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Cengage Learning
Cengage Learning

... straining; treat chronic constipation from nondietary causes and movable intestinal blockages; and evacuate the GI tract before surgery, radiography, or ...
Whole-body high-field MRI shows no skeletal muscle degeneration
Whole-body high-field MRI shows no skeletal muscle degeneration

... Molecular genetic analyses demonstrated recessive CLCN1 mutations in all patients. Two related patients were compound heterozygous for two novel CLCN1 mutations, Q160H and L657P. None of the patients showed skeletal muscle signal changes indicative of fatty muscle degeneration or edema. Two patients ...
Telenzepine is at least 25 times more potent than pirenzepine
Telenzepine is at least 25 times more potent than pirenzepine

... and of 50 mg pirenzepine (p_0-01). On a molar basis telenzepine proved to be about 25 times more potent than pirenzepine to inhibit acid output. Mean peptone volumes which had to be added during the secretory studies did not show significant differences within the test with pirenzepine or telenzepin ...
Recreational ketamine: from pleasure to pain
Recreational ketamine: from pleasure to pain

... damage and scarring. This is a concern of ours, as the worst-affected patients have required major surgery, i.e. cystectomy and bladder reconstruction, with all its inherent risks. Such surgery should only be done after careful counselling and a sustained attempt to stop ketamine use. Ketamine has b ...
Nuedexta Prescribing Information
Nuedexta Prescribing Information

... The quinidine component of NUEDEXTA is intended to inhibit CYP2D6 so that higher exposure to dextromethorphan can be achieved compared to when dextromethorphan is given alone [see Warnings and Precautions (5.4) and Clinical Pharmacology (12.3), (12.5)]. Approximately 7-10% of Caucasians and 3-8% of ...
sucralfate tablets, usp - Nostrum Laboratories Inc.
sucralfate tablets, usp - Nostrum Laboratories Inc.

... the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. (See DOSAG ...
Association of Interleukin-1 Receptor Antagonist Gene 86bp VNTR
Association of Interleukin-1 Receptor Antagonist Gene 86bp VNTR

... out method [9]. The 86 bp VNTR region of IL-1Ra gene was analyzed by polymerase chain reaction (PCR). Two oligonucleotide primers forward: 5'- CTC AGC AAC ACT CCT AT -3' and reverse: 5-' TTC CAC CAC ATG GAA C -3' based on flanking region of the IL-1Ra gene were used. PCR reaction was performed in a ...
HPS2 THRIVE IJHNFM ISIFMC_position_paper FINAL REVISION
HPS2 THRIVE IJHNFM ISIFMC_position_paper FINAL REVISION

... investigators “tested a drug in patients who, on average, had no indication to take it." MVE reduction with ERNL was strongly predicted by baseline LDLC (heterogeneity p=0.02), with apparent net benefit if LDL-C was above 58 mg/dl at study entry. Therefore and importantly, this study population was ...
neobiocon and abraxis bioscience launch abraxane in the uae for
neobiocon and abraxis bioscience launch abraxane in the uae for

... advance in taxane therapy for the treatment of breast cancer. This unique product eliminates the need for chemical solvents and allows for higher doses of paclitaxel without compromising safety and tolerability.” Rakesh Bamzai, President- Marketing at Biocon, said, “The launch of ABRAXANE reiterates ...
adverse reactions were defined by any of the
adverse reactions were defined by any of the

... antibodies to other products may be misleading. Using an ELISA assay, anti-human antichimeric antibody (HACA) was detected in 4 of 356 (1.1%) patients with low-grade or follicular NHL receiving single-agent Rituxan. Three of the four patients had an objective clinical response. The clinical relevanc ...
itopride - European Medical Journal
itopride - European Medical Journal

... mg TID was at p<0.001. The quality of life (QoL) of the treated individuals, evaluated at the end of the study, was also better than in the placebo group. The Nepean Dyspepsia Index QoL score improved by a mean of 13.2±19.4 with placebo, and by 18.0± 21.9 with itopride. The dosage used within the st ...
ANALYSIS  OF COMPARTMENT  MODELS, KINETICS  OF
ANALYSIS OF COMPARTMENT MODELS, KINETICS OF

... 1st order metabolism or extra renal excretion rate constant can also be calculated subsequently from the difference [KE-Ke] = Km Direct measurement of bioavailability can also be done without fitting the data to a mathematical model If plasma level time data is also available, coupled with urinary e ...
Pediatric Pharmacotherapy
Pediatric Pharmacotherapy

... orthotopic heart transplantation. The authors compared this sample to the preceding 22 transplanted children who served as historical controls. Routine perioperative cyclosporine (CyA), azathioprine (AZA), and steroids were administered, followed by a protocol of ATS for 3 days and 6 weeks of 30-50 ...
Does Mendel`s work suggest that this is the only gene in the pea
Does Mendel`s work suggest that this is the only gene in the pea

... identified gene homologs in Pisum sativum (pea), Arabidopsis thaliana, and Festuca pratensis (meadow fescue), mutations of which partially disable plant senescence. The biochemical properties and map location of this gene in pea indicate that it is the same locus that determines yellow (I) and green ...
Cystic Fibrosis Transmembrane Conductance Regulator
Cystic Fibrosis Transmembrane Conductance Regulator

... United Arab Emirates The first study to identify the genetic mutations responsible for cystic fibrosis among the UAE national population was undertaken by Frossard et al. (1994). Eight families with one child suffering from CF and a group of 30 random unrelated UAE nationals were used for the study. ...
Divergent Evolution of Duplicate Genes Leads to Genetic
Divergent Evolution of Duplicate Genes Leads to Genetic

... [email protected] ...
Recommended Design Features of Future Clinical Trials
Recommended Design Features of Future Clinical Trials

... point adjudication, and consideration should be given to prespecifying objective criteria triggering the initiation of nonstudy salvage therapy. 4. Clinical end points can be included as superiority components in a hierarchical primary efficacy end point, after first establishing noninferiority for ...
Answer the following questions
Answer the following questions

... January 2004 Answer the following questions: ---------------------------------------------1) Contrast conjugation and transduction. 2) Give an account on intradermal tests and their value in diagnosis of some diseases. 3) How can meningococci and gonococci be distinguished in the clinical laboratory ...
Does Mendel`s work suggest that this is the only gene in the pea
Does Mendel`s work suggest that this is the only gene in the pea

... identified gene homologs in Pisum sativum (pea), Arabidopsis thaliana, and Festuca pratensis (meadow fescue), mutations of which partially disable plant senescence. The biochemical properties and map location of this gene in pea indicate that it is the same locus that determines yellow (I) and green ...
The Biological Influence of Mutation Order on - e
The Biological Influence of Mutation Order on - e

... tumorigenesis, inaccessible in most cancers, and their chronic clinical course permits longitudinal studies. Here, we have investigated the influence of mutation order in patients with myeloproliferative neoplasms carrying mutations in both JAK2 and TET2; mutations in both genes are present in about ...
Self-Intoxication with Baclofen in Alcohol
Self-Intoxication with Baclofen in Alcohol

... patients were transported to the ED by ambulance, and five were escorted by a mobile emergency team (an EP and a nurse with availability of advanced life support), because of coma (GCS < 6) (Patients 3, 6, 8 and 11) and seizures (Patient 9). Three patients who had co-ingested benzodiazepines with ba ...
Nitrous oxide (N2O/O2) Sedation - The Children`s Medical Center of
Nitrous oxide (N2O/O2) Sedation - The Children`s Medical Center of

... Physical and chemical properties of N2O • Nitrous oxide is a sweet smelling, colorless gas • At room temperature, N2O is a gas. When compressed into a cylinder, it becomes a liquid. • The substance itself is not flammable, but will support combustion. Exposure to a combustible substance or flame wil ...
Cholesterol Medication Fact Sheets
Cholesterol Medication Fact Sheets

... This results in lowering triglyceride and LDL cholesterol levels. It also raises HDL cholesterol. Generally LDL cholesterol is reduced by 15-30%, triglyceride is reduced by 40%, and HDL is increased by 20%. Nicotinic acid has also been shown to slow progression or reverse the process of atherosclero ...
uh-lee-uls
uh-lee-uls

... • Recessive is hidden by a dominant allele • The only was a recessive allele shows up is if the organism has TWO recessive alleles for a particular trait. ...
Serotonin Syndrome Caused by Moclobemide
Serotonin Syndrome Caused by Moclobemide

... response can be observed. Both drugs are metabolised by CYP2C19 enzyme. The other enzymes CYP1A2 and CYP2D6 responsible for clomipramine metabolism are inhibited by moclobemide (19). Moclobemide has been shown to have similar antidepressant efficacy to tricyclic antidepressants, selective serotonin ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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