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Corneal dystrophies in Japan
Corneal dystrophies in Japan

... (LCDIIIA), was found in Japanese patients (Yamamoto et al. 1998). In our study, four members of a family with GDLD were recorded. However, there were no symptoms of LCDIIIA, even in the 85-year-old father (Ha et al. 2000). Proband with GDLD has two kinds of mutations, homozygous Q118X of the M1S1 ge ...
Printable version
Printable version

... began with crosses where he followed the inheritance of one trait. Although he didn’t know it, each trait he studied was controlled by one gene locus (a single pair of alleles.) This type of cross is called a monohybrid cross. „ For example, Mendel followed the inheritance of flower color, which exi ...
guidelines on male lower urinary tract symptoms (luts)
guidelines on male lower urinary tract symptoms (luts)

... higher PSA concentration, advanced age). Combination treatment is better than monotherapy at reducing symptoms and improving Qmax, and better than α1-blockers at reducing the risk of acute urinary retention and the need for surgery. The α1-blocker may be discontinued after 6 months in men with moder ...
Overview of Drug Testing Methods I: ADME - BIDD
Overview of Drug Testing Methods I: ADME - BIDD

... „Every human differs (more or less) “ The phenotype can be distinguished by the actual activity or the amount of the expressed CYP enzyme. The genotype, however, is determined by the individual DNA sequence. Human: two sets of chromosomes ...
Misc topic, Medicine and Drugs
Misc topic, Medicine and Drugs

... Other drugs work in the opposite way--as antagonists. These drugs bind to the receptor, but do not produce a response. Because the drug prevents the receptor from binding to the normal hormone or neurotransmitter, it has an inhibitory effect on the naturally occurring substance. Examples of antagoni ...
Section 34_Addiction Medications 2_68 slides
Section 34_Addiction Medications 2_68 slides

... in controlled studies has been mild in intensity and of short duration The likelihood for buprenorphineprecipitated withdrawal is low, and even when it does occur, it is mild in intensity and short in duration ...
File - Lauren Watson
File - Lauren Watson

tetrahydrogestrinone (THG)
tetrahydrogestrinone (THG)

... periods up to 12 days in direct comparison to testosterone propionate (o.1mg/animal/day s. c.): THG induced (a dose dependent) androgenic effect on prostate and vesicular seminales parameters and LH serum levels in doses of 1,3,10mg/animal. This androgenic stimulation could be antagonized by the sim ...
Formulation and Evaluation of Fenofibrate Tablets Using
Formulation and Evaluation of Fenofibrate Tablets Using

... Fenofibrate is a drug of the fibrate class. It is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. Like other fibrates, it reduces both low-density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels, as well as increasing high-density lipoprotein ...
N Engl J Med, 2015, 373: 511-520
N Engl J Med, 2015, 373: 511-520

... Idarucizumab [package insert]. Available at: http://www.uptodate.com/contents/ idarucizumab-druginformation?source =search_result&search=idarucizumab&selectedTitle =1~16. Accessed February 17, 2016. Nitzki-George, D, Wozniak I, Caprini, J. Current State of Knowledge on Oral Anticoagulant Reversal Us ...
Educational Items Section Hardy-Weinberg model Atlas of Genetics and Cytogenetics
Educational Items Section Hardy-Weinberg model Atlas of Genetics and Cytogenetics

... not, the genotype frequencies (D, H, R) can be used to calculate the allele frequencies (p,q), from : p = D + H/2, q = R + H/2. Whereas, if and only if we are subject to HW, the genotype frequencies can be calculated from the allele frequencies, from D = p2, H = 2pq, R = q2. The dominance relationsh ...
Microbiology Guide to Interpreting Minimum Inhibitory Concentration
Microbiology Guide to Interpreting Minimum Inhibitory Concentration

... Next to each antibiotic is the susceptibility interpretation: S (sensitive), I (intermediate) or R (resistant), followed by the MIC in μg/ml. Sensitive implies that the organism is inhibited by the serum concentration of the drug that is achieved using the recommended dosage; intermediate includes i ...
Beta Blockers in Mental Retardation and Developmental Disorders
Beta Blockers in Mental Retardation and Developmental Disorders

... were able to be reduced during propranolol treatment.) Fourth, only 4 of the 11 studies employed some objective measures to assess change in aggression, and none used such indices to assess preto postmedication effects for all subjects. This lack of objective measurements undermines confidence in th ...
AGGRENOX Prescribing Information
AGGRENOX Prescribing Information

... Because AGGRENOX contains aspirin, counsel patients who consume three or more alcoholic drinks every day about the bleeding risks involved with chronic, heavy alcohol use while taking aspirin. 5.2 Renal Failure Avoid aspirin in patients with severe renal failure (glomerular filtration rate less than ...
Supplementary Data The complete 12 Mb genome and
Supplementary Data The complete 12 Mb genome and

... gene-sets were defined by searching RAST results by subsystem or gene function. Colours indicate the type of gene-set: secondary metabolism (green), central/intermediary metabolism (yellow), genes located on an extrachromosomal element (purple) and tRNA genes (orange). ...
Chapter 5 Drug Labels and Package Inserts
Chapter 5 Drug Labels and Package Inserts

...  Powder forms of drugs must be reconstituted by adding a liquid for administration before you can give the drug.  Directions for reconstituting are on the label.  Label indicates the time period within which they can be safely ...
CHAPTER e50 Poisoning and Drug Overdosage - McGraw
CHAPTER e50 Poisoning and Drug Overdosage - McGraw

... discovery may reveal a suicide note or a container of drugs or chemicals. The imprint code on pills and the label on chemical products may be used to identify the ingredients and potential toxicity of a suspected poison by consulting a reference text, a computerized database, the manufacturer, or a ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These
HIGHLIGHTS OF PRESCRIBING INFORMATION These

... significant increase in bupropion and naltrexone systemic exposure [see Warnings and Precautions (5.3) and Clinical Pharmacology (12.3)]. Patients may develop elevated blood pressure or heart rate during CONTRAVE treatment; the risk may be greater during the initial three months of therapy [see Warn ...
The following are pertinent excerpts from the report prepared by
The following are pertinent excerpts from the report prepared by

... Depot is hot flashes. Like other treatment options, LH-RH analogs may cause impotence. Symptoms may worsen over the first few weeks of treatment" . For precocious puberty: "In clinical studies, the most frequent adverse event related to therapy with Lupron Depot-PED was an injection site reaction, s ...
Présentation PowerPoint - European Atherosclerosis Society
Présentation PowerPoint - European Atherosclerosis Society

... Risk factor screening including the lipid profile should be considered in men >40 years old and in women >50 years of age or post-menopausal. A risk estimation system such as SCORE can assist in making logical management decisions, and may help to avoid both under- and overtreatment. Certain individ ...
The following are pertinent excerpts from the report prepared by
The following are pertinent excerpts from the report prepared by

... Depot is hot flashes. Like other treatment options, LH-RH analogs may cause impotence. Symptoms may worsen over the first few weeks of treatment" . For precocious puberty: "In clinical studies, the most frequent adverse event related to therapy with Lupron Depot-PED was an injection site reaction, s ...
GIST clinical trials - The Life Raft Group
GIST clinical trials - The Life Raft Group

... Available in other countries via a “Treatment use protocol” administered by EmergingMed (1-800-620-6104) Phase II continuous use trial is closed New phase IIIb trial will test 800 mg Gleevec vs. continuous use Sutent (37.5 mg) in GIST that is resistant to 400 mg Gleevec. ...
The following are pertinent excerpts from the report
The following are pertinent excerpts from the report

... Depot is hot flashes. Like other treatment options, LH-RH analogs may cause impotence. Symptoms may worsen over the first few weeks of treatment" . For precocious puberty: "In clinical studies, the most frequent adverse event related to therapy with Lupron Depot-PED was an injection site reaction, s ...
gastrointestinal agents - Magellan Health Services || TennCare Portal
gastrointestinal agents - Magellan Health Services || TennCare Portal

... for prescription drugs for the TennCare program. o The TennCare Pharmacy Advisory Committee shall submit to the bureau of TennCare both specific and general recommendations for drugs to be included on any state PDL adopted by the bureau. In making its recommendations, the committee shall consider fa ...
Chapter 5 Drug Labels and Package Inserts
Chapter 5 Drug Labels and Package Inserts

...  Powder forms of drugs must be reconstituted by adding a liquid for administration before you can give the drug.  Directions for reconstituting are on the label.  Label indicates the time period within which they can be safely ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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