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Genes Identified by Visible Mutant Phenotypes Show Increased Bias
Genes Identified by Visible Mutant Phenotypes Show Increased Bias

... (Zea mays L.) genes which have been the subject of a disproportionate share of publications recorded at MaizeGDB. We manually anchored these ‘‘classical’’ maize genes to gene models in the B73 reference genome, and identified syntenic orthologs in other grass genomes. In addition to proofing the mos ...
Commentary
Commentary

... of a price reduction would be called into question if there were inequalities in marginal costs between the Rx and OTC markets. In this situation, the postswitch price might increase or not be reduced significantly. Accepted for publication February 12, 2002. Printed in the USA. Reproduction in whol ...
Urine Drug Testing Practices - Canadian Nuclear Safety Commission
Urine Drug Testing Practices - Canadian Nuclear Safety Commission

... therapeutically for the control of acute glaucoma and nausea that often accompanies chemotherapy for various forms of cancer. Clinical research studies are investigating the use of marijuana therapeutically using routes of drug administration other than by smoking. Marijuana is abused due to its’ eu ...
Analgesic Drugs
Analgesic Drugs

... of 1914. It originally applied to drugs that produce insensibility or stupor, especially the opioids (e.g., morphine, heroin). Currently used in clinical settings to refer to any medically used controlled substances and in legal settings to refer to any illicit or “street” drug. (NOTE: This term is ...
Product Leaflet - Sivem Pharmaceuticals
Product Leaflet - Sivem Pharmaceuticals

... levels. ...
BPA leaflet testing and inheritance
BPA leaflet testing and inheritance

... and “Drugs and Porphyria” leaflets. Relatives need a genetic test, to find if they have an acute porphyria, so they can avoid the triggers. (Women are particularly at risk hormone changes can help trigger attacks.) This may not prevent attacks entirely but, if the porphyria is known, an attack can b ...
Evidence-Based Pharmacological Treatment of Geriatric Bipolar Disorder Robert C. Young, MD *
Evidence-Based Pharmacological Treatment of Geriatric Bipolar Disorder Robert C. Young, MD *

... thirds of those over the age of 65 were treated with LI, and only 31% were receiving anticonvulsants; the proportion of older patients treated with LI was significantly higher than the proportion of younger patients [14]. Table 1 lists 12 studies that include assessment of LI side effects. These repor ...
summary of product characteristics
summary of product characteristics

... been reported. An interaction study of buprenorphine with ketoconazole (a potent inhibitor of CYP3A4) resulted in increased Cmax and AUC of buprenorphine (approximately 70% and 50% respectively) and, to a lesser extent, of the metabolite, norbuprenorphine. Patients receiving buprenorphine should be ...
Monitored Anesthesia Care with Dexmedetomidine: A
Monitored Anesthesia Care with Dexmedetomidine: A

... 88.9% 关56/63兴, respectively; P ⬍ 0.001 for both comparisons; Table 2). Additionally, significantly higher doses of fentanyl were required for the placebo group during the infusion period compared with both dexmedetomidine 0.5- and 1-␮g/kg treatment groups (144.4 ␮g vs 84.8 and 83.6 ␮g, respectively; ...
Case report / Olgu sunumu AN ACUTE DYSTONIA CASE INDUCED
Case report / Olgu sunumu AN ACUTE DYSTONIA CASE INDUCED

... A patient admitted with complaints of muscle contractions in neck, shoulder and arm which started recently after quetiapine administration. As a result the patient developed dystonia after adding a single dose of 12.5 mg/day quetiapine while taking trazodone and fluoxetine treatment. In this paper w ...
Update of codeine safety and efficacy review
Update of codeine safety and efficacy review

... to admission. 20% of these received codeine. 37% received codeine during the admission. Patients receiving codeine had higher initial pain scores than those who did not. Codeine did not greatly improve the pain scores and 10% required step up analgesia. ...
lycopene in the management of oral submucous fibrosis
lycopene in the management of oral submucous fibrosis

... well as during follow-up. DISCUSSION Oral submucous fibrosis is well known for its chronic and resistant nature. The conservative drug treatment that is currently available for OSF is clearly inadequate. No single drug has provided complete relief of symptoms of OSF 2; this has lead to the use of co ...
The role of the laboratory in treatment with new oral anticoagulants
The role of the laboratory in treatment with new oral anticoagulants

... efficacy and safety will be the same. It is likely that clinicians will consider ‘monitoring’ treatment with a view to dose adjustment in these patients. Examples might include establishing the dose required to achieve average therapeutic levels: 1 in patients at extremes of body weight; 2 in specif ...
Imipramine and Alprazolam Effects on Stress Test Reactivity in
Imipramine and Alprazolam Effects on Stress Test Reactivity in

... Ballenger 1987; Ballenger et al 1988). Certain aspects of the biochemical and neurophysiological mechanisms by which these drugs affect anxiety are understood (Hsiao and Potter 1990), and some information is available on their actions at the psychophysiological levels in humans. Anxiolytic drugs wou ...
Management of malignant ventricular arrhythmias and cardiac arrest
Management of malignant ventricular arrhythmias and cardiac arrest

... survival in a high-risk group of patients (21). Patients with a previous myocardial infarction, a LVEF ⬍35%, and nonsustained ventricular tachycardia underwent electrophysiologic testing. Patients with inducible sustained ventricular tachycardia not suppressed with intravenous procainamide were sele ...
TAG Mail 2 December 2015 The purpose of TAG Mail is to assist
TAG Mail 2 December 2015 The purpose of TAG Mail is to assist

... 3rd International Short Film and Photography Festival, May 2016 The participants' short films and photos should cover one of the following issues: - Primary health care understood as the essential health care accessible to all individuals and families in the community by means acceptable to them, wi ...
Chapter 5. Genetic Interactions and Pathways
Chapter 5. Genetic Interactions and Pathways

... understand the architecture of the pathway in which they act. To order genes within a pathway, we will describe methods for genes that act as switches in regulatory pathways and genes that interact in a metabolic pathway, as the logic used to order genes in these types of pathways differ. Included i ...
Clinical Evaluation of Topical Application of Doxycycline 3% +
Clinical Evaluation of Topical Application of Doxycycline 3% +

... Medical history was recorded for the selected patients, also all the clinical periodontal parameters were noted at the baseline which was followed by SRP. In each patient, on the completion of SRP, selected sites with probing depths more than 4 mm were randomly designated to either the A or B group, ...
Poster presentation
Poster presentation

... Introduction/Background Chloroquine has been very valuable for the chemotherapy of malaria for several decades by virtue of its safety, wide availability and affordability. However, chloroquine is fast becoming ineffective in the management of malaria due the development of chloroquine resistant pl ...
Sibutramine - Practical Diabetes
Sibutramine - Practical Diabetes

... Key points • Sibutramine is a drug that can be used to facilitate weight loss in obese patients, including those with type 2 diabetes mellitus • The response to treatment should be reviewed on a regular basis and the drug discontinued if no efficacy is demonstrated • Although side effects of increas ...
Physiological Genomics of Antidepressant Targets: Keeping the
Physiological Genomics of Antidepressant Targets: Keeping the

... identification of genetic variants that actually change the structure of SERT proteins and lead to demonstrable f unctional variation in 5-HT transport activity would be exceedingly usef ul in understanding how SERT dysf unction supports disease states. To date studies searching for coding variants ...
Antibiotic Resistance in Acne Treatment
Antibiotic Resistance in Acne Treatment

... carriage rates in the nose, and resistance increased significantly and substantially in the treated group versus patients receiving vehicle (63% vs. 37%) by the end of the treatment period.22 For all the potentially pathogenic organisms that develop resistance to anti-acne antibiotics, the question ...
Formulation and evaluation of Pseudoephedrine hydrochloride and
Formulation and evaluation of Pseudoephedrine hydrochloride and

... parameters such as area, hardness, surface characteristics and size can significantly affect the rate of dissolution of drugs contained in a complex system. The selection of wet granulation technique for matrix tablet preparation was based on previously reported study which suggested that wet granul ...
MEDROL  PRESENTATION Methylprednisolone (4 mg or 100 mg) tablets
MEDROL PRESENTATION Methylprednisolone (4 mg or 100 mg) tablets

... of corticosteroid is administered every other morning. The purpose of this mode of therapy is to provide a patient requiring long-term pharmacologic dose treatment with the beneficial effects of corticoids while minimising certain undesirable effects, including pituitary-adrenal suppression, the Cus ...
Use of the C4.5 machine learning algorithm to test a clinical
Use of the C4.5 machine learning algorithm to test a clinical

... DSS reasoning. The knowledge extracted from the DSS was represented using rules and decision lists as alternatives to decision trees. Rules were more verbose than the tree. The decision list was a little more concise, but it was easier to compare the tree with the textual CG, due to the tree-like se ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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