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Duration of Dual Antiplatelet Therapy after Coronary Stent Placement
Duration of Dual Antiplatelet Therapy after Coronary Stent Placement

... ○ Follow-up of discontinuation of study medication for additional 3 months ○ High retention rate for follow up (94.3% across both treatment groups) There may be additional benefit to continue thienopyridine use beyond 12 months in patients with no major cardiovascular events, bleeding events, or ste ...
Asthma Technology
Asthma Technology

Evolutionary Algorithms
Evolutionary Algorithms

... • if the probability that a certain number of genes is exchanged between the parent chromosomes is not the same for all possible numbers of genes • undesired, because it causes partial solutions of different lengths to have different chances of progressing to the next generation • distributional bia ...
06_chapter_3
06_chapter_3

... Propofol is highly protein-bound in vivo and is metabolized by conjugation in the liver.(90) Its rate of clearance exceeds hepatic blood flow, suggesting an extrahepatic site of elimination as well.(91) The half life of elimination of propofol has been estimated at between 2 and 24 hours. However, i ...
Pharmacologic Advances in Canine and Feline Reproduction TOPICAL REVIEW
Pharmacologic Advances in Canine and Feline Reproduction TOPICAL REVIEW

... agonists, antiprogestational agents). However, current lack of availability in the United States and expense have limited the use of these agents. Because of manufacturer discontinuation of some older products and limited availability of newer agents, there has been an overall decline in drug option ...
Herbal medicinal products for non-ulcer dyspepsia
Herbal medicinal products for non-ulcer dyspepsia

... fewer gastrointestinal symptoms compared with the placebo group (P ¼ 0.003). The symptoms that showed most improvement were stomach pains, bilious complaints, flatulence, nausea and sensation of fullness. Eight patients reported adverse events during the study, five whilst receiving placebo (insomni ...
Document
Document

... (from maternal heterosis) when crossbred ewes are used in place of purebred ewes. This combining of maternal and individual heterotic effects is one reason why three-way crosses are common in animal breeding, generally by crossing a male from line A with a hybrid female (from a B x C cross). ...
T s e n
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... concurrent with macrolide antibiotics (erythromycin), cyclosporine, diltiazem, verapamil AR: bloating, constipation, sequestration of anionic and amphipathic lipid-soluble drugs (thyroxine, digoxin, coumadine, furosemide) and Vit A, D, E, K. ...
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... True-breeding or homozygous • True-breeding means that they only have one version of a trait to pass on or homozygous. • Sometimes we refer to homozygous organisms as being a “pure bred”. • If a pea plant came from parents that were tall, it is tall and all of its offspring are tall when crossed wi ...
Genetic Variation of Multilocus Traits
Genetic Variation of Multilocus Traits

... Most traits of interest, however, are expected to be influenced by numerous loci A number of factors must be considered for traits that are influenced by more than one locus including ...
Interventional Spine and Pain Procedures in Patients - cmp
Interventional Spine and Pain Procedures in Patients - cmp

Depakote 250mg
Depakote 250mg

... Although the pharmacokinetics of Depakote are modified in the elderly, they have limited clinical significance and dosage should be determined on the basis of clinical response. Children and adolescents The safety and efficacy of Depakote for the treatment of manic episodes in bipolar disorder have ...
Effects of Pioglitazone and Rosiglitazone on Blood Lipid Levels and
Effects of Pioglitazone and Rosiglitazone on Blood Lipid Levels and

... Buckgrolmd: The antihyperglycemic effects of pioglitazone hydrochloride and rosiglitazone maleate are well documented. The results of clinical trials and observational studies have suggested, however, that there are individual differences in the effects of these drugs on blood lipid levels. Objectiv ...
KLONOPIN® TABLETS (clonazepam)
KLONOPIN® TABLETS (clonazepam)

... enhance the activity of gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Convulsions produced in rodents by pentylenetetrazol or, to a lesser extent, electrical stimulation are antagonized, as are convulsions produced by photic stimulation in susce ...
Title Improving clinical trial efficiency by biomarker
Title Improving clinical trial efficiency by biomarker

... Affiliation: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands. ...
Provisional PDF - Nanoscale Research Letters
Provisional PDF - Nanoscale Research Letters

... an animal experiment was in favor of the Ethical Committee of the Sun Yat-sen University (Guangzhou, China) and performed in accordance with the National Institute of Health and Nutrition Guidelines for the Care and Use of Laboratory Animals. Six beagle dogs (1.2 to 2.0 years of age) weighing 12 to ...
Minnesota Statutes 2016, Section 152.01
Minnesota Statutes 2016, Section 152.01

... (2) with respect to a particular person, if the person represents or intends that the substance have a​ stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to​ or greater than the stimulant, depressant, or hallucinogenic effect on the central n ...
Module 2: The Science of Addiction
Module 2: The Science of Addiction

... Use of medications as a component of treatment can be an important in helping the person to achieve their treatment goals. Opioid addiction affects a large number of people, yet many people do not seek treatment or treatment is not available when they do. Expanding treatment options can  make treat ...
Bacterial Growth Kinetics of "M. lufu" in the Presence and Absence
Bacterial Growth Kinetics of "M. lufu" in the Presence and Absence

... technique. In previous papers we have reported on bacterial growth kinetic studies to quantify the synergistic action of dihydrofolate inhibitors like trimethoprim in combination with sulfonamides and sulfones using E. colt as a test organism ( 1 ". 17 .'""). Other than the application of special tr ...
magnesium sulfate (epsom salt)
magnesium sulfate (epsom salt)

... medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum informat ...
SERIES ‘‘THE GENETIC AND CARDIOVASCULAR ASPECTS OF OBSTRUCTIVE SLEEP APNOEA/HYPOPNOEA SYNDROME’’
SERIES ‘‘THE GENETIC AND CARDIOVASCULAR ASPECTS OF OBSTRUCTIVE SLEEP APNOEA/HYPOPNOEA SYNDROME’’

... chest wall compliance [44]. There is increasing evidence that adipokines, such as leptin, may affect regulation of the respiratory centre [45]. The heritability in BMI in large sample sizes is thought to be between 25% and 40%; therefore, a strong environmental influence is present [46]. Susceptibil ...
PREPARATION AND CHARACTERIZATION OF ORODISPERSIBLE TABLETS OF CANDESARTAN
PREPARATION AND CHARACTERIZATION OF ORODISPERSIBLE TABLETS OF CANDESARTAN

... superdisintegrants. Prepared tablets disintegrate within few seconds without need of water; thereby enhance absorption possibility may increase leading to increased bioavailability. Thus the present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and i ...
Formulation and Evaluation of Itopride Hydrochloride Floating
Formulation and Evaluation of Itopride Hydrochloride Floating

... Oral drug delivery is the most widely utilized route of administration for systemic delivery of drugs via pharmaceutical products of different dosage form among all the explored routes. Oral route is considered most natural, uncomplicated, convenient and safe due to its ease of administration, patie ...
Familial spontaneous pneumothorax and mutation CASE STUDY
Familial spontaneous pneumothorax and mutation CASE STUDY

... birth revealed an oval soft tissue mass in the left lower lobe containing cysts, which appeared to regress on follow-up scan. There were no distinguishing features to this lesion. It gradually transformed into a persistent soft tissue opacity in the left lower lobe. Sonographic examination of the ki ...
Population Genetics and Evolution Lab
Population Genetics and Evolution Lab

... In this exercise, we will be adding selection to make it a more realistic situation. In this case, there is 100% selection against homozygous recessive offspring. The recessive allele in this case is mutated making an “aa” individual non-viable. “Aa” and “AA” are viable and will be able to reproduce ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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