• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Should we be concerned about herbal remedies
Should we be concerned about herbal remedies

... particularly India, for patients to seek concurrent treatment through more than one Indian Medicinal System as well as allopathy, or in Chinese herbalism to fraudulently incorporate pharmaceuticals in some remedies. This only compounds issues related to recognizing the source of potential side effec ...
Treatment of Hepatitis C in Patients with HIV
Treatment of Hepatitis C in Patients with HIV

... therapy have demonstrated comparable rates of sustained virologic response in coinfected and monoinfected patients (Figure 4), providing convincing evidence that coinfected patients may no longer require the designation of a special or “treatment refractory” population. It should be noted that these ...
A Linear Dose-Response Curve at the Motor Endplate
A Linear Dose-Response Curve at the Motor Endplate

... muscle. The size of the response and the form of the dose-response curve were considered to be intimately related to an initial action of the drug at the receptor. Originally the response was thought to be directly related to the proportion of receptors occupied (Occupation Theory), the number of re ...
MELATONIN for treatment of sleep onset insomnia and
MELATONIN for treatment of sleep onset insomnia and

... that provided evidence for the efficacy of Circadin® tablets used off-label in children with sleep disorders and ADHD. Limited evidence for unlicensed melatonin products was identified from 2 small (n = 105 and 19) short-term randomised controlled trials (RCTs) and one small, long-term follow-up st ...
Priority Issues From the AAMI/FDA Infusion Device Summit
Priority Issues From the AAMI/FDA Infusion Device Summit

... On Oct. 5–6, 2010, a remarkable group of diverse experts came together to change the world of infusion devices. The AAMI/FDA Infusion Device Summit opened with this quote from Margaret Mead: “Never doubt that a group of thoughtful, committed citizens can change the world. Indeed, it is the only thin ...
Prescribing information - Upsher
Prescribing information - Upsher

... congenital anomalies or other adverse fetal outcomes following metronidazole exposure during pregnancy. Three studies conducted to assess the risk of infant cancer following systemic metronidazole exposure during pregnancy did not show an increased risk; however, the ability of these studies to dete ...
Know your patient`s renal function
Know your patient`s renal function

... every 10 years after 40 years of age.2,3 Up to 90% of renal function can be lost before symptoms become evident.4 For many medicines a decline in renal function can profoundly impact upon the safety and efficacy of treatment. Analysis of the DVA health claims database indicates that 27% of veterans ...
pain - Conferences
pain - Conferences

... • Effective as oxycodone CR in chronic moderate to severe pain6* • Superior GI tolerability vs oxycodone CR6* • Significantly greater improvement in 7 of 8 SF-36 health-related measures of quality of life compared with oxycodone CR6* • Sustained relief to 1 year, with similar adverse effects to that ...
Fatal intoxication due to tramadol alone Case report and review of
Fatal intoxication due to tramadol alone Case report and review of

... inotropic therapy. The patient was ventilated in a pressurecontrolled mode. Because of progressive hepatic failure, with ammonia levels as high as 175 IU/l, a liver biopsy was performed the next day, showing both steatosis and centrolobular necrosis. Therapy was mainly supportive including the initi ...
Silent polymorphisms in the RYR1 gene do not modify the
Silent polymorphisms in the RYR1 gene do not modify the

... Conclusions: Considering that patient’s relatives showed no pathologic phenotype, and the phenotype presented by the patient is within the range observed in other central core disease patients with the same mutation, it was concluded that the c.14256 A > C polymorphism alone is not responsible for d ...
Potent inhibition of human cytochrome P450 3A isoforms
Potent inhibition of human cytochrome P450 3A isoforms

... human livers (Shimada et al., 1994), is capable of metabolizing structurally diverse compounds, such as diltiazem, midazolam, erythromycin, and cyclosporine (Rendic, 2002). CYP3A5, which is polymorphically expressed in the liver (Kuehl et al., 2001), also can catalyze oxidations of a variety of drug ...
Your Guide to Taking
Your Guide to Taking

... (gastrointestinal stromal tumor) that cannot be treated with surgery or that has spread to other parts of the body and for which they have received previous treatment with certain medicines. STIVARGA has not been used to treat children less than 18 years of age. This brochure can help you understand ...
www.ijpbs.com Rishikesh S Deshmukh*et al Int J Pharm Bio Sci
www.ijpbs.com Rishikesh S Deshmukh*et al Int J Pharm Bio Sci

... The description, characterization and quantitation of the identified and unidentified impurities present in new drug substances is known as impurity profile. Impurity is defined as any substance coexisting with the original drug, such as starting material or intermediates or that is formed, due to a ...
Update on the evaluation of hypersensitivity reactions to
Update on the evaluation of hypersensitivity reactions to

... BP up to a concentration of 10 000 IU/ml in skin testing may increase the allergological work-up sensitivity, it is recommended that in case of negative results to the classical penicillin reagents (PPL and MDM), BP should also be tested. Finally, subjects who have experienced immediate reactions to ...
Anesthesia in Proctology
Anesthesia in Proctology

... effects of epinephrine. Anesthesiology 1971;34:514–522. 4. Clery AP. Local anesthesia containing hyaluronidase and adrenaline for anorectal surgery experiences with 576 operations. Proc R Soc Med 1973;66:680–681. 5. Cuccia G, Forster A and Marti M-C. Positioning and anesthesia for anorectal surgery. ...
Orally Disintegrating Tablets
Orally Disintegrating Tablets

... ew drug-delivery technologies are often championed by contract manufacturing organizations. For new technologies that provide significant clinical as well as financial value, research and innovation in the contractmanufacturing and pharmaceutical segments lead to the emergence of numerous competing ...
Risperdal/Risperdal M-Tab/ Risperdal Consta (risperidone)
Risperdal/Risperdal M-Tab/ Risperdal Consta (risperidone)

... symptoms (EPS) when the dosage of Risperdal exceeds 6 mg/day. EPS are neurological disturbances produced by antipsychotics (or other causes) in the area of the brain that controls motor coordination. These side effects include muscle rigidity, tremors, drooling, restlessness, a “mask-like” facial ex ...
Ibrutinib
Ibrutinib

... (PCYC-1112-CA) was conducted in patients with CLL/SLL. Patients (n=391) were randomized 1:1 to receive either ibrutinib 420 mg daily until disease progression or unacceptable toxicity, or ofatumumab for up to 12 doses (300/2000mg). Fifty-seven (n=57) patients randomized to ofatumumab crossed over fo ...
Pain - Full Circle Center for Integrative Medicine
Pain - Full Circle Center for Integrative Medicine

...  Work by affecting neurotransmitters  Do not only work for treating pain by improving ...
HYDROXYZINE
HYDROXYZINE

... control emesis, and reduce narcotic dose (injection) • Nausea and vomiting (injection) • Insomnia ...
spanish interdisciplinary committee for cardiovascular disease
spanish interdisciplinary committee for cardiovascular disease

... risk factors for atherosclerotic vascular disease. The major atherothrombotic complications of hypercholesterolemia lead to elevated morbidity and are the main cause of death worldwide.2 Thus, the prevention and management of hypercholesterolemia in the context of cardiovascular risk management is a ...
Therapeutic approaches in arterial thrombosis
Therapeutic approaches in arterial thrombosis

... application of existing therapies, clearly, truly effective treatment of the thrombotic consequences of atherosclerosis requires not only the development of drugs to be used as primary care on a chronic basis to prevent thrombosis and its ischemic complications but also to block the contribution of ...
Tall
Tall

... flip. . . So can use probability to predict outcomes of genetic crosses. ...
A Nationwide Study of ADHD Drug Use among Adults in
A Nationwide Study of ADHD Drug Use among Adults in

... To the wonderful people at the Centre of Public Health, you are all amazing and it has been a privilege to learn from you and work with. To Dóra Ólafsdóttir, thank you for guiding through the paperwork, being a constant source of valuable information and your willingness to assist. To Thor Aspelund, ...
Chapter 3: Effects Of Amphetamine-Type Stimulants
Chapter 3: Effects Of Amphetamine-Type Stimulants

... comparing the findings because criteria for drug use and diagnostic cut-off scores differed between the surveys. In the NDSHS, those who had used the drug at least once in the previous month had the following K10 scores: for meth/amphetamine, 36% were low risk, 33% medium risk, 21% high risk and 10% ...
< 1 ... 224 225 226 227 228 229 230 231 232 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report