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PRESENTATION - FINAL - Critical Path to TB Drug Regimens
PRESENTATION - FINAL - Critical Path to TB Drug Regimens

... the timepoint for comparison will still be defined by the SOC control group (24 mos vs 6 mos) ...
Atacand - DavisPlus
Atacand - DavisPlus

... ● Decrease in BP without appearance of excessive side effects. Antihypertensive ef- ...
PDF
PDF

... antiplatelet agents may have altered effects in different patients. He was amongst the first to define how different genetic polymorphisms may affect profiles on individual response to antiplatelet therapy. Further, his discoveries have led to the identification of specific drug-drug interactions wi ...
Document
Document

... 36 healthy, volunteers This gives them the rate of absorption, or bioavailability, of the generic drug, which they can then compare to that of the innovator drug The generic version must deliver the same amount of active ingredients into a patient's bloodstream in the same amount of time as the inno ...
Questions 2011-engl
Questions 2011-engl

... (1) less informative than a cytogenetic banding analysis alone. (2) a high resolution method. (3) sometimes hard to interpret due to copy number polymorphism of the human genome. (4) to be done without computer based supporting software. (5) a method, which only detected gain and loss of genetic mat ...
Slide 1
Slide 1

... pathologic conditions (impaired physiological function). ...
The right to a child
The right to a child

How Drugs Enter The Body (1)
How Drugs Enter The Body (1)

... Water Soluble substances pass through the body more quickly. Factors Effecting the Process of Biodegradation - Quantity - larger the amount, more quickly metabolized (except for alcohol) - Type of drug ...
SCP Sodium Aurothiomalate Oct 2012
SCP Sodium Aurothiomalate Oct 2012

... Dose (posology & method of administration) (click here for details) An initial test dose of 10 mg should be given in the first week followed by weekly doses of 50 mg until signs of remission occur. At this point 50 mg doses should be given at two week intervals until full remission occurs. With full ...
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... Drug Types • Types – Psychoactive – alters mood or consciousness; ...
Basic Principles of Genetics: Printable Crossword Puzzle
Basic Principles of Genetics: Printable Crossword Puzzle

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Date - Skills Commons
Date - Skills Commons

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Pharmacokinetic processes: liberation
Pharmacokinetic processes: liberation

1. An introduction to drugs, their action and discovery
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Drugs
Drugs

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phenelzine (fen-el-zeen) - DavisPlus
phenelzine (fen-el-zeen) - DavisPlus

... cidal tendencies, especially during early therapy. Restrict amount of drug available to patient. Monitor BP and pulse rate before and frequently during therapy. Report significant changes promptly. Monitor intake and output ratios and daily weight. Assess patient for peripheral edema and urinary ret ...
L-Viava 1 g/10 ml 10 Vials of 10 ml
L-Viava 1 g/10 ml 10 Vials of 10 ml

... should be regularly monitored and where it is necessary to carry out the dosage adjustment of hypoglycemic drugs and insulin. THE INFLUENCE ON THE ABILITY TO DRIVE AND TO OPERATE MECHANISMS Drug doesn’t influence on the ability to drive or operate with mechanisms. APPLICATION DURING PREGNANCY AND LA ...
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19 Common pharmacology

... • Albumin, lipoproteins, 1-acid gycoprotein and globulins • specific proteins-carriers: glucocorticosteroids – transcortin, vitamin В12 – transcobalamin, iron ions – transferrin, copper ions – ceruloplasmin free and bound with proteins forms of a drug stay in condition of dynamic balance ...
Regulatory Guidance for Genetic Testing
Regulatory Guidance for Genetic Testing

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OptumRx - National Labor and Management Conference
OptumRx - National Labor and Management Conference

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factors modifying drug dose-response relationship
factors modifying drug dose-response relationship

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Drug Information Summary - Nalbuphine
Drug Information Summary - Nalbuphine

... itch (OII), a phenomenon which has both central and peripheral mechanisms. (The commonly used option, diphenhydramine or Benadryl, is sedating, and potentially dangerous in the elderly.) Nalbuphine also has analgesic properties on its own. It is equianalgesic to morphine, so doses administered at a ...
170 KB
170 KB

... Bromhexine may increase the concentration of concurrently administered antibiotics in bronchial secretions. No clinically relevant interactions with other medications have been reported. Statement on Usage During Pregnancy and Lactation Pregnancy There is no data on the use of bromhexine in pregnant ...
Driver Diagrams - Ohio Hospital Association
Driver Diagrams - Ohio Hospital Association

... • Use ISMP assessment tool • Assess clinical staff knowledge (pre-test); Educate; 6 wks post test; Target gaps • HAMS-Insulin, Anticoagulants/Antithrombolytics, Narcotics, Sedatives ...
Predicting the Cost and Pace of Pharmacogenomic Advances
Predicting the Cost and Pace of Pharmacogenomic Advances

... confirmatory report (or a subsequent meta-analysis, where available) each association’s percent attributable risk for its adverse outcome (Table S1). For each drug we used product inserts, US Food and Drug Administration safety reports, and Medline to determine its adverse-outcome profile, defined a ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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