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Click here to view the presentation slides

... cannot be used together (with other biologics) increased common & rare infections (TB) Must stop drug during infection/surgery (flare risk) ? Patients with chronic infections (bronchiectasis, COPD, bone & joint, TB, hepatitis) COST - rationing (“NICE guidelines”) ?? long term side effects  BSRBR ...
presentation here.
presentation here.

...  “…a state of adaptation that is manifested by a drug class-specific abstinence syndrome following abrupt cessation, rapid dose reduction, decreasing blood level of the drug, and/or administration of an antagonist”  Also occurs in antihypertensives and steroids  Not a problem when dosage tapered ...
KETHEA MOSAIC Supporting drug addicted - SMES
KETHEA MOSAIC Supporting drug addicted - SMES

... • The drug users consist a special group among the emigrants/refugees • Case of “double exclusion” : drug addiction’s stigma and stigma of being “stranger” • Apart from the social exclusion, two other facts that increase the percentage of drug addicts (emigrants & refugees), are: a. The availability ...
Cardiology
Cardiology

... choose not to be tested for PSEN1 and PSEN2, two genes thought to be responsible for ~1% of dilated cardiomyopathy, but also known to cause an increased risk for early-onset Alzheimer’s disease. Testing may also reveal carrier status for recessive or X-linked conditions, including Barth syndrome and ...
Epic Pharmacy Circuit Newsletter
Epic Pharmacy Circuit Newsletter

... of stroke must be assessed using the CHA2DS2-VASc score4 evaluating age, sex, blood pressure, other comorbidities and stroke risk factors to determine their annual stroke risk percentage based on a score between 0 and 9. Patients who score zero are classified as low risk and do not require any anti- ...
Study Guide for Test
Study Guide for Test

... 1. Law of Dominance 2. Law of Segregation 3. Law of Independent Assortment ...
“What You Need To Know About Prescription Drugs in York County!”
“What You Need To Know About Prescription Drugs in York County!”

... • It is estimated that 40 percent of prescription drugs - particularly pain-killers, antibiotics, and cardiovascular medicine - that are prescribed outside of hospitals go unused every year. Left in the home, they present a serious health and safety hazard. Flushed down the drain, they contaminate o ...
CYP2C19 - Cleveland Heart Lab
CYP2C19 - Cleveland Heart Lab

... 1. Desta Z et al. Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet. 2002; 41: 913-958. 2. Product Information for Plavix (Sanofi/Aventis US). Label Information, approved Feb 2011. www.accessdata.fda.gov/drugsatfda_docs/label/2011/020839s052lbl.pdf. Accessed ...
Definitions (foundation
Definitions (foundation

... Chromosome ...
CHEMICAL MESSENGERS
CHEMICAL MESSENGERS

... mouth’s mucous membranes ...
Why do we need Pharmacovigilance?
Why do we need Pharmacovigilance?

... Adverse drug reactions • ADR is defined as any harm associated with the use of given drugs at a normal dosage during normal use. • ADRs may occur following a single dose or prolonged administration of a drug or result from the combination of two or more drugs. • The meaning of ADR differs from the ...
The Transfer of Genetic Characteristics
The Transfer of Genetic Characteristics

... particular trait. Phenotype refers to the physical appearance of an individual resulting from the expression of a genotype. ...
Integration with robot drug dispenser
Integration with robot drug dispenser

... preparation process. There are also clearly going to be cost savings – from nurses spending less time having to measure out patients’ medication, for example. At the moment the robot is working in four wards, packing the drugs the ward carries in its standard medication range. This creates a managed ...
document
document

... hypertension, including a condition known as cardiac fibrosis. ...
Genetics - Fort Bend ISD
Genetics - Fort Bend ISD

... • reproduction of gametes (Similar to mitosis, but there are 2 divisions, ending with ½ the number of chromosomes of the parent cell.) ...
A PRIMER OF DRUG ACTION
A PRIMER OF DRUG ACTION

... • Binding to a receptor site normally occupied by a neurotransmitter but not initiating a transmitterlike action blocks access of the transmitter to its binding site, which inhibits the normal physiological action of the transmitter. This is called an antagonistic action and the drug is termed and a ...
Biological approaches discussion points
Biological approaches discussion points

...  If we know what causes illness then we ...
Autoimmunity: relative risks
Autoimmunity: relative risks

... including gain- vs loss-of-function of risk allele • While many genes implicated, only a few have led to novel therapies…and those occur at the intersection of multiple alleles & ...
Big
Big

... interact with the body to improve health Traditional process of drug discovery was largely serendipitous (or not!) Recently, attempts at “rational drug design” – Started with solved protein structures – Now involves genomic sequence, gene expression arrays, high throughput chemical synthesis, bioinf ...
cansearch research laboratory
cansearch research laboratory

... Blood and Marrow Transplantation Group (EBMT) (ClinicalTrials.gov Identifier: NCT01257854) initiated by our group. In addition to genotype or haplotype based analysis, our studies also emphasizes the importance of other prognostic factors such as age, gender, co-medication and consideration of gene- ...
The HapMap project and its application to genetic
The HapMap project and its application to genetic

... development of more effective, safer medicines requires understanding of the genetic factors which govern variable drug response in different individuals. Recent advances in genetics and genomics are paving the way to develop diagnostic tests that will enable the administration of drugs to be tailor ...
Chapter 16-1 - greinerudsd
Chapter 16-1 - greinerudsd

... Small population may not fit the predicted genetic probabilities ...
ace inhibitors
ace inhibitors

... mellitus, these drugs prevent or slow the progression of kidney disease; as a result, they are often prescribed for patients whose blood pressure is normal. 2) What is an “ACE Inhibitor cough”? Cough is one of the most common side effects associated with ACE Inhibitor therapy. The severity of cough ...
Eschenbacher High Alert Medication Presentation October 2007
Eschenbacher High Alert Medication Presentation October 2007

... Benzodiazepines Warfarin Insulin IV ...
shands - UF Health Professionals
shands - UF Health Professionals

... of death, sometimes associated with dysphagia, pneumonia, and/or significant debility after treatment with BTX-A. There have also been rare reports of cardiovascular events including arrhythmias and myocardial infarctions, some with fatal outcomes —although the exact relationship with BTX-A use has ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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