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Pharmacotherapeutic action of Dasanga Guggulu
Pharmacotherapeutic action of Dasanga Guggulu

... an effective and less side effective drug for this ailment. Even though there are number of synthetic drugs available in the market, they have considerable side effects such as headache, difficulty in sleeping, flushing of the skin, muscle aches, drowsiness, memory loss etc. So there is a great dema ...
Prescribing Information
Prescribing Information

... tolerance, elevation in blood pressure, behavioral and mood changes, increased appetite and weight gain. (6)  Specific adverse reactions resulting from drug use in children under 2 years of age are increased risk of infections, hypertension, irritability, Cushingoid symptoms, cardiac hypertrophy an ...
Pharmacological management for agitation and aggression in
Pharmacological management for agitation and aggression in

... Randomised controlled trials (RCTs) that evaluated the efficacy of drugs acting on the central nervous system for agitation and/or aggression, secondary to ABI, in participants over 10 years of age. Data collection and analysis We independently extracted data and assessed trial quality. Studies of p ...
Antifungal drugs and resistance: Current concepts
Antifungal drugs and resistance: Current concepts

Acute vasodilator testing in idiopathic pulmonary
Acute vasodilator testing in idiopathic pulmonary

... receptor antagonists [18] and phosphodiesterase inhibitors [19], all of which have shown efficacy in large-scale clinical trials. Accordingly, the value of acute vasoreactivity testing is two-fold: 1) to identify the small group of PAH patients who may benefit from less expensive simple vasodilator ...
adrenaline acid tartrate injection
adrenaline acid tartrate injection

... individuals. The possibility of an allergic reaction to sodium metabisulfite should be considered in asthmatic patients who show paradoxical worsening of their condition following use of the drug. GANGRENE Inter-arterial administration must be avoided as marked vasoconstriction may result in gangren ...
Assessing Statin Therapy: What are Their Differences? - Pri-Med
Assessing Statin Therapy: What are Their Differences? - Pri-Med

... McKenney JM, Davidson MH, Jacobson TA, Guyton JR; for the National Lipid Association Statin Safety Assessment Task Force. Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force. Am J Cardiol. 2006 Apr 17;97(8A):89C-94C. Sharp Collaborative Group. ...
Herbs
Herbs

... significantly increase selfratings of calmness and reduce self-ratings of alertness. The 300mg dose increased speed in a mathematical test lacking an effect on accuracy. ...
Curriculum prepared by Leanne M. Yanni, MD
Curriculum prepared by Leanne M. Yanni, MD

... of the medications for neuropathic pain at about 3. However, number needed to harm (NNH) is about 14. 6 DOSING and TITRATION: All TCAs are dosed the same with the exception of cyclobenzaprine. TCAs should be started at low doses (10-25mg) and slowly titrated (every 3-7 days) to minimize adverse effe ...
heparin (hep-a-rin) - DavisPlus
heparin (hep-a-rin) - DavisPlus

... doxycycline, epirubicin, filgrastim, gentamicin, haloperidol, hydroxyzine, idarubicin, ketamine, levofloxacin, mitoxandrone, mycophenolate, palifermin, papaverine, pentamidine, phenytoin, protamine, quinupristin/dalfopristin, reteplase, tobramycin, trimethoprim/sulfamethoxazole, vancomycin. ● Additi ...
7. antihyperlipidemics
7. antihyperlipidemics

... Lovastatin and simvastatin are prodrugs, due to the inactive closed lactone ring. The closed ring is opened, becoming active, when drugs are passing through the GIT. Atorvastatin, fluvastatin, and rosuvastatin are fluorine-containing congeners that are active as given (due to the already open lacto ...
Case Report Section
Case Report Section

... metaphases. Fluorescence in situ hybridization study showed rearrangement of the MLL gene in interphase and metaphase cells revealing that the break-apart 5'MLL segment is translocated to the derivative X chromosome. The patient achieved a complete hematological remission with chemotherapy one month ...
Non-ST Segment Elevation Myocardial Infarction Associated with IV
Non-ST Segment Elevation Myocardial Infarction Associated with IV

... therapy, and the symptoms should be investigated for cardiac events in light of the published cases. Patients experiencing IVIG-associated myocardial infarction should be treated according to the current standard of care and treatment guidelines. IVIG should not be administered during myocardial inf ...
Antihistamines - Take Control of your Health
Antihistamines - Take Control of your Health

... are usually an allergic reaction to food or medicine, but other substances and factors, including stress, can trigger them too. Up to 24 percent of the people in the U.S. will get hives at some point, according to the American Academy of Allergy Asthma and Immunology (AAAAI). Hives are usually harml ...
Molecular Basis of Multidrug Transport by ATP
Molecular Basis of Multidrug Transport by ATP

... ATP hydrolysis. ABC multidrug transporters are also expressed in microorganisms in which they confer resistance to antibiotics and other cytotoxic compounds. Examples in microorganisms include LmrA in Lactococcus lactis (van Veen et al., 1998; Putman et al., 2000), Pdr5p, Ycf1p and Yor1p in Saccharo ...
behavioral geneticists` best friend?
behavioral geneticists` best friend?

... of a different behavioral test conducted by the Swedish Dog Training Center on two different breeds: German Shepherd Dogs and Labrador Retrievers. To allow comparisons of the genetic parameters across breeds, the same linear regression model was applied to both data sets. The heritabilities of the s ...
Gene-Environment Interaction: Definitions and Study Designs
Gene-Environment Interaction: Definitions and Study Designs

... cancer in the general population, but individuals with xeroderma pigmentosum are deficient in an enzyme required for repair of DNA damage induced by UV radiation, and hence have even higher risk. If sun exposure could be prevented completely in these persons, they would not have increased risk for s ...
LOMO 3-2014.indd
LOMO 3-2014.indd

... enzyme responsible for hydrolyzing urea into ammonium and carbon dioxide, but only certain microorganisms can synthesize urease. In uremic patients, it has been shown that at high plasma urea concentrations, the fecal urease activity is increased. Thus, the increase in colon bacterial urease is cons ...
iCup®/ iCup® - Drug testing supplies from CLIA waived,Inc, drug tests
iCup®/ iCup® - Drug testing supplies from CLIA waived,Inc, drug tests

... PCP is used in powder, capsule, and tablet form. The powder is either snorted or smoked after mixing it with marijuana or vegetable matter. PCP is most commonly administered by inhalation but can be used intravenously, intra-nasally, and orally. After low doses, the user thinks and acts swiftly and ...
Genetic Diversity of Rhizobium leguminosarum as Revealed
Genetic Diversity of Rhizobium leguminosarum as Revealed

... where the groups did not correspond to geographic location. Similar pattern was previously reported by Yang and Zhou [27] where they found that rhizobia population in China probably originated from those of Japan and North America. The phylogenetic relationship (Fig. 2) showed that isolates from low ...
PDF - Atlas of Genetics and Cytogenetics in Oncology and
PDF - Atlas of Genetics and Cytogenetics in Oncology and

... frequencies (D, H, R) can be used to calculate the allele frequencies (p,q), from : p = D + H/2, q = R + H/2. Whereas, if and only if we are subject to HW, the genotype frequencies can be calculated from the allele frequencies, from D = p2, H = 2pq, R = q2. The dominance relationships between allele ...
674 - The AIDS InfoNet
674 - The AIDS InfoNet

Sequential Elimination of Major-Effect Contributors Identifies
Sequential Elimination of Major-Effect Contributors Identifies

... 1998; Satagopan et al. 2007), many of these strategies have had poor success rates, due to the confounding effects of major loci and epistasis (Flint et al. 2005). In a recent study, a two-stage search strategy was used to first map the major-effect QTL and then to partition segregants on the basis ...
VALIUM brand of diazepam TABLETS Rx Only WARNING: RISKS
VALIUM brand of diazepam TABLETS Rx Only WARNING: RISKS

... mg/m2 basis). Cleft palate and encephalopathy are the most common and consistently reported malformations produced in these species by administration of high, maternally toxic doses of diazepam during organogenesis. Rodent studies have indicated that prenatal exposure to diazepam doses similar to th ...
Guide for Drug Level Monitoring of Commonly Used Medications
Guide for Drug Level Monitoring of Commonly Used Medications

... Note: This reference should be used in conjunction with the appropriate clinical judgment of the health care team How do I interpret a level? Concentrations drawn after a dose typically represent a peak level Trough concentrations are usually drawn within 30 minutes prior to a dose If a level was no ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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