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At the end of this unit, the student should be... 1. Convert pounds to kilograms.
At the end of this unit, the student should be... 1. Convert pounds to kilograms.

... Recognize if the drug is safe to administer by comparing the RSD to the ordered dose. Calculate the safe dosage using kilograms of body weight. Calculate the amount of drug to be administered. Interpret information on a drug label. Question whether to administer or withhold a medication due to unsaf ...
design and evaluation of controlled release tablets of
design and evaluation of controlled release tablets of

... (PEG rate of 88.50%). Therefore, they suggested PEG rate of about 90–150% for matrix tablet formulations, and the exact ratio could be formulated according to the resulting table.6 (2010) Larsson et al., have reported four different HPMC batches and characterized properties related to critical func ...
(oxycodone HCL 10 mg, paracetamol 325 mg)
(oxycodone HCL 10 mg, paracetamol 325 mg)

... established; thus, women who are planning to become pregnant or are pregnant should consult with their physician before taking PERCOCET tablets. 8. Nursing mothers should consult with their physicians about whether to discontinue nursing or discontinue PERCOCET tablets because of the potential for s ...
Genetic variation of ApoB 3′ hyper variable region polymorphism
Genetic variation of ApoB 3′ hyper variable region polymorphism

... of Indian populations for carrying out population studies at the genetic level, linkage analysis and forensic purposes. The two subpopulations selected for the present study, viz. Bhargavas and Chaturvedis follow strict surname endogamy. However, within the group exogamy is followed at gotra level a ...
package insert
package insert

... anticoagulation, coagulation tests suitable for the anticoagulant used (e.g., aPTT and anti-Factor Xa activity) are to be performed regularly, at close intervals, and in particular in the first hours following the start or withdrawal of ATryn. Additionally, monitor the patients for the occurrence of ...
Successful cases of Traceability in the Healthcare Sector in
Successful cases of Traceability in the Healthcare Sector in

... subject of a wide and productive development. Its implementation defined an important paradigm change for the market and especially, for the surveillance of the distribution of drugs at a federal level. The interaction with the system increases exponentially and speaks of the commitment of the diffe ...
Progress in Drug Delivery to the Central Nervous System by the
Progress in Drug Delivery to the Central Nervous System by the

... transporters have been identified in boundary tissues between blood and CNS compartments. Some of them are involved in the active supply of nutrients and have been ...
Antiobesity Pharmacotherapy for Patients with Type 2 Diabetes
Antiobesity Pharmacotherapy for Patients with Type 2 Diabetes

... The US Food and Drug Administration (FDA) approved the following drugs for use in adults with a BMI ≥30 (obese) or ≥27 (overweight) who had at least one weight-related condition such as type 2 diabetes, hypertension, or dyslipidemia. Orlistat Orlistat is a gastrointestinal lipase inhibitor that redu ...
Germline Working Group Status
Germline Working Group Status

... Abacavir – HLA-B57:01 • Approximately 6% of European ancestry patients are hypersensitive to Abacavir • Hypersensitivity can produce life threatening reaction • Genetic test can predict hypersensitivity Martin et al, 2012 CPIC Guidelines ...
No Slide Title
No Slide Title

... Another Example: Analyzing tightly linked SNPs: SNPs (single nucleotide polymorphisms) tend to be more stable and more abundant than microsatellite markers. They are predominately biallelic, so we would like to use several tightly linked markers simultaneously to increase the overall information co ...
Pain Assessment and Management in Companion Animals
Pain Assessment and Management in Companion Animals

... of acute and post-surgical pain. NSAID analgesia is mediated through both peripheral (anti-inflammatory/anti-peripheral sensitisation) and central (anti-central sensitisation) mechanisms. NSAIDs complement the analgesic effects of opioids; they are generally long acting and have good bioavailability ...
Comparison of antiepileptic drug prescribing in children in three
Comparison of antiepileptic drug prescribing in children in three

... limited data available at present Similarly, a Dutch study using a pharmacy prescription database (InterAction database) has also reported that the use of lamotrigine among youth aged 0–19 years has increased between 1997 and 2005 (van de Vrie-Hoekstra et al., 2008). Another study analyzed data from ...
Suboxone Patient Packet - Beaumont Behavioral Health
Suboxone Patient Packet - Beaumont Behavioral Health

...  After the first hour, many people say they feel pretty good for most of the day. Responses to SUBOXONE will vary based on factors such as tolerance and metabolism, so each patient’s dosing is individualized. Your doctor may increase your dose of SUBOXONE during the first week to help you from feel ...
Cardiovascular Active Medications
Cardiovascular Active Medications

... Cardiovascular Active Medications Drug dose calculations • Not all drugs labeled in a uniformed manner • Drugs labeled z % contains z gram/dl e.g mannitol 20% • Concentration given as a ratio e.g epinephrine1:10.000. bupi. 0.5% + epinephrine 1:200.000 means 5μg for each ml ...
A summary of the health harms of drugs
A summary of the health harms of drugs

... Volatile inhalants ...
Therapeutic Agents for Alzheimer`s Disease
Therapeutic Agents for Alzheimer`s Disease

... (Nemenda; Forest) are either acetylcholinesterase or N-methyl-D-aspartate antagonists. These are only palliative solutions, however, and side effects remain an important concern. Clearly, the search for more potent and effacious drugs for the treatment of AD is one of the most pressing pharmacologic ...
Medication-Assisted Treatment for Opiate Use Disorders
Medication-Assisted Treatment for Opiate Use Disorders

... The CRAFFT screen for youth-Part B C - Have you ever ridden in a CAR driven by someone (including yourself) who was "high" or had been using alcohol or drugs? R - Do you ever use alcohol or drugs to RELAX, feel better about yourself, or fit in? A - Do you ever use alcohol/drugs while you are by you ...
SNP Discovery and Genotyping Workshop (PowerPoint)
SNP Discovery and Genotyping Workshop (PowerPoint)

... 2. SNP Selection: How do I choose SNPs that are informative? (i.e. assessing SNP correlation - linkage disequilibrium) 3. SNP Associations: What analyses can I perform after genotyping these SNPs? (e.g. single SNP data, haplotype data) 4. SNP Replication/Function: ...
Whole Exome Re-Sequencing Implicates CCDC38 and
Whole Exome Re-Sequencing Implicates CCDC38 and

... association with lung function in genome-wide association studies, eleven have been reported to show association with airflow obstruction. Although the main risk factor for COPD is smoking, some individuals are observed to have a high forced expired volume in 1 second (FEV1) despite many years of he ...
Heredity
Heredity

... Mendel collected data for 7 pea traits ...
Metal-Based Therapeutics for Leishmaniasis
Metal-Based Therapeutics for Leishmaniasis

... resistance development is so high (up to 65%) that these drugs are becoming obsolete. Although acquired resistance is the most limiting factor for the application of pentavalent antimonials, these drugs present other important drawbacks such as low efficacy for some forms of leishmaniasis and toxic ...
Book Chapters, Monographs, Books
Book Chapters, Monographs, Books

... 20. Heinzerling K., Shoptaw S., Peck J., Yang X., Liu J., Ling W., (2006) Randomized, Placebo-Controlled Trial of Baclofen and Gabapentin for the Treatment of Methamphetamine Dependence. Drug and Alcohol Dependence May 29 21. Larkins S, Reback CJ, Shoptaw S. (2006) HIV risk behaviors among gay male ...
VI.2 Elements for a Public Summary
VI.2 Elements for a Public Summary

... Worldwide about 5 million people are affected by Parkinson’s disease. Most individuals who develop Parkinson's disease are 60 years of age or older. Parkinson's disease occurs in approximately 1% of individuals aged 60 years and in about 4% of those aged 80 years. Since overall life expectancy is ri ...
Significance of “beta blocker rebound phenomenon” and
Significance of “beta blocker rebound phenomenon” and

... drugs used in cardiology. The list of BBs’ adverse effects is longer than any of other antihypertensive medications [2]. In many patients this may result in the idea to quit BB therapy, and it commonly occurs in a wrong way (without dose tapering). Thus, whatever the cause of mistake (patient is not ...
Genetic Research and Testing in Sport and Exercise Science
Genetic Research and Testing in Sport and Exercise Science

... Genetic testing might in future also be used to identify those who are most likely to benefit medically from exercise programmes. Such tests might be developed if we were to identify for example genetic variants that determine the magnitude of the reduction in glucose, blood pressure or cholesterol ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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