• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
New Insights into the Statin-Cholesterol Controversy
New Insights into the Statin-Cholesterol Controversy

... Statins, Cholesterol, and Therapeutic Efficacy ...
Genetic identification of AChE as a positive modulator of addiction to
Genetic identification of AChE as a positive modulator of addiction to

... with 58% of the time spent in the brown compartment). (B) Habituation curve. Percentage of time spent in the brown versus the white compartment [see (A)] in 15 min measurements over 5 consecutive days (one trial per day). Each bar represents the average of five fish, with standard errors indicated. Th ...
ANTIVIRAL AGENTS pharm
ANTIVIRAL AGENTS pharm

... Viruses are obligate intracellular parasites; their replication depends on primarily on systemic processes of the host cell. most anti-viral agents have proved of little use therapeutically since the virus uses host-cell metabolic reactions and thus, for the most part, anti-viral agents will also be ...
practical approach to medical management of glaucoma
practical approach to medical management of glaucoma

... 35% REDUCTION • Prostaglandin analogues • Latanoprost 0.005% requires cold chain except new Latoprost RT. • Bimatoprost 0.03% most effective of all PG analogues but more side effects, hyperemia, trichomegaly, darkening of lids and iris pigmentation. • Travoprost 0.004% ...
Anti-inflammatory and Analgesic Activity of Methanolic Extract of
Anti-inflammatory and Analgesic Activity of Methanolic Extract of

... Analgesics are drugs that selectively relieve pain by acting in the CNS or on peripheral pain mechanisms, without significantly altering consciousness. Analgesics relieve pain, without affecting its cause. Analgesics are divided into two groups, opioid analgesic and non-opioid analgesic [3]. The use ...
Hydrocodone Bitartrate and Acetaminophen Tablets USP 5 mg/325
Hydrocodone Bitartrate and Acetaminophen Tablets USP 5 mg/325

... hypersensitivity and anaphylaxis associated with use of acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention. ...
drug delivery
drug delivery

... • The AngioSculptX catheter is intended to treat a single lesion in a single patient; do not re-use the AngioSculptX catheter to dilate additional lesions. • Prior to angioplasty, examine the catheter to verify functionality, catheter integrity and to ensure that its size and length are suitable f ...
8th grade Chapter 8
8th grade Chapter 8

... B. The alleles within the gametes of one parent are written across the top of the square. C. The alleles within the gametes of the other parent are written down the side of the square. D. The products of the different possible fusion of gametes are written in the appropriate boxes to show the differ ...
(PSD) March 2015 PBAC Meeting
(PSD) March 2015 PBAC Meeting

... The IPSOS Oncology Monitor dataset (quarter 4 2012 - quarter 3 2013) found that fludarabine + cyclophosphamide + rituximab (FCR, which would include FCR-lite) was the most commonly used regimen in second and later lines of therapy (used in 30% of patients), while rituximab monotherapy (± prednisone) ...
April 23, 2009 Division of Dockets Management Food and Drug
April 23, 2009 Division of Dockets Management Food and Drug

... been cleared by FDA and such autoinjector is in fact safer than the reference drug product’s autoinjector in that it includes additional safety features that are required by the FDA adopted consensus standards used to clear such device. In fact, King’s argument, if accepted, would mean that applican ...
Dementia
Dementia

... HEPATIC SYSTEM (1 of 2) • Decrease in liver volume • 40% reduction in liver blood flow  Anesthesia and abdominal surgery also reduce blood flow  Reduced maintenance requirements for drugs that are rapidly cleared by the liver  Modest reduction in the rate of hepatic metabolism for drugs slowly cl ...
Strategies for getting rid of horn genes in poll-Merino
Strategies for getting rid of horn genes in poll-Merino

... alleles for horns – i.e. the HH genotype. Polled animals can have a genotype of either PP or PH. The test for the horn gene is based on a marker that is close to the gene that provides information on the combination of alleles. Based on our observations in the Information Nucleus we can predict whet ...
PRELIMINARY STUDIES ON GASTRO-PROTECTIVE CHIMERIC DERIVATIVE OF BIPHENYL
PRELIMINARY STUDIES ON GASTRO-PROTECTIVE CHIMERIC DERIVATIVE OF BIPHENYL

... in combination. The most common adverse reactions of NSAIDs reported to drug regulatory authorities are of gastrointestinal (GI) origin followed by renal damage, skin reactions, blood dyscrasias, headaches and nausea2. COX-2 inhibitors decrease incidence of GIT adverse effects, but have significant ...
ASHP Technical Assistance Bulletin on Compounding Nonsterile
ASHP Technical Assistance Bulletin on Compounding Nonsterile

... is not available, the pharmacist should use professional judgment and may have to obtain the highest-grade chemical possible. Chemical grades that may be considered in this situation are ACS grade (meeting or exceeding specifications listed for reagent chemicals by the American Chemical Society) and ...
united states securities and exchange commission - corporate
united states securities and exchange commission - corporate

... Further Development of CD101 Topical for VVC to be discontinued CD101 IV development program in candidemia and invasive candidiasis (including Phase 2 STRIVE trial) continuing and remains on track Company to Host Conference Call Today at 5:30 a.m. PT SAN DIEGO, February 21, 2017 – Cidara Therapeutic ...
QA324_3_Which_Drugs_Cause_NMS
QA324_3_Which_Drugs_Cause_NMS

... patient experienced symptoms of NMS due to a reduced dose of amantadine which resolved on the dose being increased. The symptoms recurred following re-challenge, then resolved the dose was increased.(21) Bromocriptine and levodopa have been used successfully as treatments for NMS caused by dopamine ...
Lidocaine HCI 2% and Epinephrine 1:50,000 Injection Lidocaine
Lidocaine HCI 2% and Epinephrine 1:50,000 Injection Lidocaine

... The safety and effectiveness of lidocaine depend on proper dosage, correct technique, adequate precautions and readiness for emergencies. Consult standard textbooks for specific techniques and precautions for various regional anesthetic procedures. Resuscitative equipment, oxygen and other resuscita ...
Spinocerebellar Ataxia with Oculomotor Apraxia
Spinocerebellar Ataxia with Oculomotor Apraxia

... the most frequent presenting sign, as in our patient. It is characterized by cerebellar atrophy, peripheral neuropathy (100% of cases), OMA (50% of cases), and frequently elevated serum alpha-fetoprotein, while our patient presented normal values. Genetic examination on chromosome 9q34 showed SETX m ...
Recent advances in the molecular genetics of congenital
Recent advances in the molecular genetics of congenital

... APS1 families (A and B). Subject II-1, family A has only the mutant 216 bp band, and neither of the wild-type digestion products, demonstrating that he is homozygous for the 13 bp deletion. His mother I-2, can be seen to be heterozygous for this deletion. In contrast, his father I-1, has only the wi ...
Cocaine Abuse
Cocaine Abuse

... the rest of the body. The effects of the drug vary greatly, depending on the route of administration, amount, purity, and effects of the added ingredients. The effect also varies with the user’s emotional state while taking the drug. This is based on the user’s attitude toward the drug, the physical ...
Opioid Antagonists Under Heavy Sedation or General Anesthesia as
Opioid Antagonists Under Heavy Sedation or General Anesthesia as

... A search of ClinicalTrials.gov in November 2015 did not identify any ongoing or unpublished trials that would likely influence this review. Summary of Evidence The evidence for ultrarapid detoxification under general anesthesia in individuals who have opioid addiction includes both randomized and no ...
Drug abuse treatment as an HIV prevention strategy
Drug abuse treatment as an HIV prevention strategy

... that drug abuse treatment, especially MMT, is associated with decreased injection and sex-related HIV risk behaviors. The changes are most apparent in drug use, where 16 of the 17 studies examining drug use found that treatment was associated with less HIV risk (generally evidenced by less injection ...
Product Monograph - AstraZeneca Canada
Product Monograph - AstraZeneca Canada

... Dosage should be individualized, and patient response should be monitored by the prescribing physician on an ongoing basis. BRICANYL TURBUHALER Adults and Children ≥ 6 Years The generally recommended dose of BRICANYL TURBUHALER (terbutaline sulfate) is one inhalation (0.5 mg) taken as required. This ...
Educational Items Section Genetic Linkage Analysis Atlas of Genetics and Cytogenetics
Educational Items Section Genetic Linkage Analysis Atlas of Genetics and Cytogenetics

... different places on the genome, can give rise to the same disorder. This is known as genetic heterogeneity of localization. One of the following two tests is used to identify heterogeneity of this type, the "Predivided ...
Product
Product

... • 200mg/d of a standardized extract of the root containing 4-7% ginsenosides; it is recommended to take for 4 weeks then stop for 1-2 weeks. •Adverse Effects •much listed but close evaluation indicates wide safety; reports of problems may be associated with poor products and adulterated products •Dr ...
< 1 ... 221 222 223 224 225 226 227 228 229 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report