• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
What Rx is he taking?
What Rx is he taking?

... paradigm typically consists of… • 1st line Rx – used most - BEST CASE? • 2nd line Rx – used when one or more first line drugs have unacceptable side effects/don’t work; sometimes used in combination with first line • 3rd line Rx – more potent, more side effects; used when 1st and 2nd line both fail, ...
drug analysis - WordPress.com
drug analysis - WordPress.com

... of metabolism. This means that when the mechanism is saturated, the plasma level rises rapidly for small increments in dose • Carbamazepine and valproate are usually monitored, especially if in combination, as they and phenytoin and phenobarbitone all compete for albumin binding sites and allowances ...
Recently Introduced Products
Recently Introduced Products

... Ozurdex consists of a specially designed drug delivery system that is injected into the eye by an ophthalmologist. The recommended dose is one implant into the affected eye, and retreatment may occur at an interval of approximately 6 months. Repeat doses are intended for patients who initially respo ...
BIOL 106
BIOL 106

... ...
16-pharmacologyppt3005
16-pharmacologyppt3005

... Additive action: Combination of 2 similar drugs is equal to the sum of effect of each (Drug A 10% + Drug B 20% = 30%). Idiosyncrgistic: Unexpected effect that may appear in the patient following administration of the drug idiosyncrgistic reaction, which are due to genetic deficience of enzymes are p ...
Medication Administration
Medication Administration

... • The medicines are legally prescribed. • The patient receiving the medicine is informed that it will be administered by a student, and agrees to the process. • The registered nurse/midwife supervises the student from the selection of medicine through to its administration and is responsible for the ...
In the prehospital setting, the goal of emergency pharmacology is to
In the prehospital setting, the goal of emergency pharmacology is to

... through the skin), enteral (absorbed somewhere along the gastrointestinal tract), and parenteral (any route of administration that does not cause the drug to be absorbed through the skin, mucous membranes, or gastrointestinal tract). Every medication has varying effects on the body. The study of the ...
510-08Pgenetics - dan
510-08Pgenetics - dan

... absorption of some drugs (digoxin) by altering carrier proteins or barrier compounds in the GI tract. – 5-hydroxytryptamine transporter polymorphisms can affect the neuronal reuptake of serotonin, an important neurotransmitter. – Plasma cholinesterase, which readily breaks down succinylcholine, tetr ...
Module 22 Notes
Module 22 Notes

... Found in beer, wine, and liquor The _____ most used psychoactive drug (caffeine first) Slows thinking, and impairs _______ activity Blood Alcohol Content (BAC) A measure of how much _______ is in a person’s bloodstream Alcohol _______ the parts of the brain responsible for controlling ________ and m ...
the combination of two snps in the abcc2 gene, coding for multidrug
the combination of two snps in the abcc2 gene, coding for multidrug

... Summary: Several findings indicate a role for ABC-type (ATP-binding cassette) drug efflux transport proteins in influencing the variability of clinical opioid effects. This phenomenon is attributed to variations in expression and activity secondary to genetic and environmental factors, leading to va ...
A reality check for personalised medicine: just a few errors in
A reality check for personalised medicine: just a few errors in

... overall efficiency… • And avoids ‘wasting’ scarce resource of kidney: a genuine ethical dilemma ...
Table of Valid Genomic Biomarkers in the Context of
Table of Valid Genomic Biomarkers in the Context of

... Drugs sharing the context of a specific biomarker in their labels have had their pharmacogenomic information extracted into this table. This information can be accessed by placing the mouse over the symbol under the right side of the drug name. All approved drugs in this table are linked to labels a ...
A SURVEY OF UTILIZATION OF MEDICATIONS WITHOUT PRESCRIPTION AMONG IN
A SURVEY OF UTILIZATION OF MEDICATIONS WITHOUT PRESCRIPTION AMONG IN

... abuse in general population. During the chronic drug therapy of the patient used other medication for particular illness (without physician knowledge) will cause one drug is changed by presence of other drug(s), food, drink or environmental chemicals. When therapeutic combination could lead to an un ...
Basic Biopharmaceutics
Basic Biopharmaceutics

... How Drugs Work • When a drug produces an effect, it is interacting at a molecular level with cellular material or structure. • Cellular material directly involved in the action of the drug is called a receptor. • The receptor is described as a lock into which the drug molecule fits as a key. • Drug ...
a) - WordPress.com
a) - WordPress.com

... Tour the pharmacy department and all other areas in the hospital where pharmacists are located Tour the main areas of the hospital, noting where any drug distribution system areas are located If possible, tour other regional hospitals to observe different drug distribution systems Complete the gener ...
ISHIK UNIVERSITY FACULTY OF DENTISTRY
ISHIK UNIVERSITY FACULTY OF DENTISTRY

... by the acid juice of the stomach, but are dissolved in the intestinal juice (alkaline) only. ◦ Preventing gastric irritation and alteration of the drug in the stomach. ◦ To get the desired concentration of the drug in intestine. ◦ To delay the absorption of the drug ...
Slide 1
Slide 1

... Kidney : Ionized drugs > non ionized drugs Alkalinization ( Phenobarbital ) Bicarbonate Acidification ( Amphetamine ) Vitamin C G.I.Tract : Morphine Lungs : Anesthetics Saliva : Dermatitis ( some intravenous drugs ) Mammilary glands : pH= 6.5 Morphine ...
Meiji announces Initiation of Phase II/III and Long
Meiji announces Initiation of Phase II/III and Long

... “Meiji”) announces that it has initiated Phase II/III confirmatory and Phase III long-term clinical trials of ME2125 (development code name, INN: safinamide) as add-on therapy to levodopa in Japanese patients with Parkinson’s disease with the "wearing-off" phenomenon*1. ME2125 is a selective monoami ...
Slide 1
Slide 1

... Kidney : Ionized drugs > non ionized drugs Alkalinization ( Phenobarbital ) Bicarbonate Acidification ( Amphetamine ) Vitamin C G.I.Tract : Morphine Lungs : Anesthetics Saliva : Dermatitis ( some intravenous drugs ) Mammilary glands : pH= 6.5 Morphine ...
Biomedical Therapies
Biomedical Therapies

... – Using electricity to shock the brain, thereby calming the neural centers where overactivity produces depression – Patient is anesthetized (unconscious) – Given a muscle relaxant – Their brain is shocked with about 100 volts – Side effects: memory loss – Effective for severe depression that hasn’t ...
PROFESI KEFARMASIAN (I)
PROFESI KEFARMASIAN (I)

... The drug in a particular dosage form is not commercially available on the market The extraordinary low or high dose is needed (young children, elderly people, special situations – e.g., intoxications). In this case right dosage strength need not be readily commercially available for every patient Th ...
Deprescribing in older adults - Ohio Medical Directors Association
Deprescribing in older adults - Ohio Medical Directors Association

... Distribution refers to the locations in the body a drug penetrates and the time required for the drug to reach these levels; expressed as the volume of distribution (Vd) ...
Ch 17 Evolution of Populations
Ch 17 Evolution of Populations

... CH 17 EVOLUTION OF POPULATIONS 17.1 Genes and Variation ...
The Psychology and Physiology of Street Drugs Amie J. Hatch
The Psychology and Physiology of Street Drugs Amie J. Hatch

... Updates on Spice and Bath Salts Spice Case Reports ...
dental second assessment
dental second assessment

< 1 ... 1229 1230 1231 1232 1233 1234 1235 1236 1237 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report