Late cardiotoxicity
... The incidence of heart failure was approximately 4% when the cumulative dose was between 500 and 550 mg/m2, but increased to 18% when the dose was increased to 551–600 mg/m2 and to as much as 36% when the total dose was at least 601 mg/m2 The prognosis of the cardiomyopathy, once developed, is grave ...
... The incidence of heart failure was approximately 4% when the cumulative dose was between 500 and 550 mg/m2, but increased to 18% when the dose was increased to 551–600 mg/m2 and to as much as 36% when the total dose was at least 601 mg/m2 The prognosis of the cardiomyopathy, once developed, is grave ...
Tumour necrosis factor α -308G/A gene polymorphism
... and percentages) in tables. Multiple logistic regression models were used to compare the distribution of genotypes between cases and controls and to determine the association between TNFα308 G/A polymorphism and knee OA. To adjust differences in age, BMI, and gender between the groups, these three v ...
... and percentages) in tables. Multiple logistic regression models were used to compare the distribution of genotypes between cases and controls and to determine the association between TNFα308 G/A polymorphism and knee OA. To adjust differences in age, BMI, and gender between the groups, these three v ...
Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid
... does not occur in most patients within the normal therapeutic dose range and does not involve the therapeutic effects of the drug. One of the mechanisms of IDT is that a drug or reactive metabolite acting as a hapten modifies several proteins and finally the immune response is induced (Uetrecht, 200 ...
... does not occur in most patients within the normal therapeutic dose range and does not involve the therapeutic effects of the drug. One of the mechanisms of IDT is that a drug or reactive metabolite acting as a hapten modifies several proteins and finally the immune response is induced (Uetrecht, 200 ...
NEW ZEALAND DATA SHEET VOLTAREN® Description
... Gastrointestinal bleeding, ulceration or perforation, which may increase with dose or duration of use and which can be fatal, have been reported with all NSAIDs, including diclofenac, and may occur at any time during treatment, with or without warning symptoms or a previous history of serious gastro ...
... Gastrointestinal bleeding, ulceration or perforation, which may increase with dose or duration of use and which can be fatal, have been reported with all NSAIDs, including diclofenac, and may occur at any time during treatment, with or without warning symptoms or a previous history of serious gastro ...
Nutrition in the septic Patient
... Critically Ill, Ventilated Patients Clearly, total caloric intake has a greater impact on CO2 production and respiratory function than does the ratio of CHO/fat (varying CHO content from 40-75% of total calories has little impact) Recommend 1.2 to 1.5 times REE (up to 5 mg/kg/min CHO infusion – 40 t ...
... Critically Ill, Ventilated Patients Clearly, total caloric intake has a greater impact on CO2 production and respiratory function than does the ratio of CHO/fat (varying CHO content from 40-75% of total calories has little impact) Recommend 1.2 to 1.5 times REE (up to 5 mg/kg/min CHO infusion – 40 t ...
High Altitude Notes - Global Adventure Challenges
... High Altitude Notes... Further Conditions Associated With High Altitude High Altitude Retinal Haemorrhages (minute blood blisters at the back of the eye) are common around 5000m but very rarely cause any problems but, if they appear to enlarge, descent is advised. Sleep may deteriorate with hypoxia ...
... High Altitude Notes... Further Conditions Associated With High Altitude High Altitude Retinal Haemorrhages (minute blood blisters at the back of the eye) are common around 5000m but very rarely cause any problems but, if they appear to enlarge, descent is advised. Sleep may deteriorate with hypoxia ...
Heart Listen - Men`s Health Network
... ing from one or more types of cardiovasIn addition to the emphasis on lowering blood cholesterol, cular disease. It also reminds us that new evidence has surfaced suggesting that the buildup of CVD claims more lives each year than the next plaque in the coronary arteries not only can be reduced but ...
... ing from one or more types of cardiovasIn addition to the emphasis on lowering blood cholesterol, cular disease. It also reminds us that new evidence has surfaced suggesting that the buildup of CVD claims more lives each year than the next plaque in the coronary arteries not only can be reduced but ...
choice of sedation for critically ill patients: a rational approach
... would have little effect on cardiovascular function; fast onset; fast offset with minimal respiratory depression, if possible; and have no active metabolites. This drug would have no interactions with other medications; no pain on injection; no tolerance or withdrawal; be safe for all ages and have ...
... would have little effect on cardiovascular function; fast onset; fast offset with minimal respiratory depression, if possible; and have no active metabolites. This drug would have no interactions with other medications; no pain on injection; no tolerance or withdrawal; be safe for all ages and have ...
"Drug-induced hyperhidrosis and hypohidrosis".
... can be noticeable or subtle, depending on the drug’s anticholinergic potency, receptor specificity, dose, route of administration, elimination half-life and individual patient variability. The elderly are especially vulnerable, because elimination time of the anticholinergic drug may be increased, o ...
... can be noticeable or subtle, depending on the drug’s anticholinergic potency, receptor specificity, dose, route of administration, elimination half-life and individual patient variability. The elderly are especially vulnerable, because elimination time of the anticholinergic drug may be increased, o ...
曹永孝
... The β antagonists have salutary effects in this condition. These beneficial effects relate to blockade of adrenoceptors and to the inhibition of peripheral conversion of thyroxine to triiodothyronine. Propranolol has been used extensively in patients with ...
... The β antagonists have salutary effects in this condition. These beneficial effects relate to blockade of adrenoceptors and to the inhibition of peripheral conversion of thyroxine to triiodothyronine. Propranolol has been used extensively in patients with ...
SW_293 5_Benzodiazepines final
... a. Inter-patient variability and differing half-lives mean the figures can never be exact and should be interpreted using clinical and pharmaceutical knowledge. b. These equivalents do not agree with those used by some authors. They are firmly based on clinical experience but may vary between indivi ...
... a. Inter-patient variability and differing half-lives mean the figures can never be exact and should be interpreted using clinical and pharmaceutical knowledge. b. These equivalents do not agree with those used by some authors. They are firmly based on clinical experience but may vary between indivi ...
Adding topiramate to valproate therapy may cause reversible
... series of partial seizures. Seizures were controlled by escalating the dose of LZP (up to 5 mg/day) and TPM was increased to a daily dose of 250 mg. At that time, liver function tests remained normal. VPA was kept stable at 3600 mg/d (serum level 95 lg/mL). A few weeks after the final TPM dose incre ...
... series of partial seizures. Seizures were controlled by escalating the dose of LZP (up to 5 mg/day) and TPM was increased to a daily dose of 250 mg. At that time, liver function tests remained normal. VPA was kept stable at 3600 mg/d (serum level 95 lg/mL). A few weeks after the final TPM dose incre ...
chloromycetin* eye drops
... Bone marrow hypoplasia, including aplastic anaemia and death, has been rarely reported following local application of chloramphenicol. Chloramphenicol should be used with caution in patients who have been identified as having an individual or family history of blood disorders. Chloramphenicol should ...
... Bone marrow hypoplasia, including aplastic anaemia and death, has been rarely reported following local application of chloramphenicol. Chloramphenicol should be used with caution in patients who have been identified as having an individual or family history of blood disorders. Chloramphenicol should ...
Page 1 Clinical Practice Guideline: Management of Asthma • Identify
... Legal Disclaimer: Clinical practice guidelines made available by ‘Ohana are informational in nature and are not a substitute for the professional medical judgment of treating physicians or other health care practitioners. These guidelines are based on information available at the time and may not be ...
... Legal Disclaimer: Clinical practice guidelines made available by ‘Ohana are informational in nature and are not a substitute for the professional medical judgment of treating physicians or other health care practitioners. These guidelines are based on information available at the time and may not be ...
Hardy Weinberg Equilibrium Notes - 2015 2016
... 11. Explaining Equation #1: This equation is true for any population where there are only two alleles, one dominant and one recessive for a particular trait. Let’s say our alleles are “A” and “a”. In this equation “p” represents the frequency of “A” (the dominant allele) expressed as a decimal in th ...
... 11. Explaining Equation #1: This equation is true for any population where there are only two alleles, one dominant and one recessive for a particular trait. Let’s say our alleles are “A” and “a”. In this equation “p” represents the frequency of “A” (the dominant allele) expressed as a decimal in th ...
Is COPD in adulthood really so far removed from early development? EDITORIAL
... genetic alteration in the genes involved in early development may disturb normal structural formation and function in one or more affected organs/systems, and hence cause clinically diagnosed congenital diseases in children. In addition to the genetic alterations described previously, genetic change ...
... genetic alteration in the genes involved in early development may disturb normal structural formation and function in one or more affected organs/systems, and hence cause clinically diagnosed congenital diseases in children. In addition to the genetic alterations described previously, genetic change ...
Press Release Sun Pharma launches first branded ophthalmic
... (NSAID) indicated for the treatment of postoperative inflammation and prevention of ocular pain in patients undergoing cataract surgery, BromSite™ will be marketed by Sun Ophthalmics, the company’s branded ophthalmic business division. BromSite is the first branded product launched by the company in ...
... (NSAID) indicated for the treatment of postoperative inflammation and prevention of ocular pain in patients undergoing cataract surgery, BromSite™ will be marketed by Sun Ophthalmics, the company’s branded ophthalmic business division. BromSite is the first branded product launched by the company in ...
anti-seizure medication review - Idaho Society of Health
... • Drug rash with eosinophilia and systemic symptoms(DRESS) ...
... • Drug rash with eosinophilia and systemic symptoms(DRESS) ...
Genetic of Non-syndromic Cleft Lip and Palate
... nonsyndromic cases. However, the results of earlier candidate-genebased association studies, performed in different populations, have been conflicting, with only a few candidate loci being implicated in OC phenotypes. This inconsistency indicates the challenges in searching associations with a relat ...
... nonsyndromic cases. However, the results of earlier candidate-genebased association studies, performed in different populations, have been conflicting, with only a few candidate loci being implicated in OC phenotypes. This inconsistency indicates the challenges in searching associations with a relat ...
Human Genetics: Dominant & Recessive Trait
... The alleles for curly hair and straight hair are examples of alleles for a trait that are codominant. Individuals with curly hair are homozygous for curly hair alleles. Individuals with straight hair are homozygous for straight hair alleles. Individuals who are heterozygous, with one of each allele ...
... The alleles for curly hair and straight hair are examples of alleles for a trait that are codominant. Individuals with curly hair are homozygous for curly hair alleles. Individuals with straight hair are homozygous for straight hair alleles. Individuals who are heterozygous, with one of each allele ...
REQUIRED COMPETENCY AREAS, GOALS, AND OBJECTIVES
... • Responds appropriately to notifications and alerts in electronic medical records and other information systems that support medication ordering processes (based on factors such as patient weight, age, gender, comorbid conditions, drug interactions, renal function, and hepatic function). • Provides ...
... • Responds appropriately to notifications and alerts in electronic medical records and other information systems that support medication ordering processes (based on factors such as patient weight, age, gender, comorbid conditions, drug interactions, renal function, and hepatic function). • Provides ...
Opposing effects of target overexpression reveal drug mechanisms
... identification remains a major challenge in pharmaceutical development. Despite the evolutionary and pharmacological importance of resistance by target overexpression, it remains unclear why this phenomenon is only seen for some drugs but not others. Here we address this question by examining antibio ...
... identification remains a major challenge in pharmaceutical development. Despite the evolutionary and pharmacological importance of resistance by target overexpression, it remains unclear why this phenomenon is only seen for some drugs but not others. Here we address this question by examining antibio ...
Shastry, B.S. 2002. SNP alleles in human disease and evolution
... at different loci, and hence can be studied by both linkage and association methods. In haplotype association studies, multitype genotypes are reduced to haplotypes and this has proved to be a more efficient mapping technique than that of SNP analysis. SNPs in pharmacology Another potential applicat ...
... at different loci, and hence can be studied by both linkage and association methods. In haplotype association studies, multitype genotypes are reduced to haplotypes and this has proved to be a more efficient mapping technique than that of SNP analysis. SNPs in pharmacology Another potential applicat ...
Numbers of - TeacherWeb
... Bovari and Sutton’s insight linking gene transmission with chromosome behavior in meiosis (1902) provided the missing elements. Today, we refer to the combination of evolution through natural selection and genetics as neo-Darwinism. To fully understand the connection between evolution and genetics, ...
... Bovari and Sutton’s insight linking gene transmission with chromosome behavior in meiosis (1902) provided the missing elements. Today, we refer to the combination of evolution through natural selection and genetics as neo-Darwinism. To fully understand the connection between evolution and genetics, ...