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LETTERS
LETTERS

... COX-2 inhibitors should reduce their activity and also should act synergistically with the antiplatelet activity of COX-1 inhibitors. A clinical trial of a selective COX-2 inhibitor plus aspirin (an irreversible COX-1 inhibitor), compared with aspirin alone, would be of great interest. Furthermore, ...
INVESTIGATION OF WEIGHT GAIN AMONG PSYCHOTIC
INVESTIGATION OF WEIGHT GAIN AMONG PSYCHOTIC

... with long term treatment with these drugs. In a randomized 5 month study of the effects of the olanzapine and risperidone on metabolic changes in chronic schizophrenic patients ,appetite changes were assessed using two scales and were correlated with weight gain and metabolic changes .There is evid ...
public exam_basic genetics_R1
public exam_basic genetics_R1

... They are non-identical twins because their blood groups are different, implying that they are genetically different ...
Full Prescribing Information including BOXED WARNING
Full Prescribing Information including BOXED WARNING

... large apparent volume in the body (>700 L), suggesting extensive distribution into tissues. Concentrations in lung, kidney, liver, bone, stomach, spleen and muscle were found to be two to three times higher than corresponding concentrations in plasma, and the uptake into keratinous tissues, skin in ...
Genome-wide association studies for complex traits: consensus
Genome-wide association studies for complex traits: consensus

... the allelic architecture of multifactorial traits. At the same time, much has been learned about the successful prosecution of association studies on such a scale. This Review highlights the knowledge gained, defines areas of emerging consensus, and describes the challenges that remain as researcher ...
0.9% Sodium Chloride Injection, USP
0.9% Sodium Chloride Injection, USP

... Plasma electrolyte concentrations should be closely monitored in the pediatric population because of their impaired ability to regulate fluids and electrolytes. Geriatrics Clinical studies of 0.9% Sodium Chloride injection, USP did not include sufficient numbers of subjects aged 65 and over to deter ...
role of biodegradable polymers in drug delivery
role of biodegradable polymers in drug delivery

... degradable in vivo, either enzymatically or nonenzymatically, to produce biocompatible or nontoxic by-products. These polymers can be metabolized and excreted via normal physiological pathways. They are classified into three groups, namely natural, semi synthetic, and synthetic, based on their sourc ...
A stability indicating RP-HPLC method for the determination of
A stability indicating RP-HPLC method for the determination of

... sensory neuropathy, chronic fatigue syndrome and painful paresthesias related to multiple sclerosis. Typically lower dosages are required for pain modification of 10 to 50 mg daily. A randomized controlled trial published in June 2005 found that amitriptyline was effective in functional dyspepsia th ...
public exam_basic genetics_R1
public exam_basic genetics_R1

... They are non-identical twins because their blood groups are different, implying that they are genetically different ...
Product Monograph Template - Standard
Product Monograph Template - Standard

... countries with mainly Caucasian populations, these reactions are estimated to occur in 1 to 6 per 10,000 new users, but in some Asian countries (e.g., Taiwan, Malaysia and the Philippines) the risk is estimated to be about 10 times higher. Human Leukocyte Antigens (HLA)-A*3101 and HLA-B*1502 may be ...
ABC Clinical Guide 2003.qxd - American Botanical Council
ABC Clinical Guide 2003.qxd - American Botanical Council

... quite safe, some authorities recommend that patients with high blood pressure (especially greater than 180/90) should consult a healthcare provider before using eleuthero. It should not be used during the acute phase of infections, although it may be used concurrently with antibiotics for the treatm ...
Investigator Time and Perceived Value – Workstream 2 Summary of
Investigator Time and Perceived Value – Workstream 2 Summary of

... 63 agreements to complete the data forms were obtained and assigned a site ID and blinded data forms Each of these 63 were contacted/reminded ~6 times 5 prospective data sets were returned 6 retrospective data sets were returned ...
Indigenous Peoples - Council for Responsible Genetics
Indigenous Peoples - Council for Responsible Genetics

... People inherit a mix of genes from each of their parents. Each of your genes is present in two copies. One copy comes from your mother, and the other copy from your father, but the two copies do not always have an equal impact on your biology. This can contribute to your being more like your father ...
Document
Document

... The CATALYST is to be done independently and silently. Answer the following questions in your notebook: ...
PAMAM Dendrimer Conjugates for Intracellular Delivery of N
PAMAM Dendrimer Conjugates for Intracellular Delivery of N

... investigation of its other therapeutic applications. Even though NAC proved to be a very therapeutic drug, delivery problems remain. The stability of NAC is low which increases the effective dose required. The high protein binding is another problem associated with NAC therapies since it affects act ...
PERCOCET Tablets Rx only Prescribing Information DESCRIPTION
PERCOCET Tablets Rx only Prescribing Information DESCRIPTION

... administration. With overdosage, absorption is complete in 4 hours. Paracetamol is relatively uniformly distributed throughout most body fluids. Binding of the drug to plasma proteins is variable; only 20% to 50% may be bound at the concentrations encountered during acute intoxication. Metabolism an ...
Extensions and Modifications of Basic Principles
Extensions and Modifications of Basic Principles

... In 1983, a molecular geneticist at Massachusetts General Hospital named James Gusella determined that the gene causing Huntington disease is located near the tip of the short arm of chromosome 4. Gusella determined its location by analyzing DNA from members of the largest known family with Huntingto ...
Activity of Argyreia speciosa and Acorus calamus
Activity of Argyreia speciosa and Acorus calamus

... and are still the most widely used group of pharmacological agents. From the vast array of materia medica of the indigenous system, many plants have been reported to have activity against CNS disorders and act as very useful remedies for the alleviation of human suffering [3]. Increasing number of p ...
A look at Marijuana in 2014 - University of Nevada, Reno School of
A look at Marijuana in 2014 - University of Nevada, Reno School of

... - Medicinal cannabis extract indicated for the relief of multiple sclerosis (MS) symptoms and the treatment of severe neuropathic-related cancer pain. • Epidiolex, a CBD-based drug recently created to treat certain forms of childhood epilepsy. It has not gone through clinical trials yet in the U.S. ...
Update on Alcohol, Other Drugs, and Health
Update on Alcohol, Other Drugs, and Health

... Interestingly, consumption amounts did not increase even as AUD symptoms doubled. This is counterintuitive, since consumption and AUD are usually correlated, and since people who experience alcohol effects at lower amounts are less likely to develop problems. It may be that more frequent use with mo ...
St. John`s Wort
St. John`s Wort

... Although St. John’s Wort is widely used and accepted in Europe, specifically Germany, it is not FDA approved in the United States for medical purposes Since it is not regulated in the U.S., there is no regulatory oversight of the manufacturing, distributing and labeling of St. John’s Wort, therefore ...
cutting edge - Amazon Web Services
cutting edge - Amazon Web Services

... have been possible without the support of several amazing and talented people. I’d especially like to express my gratitude to Janis ...
Incretin based therapy in type 2 diabetes
Incretin based therapy in type 2 diabetes

... cases of hemorrhagic or necrotizing pancreatitis in patients using sitagliptin, were reported to the Agency between October 16, 2006 and February 9, 2009.  FDA recommended that healthcare professionals should monitor patients carefully for the development of pancreatitis after initiation or dose in ...
Table of Common Herbs and Supplements
Table of Common Herbs and Supplements

... H/A, rash, dizziness Bleeding, bruising ↑risk CVA Mastalgia, uterine bleeding ↑risk hormone-associated female cancers Hepatotoxicity Drug Interactions CYP 450 2D6 drugs Anticoagulant drugs ↑ bleeding from salicylate ingredient Antihypertensives-↓BP Hepatotoxic drugs→liver failure Chemotherapeutic dr ...
Therapeutic Interchange Policy (TIP)
Therapeutic Interchange Policy (TIP)

... (Updated Mar 2015)* The following interchanges have been implemented to ensure rational use of select drugs, to decrease drug expenditures, and to allow interpretation of orders when the strength or dosage form is not indicated or not available. In exceptional clinical situations, the physician may ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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