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and Paul J. Seligman, MD, MPH
and Paul J. Seligman, MD, MPH

... of the COX-2 selective NSAIDs is derived from a small number of long-term placebo- and active-controlled clinical trials in patients with arthritis or in the disease prevention setting. We will briefly summarize the available data from the long-term controlled clinical trials for the three approved ...
What Is The “Safest” Non-Steroidal Anti
What Is The “Safest” Non-Steroidal Anti

... Abstract: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) which are widely used in clinical practice are also very well-known for their various adverse reactions. Each NSAID has its own unique safety profile and selecting an appropriate NSAID must be individualized for each patient based on his or he ...
Document
Document

... These two alleles are inherited, one parent If the offspring from each _______. receives a dominant allele from one parent, that dominant trait will ...
dbl™ adrenaline injection 1:10000
dbl™ adrenaline injection 1:10000

... Syncope has occurred following administration to asthmatic children. In patients with Parkinsonian syndrome the drug increases rigidity and tremor. Intra-arterial administration should be avoided since marked vasoconstriction may result in gangrene. Intramuscular injection into the buttocks should b ...
ANTI-ARRHYTHMIC DRUGS
ANTI-ARRHYTHMIC DRUGS

... More marked cardiac antimuscarinic effects than quinidine → slows AV conduction ...
020-Addiction (Psychological Disorders)
020-Addiction (Psychological Disorders)

... others, perhaps because the initial phases of circuit-building provided a better base, just like the architecture of houses may differ in terms of their functionality. We are working to understand the brain structure and function that result from the powerful combination of genes building the initia ...
Genetic diversity and connectivity shape herbivore load within an
Genetic diversity and connectivity shape herbivore load within an

... diversity in both years and both spatial scales examined. Spatial connectivity of hosts increased herbivore diversity as well as abundance. While the similarity of herbivore communities increased with the genetic similarity among hosts, the effect of geographic distance was stronger. Overall, our fi ...
How to order genetic testing for Hemophilia A and B
How to order genetic testing for Hemophilia A and B

... Testing for hemophilia is not entirely straightforward, for reasons we’ll get into soon. I also work in a laboratory that performs this diagnostic testing, and in my experience, about a quarter of the orders we receive for a test specific to severe hemophilia A are cancelled because we find out the ...
Antiviral Drugs for Viruses Other Than Human Immunodeficiency Virus
Antiviral Drugs for Viruses Other Than Human Immunodeficiency Virus

... is often self-limited, and antiviral treatment is generally not recommended.7 However, oral acyclovir may be indicated for severe cases, for those with recurrent orolabial herpes, and in those who are immunocompromised.7,8 Intravenous acyclovir is the first-line treatment for HSV encephalitis9 and s ...
Question paper - Unit F225/01 - Genetics, control and ageing
Question paper - Unit F225/01 - Genetics, control and ageing

... (b) The gene which determines the ABO blood group of a person is located on chromosome 9. The gene responsible for nail patella syndrome is also located on this chromosome. Fig. 1.1 is a diagram showing an event which takes place during meiosis. The letters D to H represent the loci of some of the g ...
Lactulose and Ispaghula Husk Granules
Lactulose and Ispaghula Husk Granules

... Lactulose is a synthetic disaccharide that consists of fructose and galactose. As there is no corresponding disaccharidase in the human intestinal mucosal cells, Lactulose is not split in the small intestine and therefore it is not absorbed. In the colon it is metabolized to organic acids in short c ...
Room Temperature Stable Formoterol Metered Dose
Room Temperature Stable Formoterol Metered Dose

... change out to 6 months (and minimal variability), when this data is evaluated in accordance with the International Committee of Harmonisation (ICH) guidelines[4], the system would not require refrigerated storage and would have a shelf life of at least 12 months ambient/in use period. The data at 40 ...
Acinetobacter R E V I E W S O F A... I N V I T E D A R T... Joel Fishbain
Acinetobacter R E V I E W S O F A... I N V I T E D A R T... Joel Fishbain

... A. baumannii is often identified in the sputum samples of patients with mechanical ventilation. This quandary of pathogenicity has added to the difficulty of treating these highly resistant organisms, because many therapeutic strategies are associated with significant toxicity. The in-hospital attri ...
Judy Leung
Judy Leung

... in Hanoi, followed World Health Organization guidelines in her treatment of patients but concluded it had no effect on the disease. "We place no importance on using this drug on our patients," she said. "Tamiflu is really only meant for treating ordinary type A flu. It was not designed to combat H5N ...
Beta-agonists • friends or foes? C-G. ofdahl, N .Svedmyr L
Beta-agonists • friends or foes? C-G. ofdahl, N .Svedmyr L

... in the population during this 10 yrs period. This study was performed as a case-control investigation with a matched control group within this population without any fatal or near fatal events. An increased odds ratio was found, as expected, for death and near death events for most drugs used in ast ...
The JNC 7 Report Prevention, Detection, Evaluation, and Treatment
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... the key messages: (1) In persons older than 50 years, systolic blood pressure (BP) of more than 140 mm Hg is a much more important cardiovascular disease (CVD) risk factor than diastolic BP; (2) The risk of CVD, beginning at 115/75 mm Hg, doubles with each increment of 20/10 mm Hg; individuals who a ...
No Slide Title
No Slide Title

... Allopurinol (Zyloprim™) •inhibitor of xanthine oxidase •effectively blocks formation of uric acid •how supplied - 100 mg & 300 mg tablets •pregnancy category C **Drugs are characterized according to their effects on pregnancy (fetus) into several categories A,B,C,D,X. A is the safest, X: completely ...
- Journal of Stroke and Cerebrovascular Diseases
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... of patient age, sex, and the severity of the stroke. Treatment in a stroke unit was not associated with an extended hospital stay. Analysis of prespecified subgroups in the ICTUS (Fig 2) demonstrated a possible beneficial effect of citicoline compared with placebo in patients not treated with rt-PA ...
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... one patient, and little or none in another ...
Herbal CNS stimulants - International Journal of Herbal Medicine
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... CNS stimulants are the psychoactive drugs which induce temporary improvements in mental and physical function by enhancing the activity of central nervous system (CNS). They provide great benefits for a range of disorders but still they are widely used as illicit substances of abuse. Amphetamine and ...
In vitro metabolism and drug-drug interaction potential of irosustat, a
In vitro metabolism and drug-drug interaction potential of irosustat, a

... developed with these sites of metabolism blocked, thereby slowing metabolic clearance. A second possible consequence of drug metabolism is the formation of active metabolites (those having the desired activity to an extent similar to/or greater than the parent drug). In some of these cases, the drug ...
Genetic Control of Canine Hip Dysplasia
Genetic Control of Canine Hip Dysplasia

... Figure 1—The objective of any diagnostic test for genetic disease is to lower the frequency of “bad genes” in the gene pool. This entails using the results of the genetic test, the phenotype, to estimate the genotype. Dogs are permitted to enter the gene pool based on normal results of the test (arr ...
Clinical Concepts - Addiction Treatment Forum
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... to be a distinguishing factor between groups. Buprenorphine-treated patients were significantly (P < 0.0001) younger than those receiving either LAAM or methadone. Younger patients have been suggested as a primary target population for buprenorphine (as also noted in the news articles mentioned abov ...
FORMULATION AND EVALUATION OF OXICONAZOLE NITRATE
FORMULATION AND EVALUATION OF OXICONAZOLE NITRATE

... increase the residence time of OXZ in the vagina. This purpose can be achieved by gelling of the OXZ using bioadhesive gelling agent. A gel can be described as the cross-linked material that retains a large amount of solvent inside its medium and if the solvent retained in organic one, such material ...
Product Monograph - Ask Novartis Pharma
Product Monograph - Ask Novartis Pharma

... Overall incidence of atrial fibrillation in the 3-year postmenopausal osteoporosis trial (HORIZON-PFT) using ACLASTA® (zoledronic acid) 5 mg dose yearly, was 2.5% (96 out of 3,862) and 1.9% (75 out of 3,852) in patients receiving zoledronic acid and placebo, respectively. The rate of atrial fibrilla ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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