduction .It is the biological process by which new “offspring” individual organisms are produced from their parents1 A childless ...
Moving mountains to serve cancer patients
Moving mountains to serve cancer patients

... demonstrated by chemical footprinting, mass spectrometry, and other biochemical data. • Although multiple pathways may be modulated, unacceptable toxicity following APE1 inhibition has not been observed in animal or human studies. • Preclinical data supports the use of the drug as a single agent; fu ...
The Role Of Preclinical Models In The Development Of Psychotropic
The Role Of Preclinical Models In The Development Of Psychotropic

... predictions about the potential of the compound in the clinic. The ability to rapidly and efficiently identify treatments that may be shown clinically to have some advantages over the older treatments is an advantage of this approach. Nevertheless, these screening paradigms do not provide ways to pr ...
Sexually reproducing organisms in nearly all cases have termed
Sexually reproducing organisms in nearly all cases have termed

... as the ’father of genetics’, He carried out some pioneering work using pea p~ants to study the inheritance pa~erns of a number of traits (characteristics). Mendel observed that characters could be masked in one generation of peas but could reappear in later generations. He showed that inheritance in ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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